Results 11 to 20 of about 8,298 (167)

Green Chiral HPLC Method for Lumefantrine Analysis: Method Development, Greenness Assessment, and Computational Studies. [PDF]

Chirality
A green chiral HPLC method was developed and validated for the determination of lumefantrine enantiomers. The method employs ethanol as a mobile phase as a sustainable and efficient alternative to hexane. The chiral recognition mechanism and elution order of the enantiomers were investigated using electronic circular dichroism and molecular docking ...
Mohr A, das Neves GM, Segala É, Eifler-Lima VL, Steppe M.   +4 more
europepmc   +2 more sources

Formulation, process development and evaluation of artemether and lumefantrine soft gelatin capsule

Journal of Pharmacy and Bioallied Sciences, 2012
Artemether and Lumefantrine capsules are indicated for the treatment of P. falciparum malaria cases resistant to both chloroquine and sulphadoxine, pyrimethamine combination. Both artemether and lumefantrine act as blood schizontocides.
A Patel, A Lodha, J Chaudhuri, P Jadia, T Joshi, J Dalal   +5 more
doaj   +1 more source

Evidence for linkage of pfmdr1, pfcrt, and pfk13 polymorphisms to lumefantrine and mefloquine susceptibilities in a Plasmodium falciparum cross

International Journal for Parasitology: Drugs and Drug Resistance, 2020
Background: Lumefantrine and mefloquine are used worldwide in artemisinin-based combination therapy (ACT) of malaria. Better understanding of drug susceptibility and resistance is needed and can be obtained from studies of genetic crosses.
Sean T. Windle, Kristin D. Lane, Nahla B. Gadalla, Anna Liu, Jianbing Mu, Ramoncito L. Caleon, Rifat S. Rahman, Juliana M. Sá, Thomas E. Wellems   +8 more
doaj   +1 more source

Prescribing Pattern of Anti-malarial Drugs with Particular Reference to the use of Artesunate in Complicated Plasmodium Vivax Cases [PDF]

Journal of Clinical and Diagnostic Research, 2014
Background: In developing countries, Malaria has been found to be one of the most common cause of fever and morbidity, particularly among infants and young children.
Ashutosh Kumar Singh, Mohd Sajid Khan, Farhan Ahmad Khan   +2 more
doaj   +1 more source

Ionic Liquid Forms of the Antimalarial Lumefantrine in Combination with LFCS Type IIIB Lipid-Based Formulations Preferentially Increase Lipid Solubility, In Vitro Solubilization Behavior and In Vivo Exposure

Pharmaceutics, 2019
Lipid based formulations (LBFs) are commonly employed to enhance the absorption of highly lipophilic, poorly water-soluble drugs. However, the utility of LBFs can be limited by low drug solubility in the formulation.
Erin Tay, Tri-Hung Nguyen, Leigh Ford, Hywel D. Williams, Hassan Benameur, Peter J. Scammells, Christopher J. H. Porter   +6 more
doaj   +1 more source

Stability-indicating HPLC-DAD/UV-ESI/MS impurity profiling of the anti-malarial drug lumefantrine

Malaria Journal, 2011
Background Lumefantrine (benflumetol) is a fluorene derivative belonging to the aryl amino alcohol class of anti-malarial drugs and is commercially available in fixed combination products with β-artemether.
Duchateau Luc, Burvenich Christian, Van Dorpe Sylvia, Vangheluwe Elien, Baert Bram, Suleman Sultan, Verbeken Mathieu, Jansen Frans H, De Spiegeleer Bart   +8 more
doaj   +1 more source

Antimalarial Drug Repurposing of Epirubicin and Pelitinib in Combination with Artemether and Lumefantrine

Pharmaceuticals
Background: Drug therapy remains the principal management strategy for malaria but is increasingly challenged by the emergence of drug-resistant malaria parasites.
Douglas O. Ochora, Reagan M. Mogire, Bernard M. Murithi, Farid Abdi, Erick N. Ondari, Rael J. Masai, Edwin Mwakio, Agnes Cheruyiot, Abiy Yenesew, Hoseah M. Akala   +9 more
doaj   +1 more source

Quality Assessment of Artemether-Lumefantrine Samples and Artemether Injections Sold in the Cape Coast Metropolis

Journal of Tropical Medicine, 2016
Most prescribers and patients in Ghana now opt for the relatively expensive artemether/lumefantrine rather than artesunate-amodiaquine due to undesirable side effects in the treatment of uncomplicated malaria.
James Prah, Elvis Ofori Ameyaw, Richmond Afoakwah, Patrick Fiawoyife, Ernest Oppong-Danquah, Johnson Nyarko Boampong   +5 more
doaj   +1 more source

Audit of failure rate of Coartem to treat falciparum malaria at single fourteen day follow up

South African Family Practice, 2002
Objective: To assess the failure rate of the new first line treatment regime for uncomplicated falciparum malaria in KwaZulu-Natal of Coartem tablets (20mg aftemether and 120mg lumefantrine - Novartis South Africa (PTY Ltd. Design: A before-after study.
C.H. Vaughan Williams, C. La Cock, G.F.J. Henry, A.J. Ross   +3 more
doaj   +1 more source

Deprotektive Alkylierung: Eine Plattform zur Umsetzung von Alkoholen zu Aminen mittels Nonafluormesitylensulfonamiden

Angewandte Chemie, Volume 138, Issue 43, 19 October 2026.
Die direkte Umwandlung von Alkoholen in tertiäre oder sekundäre Amine in einem Reaktionsschritt unter Verwendung von Nms‐Amiden wird beschrieben. Die Transformation zeichnet sich durch eine breite Toleranz gegenüber verschiedenen funktionellen Gruppen und eine hohe Stereospezifität aus, was ihre Eignung für die Synthese isotopenmarkierter Arzneimittel ...
Jakub Brześkiewicz, Kunj Kapur, Boris Maryasin, Nuno Maulide   +3 more
wiley   +1 more source