Results 1 to 10 of about 3,298 (171)

PfMDR1: mechanisms of transport modulation by functional polymorphisms. [PDF]

PLoS ONE, 2011
ATP-Binding Cassette (ABC) transporters are efflux pumps frequently associated with multidrug resistance in many biological systems, including malaria.
Pedro Eduardo Ferreira, Gabrielle Holmgren, Maria Isabel Veiga, Per Uhlén, Akira Kaneko, José Pedro Gil   +5 more
doaj   +3 more sources

PfMDR1 Transport Rates Assessed in Intact Isolated Plasmodium falciparum Digestive Vacuoles Reflect Functional Drug Resistance Relationship with pfmdr1 Mutations [PDF]

Pharmaceuticals, 2022
Drug resistance often emerges from mutations in solute transporters. Single amino acid exchanges may alter functionality of transporters with ‘de novo’ ability to transport drugs away from their site of action. The PfMDR1 transporter (or P-glycoprotein 1)
Nina Simon, Cornelia Voigtländer, Barbara Kappes, Petra Rohrbach, Oliver Friedrich   +4 more
doaj   +2 more sources

Clinical isolates of uncomplicated falciparum malaria from high and low malaria transmission areas show distinct pfcrt and pfmdr1 polymorphisms in western Ethiopia [PDF]

Malaria Journal, 2023
Background Pfcrt gene has been associated with chloroquine resistance and the pfmdr1 gene can alter malaria parasite susceptibility to lumefantrine, mefloquine, and chloroquine.
Geletta Tadele, Aminata Jawara, Mary Oboh, Eniyou Oriero, Sisay Dugassa, Alfred Amambua-Ngwa, Lemu Golassa   +6 more
doaj   +2 more sources

Plasmodium falciparum Drug Resistance Genes pfmdr1 and pfcrt In Vivo Co-Expression During Artemether-Lumefantrine Therapy [PDF]

Frontiers in Pharmacology, 2022
Background: Artemisinin-based combination therapies (ACTs) are the global mainstay treatment of uncomplicated Plasmodium falciparum infections. PfMDR1 and PfCRT are two transmembrane transporters, associated with sensitivity to several antimalarials ...
M. Silva, M. Silva, M. Malmberg, M. Malmberg, S. D. Otienoburu, A. Björkman, B. Ngasala, A. Mårtensson, J. P. Gil, J. P. Gil, J. P. Gil, M. I. Veiga, M. I. Veiga   +12 more
doaj   +4 more sources

Mechanistic basis for multidrug resistance and collateral drug sensitivity conferred to the malaria parasite by polymorphisms in PfMDR1 and PfCRT.

PLoS Biology, 2022
Polymorphisms in the Plasmodium falciparum multidrug resistance protein 1 (pfmdr1) gene and the Plasmodium falciparum chloroquine resistance transporter (pfcrt) gene alter the malaria parasite's susceptibility to most of the current antimalarial drugs ...
Sarah Heckmatt Shafik, Sashika Natasha Richards, Ben Corry, Rowena Elizabeth Martin   +3 more
doaj   +2 more sources

Structural and mechanistic insights into the inhibition of Plasmodium falciparum MDR1 [PDF]

Nature Communications
Malaria, caused by the parasite Plasmodium falciparum, remains a significant global health threat, with multidrug resistance posing a major challenge to treatment. The P-glycoprotein homolog P.
Ziyan Zhao, Jialu Li, Xinye Wang, Xiaofeng Liu, Nan Wang, Hanwen Xu, Cantao Quan, Yu Gao, Jing Zhang, Xiang Wang, Li Guo, Nobutaka Kato, Dong Deng, Xin Jiang   +13 more
doaj   +2 more sources

Molecular surveillance of the Plasmodium falciparum Pfmdr1 N86Y mutation linked to antimalarial drug resistance in Mbouda, Cameroon [PDF]

Tropical Diseases, Travel Medicine and Vaccines
Background Malaria, mainly caused by Plasmodium falciparum, remains a major health concern in Cameroon due to the emergence of drug-resistant parasite strains. The Plasmodium falciparum multidrug resistance 1 (Pfmdr1) gene, particularly the N86Y mutation,
Noumedem Anangmo Christelle Nadia, Vincent Ngouana, Yamssi Cedric, Dayang Louis Djakbe, Wansi Innes, Tchuenkam Kom Pacome, Gamago Nkadeu Guy Armand, Guela Djoukou Mba Edna, Toumko Towa Merveille, Zhong Fuyou, Haibo Hu   +10 more
doaj   +2 more sources

Molecular surveillance of the Pfmdr1 N86Y allele among Congolese pregnant women with asymptomatic malaria

Malaria Journal, 2020
Background Malaria in pregnancy is associated with considerable morbidity and mortality. Regular surveillance of artemisinin-based combination therapy tolerance, or molecular makers of resistance, is vital for effective malaria treatment, control and ...
Louis Regis Dossou-Yovo, Francine Ntoumi, Felix Koukouikila-Koussounda, Jeannhey Christevy Vouvoungui, Ayodele Adedoja, David Nderu, Thirumalaisamy P. Velavan, Arsène Lenga   +7 more
doaj   +1 more source

Different patterns of pfcrt and pfmdr1 polymorphism in Plasmodium falciparum isolates from Tehama region, Yemen [PDF]

PeerJ, 2016
Introduction. Despite the efforts of the malaria control programme, malaria morbidity is still a common health problem in Yemen, with 60% of the population at risk. Plasmodium falciparum is responsible for 99% of malaria cases.
Wahib M. Atroosh, Hesham M. Al-Mekhlafi, Adel Al-Jasari, Hany Sady, Salwa S. Dawaki, Fatin N. Elyana, Mona A. Al-Areeqi, Nabil A. Nasr, Awatif M. Abdulsalam, Lahvanya R. Subramaniam, Meram Azzani, Init Ithoi, Yee Ling Lau, Johari Surin   +13 more
doaj   +2 more sources

Expansion of a Specific Plasmodium falciparum PfMDR1 Haplotype in Southeast Asia with Increased Substrate Transport

mBio, 2020
Artemisinin-based combination therapies (ACTs) have been vital in reducing malaria mortality rates since the 2000s. Their efficacy, however, is threatened by the emergence and spread of artemisinin resistance in Southeast Asia.
Carla Calçada, Miguel Silva, Vitória Baptista, Vandana Thathy, Rita Silva-Pedrosa, Diana Granja, Pedro Eduardo Ferreira, José Pedro Gil, David A. Fidock, Maria Isabel Veiga   +9 more
doaj   +1 more source