Results 31 to 40 of about 11,360 (208)

Effectiveness of Artemether-Lumefantrine Provided by Community Health Workers in Under-five Children with Uncomplicated Malaria in Rural Tanzania: An Open Label Prospective Study. [PDF]

, 2011
\ud Home-management of malaria (HMM) strategy improves early access of anti-malarial medicines to high-risk groups in remote areas of sub-Saharan Africa.
Petzold, M.G, Blessborn, D, Mårtensson, A, Malmberg, M, Carlsson, A.M, Gil, José P, Ngasala, Billy E, Malmberg Maja, Petzold, MG, Max G Petzold, Carlsson, Anja M, Ferreira, P.E, Premji, Z., Premji, Zul, Ferreira Pedro E, Pedro E Ferreira, Malmberg, Maja, Carlsson, Anja M., Gil, José Pedro, Bergqvist, Y, Bergqvist, Yngve, Ferreira, PE, Ngasala, B.E, Bergqvist, Y., Ferreira, Pedro E, Billy E Ngasala, Premji, Z, Gil, Jose P., Maja Malmberg, Zul Premji, Mårtensson, Andreas, Ngasala, Billy E., Yngve Bergqvist, Blessborn, Daniel,, Martensson, A., Petzold, Max G, Bergqvist, Yngve,, Mårtensson Andreas, Carlsson, AM, Ngasala Billy E, Gil, J.P., Petzold, M.G., Premji Zul, Ferreira, P.E., Ferreira, Pedro, José P Gil, Carlsson Anja M, Andreas Mårtensson, Ngasala, BE, Blessborn, D., Malmberg, M., Gil, J.P, Daniel Blessborn, Gil, JP, Blessborn Daniel, Petzold, Max G., Blessborn, Daniel, Anja M Carlsson, Gil José P, Ferreira, Pedro E., Carlsson, A.M., Petzold Max G, Bergqvist Yngve, Ngasala, B.E., Malmberg, M,   +64 more
core   +1 more source

Audit of failure rate of Coartem to treat falciparum malaria at single fourteen day follow up

South African Family Practice, 2002
Objective: To assess the failure rate of the new first line treatment regime for uncomplicated falciparum malaria in KwaZulu-Natal of Coartem tablets (20mg aftemether and 120mg lumefantrine - Novartis South Africa (PTY Ltd. Design: A before-after study.
C.H. Vaughan Williams, C. La Cock, G.F.J. Henry, A.J. Ross   +3 more
doaj   +1 more source

Measurement of adherence, drug concentrations and the effectiveness of artemether-lumefantrine, chlorproguanil-dapsone or sulphadoxine-pyrimethamine in the treatment of uncomplicated malaria in Malawi [PDF]

, 2009
Sulphadoxine-pyrimethamine (SP) is the only single dose therapy for uncomplicated malaria, but there is widespread resistance. At the time of this study, artemether-lumefantrine (AL) and chlorproguanil-dapsone (CPD), both multi-dose regimes, were ...
Hughes Dyfrig A, Mavuto Mukaka, Montgomery, Jacqui, Peter A Winstanley, Wootton, Dan, Winstanley Peter A, David G Lalloo, Molyneux Malcolm E, Bell, David J., Ward, Steve, Ward, Steve A., Chimpeni Phillips, Mukaka, Mavuto, Dyfrig A Hughes, Hughes, Dyfrig A., Steve A Ward, Wootton, Daniel G., Molyneux, Malcolm E., Lalloo David G, Phillips Chimpeni, Malcolm E Molyneux, Bell David J, Kayange Noel, Jacqui Montgomery, Ward Steve A, David J Bell, Noel Kayange, Mukaka Mavuto, Hughes, Dyfrig, Kayange, Noel, Lalloo, David G., Wootton Dan, Lalloo, David; id_orcid, Chimpeni, Phillips, Winstanley, Peter, Montgomery Jacqui, Dan Wootton, Winstanley, Peter A.   +37 more
core   +1 more source

Polymorphisms in Plasmodium falciparum chloroquine resistance transporter and multidrug resistance 1 genes: parasite risk factors that affect treatment outcomes for P. falciparum malaria after artemether-lumefantrine and artesunate-amodiaquine. [PDF]

