Results 1 to 10 of about 2,161 (132)

The Impact of <i>pfmdr1</i> Gene Copy Number on the Efficacy of Dihydroartemisinin-Piperaquine in Treating Malaria in West Sumba and Kupang Districts, East Nusa Tenggara, Indonesia. [PDF]

J Parasitol Res
The efficacy of antimalarial treatment, particularly artemisinin‐based combination therapy (ACT), continues to face persistent threats due to the development of drug resistance in Plasmodium falciparum. Although artemisinin derivatives remain effective, ACT regimen failure often results from decreased efficacy of the companion drug.
Irdayanti I, Aswad H, Asih PBS, Rozi IE, Herdiana H, Diptyanusa A, Prameswari HD, Yusuf Y, Bahrani B, Hidayah N, Artika IM, Syafruddin D.   +11 more
europepmc   +2 more sources

Polymorphism of <i>pfmdr1</i> Gene Mutation Conferring Resistance to Artemisinin-Based Combination Therapy in <i>Plasmodium falciparum</i> in Patients at Gulu Regional Referral Hospital in Northern Uganda. [PDF]

J Parasitol Res
Background Malaria is one of the most devastating infectious diseases in humans, and antimalarial drugs have been used to combat it with minimal success. Worldwide, malaria treatment is threatened by the emergence and spread of artemisinin resistance, which is associated with mutations in the PfK13 propeller domain. In Sub‐saharan Africa, data relating
Amito FP, Angwech H, Ojok L, Wokorach G, Ochaya S, Ogwang Q, Opiro R, Echodu R.   +7 more
europepmc   +2 more sources

Molecular Markers of Antimalarial Drug Resistance in Plasmodium falciparum From Kumasi, Ghana, 2023. [PDF]

Trop Med Int Health
ABSTRACT Objectives Artemisinin partial resistance has emerged in East Africa and is feared to spread across the continent, potentially compromising artemisinin‐based combination treatment. Molecular markers can serve as early warning signals for the development of specific drug resistance.
Kegya AD, Oppong E, Darko E, Boateng KA, Phillips RO, Heinemann M, Ramharter M, Igiraneza C, Ndoli JM, Mockenhaupt FP, van Loon W.   +10 more
europepmc   +2 more sources

Structural and mechanistic insights into the inhibition of Plasmodium falciparum MDR1 [PDF]

Nature Communications
Malaria, caused by the parasite Plasmodium falciparum, remains a significant global health threat, with multidrug resistance posing a major challenge to treatment. The P-glycoprotein homolog P.
Ziyan Zhao, Jialu Li, Xinye Wang, Xiaofeng Liu, Nan Wang, Hanwen Xu, Cantao Quan, Yu Gao, Jing Zhang, Xiang Wang, Li Guo, Nobutaka Kato, Dong Deng, Xin Jiang   +13 more
doaj   +2 more sources

A Novel Antimalarial Agent that Inhibits Protein Synthesis in Plasmodium falciparum. [PDF]

Angew Chem Int Ed Engl
Compound 31 represents a promising avenue for the development as an antimalarial agent with a potent activity profile (PfNF54 IC50 ± s.d. = 3.9 ± 0.4 nM). It has a novel mode of action by binding to cytosolic ribosomal subunits, thereby inhibiting protein synthesis in the parasite.
Bravo P, Diamanti E, Hamed MM, Bizzarri L, Wiedemar N, Passecker A, Brancucci NMB, Albisetti A, Gumpp C, Illarionov B, Fischer M, Witschel M, Schehl T, Hahne H, Mäser P, Rottmann M, Hirsch AKH.   +16 more
europepmc   +2 more sources

Molecular surveillance of the Plasmodium falciparum Pfmdr1 N86Y mutation linked to antimalarial drug resistance in Mbouda, Cameroon [PDF]

Tropical Diseases, Travel Medicine and Vaccines
Background Malaria, mainly caused by Plasmodium falciparum, remains a major health concern in Cameroon due to the emergence of drug-resistant parasite strains. The Plasmodium falciparum multidrug resistance 1 (Pfmdr1) gene, particularly the N86Y mutation,
Noumedem Anangmo Christelle Nadia, Vincent Ngouana, Yamssi Cedric, Dayang Louis Djakbe, Wansi Innes, Tchuenkam Kom Pacome, Gamago Nkadeu Guy Armand, Guela Djoukou Mba Edna, Toumko Towa Merveille, Zhong Fuyou, Haibo Hu   +10 more
doaj   +2 more sources

PfMDR1 Transport Rates Assessed in Intact Isolated Plasmodium falciparum Digestive Vacuoles Reflect Functional Drug Resistance Relationship with pfmdr1 Mutations

Pharmaceuticals, 2022
Drug resistance often emerges from mutations in solute transporters. Single amino acid exchanges may alter functionality of transporters with ‘de novo’ ability to transport drugs away from their site of action. The PfMDR1 transporter (or P-glycoprotein 1)
Nina Simon, Cornelia Voigtländer, Barbara Kappes, Petra Rohrbach, Oliver Friedrich   +4 more
doaj   +1 more source

PfMDR1: mechanisms of transport modulation by functional polymorphisms. [PDF]

PLoS ONE, 2011
ATP-Binding Cassette (ABC) transporters are efflux pumps frequently associated with multidrug resistance in many biological systems, including malaria.
Pedro Eduardo Ferreira, Gabrielle Holmgren, Maria Isabel Veiga, Per Uhlén, Akira Kaneko, José Pedro Gil   +5 more
doaj   +1 more source

Clinical isolates of uncomplicated falciparum malaria from high and low malaria transmission areas show distinct pfcrt and pfmdr1 polymorphisms in western Ethiopia

Malaria Journal, 2023
Background Pfcrt gene has been associated with chloroquine resistance and the pfmdr1 gene can alter malaria parasite susceptibility to lumefantrine, mefloquine, and chloroquine.
Geletta Tadele, Aminata Jawara, Mary Oboh, Eniyou Oriero, Sisay Dugassa, Alfred Amambua-Ngwa, Lemu Golassa   +6 more
doaj   +1 more source

Mechanistic basis for multidrug resistance and collateral drug sensitivity conferred to the malaria parasite by polymorphisms in PfMDR1 and PfCRT.

PLoS Biology, 2022
Polymorphisms in the Plasmodium falciparum multidrug resistance protein 1 (pfmdr1) gene and the Plasmodium falciparum chloroquine resistance transporter (pfcrt) gene alter the malaria parasite's susceptibility to most of the current antimalarial drugs ...
Sarah Heckmatt Shafik, Sashika Natasha Richards, Ben Corry, Rowena Elizabeth Martin   +3 more
doaj   +1 more source