Malaria Journal, 2009 Background The combination of artesunate and mefloquine was introduced as the national first-line treatment for Plasmodium falciparum malaria in Cambodia in 2000.
Wongsrichanalai Chansuda +15 more
doaj +5 more sources
Prevalence of pfk13 and pfmdr1 polymorphisms in Bounkiling, Southern Senegal [PDF]
PLOS ONE, 2021 Background Delayed Plasmodium falciparum parasite clearance has been associated with Single Nucleotide Polymorphisms (SNPs) in the kelch protein propeller domain (coded by pfk13 gene). SNPs in the Plasmodium falciparum multidrug resistance gene 1 (pfmdr1) are associated with multi-drug resistance including the combination artemether-lumefantrine.
Ambroise Ahouidi +5 more
openaire +5 more sources
Monitoring PfMDR1 transport in Plasmodium falciparum [PDF]
Malaria Journal, 2015 The Plasmodium falciparum multidrug resistance 1 transporter, PfMDR1, contains five amino acid polymorphisms that are suggested to be involved in altered drug transport from the parasite's cytosol into the digestive vacuole (DV). Transport of a substrate into another intracellular compartment influences drug availability at its site of action ...
Reiling, Sarah J., Rohrbach, Petra
openaire +4 more sources
Plasmodium falciparum pfmdr1 Amplification, Mefloquine Resistance, and Parasite Fitness [PDF]
Antimicrobial Agents and Chemotherapy, 2009 ABSTRACT Mefloquine is widely used in combination with artemisinin derivatives for the treatment of falciparum malaria. Mefloquine resistance in Plasmodium falciparum has been related to increased copy numbers of multidrug-resistant gene 1 ( pfmdr1 ). We studied the ex vivo dynamics
Preechapornkul, P +7 more
openaire +4 more sources
The role of pfmdr1 in Plasmodium falciparum tolerance to artemether‐lumefantrine in Africa [PDF]
Tropical Medicine & International Health, 2007 SummaryObjective Artemether‐lumefantrine (AL), presently the most favoured combination therapy against uncomplicated Plasmodium falciparum malaria in Africa, has recently shown to select for the pfmdr1 86N allele. The objective of this study was to search for the selection of other mutations potentially involved in artemether‐lumefantrine tolerance ...
Sisowath, Christin +7 more
openaire +5 more sources
Plasmodium falciparum Drug Resistance Genes pfmdr1 and pfcrt In Vivo Co-Expression During Artemether-Lumefantrine Therapy [PDF]
Frontiers in Pharmacology, 2022 Background: Artemisinin-based combination therapies (ACTs) are the global mainstay treatment of uncomplicated Plasmodium falciparum infections. PfMDR1 and PfCRT are two transmembrane transporters, associated with sensitivity to several antimalarials ...
M. Silva +12 more
doaj +3 more sources
Resistance to Antimalarials in Southeast Asia and Genetic Polymorphisms in pfmdr1 [PDF]
Antimicrobial Agents and Chemotherapy, 2003 ABSTRACT Resistance to antimalarial drugs is a public health problem worldwide. Molecular markers for drug-resistant malaria, such as pfcrt and pfmdr1 polymorphisms, could serve as useful surveillance tools. To evaluate this possibility, sequence polymorphisms in pfcrt
Amy L, Pickard +8 more
openaire +4 more sources
pfmdr1 GENOTYPING AND IN VIVO MEFLOQUINE RESISTANCE ON THE THAI-MYANMAR BORDER [PDF]
The American Journal of Tropical Medicine and Hygiene, 2005 Molecular markers have been proposed as a method of monitoring malaria drug resistance and could potentially be used to prolong the life span of antimalarial drugs. Single nucleotide polymorphisms (SNPs) in the Plasmodium falciparum gene pfmdr1 and increased gene copy number have been associated with in vitro drug resistance but have not been well ...
Amy L, Nelson +8 more
openaire +4 more sources
Mefloquine resistance in Plasmodium falciparum and increased pfmdr1 gene copy number [PDF]
The Lancet, 2004 The borders of Thailand harbour the world's most multidrug resistant Plasmodium falciparum parasites. In 1984 mefloquine was introduced as treatment for uncomplicated falciparum malaria, but substantial resistance developed within 6 years. A combination of artesunate with mefloquine now cures more than 95% of acute infections.
Price, Ric N. +11 more
openaire +4 more sources
Increased pfmdr1 gene copy number and the decline in pfcrt and pfmdr1 resistance alleles in Ghanaian Plasmodium falciparum isolates after the change of anti-malarial drug treatment policy [PDF]
Malaria Journal, 2013 Con la introducción de la terapia combinada basada en artemisinina (ACT) en 2005, el monitoreo de la eficacia de los medicamentos contra la malaria, que incluye el uso de herramientas moleculares para detectar marcadores genéticos conocidos de resistencia a los parásitos, es importante para obtener información de primera mano sobre los cambios en la ...
Nancy Duah +12 more
openaire +3 more sources