Results 1 to 10 of about 4,262 (206)

Identification of a mutant PfCRT-mediated chloroquine tolerance phenotype in Plasmodium falciparum. [PDF]

PLoS Pathogens, 2010
Mutant forms of the Plasmodium falciparum transporter PfCRT constitute the key determinant of parasite resistance to chloroquine (CQ), the former first-line antimalarial, and are ubiquitous to infections that fail CQ treatment.
Stephanie G Valderramos, Juan-Carlos Valderramos, Lise Musset, Lisa A Purcell, Odile Mercereau-Puijalon, Eric Legrand, David A Fidock   +6 more
doaj   +6 more sources

The Knock-Down of the Chloroquine Resistance Transporter PfCRT Is Linked to Oligopeptide Handling in Plasmodium falciparum.

Microbiology Spectrum, 2022
The chloroquine resistance transporter, PfCRT, is an essential factor during intraerythrocytic development of the human malaria parasite Plasmodium falciparum.
Michael P. Barrett, Michael Lanzer, Cecilia P Sanchez   +2 more
exaly   +3 more sources

Changing genetic profiles of Plasmodium falciparum piperaquine resistance in Southeast Asia over 25 years [PDF]

Antimicrobial Agents and Chemotherapy
Piperaquine resistance in Plasmodium falciparum has emerged in Southeast Asia and is strongly associated with mutations in the pfcrt gene and amplification of pfplasmepsin2/3.
Suttipat Srisutham, Kanokon Suwannasin, Aungkana Saejeng, Nardlada Khantikul, Rungniran Sugaram, Aung Pyae Phyo, Stephane Proux, Tiengkham Pongvongsa, Chea Nguon, Rupam Tripura, Nguyen Hoang Chau, Dysoley Lek, Nghia Ho Dang Trung, Thomas J. Peto, James J. Callery, Rob W. van der Pluijm, Chanaki Amaratunga, Mehul Dhorda, Lorenz von Seidlein, Mayfong Mayxay, Nguyen Thanh Thuy-Nhien, Paul N. Newton, Nicholas P. J. Day, Elizabeth A. Ashley, Francois H. Nosten, Frank M. Smithuis, Nicholas J. White, Arjen M. Dondorp, Mallika Imwong   +28 more
doaj   +2 more sources

Evolution of Fitness Cost-Neutral Mutant PfCRT Conferring P. falciparum 4-Aminoquinoline Drug Resistance Is Accompanied by Altered Parasite Metabolism and Digestive Vacuole Physiology. [PDF]

PLoS Pathogens, 2016
Southeast Asia is an epicenter of multidrug-resistant Plasmodium falciparum strains. Selective pressures on the subcontinent have recurrently produced several allelic variants of parasite drug resistance genes, including the P.
Stanislaw J Gabryszewski, Satish K Dhingra, Jill M Combrinck, Ian A Lewis, Paul S Callaghan, Matthew R Hassett, Amila Siriwardana, Philipp P Henrich, Andrew H Lee, Nina F Gnädig, Lise Musset, Manuel Llinás, Timothy J Egan, Paul D Roepe, David A Fidock   +14 more
doaj   +3 more sources

Genetic diversity and evolutionary perspectives of Pfcrt in Plasmodium falciparum: insights from Indian and global isolates [PDF]

Malaria Journal
Background Chloroquine resistance in Plasmodium falciparum (Pf) driven by mutations in the Pf chloroquine resistance transporter (Pfcrt) gene continues to pose a challenge to malaria control in endemic regions like India.
Geetika Narang, Joseph Hawadak, Jahnvi Jakhan, Vineeta Singh   +3 more
doaj   +2 more sources

Investigation of the Plasmodium falciparum food vacuole through inducible expression of the chloroquine resistance transporter (PfCRT). [PDF]

PLoS ONE, 2012
Haemoglobin degradation during the erythrocytic life stages is the major function of the food vacuole (FV) of Plasmodium falciparum and the target of several anti-malarial drugs that interfere with this metabolic pathway, killing the parasite.
Florian Ehlgen, James S Pham, Tania de Koning-Ward, Alan F Cowman, Stuart A Ralph   +4 more
doaj   +3 more sources

No seasonal accumulation of resistant P. falciparum when high-dose chloroquine is used. [PDF]

PLoS ONE, 2009
Potentially chloroquine resistant P. falciparum, identified by the 76T haplotype in the chloroquine resistance transporter (pfcrt 76T), are highly prevalent throughout Africa.
Johan Ursing, Poul-Erik Kofoed, Amabelia Rodrigues, Lars Rombo   +3 more
doaj   +1 more source

PfCRT mutations conferring piperaquine resistance in falciparum malaria shape the kinetics of quinoline drug binding and transport.

PLoS Pathogens, 2023
The chloroquine resistance transporter (PfCRT) confers resistance to a wide range of quinoline and quinoline-like antimalarial drugs in Plasmodium falciparum, with local drug histories driving its evolution and, hence, the drug transport specificities ...
Guillermo M Gomez, Giulia D'Arrigo, Cecilia P Sanchez, Fiona Berger, Rebecca C Wade, Michael Lanzer   +5 more
doaj   +1 more source

Evidence for the early emergence of piperaquine-resistant Plasmodium falciparum malaria and modeling strategies to mitigate resistance.

PLoS Pathogens, 2022
Multidrug-resistant Plasmodium falciparum parasites have emerged in Cambodia and neighboring countries in Southeast Asia, compromising the efficacy of first-line antimalarial combinations.
Jennifer L Small-Saunders, Laura M Hagenah, Kathryn J Wicht, Satish K Dhingra, Ioanna Deni, Jonathan Kim, Jeremie Vendome, Eva Gil-Iturbe, Paul D Roepe, Monica Mehta, Filippo Mancia, Matthias Quick, Margaret J Eppstein, David A Fidock   +13 more
doaj   +1 more source

Microsatellite polymorphism within pfcrt provides evidence of continuing evolution of chloroquine-resistant alleles in Papua New Guinea

Malaria Journal, 2007
Background Polymorphism in the pfcrt gene underlies Plasmodium falciparum chloroquine resistance (CQR), as sensitive strains consistently carry lysine (K), while CQR strains carry threonine (T) at the codon 76.
Sharma Yagya D, Reeder John, Mueller Ivo, Michon Pascal, Mehlotra Rajeev K, DaRe Jeana T, Stoneking Mark, Zimmerman Peter A   +7 more
doaj   +1 more source