Results 21 to 30 of about 8,298 (167)

Stereoselective Biotransformation: Transfer of Learning to Advance Drug Metabolism and Biocatalysis

Angewandte Chemie, Volume 138, Issue 25, 15 June 2026.
Understanding stereoselective biotransformations has implications for predicting drug disposition and response and may also inspire novel biocatalytic and biomimetic strategies to address challenges in metabolite and API synthesis. ABSTRACT Chirality is an important determinant of drug action, as enantiomers can exhibit markedly different ...
Grace A. Okunlola, Godwin A. Aleku
wiley   +2 more sources

Breakdown of Phosphatidylserine Asymmetry Following Treatment of Erythrocytes with Lumefantrine

Toxins, 2014
Background: Lumefantrine, a commonly used antimalarial drug, inhibits hemozoin formation in parasites. Several other antimalarial substances counteract parasitemia by triggering suicidal death or eryptosis of infected erythrocytes.
Kousi Alzoubi, Bassel Alktifan, Gergely Oswald, Myriam Fezai, Majed Abed, Florian Lang   +5 more
doaj   +1 more source

Deprotective Alkylation: A Platform for Alcohol‐to‐Amine Interconversion Using Nonafluoromesitylenesulfonamides

Angewandte Chemie International Edition, Volume 65, Issue 43, 19 October 2026.
The straightforward conversion of alcohols to tertiary or secondary amines employing Nms‐amides in a single operation is described. The transformation features broad functional group tolerance and high stereospecificity, underscoring its utility in the synthesis of isotope‐labeled pharmaceuticals.
Jakub Brześkiewicz, Kunj Kapur, Boris Maryasin, Nuno Maulide   +3 more
wiley   +1 more source

Efficacy of 3-day low dose quinine plus clindamycin versus artemether-lumefantrine for the treatment of uncomplicated Plasmodium falciparum malaria in Kenyan children (CLINDAQUINE): an open-label randomized trial

Malaria Journal, 2022
Background The World Health Organization recommends quinine plus clindamycin as first-line treatment of malaria in the first trimester of pregnancy and as a second-line treatment for uncomplicated falciparum malaria when artemisinin-based drug ...
Charles O. Obonyo, Elizabeth A. Juma, Vincent O. Were, Bernhards R. Ogutu   +3 more
doaj   +1 more source

No Robust Evidence of Lumefantrine Resistance [PDF]

Antimicrobial Agents and Chemotherapy, 2015
Plucinski and colleagues ([1][1]) recently published the results of a therapeutic efficacy study of artemether-lumefantrine (AL) and dihydroartemisinin-piperaquine (DP) in Zaire and Uige Provinces in Angola and concluded that there was evidence of increased lumefantrine resistance in Zaire.
Kamal Hamed, Kelli Kuhen
openaire   +2 more sources

Developmental Toxicity Study for the Antimalarial Drug Combination Cabamiquine‐Pyronaridine Using a Translational Approach

Birth Defects Research, Volume 118, Issue 10, October 2026.
ABSTRACT Background The safety of pharmacological treatments during pregnancy is a significant concern, as many medications lack comprehensive reproductive safety data. This creates gaps in therapeutic options for pregnant women, particularly malaria, which poses serious risks to maternal and fetal health.
Wookyung Kim, Geum‐Sil Cho, Andreas Gado, Tobias Hyun Ho Baeurle, Habib Karimi, Filippo Venezia, Claude Oeuvray, Thomas Spangenberg, Sebastian G. Wicha, Claudia Demarta‐Gatsi   +9 more
wiley   +1 more source

Desbutyl-Lumefantrine Is a Metabolite of Lumefantrine with Potent In Vitro Antimalarial Activity That May Influence Artemether-Lumefantrine Treatment Outcome [PDF]

Antimicrobial Agents and Chemotherapy, 2011
ABSTRACT Desbutyl-lumefantrine (DBL) is a metabolite of lumefantrine. Preliminary data from Plasmodium falciparum field isolates show greater antimalarial potency than, and synergy with, the parent compound and synergy with artemisinin.
Rina P M, Wong, Sam, Salman, Kenneth F, Ilett, Peter M, Siba, Ivo, Mueller, Timothy M E, Davis   +5 more
openaire   +2 more sources

Severe Plasmodium vivax Malaria Complicated by Secondary Hemophagocytic Lymphohistiocytosis, Disseminated Intravascular Coagulation, and Acute Pancreatitis: A Case Report

Clinical Case Reports, Volume 14, Issue 10, October 2026.
ABSTRACT Plasmodium vivax (P. vivax) malaria, once regarded as a comparatively benign infection, is increasingly recognized as a cause of severe, potentially life‐threatening multisystem disease. Concurrent secondary hemophagocytic lymphohistiocytosis (HLH), disseminated intravascular coagulation (DIC), and acute pancreatitis complicating P.
Tasnim Nafian, Md. Abul Kalam Azad, Khaled Mahbub Murshed, Kazi Ali Aftab, Rubayet Shahriar, Abdullah Al Faisal   +5 more
wiley   +1 more source

Chronic oral exposure to Artemether–lumenfantrine induced testicular and epidydimal damage, germ cell death and severe decrease sperm viability in BALB/c mice

Scientific African, 2020
Malaria is currently the world's most important parasitic infection, especially in the tropical countries, where the disease has continually been a major cause of morbidity and death.
Bintu M. Mofio, Rejoice John, Omerah Raphael Attah, Agbonu O. Adikpe, Ifukibot L. Usende   +4 more
doaj   +1 more source

Lumefantrine attenuates Plasmodium falciparum artemisinin resistance during the early ring stage

International Journal for Parasitology: Drugs and Drug Resistance, 2021
Emerging artemisinin resistance in Plasmodium falciparum malaria has the potential to become a global public health crisis. In Southeast Asia, this phenomenon clinically manifests in the form of delayed parasite clearance following artemisinin treatment.
Krittikorn Kümpornsin, Duangkamon Loesbanluechai, Cristina de Cozar, Namfon Kotanan, Kesinee Chotivanich, Nicholas J. White, Prapon Wilairat, Maria G. Gomez-Lorenzo, Francisco Javier Gamo, Laura Maria Sanz, Marcus C.S. Lee, Thanat Chookajorn   +11 more
doaj   +1 more source