Results 71 to 80 of about 11,360 (208)

Gossypiboma‐Induced Acute Abdomen Highlighting the Importance of Surgical Safety Protocols: A Case Report

Clinical Case Reports, Volume 14, Issue 6, June 2026.
ABSTRACT Gossypiboma, the medical term for a retained surgical sponge, is a rare but serious postoperative complication, accounting for nearly 50% of malpractice claims related to retained foreign bodies. Despite its importance, it is often underreported due to medicolegal concerns.
Priyanka Panwar, Jack Okumu, Daisy Denga, James Kariuki, O. W. Sibuor   +4 more
wiley   +1 more source

A Comparison of Pharmacokinetics of two Tablet Formulations Containing Artemether / Lumefantrine – Quality Criteria for Malaria Treatment Assurance [PDF]

, 2012
\ud Treatment of non-severe malaria remains a challenge to endemic areas including Tanzania. Since November 2006, Coartem® an artemisinin based combination therapy (ACT) containing artemether-lumefantrine (ALu), replaced sulphadoxine/pyrimethamine (SP ...
Alphonce, Ignace
core  

Health worker performance in the management of paediatric fevers following in-service training and exposure to job aids in Kenya. [PDF]

, 2010
BACKGROUND: Improving the way artemether-lumefantrine (AL) is provided to patients attending clinics is critical to maximize the benefit of this new medicine.
Zurovac, D, Snow, RW, Snow Robert W, Snow, Robert W., Zurovac Dejan, Webster, Jayne, Wasunna, B, Snow, Robert, Wasunna Beatrice, Jones Caroline, Bruce, J, Zurovac, Dejan, Webster Jayne, Jones, C, Jones, Caroline, Snow, Robert W, Wasunna, Beatrice, Bruce Jane, Webster, J, Bruce, Jane   +19 more
core   +1 more source

Concomitant nevirapine impacts pharmacokinetic exposure to the antimalarial artemether-lumefantrine in African children.

PLoS ONE, 2017
BackgroundThe antiretroviral drug nevirapine and the antimalarial artemisinin-based combination therapy artemether-lumefantrine are commonly co-administered to treat malaria in the context of HIV.
Liusheng Huang, Vincent Carey, Jane C Lindsey, Florence Marzan, David Gingrich, Bobbie Graham, Linda Barlow-Mosha, Phionah K Ssemambo, Portia Kamthunzi, Sharon Nachman, Sunil Parikh, Francesca T Aweeka, IMPAACT P1079 protocol team   +12 more
doaj   +1 more source

Advancing Maternal Health with Long‐Acting Therapeutics: Priorities, Efficacy and Safety Considerations, and Emerging Technologies

Clinical Pharmacology &Therapeutics, Volume 119, Issue 5, Page 1179-1194, May 2026.
Maternal health remains a critical global concern, particularly in underserved populations and in low‐ and middle‐income countries where access to safe and effective therapeutics is limited. Despite the use of medications by most women during pregnancy, the exclusion of pregnant and lactating women from clinical trials has resulted in significant data ...
Rachel K. Scott, Sharon Nachman, Ethel D. Weld, Rachel Daley, Shakir Atoyebi, Robert Bies, Catriona Waitt, Adeniyi Olagunju   +7 more
wiley   +1 more source

Physiologically‐Based Pharmacokinetic Modeling to Investigate Piperaquine Exposure in Pregnant Women Using an Individualized Profile Approach

Clinical and Translational Science, Volume 19, Issue 5, May 2026.
ABSTRACT Malaria in pregnancy poses significant risks to the mother, fetus, and neonate, necessitating effective treatment and prevention strategies. This study explored the application of an individualized (‘virtual twin’) physiologically‐based pharmacokinetic (PBPK) modeling approach to the antimalarial drug piperaquine in pregnant women.
Sonia Khier, Myriam El Gaaloul, Joel Tarning, Nada Abla   +3 more
wiley   +1 more source

Population pharmacokinetics and pharmacodynamics of lumefantrine in young Ugandan children treated with artemether-lumefantrine for uncomplicated malaria [PDF]

, 2016
Background. The pharmacokinetics and pharmacodynamics of lumefantrine, a component of the most widely used treatment for malaria, artemether-lumefantrine, has not been adequately characterized in young children. Methods.
Aweeka, F.T., McCormack, S.A., Sambol, N.C., Bergqvist, Yngve, Wanzira, H., Tchaparian, E., Bergqvist, Yngve,, Arinaitwe, E., Blessborn, Daniel, Parikh, S., Bigira, V.   +10 more
core   +2 more sources

Analytical Methods for Simultaneous Determination of Artemether and Lumefantrine: Validation and Applications (2010–2025)

Orapuh Journal
Introduction The fixed-dose combination (FDC) of artemether (ARM) and lumefantrine (LUM) is the global standard for treating uncomplicated Plasmodium falciparum malaria.
Jules Bugugu, Jordan Mwanga, Luc Mitongo Shabani, Gloria B. Dhimbe, Jérémie Kindenge Mbinze   +4 more
doaj   +1 more source

Pyronaridine–artesunate and artemether–lumefantrine for the treatment of uncomplicated Plasmodium falciparum malaria in Kenyan children: a randomized controlled non-inferiority trial

Malaria Journal, 2018
Background Pyronaridine–artesunate is a novel artemisinin-based combination therapy. The efficacy and safety of pyronaridine–artesunate were compared with artemether–lumefantrine for the treatment of uncomplicated Plasmodium falciparum malaria in ...
Johanna M. Roth, Patrick Sawa, Nicodemus Makio, George Omweri, Victor Osoti, Selpha Okach, Felix Choy, Henk D. F. H. Schallig, Pètra Mens   +8 more
doaj   +1 more source

Artemether-lumefantrine dosing for malaria treatment in young children and pregnant women: A pharmacokinetic-pharmacodynamic meta-analysis.

PLoS Medicine, 2018
BackgroundThe fixed dose combination of artemether-lumefantrine (AL) is the most widely used treatment for uncomplicated Plasmodium falciparum malaria.
Frank Kloprogge, Lesley Workman, Steffen Borrmann, Mamadou Tékété, Gilbert Lefèvre, Kamal Hamed, Patrice Piola, Johan Ursing, Poul Erik Kofoed, Andreas Mårtensson, Billy Ngasala, Anders Björkman, Michael Ashton, Sofia Friberg Hietala, Francesca Aweeka, Sunil Parikh, Leah Mwai, Timothy M E Davis, Harin Karunajeewa, Sam Salman, Francesco Checchi, Carole Fogg, Paul N Newton, Mayfong Mayxay, Philippe Deloron, Jean François Faucher, François Nosten, Elizabeth A Ashley, Rose McGready, Michele van Vugt, Stephane Proux, Ric N Price, Juntra Karbwang, Farkad Ezzet, Rajesh Bakshi, Kasia Stepniewska, Nicholas J White, Philippe J Guerin, Karen I Barnes, Joel Tarning   +39 more
doaj   +1 more source