Results 1 to 10 of about 8,206 (148)

Breakdown of Phosphatidylserine Asymmetry Following Treatment of Erythrocytes with Lumefantrine

Toxins, 2014
Background: Lumefantrine, a commonly used antimalarial drug, inhibits hemozoin formation in parasites. Several other antimalarial substances counteract parasitemia by triggering suicidal death or eryptosis of infected erythrocytes.
Myriam Fezai, Florian Lang, Kousi Alzoubi   +2 more
exaly   +3 more sources

Pharmacokinetics, safety and efficacy of an optimized dose of artemether–lumefantrine in the treatment of acute uncomplicated Plasmodium falciparum malaria in neonates and infants of less than 5 kg body weight: a multicentre, open-label, single-arm phase 2/3 study (CALINA) [PDF]

Tropical Medicine and Health
Background Treatment recommendations for malaria in infants of 
Gildas Wounounou, Alfred B. Tiono, Bernhards Ogutu, Christine Manyando, Issaka Sagara, Stefan Schneitter, Quique Bassat, Myriam El Gaaloul, Anne Claire Marrast, Ivan Demin, Cornelis Winnips, Celine Risterucci, Sophie Hugot, Georg Hofstetter, Zhiyan Qian, Guoqin Su, Jie Zhang, Katalin Csermak Renner, Marc Cousin, Vinay Kumar Venishetty, Sarfaraz Sayyed, Preetam Gandhi, Berenger Kabore, The CALINA study group   +23 more
doaj   +2 more sources

Prevalence of malaria resistance-associated mutations in Plasmodium falciparum circulating in 2017–2018, Bo, Sierra Leone

Frontiers in Microbiology, 2022
IntroductionIn spite of promising medical, sociological, and engineering strategies and interventions to reduce the burden of disease, malaria remains a source of significant morbidity and mortality, especially among children in sub-Saharan Africa.
Tomasz A. Leski, Chris Rowe Taitt, Sophie M. Colston, Umaru Bangura, Andrew Holtz, Chadwick Y. Yasuda, Nathanael D. Reynolds, Joseph Lahai, Joseph M. Lamin, Victoria Baio, Rashid Ansumana, Rashid Ansumana, David A. Stenger, Gary J. Vora   +13 more
doaj   +1 more source

Potential Antimalarial Activity of Artemether/Lumefantrine/Doxycycline: A Study in Mice Infected with Plasmodium berghei

Biology, Medicine & Natural Product Chemistry, 2022
Antimalarial drug resistance is one of the greatest challenges towards eradicating malaria. Exploring new combination therapies can overcome resistance challenges.
Udeme Owunari Georgewill, Elias Adikwu
doaj   +1 more source

Solidification of Self-Emulsifying Drug Delivery Systems as a Novel Approach to the Management of Uncomplicated Malaria

Pharmaceuticals, 2022
Malaria affects millions of people annually, especially in third-world countries. The mainstay of treatment is oral anti-malarial drugs and vaccination. An increase in resistant strains of malaria parasites to most of the current anti-malarial drugs adds
Eun Bin Seo, Lissinda H. du Plessis, Joe M. Viljoen   +2 more
doaj   +1 more source

Modelling the optimal dosing schedule for artemether-lumefantrine chemoprophylaxis against malaria

BMC Research Notes, 2022
Objective Antimalarial chemoprophylaxis for high risk groups in endemic areas of Southeast Asia has the potential to reduce malaria transmission and accelerate elimination.
Joel Tarning, Lorenz von Seidlein, Arjen M. Dondorp, Nicholas J. White, Richard J. Maude   +4 more
doaj   +1 more source

Lumefantrine plasma concentrations in uncontrolled conditions among patients treated with artemether-lumefantrine for uncomplicated plasmodium falciparum malaria in Mwanza, Tanzania

International Journal of Infectious Diseases, 2022
Background: Therapeutic efficacy of artemether-lumefantrine is highly dependent on adequate systemic exposure to the partner drug lumefantrine particularly day 7 lumefantrine plasma concentration.
Karol J Marwa, Anthony C Liwa, Eveline T Konje, Stanley Mwita, Erasmus Kamugisha, Göte Swedberg   +5 more
doaj   +1 more source

Investigating In Vitro and Ex Vivo Properties of Artemether/Lumefantrine Double-Fixed Dose Combination Lipid Matrix Tablets Prepared by Hot Fusion

Pharmaceutics, 2021
Highly lipophilic antimalarial drugs, artemether and lumefantrine, whilst an effective fixed-dose combination treatment to lower the malarial disease burden, are therapeutically hindered by low aqueous solubility and varied bioavailability.
Christi A. Wilkins, Lissinda H. du Plessis, Joe M. Viljoen   +2 more
doaj   +1 more source

Methylene blue inhibits lumefantrine-resistant Plasmodium berghei

Journal of Infection in Developing Countries, 2016
Introduction: Chemotherapy still is the most effective way to control malaria, a major public health problem in sub-Saharan Africa. The large-scale use of the combination therapy artemether-lumefantrine for malaria treatment in Africa predisposes ...
Victor Irungu Mwangi, Ruth Mwende Mumo, Daniel Muthui Kiboi, Sabah Ahmed Omar, Zipporah Waithera Ng'ang'a, Hastings Suba Ozwara   +5 more
doaj   +1 more source

Prescribing Pattern of Anti-malarial Drugs with Particular Reference to the use of Artesunate in Complicated Plasmodium Vivax Cases [PDF]

Journal of Clinical and Diagnostic Research, 2014
Background: In developing countries, Malaria has been found to be one of the most common cause of fever and morbidity, particularly among infants and young children.
Ashutosh Kumar Singh, Mohd Sajid Khan, Farhan Ahmad Khan   +2 more
doaj   +1 more source