Results 51 to 60 of about 11,360 (208)

Use of artemether-lumefantrine in the treatment of asymptomatic-malaria infection in HIV-positive and HIVnegative Nigerian adults. [PDF]

Malaria /HIV co-infection is a major challenge to public health in developing countries and yet potential drug-drug interactions between antimalarial and antiviral regimens have not been adequately investigated in people with both HIV and Plasmodium ...
Chijioke-Nwauche, IN
core   +1 more source

Efficacy and safety of artemether-lumefantrine for the treatment of uncomplicated malaria in the setting of three different chemopreventive regimens. [PDF]

, 2015
BACKGROUND: The burden of malaria remains high for children in parts of Africa despite the use of insecticide-treated bed nets (ITNs). Chemoprevention has the potential of reducing the malaria burden; however, limited data exist on the efficacy and ...
Tamara Clark, Grant Dorsey, Achan, Jane, Dorsey, Grant, Mwangwa, Florence, Kapisi, James, Kamya, Moses, Seyi Soremekun, Moses Kamya, Bigira, Victor, Soremekun, Seyi, Florence Mwangwa, Clark, Tamara, Kinara, Stephen, James Kapisi, Victor Bigira, Stephen Kinara, Jane Achan   +17 more
core   +1 more source

Quality Assessment of Artemether-Lumefantrine Samples and Artemether Injections Sold in the Cape Coast Metropolis

Journal of Tropical Medicine, 2016
Most prescribers and patients in Ghana now opt for the relatively expensive artemether/lumefantrine rather than artesunate-amodiaquine due to undesirable side effects in the treatment of uncomplicated malaria.
James Prah, Elvis Ofori Ameyaw, Richmond Afoakwah, Patrick Fiawoyife, Ernest Oppong-Danquah, Johnson Nyarko Boampong   +5 more
doaj   +1 more source

Chronic oral exposure to Artemether–lumenfantrine induced testicular and epidydimal damage, germ cell death and severe decrease sperm viability in BALB/c mice

Scientific African, 2020
Malaria is currently the world's most important parasitic infection, especially in the tropical countries, where the disease has continually been a major cause of morbidity and death.
Bintu M. Mofio, Rejoice John, Omerah Raphael Attah, Agbonu O. Adikpe, Ifukibot L. Usende   +4 more
doaj   +1 more source

Lumefantrine attenuates Plasmodium falciparum artemisinin resistance during the early ring stage

International Journal for Parasitology: Drugs and Drug Resistance, 2021
Emerging artemisinin resistance in Plasmodium falciparum malaria has the potential to become a global public health crisis. In Southeast Asia, this phenomenon clinically manifests in the form of delayed parasite clearance following artemisinin treatment.
Krittikorn Kümpornsin, Duangkamon Loesbanluechai, Cristina de Cozar, Namfon Kotanan, Kesinee Chotivanich, Nicholas J. White, Prapon Wilairat, Maria G. Gomez-Lorenzo, Francisco Javier Gamo, Laura Maria Sanz, Marcus C.S. Lee, Thanat Chookajorn   +11 more
doaj   +1 more source

Age‐Related and Seasonal Variation in Malaria and Other Causes of Fever and Their Association With Clinical Outcomes in Southern Angola: A Hospital‐Based Study

Tropical Medicine &International Health, Volume 31, Issue 9, Page 1273-1283, September 2026.
ABSTRACT Background Acute febrile illnesses in sub‐Saharan Africa are often attributed to malaria, yet many patients test negative for malaria parasites. The aetiology of nonmalarial fevers remains understudied. Here, we examine likely causes of febrile illnesses and their association with poor clinical outcomes in Angola.
Helga E. M. Gonçalves, Maria Lina Antunes, Jorge Seixas, Marcelo U. Ferreira   +3 more
wiley   +1 more source

Coartem: the Journey to the Clinic. [PDF]

, 2009
Artemisinin, from which the artemether component of Coartem (artemether/lumefantrine, AL) is derived, is obtained from the plant sweet wormwood (Artemisia annua) which has been used for over 2,000 years as a Chinese herbal remedy.
Premji, Zulfiqarali G, Premji, Z.G., Premji, Zul   +2 more
core   +1 more source

Detection of novel Plasmodium falciparum coronin gene mutations in a recrudescent ACT-treated patient in South-Western Nigeria

Frontiers in Cellular and Infection Microbiology
BackgroundRoutine surveillance for antimalarial drug resistance is critical to sustaining the efficacy of artemisinin-based Combination Therapies (ACTs).
Olusola Ajibaye, Olusola Ajibaye, Yetunde Adeola Olukosi, Eniyou C. Oriero, Mary Aigbiremo Oboh, Bamidele Iwalokun, Ikechukwu Chidiebere Nwankwo, Chinaza Favour Nnam, Olawunmi Victoria Adaramoye, Somadina Chukwemeka, Judith Okanazu, Eniafe Gabriel, Emmanuel Oluwadare Balogun, Emmanuel Oluwadare Balogun, Emmanuel Oluwadare Balogun, Alfred Amambua-Ngwa   +15 more
doaj   +1 more source

Artemether-lumefantrine efficacy among adults on antiretroviral therapy in Malawi

Malaria Journal, 2023
Background When people with human immunodeficiency virus (HIV) infection (PWH) develop malaria, they are at risk of poor anti-malarial treatment efficacy resulting from impairment in the immune response and/or drug-drug interactions that alter anti ...
Wongani Nyangulu, Randy G. Mungwira, Titus H. Divala, Nginache Nampota-Nkomba, Osward M. Nyirenda, Andrea G. Buchwald, Jernelle Miller, Dominique E. Earland, Matthew Adams, Christopher V. Plowe, Terrie E. Taylor, Jane E. Mallewa, Joep J. van Oosterhout, Sunil Parikh, Matthew B. Laurens, Miriam K. Laufer, the TSCQ Study Team   +16 more
doaj   +1 more source

Implementation of artemether-lumefantrine treatment policy for malaria at health facilities in Tanzania [PDF]

, 2011
V Mugoyela1, O Minzi21Department of Medicinal Chemistry, 2Unit of Pharmacology and Therapeutics, School of Pharmacy, Muhimbili University of Health and Allied Sciences, Dar Es Salaam, TanzaniaBackground: The purpose of this study was to compare knowledge
Mugoyela V, Minzi 0, Veronica Mugoyela, Omary Minzi   +3 more
core   +1 more source