Results 81 to 90 of about 11,360 (208)

Complete Dialysis‐Free Recovery From Severe Malaria–Associated Acute Kidney Injury and Multiorgan Failure: A Case Report and Brief Literature Review

Clinical Case Reports, Volume 14, Issue 4, April 2026.
ABSTRACT Severe malaria remains a major cause of acute kidney injury and multiorgan failure in endemic regions, often requiring renal replacement therapy. However, access to dialysis is limited in many resource‐constrained settings, making outcomes highly dependent on early diagnosis and effective antimalarial treatment. We report a 32‐year‐old man who
Tamirat Godebo Woyimo, Amare Hailu Ashine, Mohammed Kedir Shukri, Yonas Damtew Bejiga, Ragasa Getachew, Yosef Bekele Bonsa, Rediet Girmaye, Tsion Haile Woldemariam, Adugna Lamessa   +8 more
wiley   +1 more source

Optimizing derivatization conditions using an experimental design and simultaneous estimation of artemether and lumefantrine by ratio first order derivative spectrophotometric method

Journal of Taibah University for Science, 2017
Artemether–lumefantrine is the most widely used artemisinin-based combination therapy for malaria. The present work aims to develop and validate a simple, accurate, precise and rapid ratio first order derivative spectrophotometric method for the ...
Jenee Christian, Purvi Shah, Margi Patel, Kalpana Patel, Tejal Gandhi   +4 more
doaj   +1 more source

Physical stability and release properties of lumefantrine amorphous solid dispersion granules prepared by a simple solvent evaporation approach

International Journal of Pharmaceutics: X, 2020
Amorphous solid dispersions (ASDs) of lumefantrine, which has low aqueous solubility, have been shown to improve bioavailability relative to crystalline formulations.
Niraj S. Trasi, Sonal V. Bhujbal, Dmitry Y. Zemlyanov, Qi (Tony) Zhou, Lynne S. Taylor   +4 more
doaj   +1 more source

Strengthening Pharmacogenomics Implementation in Africa: Challenges and Opportunities ‐ A Narrative Review

Health Science Reports, Volume 9, Issue 4, April 2026.
ABSTRACT Background and Aim The discipline of pharmacogenomics (PGx) studies the influence of genetic diversity on drug response, bringing the potential to personalized treatment and reduction of adverse effects. Although PGx integration into healthcare is progressing at a global scale, its implementation in Africa faces unique challenges and ...
Esther Mukabyiringiro, Andrew Wainaina Kinyanjui, Gachie Ruth Nthenya, Okoth Zifion Ndiege, Daniel Alaak Majok, Samuel Inshutiyimana, Ermias Mergia Terefe   +6 more
wiley   +1 more source

Artemether-Lumefantrine Treatment Failure despite adequate lumefantrine day 7 Concentration in a Traveller with Plasmodium Falciparum Malaria after Returning from Tanzania. [PDF]

Artemether-lumefantrine is currently first-line therapy of Plasmodium falciparum malaria in many countries. This report describes a treatment failure despite adequate drug concentrations in a traveller returning from sub-Saharan Africa.
Färnert, Anna, Karlsson, Lillemor, Tolfvenstam, Thomas, Lindegårdh, Niklas, Ursing, Johan, Sparrelid, Elda, Rono, Josea   +6 more
core  

PHARMACOKINETICS OF LUMEFANTRINE IN HEALTHY PAKISTANI VOLUNTEERS

Pakistan Armed Forces Medical Journal, 2011
Objective: To study the pharmacokinetics of lumefantrine in healthy Pakistani volunteers so as to see the adequacy of the regimen in vogue for the treatment of malaria and prevention of recrudescence.
Nusrat Jafery, Muzammil Hassan Najmi
doaj   +2 more sources

Can hair concentrations of artemether-lumefantrine be used as a tool to retrospectively determine drug exposure during malaria treatment?

New Microbes and New Infections
Background: Artemether-lumefantrine (AL) is the first-line treatment for uncomplicated Plasmodium falciparum malaria, with cure rates exceeding 95 %.
Jenny L. Schnyder, Marloes Vos-van der Meer, Reinier M. van Hest, Ron Mathot, Patricia Schlagenhauf, Hanna K. de Jong, Martin P. Grobusch   +6 more
doaj   +1 more source

Artesunate + amodiaquine versus artemether-lumefantrine for the treatment of uncomplicated Plasmodium falciparum malaria in the Colombian Pacific region: a noninferiority trial

Revista da Sociedade Brasileira de Medicina Tropical, 2012
INTRODUCTION: In Colombia, there are no published studies for the treatment of uncomplicated Plasmodium falciparum malaria comparing artemisinin combination therapies.
Fernando De la Hoz Restrepo, Alexandra Porras Ramírez, Alejandro Rico Mendoza, Freddy Córdoba, Diana Patricia Rojas   +4 more
doaj   +1 more source

Malaria in Bangladesh, 2000–2025: Navigating the Headwinds From Control to Elimination

Health Science Reports, Volume 9, Issue 3, March 2026.
ABSTRACT Background and Aims Bangladesh has dramatically reduced its malaria burden since 2000, confining the disease to specific geographic zones. However, the national 2030 elimination goal is now threatened by a complex interplay of biological, ecological, and social factors.
Abdullaha Al Mamun, Mustafa Sarwar A. Kayenat, K. A. M. Inzamul Islam   +2 more
wiley   +1 more source

Electrocardiographic safety evaluation of extended artemether-lumefantrine treatment in patients with uncomplicated Plasmodium falciparum malaria in Bagamoyo District, Tanzania

Malaria Journal, 2020
Background Extended artemisinin-based combination therapy (ACT) for treatment of uncomplicated Plasmodium falciparum malaria with already existing drug regimens, such as artemether-lumefantrine, might be effective in tackling the emerging ACT resistance.
Lwidiko E. Mhamilawa, Sven Wikström, Bruno P. Mmbando, Billy Ngasala, Andreas Mårtensson   +4 more
doaj   +1 more source