Results 1 to 10 of about 3,119 (153)

Genetic diversity and evolutionary perspectives of Pfcrt in Plasmodium falciparum: insights from Indian and global isolates [PDF]

Malaria Journal
Background Chloroquine resistance in Plasmodium falciparum (Pf) driven by mutations in the Pf chloroquine resistance transporter (Pfcrt) gene continues to pose a challenge to malaria control in endemic regions like India.
Geetika Narang, Joseph Hawadak, Jahnvi Jakhan, Vineeta Singh   +3 more
doaj   +3 more sources

The Knock-Down of the Chloroquine Resistance Transporter PfCRT Is Linked to Oligopeptide Handling in Plasmodium falciparum

Microbiology Spectrum, 2022
The chloroquine resistance transporter, PfCRT, is an essential factor during intraerythrocytic development of the human malaria parasite Plasmodium falciparum.
Mike Barrett, Michael Lanzer, Cecilia Sanchez   +2 more
exaly   +3 more sources

Changing genetic profiles of Plasmodium falciparum piperaquine resistance in Southeast Asia over 25 years [PDF]

Antimicrobial Agents and Chemotherapy
Piperaquine resistance in Plasmodium falciparum has emerged in Southeast Asia and is strongly associated with mutations in the pfcrt gene and amplification of pfplasmepsin2/3.
Suttipat Srisutham, Kanokon Suwannasin, Aungkana Saejeng, Nardlada Khantikul, Rungniran Sugaram, Aung Pyae Phyo, Stephane Proux, Tiengkham Pongvongsa, Chea Nguon, Rupam Tripura, Nguyen Hoang Chau, Dysoley Lek, Nghia Ho Dang Trung, Thomas J. Peto, James J. Callery, Rob W. van der Pluijm, Chanaki Amaratunga, Mehul Dhorda, Lorenz von Seidlein, Mayfong Mayxay, Nguyen Thanh Thuy-Nhien, Paul N. Newton, Nicholas P. J. Day, Elizabeth A. Ashley, Francois H. Nosten, Frank M. Smithuis, Nicholas J. White, Arjen M. Dondorp, Mallika Imwong   +28 more
doaj   +2 more sources

Additional PfCRT mutations driven by selective pressure for improved fitness can result in the loss of piperaquine resistance and altered Plasmodium falciparum physiology

mBio, 2023
Malaria elimination efforts in Southeast Asia have been hindered by multidrug-resistant Plasmodium falciparum. High-grade resistance to piperaquine (PPQ, used in combination with dihydroartemisinin) is associated with PfCRT mutations that arose in ...
Laura M. Hagenah, Satish K. Dhingra, Jennifer L. Small-Saunders, Tarrick Qahash, Andreas Willems, Kyra A. Schindler, Gabriel W. Rangel, Eva Gil-Iturbe, Jonathan Kim, Emiliya Akhundova, Tomas Yeo, John Okombo, Filippo Mancia, Matthias Quick, Paul D. Roepe, Manuel Llinás, David A. Fidock   +16 more
doaj   +2 more sources

PfCRT mutations conferring piperaquine resistance in falciparum malaria shape the kinetics of quinoline drug binding and transport.

PLoS Pathogens, 2023
The chloroquine resistance transporter (PfCRT) confers resistance to a wide range of quinoline and quinoline-like antimalarial drugs in Plasmodium falciparum, with local drug histories driving its evolution and, hence, the drug transport specificities ...
Guillermo M Gomez, Giulia D'Arrigo, Cecilia P Sanchez, Fiona Berger, Rebecca C Wade, Michael Lanzer   +5 more
doaj   +3 more sources

Molecular surveillance of antimalarial drug resistance markers in the pfcrt, pfmdr1 and pfmrp1 genes of Plasmodium falciparum isolates from southeastern Iran. [PDF]

Malar J
Jafari M, Rezapour R, Nemati F, Mehrizi AA, Pirahmadi S.   +4 more
europepmc   +2 more sources

Collateral hypersensitivity between ZY19489 and piperaquine neutralizes PfCRT-mediated drug efflux and Plasmodium falciparum resistance. [PDF]

Nat Commun
Okombo J, Ndiaye T, Qahash T, Moura IMR, Gil-Iturbe E, Hagenah LM, Bridgford JL, Bonatto V, Ward KE, Yeo T, Narwal SK, Orta LV, Anderson I, Dhingra SK, Pasaje CFA, Park H, Kim J, Guido RVC, Jiménez-Diaz MB, Angulo-Barturen I, Niles JC, Mancia F, Uhlemann AC, Mok S, Quick M, Winzeler EA, Leroy D, Llinás M, Thathy V, Fidock DA.   +29 more
europepmc   +4 more sources

Rising of antimalarial drug resistance Pfmdr1 N86Y and Pfcrt K76T gene in Ethiopia: a systematic review and meta-analysis. [PDF]

J Genet Eng Biotechnol
Yeshanew TM, Begashaw BA, Bayisa GW, Getie B, Birhane N.   +4 more
europepmc   +2 more sources

<i>Plasmodium falciparum</i> Chloroquine Resistance Transporter (PfCRT) Is a Redox-Dependent Drug Transporter. [PDF]

Biochemistry
Chernitsky-Hamd D, Roy R, Schemm J, Schall A, Petros M, Willems A, Roepe PD.   +6 more
europepmc   +3 more sources

Plasmodium falciparum Chloroquine-pfcrt Resistant Haplotypes in Brazilian Endemic Areas Four Decades after CQ Withdrawn [PDF]

Pathogens, 2023
Larissa Gomes, Claudio Tadeu Daniel-Ribeiro, Patricia Brasil   +2 more
exaly   +2 more sources