Results 11 to 20 of about 11,360 (208)

Supervised versus unsupervised antimalarial treatment with six-dose artemether-lumefantrine: pharmacokinetic and dosage-related findings from a clinical trial in Uganda [PDF]

Malaria Journal, 2006
Background A six-dose antimalarial regimen of artemether-lumefantrine (A/L) may soon become one of the most widely used drug combination in Africa, despite possible constraints with adherence and poor absorption due to inadequate nutrition, and a lack of
Ruzagira Eugene, Grandesso Francesco, Biraro Samuel, Bajunirwe Francis, Fogg Carole, Piola Patrice, Checchi Francesco, Babigumira Joseph, Kigozi Isaac, Kiguli James, Kyomuhendo Juliet, Ferradini Laurent, Taylor Walter RJ, Guthmann Jean-Paul   +13 more
doaj   +2 more sources

Desbutyl-Lumefantrine Is a Metabolite of Lumefantrine with Potent In Vitro Antimalarial Activity That May Influence Artemether-Lumefantrine Treatment Outcome [PDF]

Antimicrobial Agents and Chemotherapy, 2011
ABSTRACT Desbutyl-lumefantrine (DBL) is a metabolite of lumefantrine. Preliminary data from Plasmodium falciparum field isolates show greater antimalarial potency than, and synergy with, the parent compound and synergy with artemisinin.
Rina P M, Wong, Sam, Salman, Kenneth F, Ilett, Peter M, Siba, Ivo, Mueller, Timothy M E, Davis   +5 more
openaire   +3 more sources

Green Chiral HPLC Method for Lumefantrine Analysis: Method Development, Greenness Assessment, and Computational Studies. [PDF]

Chirality
A green chiral HPLC method was developed and validated for the determination of lumefantrine enantiomers. The method employs ethanol as a mobile phase as a sustainable and efficient alternative to hexane. The chiral recognition mechanism and elution order of the enantiomers were investigated using electronic circular dichroism and molecular docking ...
Mohr A, das Neves GM, Segala É, Eifler-Lima VL, Steppe M.   +4 more
europepmc   +2 more sources

Artemether-lumefantrine treatment of uncomplicated Plasmodium falciparum malaria : a systematic review and meta-analysis of day 7 lumefantrine concentrations and therapeutic response using individual patient data [PDF]

, 2015
Achieving adequate antimalarial drug exposure is essential for curing malaria. Day 7 blood or plasma lumefantrine concentrations provide a simple measure of drug exposure that correlates well with artemether-lumefantrine efficacy.
Mårtensson, A, Sibley, CH, Nsanzabana, C, Bassat, Q, Ringwald, P, Faucher, JF, WorldWide Antimalarial Resistance Network Lumefantrine PK/PD Stu,, Ashley, EA, Hodel, EM, Lindegardh, NL, Davis, TME, Schramm, B, Lefèvre, G, Parikh, S, Mayxay, M, Van Vugt, M, Borrmann, S, McGready, R, Hamed, K, Jullien, V, Workman, LJ, Newton, PN, Stepniewska, K, Vugt, MV, Genton, B, Kiechel, JR, Rombo, L, White, Nicholas, Price, Richard, Kofoed, PE, Piola, P, Barnes, KI, Dahal, P, Aweeka, F, Moreira, C, Tarning, J, Nosten, F, Djimde, AA, Ursing, J, Ngasala, BE, Deloron, P, Karunajeewa, HA, Guérin, PJ, Denis, MB, Marsh, K, WorldWide Antimalarial Resistance Network (WWARN) Lumefantrine PK/PD Study Group, Price, RN, Lindegardh, N, White, NJ, Huang, L, McGready, Rose   +50 more
core   +1 more source

Adherence to artemether/lumefantrine treatment in children under real-life situations in rural Tanzania. [PDF]

, 2012
A follow-up study was conducted to determine the magnitude of and factors related to adherence to artemether/lumefantrine (ALu) treatment in rural settings in Tanzania.
Zul Premji, Simba, Daudi O, Petzold, Max, Gustafsson, Lars L, Simba, D.O., Daudi O. Simba, Tomson, G., Mahindi, M., Goran Tomson, Lars L. Gustafsson, Kakoko, Deodatus, Max Petzold, Deodatus Kakoko, Margarita Mahindi, Kakoko, D., Petzold, M., Tomson, Goran, Gustafsson, L.L., Mahindi, Margarita, Premji, Zul   +19 more
core   +1 more source