, 2014
Adequate clinical and parasitologic cure by artemisinin combination therapies relies on the artemisinin component and the partner drug. Polymorphisms in the Plasmodium falciparum chloroquine resistance transporter (pfcrt) and P.
Kamugisha, Erasmus, Piola, Patrice, Faucher, Jean-François, El-Sayed, Badria, Houzé, Sandrine, Somé, A Fabrice, Sutherland, Colin, Checchi, Francesco, Plowe, Christopher, V, Sutherland, Colin J, Otienoburu, Sabina Dahlström, Berens-Riha, Nicole, Grivoyannis, Anastasia, Davis, Timothy ME, Björkman, Anders, Asaq Molecular Marker Study Group, Rosenthal, Philip, Eyase, Frederick, Malmberg, Maja, Kariuki, Simon, Mårtensson, Andreas,, Hamour, Sally, Ogutu, Bernhards, Davis, Timothy, Wong, Rina, Sibley, Carol Hopkins, Gadalla, Nahla B, Ngasala, Billy, Ménard, Didier, Oguike, Mary, Venkatesan, Meera, Arze, Cesar, Djimdé, Abdoulaye A, Baliraine, Frederick N, Fröberg, Gabrielle, Ursing, Johan, LeBras, Jacques, Desai, Meghna, Mårtensson, Andreas, Ouédraogo, Jean-Bosco, El-Sayed, Badria B, Mwai, Leah, Thwing, Julie, Kironde, Fred, Djimde, Abdoulaye, Price, Ric, Dorsey, Grant, Johnson, Jacob, Guérin, Philippe, Somé, A. Fabrice, Oguike, Alexis Nzila Mary, LeBras, Poul-Erik Kofoed Jacques, Moriera, Clarissa, Kiechel, Jean-René, Kofoed, Poul-Erik, Dahal, Prabin, Nsanzabana, Christian, Nzila, Alexis, Wong, Rina PM, Rosenthal, Philip J, Ademowo, George, Falade, Catherine, Nsobya, Samuel L, Schramm, Birgit, Zongo, Issaka, Gadalla, Nahla, Wong, Rina P M, Plowe, Christopher V, Eshetu, Teferi, Davis, Timothy M E, Dhorda, Meghna Desai Mehul, Plowe, Christopher,, Rombo, Lars,, Dhorda, Mehul, Stepniewska, Kasia, Adam, Ishag, Price, Ric N, Borrmann, Steffen, Nosten, Francois, Rombo, Lars, Baliraine, Frederick, Zeynudin, Ahmed, Nsobya, Samuel   +82 more
core   +1 more source

Antimalarial Drug Repurposing of Epirubicin and Pelitinib in Combination with Artemether and Lumefantrine

Pharmaceuticals
Background: Drug therapy remains the principal management strategy for malaria but is increasingly challenged by the emergence of drug-resistant malaria parasites.
Douglas O. Ochora, Reagan M. Mogire, Bernard M. Murithi, Farid Abdi, Erick N. Ondari, Rael J. Masai, Edwin Mwakio, Agnes Cheruyiot, Abiy Yenesew, Hoseah M. Akala   +9 more
doaj   +1 more source

The Content of African Diets is Adequate to Achieve Optimal Efficacy with Fixed-Dose Artemether-Lumefantrine: A Review of the Evidence. [PDF]

, 2008
A fixed-dose combination of artemether-lumefantrine (AL, Coartem(R)) has shown high efficacy, good tolerability and cost-effectiveness in adults and children with uncomplicated malaria caused by Plasmodium falciparum.
Nathan Mulure, Abdulla, Salim, Kokwaro, Gilbert, Salim Abdulla, Mulure, Nathan, Ndong, A, Zulfiqarali G Premji, Ndong, A., Alice Ndong, Gilbert Kokwaro, Abdulla, S., Ndong, Alice, Mulure, N., Nwaiwu, Obiyo, Premji, Zul, Nwaiwu, O., Ogutu, Bernhards, Falade, C.O., Premji, Zulfiqarali G, Falade, Catherine O, Catherine O Falade, Sagara, Issaka, Sagara, I., Obiyo Nwaiwu, Ogutu, B., Bernhards Ogutu, Premji, Z.G., Kokwaro, G., Issaka Sagara   +28 more
core   +1 more source

