Results 51 to 60 of about 8,298 (167)

Physiologically‐Based Pharmacokinetic Modeling to Investigate Piperaquine Exposure in Pregnant Women Using an Individualized Profile Approach

Clinical and Translational Science, Volume 19, Issue 5, May 2026.
ABSTRACT Malaria in pregnancy poses significant risks to the mother, fetus, and neonate, necessitating effective treatment and prevention strategies. This study explored the application of an individualized (‘virtual twin’) physiologically‐based pharmacokinetic (PBPK) modeling approach to the antimalarial drug piperaquine in pregnant women.
Sonia Khier, Myriam El Gaaloul, Joel Tarning, Nada Abla   +3 more
wiley   +1 more source

Optimizing derivatization conditions using an experimental design and simultaneous estimation of artemether and lumefantrine by ratio first order derivative spectrophotometric method

Journal of Taibah University for Science, 2017
Artemether–lumefantrine is the most widely used artemisinin-based combination therapy for malaria. The present work aims to develop and validate a simple, accurate, precise and rapid ratio first order derivative spectrophotometric method for the ...
Jenee Christian, Purvi Shah, Margi Patel, Kalpana Patel, Tejal Gandhi   +4 more
doaj   +1 more source

Physical stability and release properties of lumefantrine amorphous solid dispersion granules prepared by a simple solvent evaporation approach

International Journal of Pharmaceutics: X, 2020
Amorphous solid dispersions (ASDs) of lumefantrine, which has low aqueous solubility, have been shown to improve bioavailability relative to crystalline formulations.
Niraj S. Trasi, Sonal V. Bhujbal, Dmitry Y. Zemlyanov, Qi (Tony) Zhou, Lynne S. Taylor   +4 more
doaj   +1 more source

Analytical Methods for Simultaneous Determination of Artemether and Lumefantrine: Validation and Applications (2010–2025)

Orapuh Journal
Introduction The fixed-dose combination (FDC) of artemether (ARM) and lumefantrine (LUM) is the global standard for treating uncomplicated Plasmodium falciparum malaria.
Jules Bugugu, Jordan Mwanga, Luc Mitongo Shabani, Gloria B. Dhimbe, Jérémie Kindenge Mbinze   +4 more
doaj   +1 more source

Artesunate + amodiaquine versus artemether-lumefantrine for the treatment of uncomplicated Plasmodium falciparum malaria in the Colombian Pacific region: a noninferiority trial

Revista da Sociedade Brasileira de Medicina Tropical, 2012
INTRODUCTION: In Colombia, there are no published studies for the treatment of uncomplicated Plasmodium falciparum malaria comparing artemisinin combination therapies.
Fernando De la Hoz Restrepo, Alexandra Porras Ramírez, Alejandro Rico Mendoza, Freddy Córdoba, Diana Patricia Rojas   +4 more
doaj   +1 more source

Complete Dialysis‐Free Recovery From Severe Malaria–Associated Acute Kidney Injury and Multiorgan Failure: A Case Report and Brief Literature Review

Clinical Case Reports, Volume 14, Issue 4, April 2026.
ABSTRACT Severe malaria remains a major cause of acute kidney injury and multiorgan failure in endemic regions, often requiring renal replacement therapy. However, access to dialysis is limited in many resource‐constrained settings, making outcomes highly dependent on early diagnosis and effective antimalarial treatment. We report a 32‐year‐old man who
Tamirat Godebo Woyimo, Amare Hailu Ashine, Mohammed Kedir Shukri, Yonas Damtew Bejiga, Ragasa Getachew, Yosef Bekele Bonsa, Rediet Girmaye, Tsion Haile Woldemariam, Adugna Lamessa   +8 more
wiley   +1 more source

Electrocardiographic safety evaluation of extended artemether-lumefantrine treatment in patients with uncomplicated Plasmodium falciparum malaria in Bagamoyo District, Tanzania

Malaria Journal, 2020
Background Extended artemisinin-based combination therapy (ACT) for treatment of uncomplicated Plasmodium falciparum malaria with already existing drug regimens, such as artemether-lumefantrine, might be effective in tackling the emerging ACT resistance.
Lwidiko E. Mhamilawa, Sven Wikström, Bruno P. Mmbando, Billy Ngasala, Andreas Mårtensson   +4 more
doaj   +1 more source

Solvent-less Synthesis, Antimalarial and Toxicity Evaluation of Lumefantrine-Copper Complex in Swiss Mice

Notulae Scientia Biologicae, 2016
The antimalarial efficacy and safety of mechanically induced solventlessly synthesized lumefantrine-copper complex were investigated in experimental mice. Parasite level in Plasmodium berghei-infected mice treated with lumefantrine - copper complex (LCC)
Rotimi Olusanya ARISE, Adedibu Clement TELLA, Oluyinka A. IYIOLA, Oluwakemi Mary AYENI, Samuel Tobi FAROHUNBI, Abeeb Abiodun YEKEEN   +5 more
doaj   +1 more source

Absence of association between Pfnfs1 mutation and in vitro susceptibility to lumefantrine in Plasmodium falciparum

International Journal for Parasitology: Drugs and Drug Resistance
Artemether-lumefantrine (AL) is the most widely used antimalarial drug for treating uncomplicated falciparum malaria. This study evaluated whether the K65Q mutation in the Plasmodium falciparum cysteine desulfurase IscS (Pfnfs1) gene was associated with ...
Weilin Zeng, Wei Zhao, Hao Wei, Yucheng Qin, Zheng Xiang, Yanrui Wu, Xi Chen, Yanmei Zhang, Hui Zhao, Mengxi Duan, Wenya Zhu, Kemin Sun, Yiman Wu, Tao Liang, Ye Mou, Cheng Liu, Xiuya Tang, Yaming Huang, Liwang Cui, Zhaoqing Yang   +19 more
doaj   +1 more source

Efficacy and safety properties of Lumefantrine-Trimethoprim-Copper complex in mice

Ceylon Journal of Science, 2018
Lumefantrine and trimethoprim are antimalarial and antibiotic drugs respectively. Even though, therapeutic agents have shown enhanced efficacy upon coordination to metal ion, antimalarial activity of lumefantrine-trimethoprim-copper complex drug has not ...
R.O. Arise, A. Olowo, M.A. Acho, O. Olufemi, A.A. Adewale, A.C. Tella   +5 more
doaj   +1 more source