Results 91 to 100 of about 108,092 (308)

Psychiatric adverse effects of chloroquine

, 2017
Chloroquine is a prototype antimalarial drug, widely used in several branches of medicine. Antimalarial drugs are used in the treatment of various dermatological, immunological, rheumatological and infectious diseases.
Tomasz Sobów, Anna Bogaczewicz
core   +1 more source

Parasitaemia and gametocytaemia after treatment with chloroquine, pyrimethamine/sulfadoxine, and pyrimethamine/sulfadoxine combined with artesunate in young Gambians with uncomplicated malaria. [PDF]

, 2001
As part of a study to assess the infectivity of gametocytes after treatment with four antimalarial regimens, the efficacy of each treatment was also determined.
Targett, G, Gijs Walraven, Jawara, M, Doherty, T, Lorenz von Seidlein, Tom Doherty, von Seidlein, L, Coleman, R, Musa Jawara, Geoffrey Targett, Rosalind Coleman, Walraven, G   +11 more
core   +1 more source

8‐Oxoguanine Modified CircMTUS1 Drives PABPC1 Phase Separation to Promote Gastric Cancer Progression and Cisplatin Resistance via Autophagy

Advanced Science, EarlyView.
ABSTRACT Gastric cancer (GC) is a major global health concern, as its prevention and treatment remain significant challenges. The 8‐oxoguanine (o8G) modification of circRNAs, alongside their capacity to orchestrate liquid‐liquid phase separation (LLPS) and autophagy, plays a pivotal role in driving tumor progression and determining therapeutic outcomes.
Lei Peng, Lurong Li, Zhenghui Zhu, Chenyang Li, Huaiming Sang, Guoxin Zhang, Xuan Li, Yini Dang, Yuanyuan Li   +8 more
wiley   +1 more source

PHARMACOKINETIC PROFILE OF CHLOROQUINE IN HEALTHY PAKISTANI SUBJECTS

Pakistan Armed Forces Medical Journal, 2008
Aim of Study: To study pharmacokinetics of chloroquine in healthy adult Pakistani subjects and evaluate the role of pharmacokinetic factor in the dynamics of drug resistance in Plasmodium falciparum. Design: This was an experimental study.
Muzammil Hasan Najmi, Mahmud Ahmad Akhtar   +1 more
doaj   +2 more sources

Two novel assays for the detection of haemin-binding properties of antimalarials evaluated with compounds isolated from medicinal plants. [PDF]

, 2002
Forty-two compounds isolated from nine plants used within South America for the treatment of malaria were tested for haemin binding using two novel, rapid screening methods.
Steele, JCP, Phelps, RJ, Meyer, DJ, Warhurst, DC, Simmonds, MSJ, J. C. P. Steele   +5 more
core   +1 more source

Renal Clearable Luminogenic Reporter for Ultrasensitive Influenza Virus Imaging and Efficient Antiviral Therapies Monitoring in Living Mice

Advanced Science, EarlyView.
A viral luminogenic reporter with chemiluminescence/fluorescence dual‐response and efficient renal clearance was developed for non‐invasive imaging and urinalysis of H1N1 virus protease, allowing for remote detection of H1N1 virus infections and monitoring of antiviral therapeutic efficacy in living mice.
Bankang Ruan, Chudan Liang, Meilin Hu, Weiping Xu, Jingjing Che, Jun Qian, Bingcai Jiang, Linna Liu, Xiancai Ma, Jiaguo Huang   +9 more
wiley   +1 more source

1H-NMR metabolite profiles of different strains of Plasmodium falciparum

Bioscience Reports, 2014
Although efforts to understand the basis for inter-strain phenotypic variation in the most virulent malaria species, Plasmodium falciparum, have benefited from advances in genomic technologies, there have to date been few metabolomic studies of this ...
Rongwei Teng, Adele M. Lehane, Markus Winterberg, Sarah H. Shafik, Robert L. Summers, Rowena E. Martin, Donelly A. van Schalkwyk, Pauline R. Junankar, Kiaran Kirk   +8 more
doaj   +1 more source

Antimalarials and the eye [PDF]

, 1989
Following the first reports in 1954 of the beneficial effects of chloroquine in cases of lupus erythematosus, this drug and its numerous derivatives have been used extensively in the treatment of systemic and discoid lupus erythematosus and rheumatoid ...
Coleiro, Joseph A.
core  

The relationship of physico-chemical properties and structure to the differential antiplasmodial activity of the cinchona alkaloids. [PDF]

, 2003
BACKGROUND: The 8-amino and 9-hydroxy substituents of antimalarial cinchona alkaloids have the erythro orientation while their inactive 9-epimers are threo.
Meyer David J, Adagu Ipemida S, Adagu, Ipemida S, Warhurst David C, Sylvia Y Lee, Meyer, David J, David C Warhurst, Craig John C, David J Meyer, Warhurst, David C, Lee, Sylvia Y, Ipemida S Adagu, Craig, John C, John C Craig, Lee Sylvia Y   +14 more
core   +1 more source

SPSB1 Promotes Subcutaneous Adipose Hyperplasia in Facial Port‐Wine Stains by Controlling HDAC1 Degradation and Stability Through Two Distinct Proteolytic Pathways

Advanced Science, EarlyView.
In PWS‐ASPCs, FOSL1 drives the expression of SPSB1. SPSB1, as part of the ESC complex, further binds to HDAC1 and promotes K29‐linked and K48‐linked polyubiquitination of HDAC1. These modifications facilitate the degradation of HDAC1 through the ALP and UPS pathways, respectively.
Hongrui Chen, Bin Sun, Yajing Qiu, Chen Hua, Xiaoxi Lin, Wei Gao   +5 more
wiley   +1 more source