Stereoselective Biotransformation: Transfer of Learning to Advance Drug Metabolism and Biocatalysis

Angewandte Chemie, Volume 138, Issue 25, 15 June 2026.
Understanding stereoselective biotransformations has implications for predicting drug disposition and response and may also inspire novel biocatalytic and biomimetic strategies to address challenges in metabolite and API synthesis. ABSTRACT Chirality is an important determinant of drug action, as enantiomers can exhibit markedly different ...
Grace A. Okunlola, Godwin A. Aleku
wiley   +2 more sources

Artemisinin combination therapies for treatment of uncomplicated malaria in Uganda. [PDF]

, 2006
OBJECTIVES: To compare the efficacy and safety of artemisinin combination therapies for the treatment of uncomplicated falciparum malaria in Uganda. DESIGN: Randomized single-blind controlled trial.
Staedke Sarah G, Rosenthal, Philip J, Yeka, Adoke, Banek, Kristin, Yeka Adoke, Dorsey, Grant, Staedke, Sarah G, Bakyaita Nathan, Dorsey Grant, Banek Kristin, Bukirwa, Hasifa, Talisuna Ambrose, Rosenthal Philip J, Talisuna, Ambrose, Rwakimari, John Bosco, Kamya Moses R, Kamya, Moses R, Bukirwa Hasifa, Wabwire-Mangen Fred, Bakyaita, Nathan, Wabwire-Mangen, Fred, Rwakimari John Bosco   +21 more
core   +1 more source

Adherence to and acceptability of artemether-lumefantrine as first-line anti-malarial treatment: evidence from a rural community in Tanzania. [PDF]

, 2010
\ud \ud Controlled clinical trials have shown that a six-dose regimen of artemether-lumefantrine (AL) therapy for uncomplicated Plasmodium falciparum malaria results in cure rates >95% with good tolerability.
Abdunoor M Kabanywanyi, Nathan Mulure, King'eng'ena, Said, Kabanywanyi Abdunoor M, Mulure, Nathan, Christian Lengeler, Prudensiana Kasim, Schlienger, Raymond, Raymond Schlienger, King'eng'ena S.,, Lengeler Christian, Blaise Genton, Mulure, N., Lengeler, C., Genton, Blaise, Lengeler, Christian, Genton Blaise, Kasim Prudensiana, Kasim, Prudensiana, Kabanywanyi, A. M., King'eng'ena Said, Schlienger Raymond, Mulure Nathan, Kabanywanyi, Abdunoor M, Schlienger, R., Said King'eng'ena, Genton, B., Kasim, P.   +27 more
core   +1 more source

Artemether-lumefantrine versus dihydroartemisinin-piperaquine for treatment of malaria: a randomized trial. [PDF]

, 2007
OBJECTIVES: To compare the efficacy and safety of artemether-lumefantrine (AL) and dihydroartemisinin-piperaquine (DP) for treating uncomplicated falciparum malaria in Uganda. DESIGN: Randomized single-blinded clinical trial.
Staedke Sarah G, Wabwire-Mangen, F, Yeka Adoke, Rwakimari, JB, Dorsey, Grant, Rwakimari John B, Nosten François, Talisuna, Ambrose O, Dorsey Grant, Kamya, MR, Greenhouse Bryan, Rosenthal, PJ, Greenhouse, B, Rosenthal Philip J, Staedke, SG, Nosten, F, Lugemwa, Myers, Rosenthal, Philip J, Yeka, Adoke, Dorsey, G, Staedke, Sarah G, Greenhouse, Bryan, Rwakimari, John B, Bukirwa, H, Bukirwa, Hasifa, Lugemwa, M, Kamya Moses R, Lugemwa Myers, Kamya, Moses R, Bukirwa Hasifa, Wabwire-Mangen Fred, Talisuna Ambrose O, Wabwire-Mangen, Fred, Talisuna, AO, Nosten, François, Yeka, A   +35 more
core   +1 more source