Results 1 to 10 of about 7,618 (105)

Can hair concentrations of artemether-lumefantrine be used as a tool to retrospectively determine drug exposure during malaria treatment? [PDF]

New Microbes and New Infections
Background: Artemether-lumefantrine (AL) is the first-line treatment for uncomplicated Plasmodium falciparum malaria, with cure rates exceeding 95 %.
Jenny L. Schnyder, Marloes Vos-van der Meer, Reinier M. van Hest, Ron Mathot, Patricia Schlagenhauf, Hanna K. de Jong, Martin P. Grobusch   +6 more
doaj   +2 more sources

Physiologically based pharmacokinetic modelling to predict artemether and lumefantrine exposure in neonates weighing less than 5 kg treated with artemether–lumefantrine to supplement the clinical data from the CALINA study [PDF]

Tropical Medicine and Health
Background Evidence-based recommendations for malaria treatment in patients weighing 
Helen Gu, Nada Abla, Vinay Kumar Venishetty, Birgit Schoeberl, Julia Zack, Heidi J. Einolf   +5 more
doaj   +2 more sources

Pharmacopeial quality of artemether–lumefantrine anti-malarial agents in Uganda [PDF]

Malaria Journal, 2023
Background Substandard anti-malarial agents pose a significant challenge to effective malaria control and elimination efforts especially in sub-Saharan Africa.
Moses Ocan, Loyce Nakalembe, Caroline Otike, Denis Omali, Allan Buzibye, Sam Nsobya   +5 more
doaj   +2 more sources

Pharmacokinetics, safety and efficacy of an optimized dose of artemether–lumefantrine in the treatment of acute uncomplicated Plasmodium falciparum malaria in neonates and infants of less than 5 kg body weight: a multicentre, open-label, single-arm phase 2/3 study (CALINA) [PDF]

Tropical Medicine and Health
Background Treatment recommendations for malaria in infants of 
Gildas Wounounou, Alfred B. Tiono, Bernhards Ogutu, Christine Manyando, Issaka Sagara, Stefan Schneitter, Quique Bassat, Myriam El Gaaloul, Anne Claire Marrast, Ivan Demin, Cornelis Winnips, Celine Risterucci, Sophie Hugot, Georg Hofstetter, Zhiyan Qian, Guoqin Su, Jie Zhang, Katalin Csermak Renner, Marc Cousin, Vinay Kumar Venishetty, Sarfaraz Sayyed, Preetam Gandhi, Berenger Kabore, The CALINA study group   +23 more
doaj   +2 more sources

Chronic oral exposure to Artemether–lumenfantrine induced testicular and epidydimal damage, germ cell death and severe decrease sperm viability in BALB/c mice

Scientific African, 2020
Malaria is currently the world's most important parasitic infection, especially in the tropical countries, where the disease has continually been a major cause of morbidity and death.
Bintu M. Mofio, Rejoice John, Omerah Raphael Attah, Agbonu O. Adikpe, Ifukibot L. Usende   +4 more
doaj   +1 more source

Efficacy of 3-day low dose quinine plus clindamycin versus artemether-lumefantrine for the treatment of uncomplicated Plasmodium falciparum malaria in Kenyan children (CLINDAQUINE): an open-label randomized trial

Malaria Journal, 2022
Background The World Health Organization recommends quinine plus clindamycin as first-line treatment of malaria in the first trimester of pregnancy and as a second-line treatment for uncomplicated falciparum malaria when artemisinin-based drug ...
Charles O. Obonyo, Elizabeth A. Juma, Vincent O. Were, Bernhards R. Ogutu   +3 more
doaj   +1 more source

Optimizing derivatization conditions using an experimental design and simultaneous estimation of artemether and lumefantrine by ratio first order derivative spectrophotometric method

Journal of Taibah University for Science, 2017
Artemether–lumefantrine is the most widely used artemisinin-based combination therapy for malaria. The present work aims to develop and validate a simple, accurate, precise and rapid ratio first order derivative spectrophotometric method for the ...
Jenee Christian, Purvi Shah, Margi Patel, Kalpana Patel, Tejal Gandhi   +4 more
doaj   +1 more source

hplc-UV method for simultaneous quantitation of artemether and lumefantrine in fixed dose combination orodispersible tablet formulation

Pakistan Journal of Pharmaceutical Sciences, 2020
This paper describes the development and validation of a high performance liquid chromatography (HPLC-UV) method for the simultaneous quantitative determination of artemether and lumefantrine in fixed dose combination tablets.
Rabia Habib, Muhammad Harris Shoaib, Farrukh Rafiq Ahmed, Fahad Siddiqui, Rabia Ismail Yousuf, Talha Saleem, Momina Zarish Khan   +6 more
doaj   +1 more source

Quality Assessment of Artemether-Lumefantrine Samples and Artemether Injections Sold in the Cape Coast Metropolis

Journal of Tropical Medicine, 2016
Most prescribers and patients in Ghana now opt for the relatively expensive artemether/lumefantrine rather than artesunate-amodiaquine due to undesirable side effects in the treatment of uncomplicated malaria.
James Prah, Elvis Ofori Ameyaw, Richmond Afoakwah, Patrick Fiawoyife, Ernest Oppong-Danquah, Johnson Nyarko Boampong   +5 more
doaj   +1 more source

Efficacy and safety of artemether–lumefantrine for treatment of uncomplicated Plasmodium falciparum malaria in Ethiopia: a systematic review and meta-analysis

Malaria Journal, 2021
Background Regular monitoring of anti-malarial drug efficacy is vital for establishing rational malaria treatment guidelines and ensuring adequate treatment outcomes.
Abdulhakim Abamecha, Daniel Yilma, Wondimagegn Adissu, Delenasaw Yewhalaw, Alemseged Abdissa   +4 more
doaj   +1 more source