Counterfeit and Substandard Test of the Antimalarial Tablet Riamet^® by Means of Raman Hyperspectral Multicomponent Analysis

Molecules, 2019
The fight against counterfeit pharmaceuticals is a global issue of utmost importance, as failed medication results in millions of deaths every year. Particularly affected are antimalarial tablets.
Timea Frosch, Elisabeth Wyrwich, Di Yan, Christian Domes, Robert Domes, Juergen Popp, Torsten Frosch   +6 more
doaj   +1 more source

Pharmacokinetic and Pharmacodynamic Characteristics of a new Pediatric Formulation of Artemether-Lumefantrine in African Children with Uncomplicated Plasmodium Falciparum Malaria. [PDF]

, 2011
The pharmacokinetic and pharmacodynamic properties of a new pediatric formulation of artemether-lumefantrine, dispersible tablet, were determined within the context of a multicenter, randomized, parallel-group study.
Lyimo, John, Tekete, Mamadou, Abdulla, Salim, Salim Abdulla, Bassat, Quique, Abdoulaye A. Djimdé, Mandomando, Inacio, Gilbert Lefèvre, Lefèvre, Gilbert, null null, Djimdé, Abdoulaye A, Mamadou Tekete, Borrmann, Steffen, John Lyimo, Quique Bassat, Steffen Borrmann, Inacio Mandomando   +16 more
core   +1 more source

Intravenous pharmacokinetics, oral bioavailability, dose proportionality and in situ permeability of anti-malarial lumefantrine in rats

Malaria Journal, 2011
Background Despite the wide spread use of lumefantrine, there is no study reporting the detailed preclinical pharmacokinetics of lumefantrine. For the development of newer anti-malarial combination(s) and selection of better partner drugs, it is long ...
Wahajuddin, Singh Sheelendra P, Raju Kanumuri SR, Nafis Asad, Puri Sunil K, Jain Girish K   +5 more
doaj   +1 more source

Early clinical development of artemether-lumefantrine dispersible tablet: palatability of three flavours and bioavailability in healthy subjects. [PDF]

, 2010
BACKGROUND\ud \ud Efforts to ease administration and enhance acceptability of the oral anti-malarial artemether-lumefantrine (A-L) crushed tablet to infants and children triggered the development of a novel dispersible tablet of A-L.
Kaiser, Guenther, Abdunoor M Kabanywanyi, Abdulla, Salim, Kabanywanyi Abdunoor M, Salim Abdulla, Reynolds Christine, Nuortti Marja, Gunther Kaiser, Christine Reynolds, Gilbert Lefevre, Nuortti, Marja, Serge Fitoussi, Yeh Ching-Ming, Fitoussi Serge, Romain Sechaud, Marja Nuortti, Kaiser, Günther, Amuri, Baraka, Ubben, David, Yeh, Ching-Ming, Steve Pascoe, David Ubben, Abdulla Salim, Amuri Baraka, Pascoe Steve, Kaiser Günther, Lefèvre, Gilbert, Pascoe, Steve, Ching-Ming Yeh, Kabanywanyi, Abdunoor M, Baraka Amuri, Ubben David, Séchaud Romain, Reynolds, Christine, Séchaud, Romain, Fitoussi, Serge, Lefèvre Gilbert   +36 more
core   +1 more source

A simple high-performance liquid chromatographic assay for concurrent quantification of lumefantrine and efavirenz in human plasma from malaria–HIV co-infected individuals

Future Journal of Pharmaceutical Sciences, 2023
Background As per current treatment guidelines, artemether-lumefantrine and efavirenz-based antiretroviral therapy are recommended drugs for falciparum malaria and human immunodeficiency virus (HIV) infections, respectively.
Adebanjo J. Adegbola, Ruth M. Ogboye, Julius O. Soyinka, Oluseye O. Bolaji   +3 more
doaj   +1 more source