Results 101 to 110 of about 11,360 (208)

Population parameter estimates from the simultaneous pharmacokinetic lumefantrine/desbutyl-lumefantrine drug-metabolite model.

, 2018
Population parameter estimates from the simultaneous pharmacokinetic lumefantrine/desbutyl-lumefantrine drug-metabolite model.
Kamal Hamed (312288), Patrice Piola (257158), Andreas Mårtensson (81466), Leah Mwai (181144), Francesco Checchi (33749), François Nosten (17237), Carole Fogg (269042), Michael Ashton (1400944), Steffen Borrmann (4910), Elizabeth A. Ashley (237173), Juntra Karbwang (96344), Nicholas J. White (35779), Philippe J. Guerin (137002), Anders Björkman (81476), Poul Erik Kofoed (5374178), Michele van Vugt (315300), Paul N. Newton (132889), Mayfong Mayxay (132900), Karen I. Barnes (265208), Mamadou Tékété (5374166), Philippe Deloron (87822), Billy Ngasala (214980), Farkad Ezzet (5374181), Johan Ursing (370814), Frank Kloprogge (5374169), Lesley Workman (368956), Kasia Stepniewska (74266), Sunil Parikh (370188), Sam Salman (597458), Francesca Aweeka (370751), Harin Karunajeewa (336719), Stephane Proux (17227), Ric N. Price (35538), Joel Tarning (387123), Gilbert Lefèvre (5374175), Sofia Friberg Hietala (5374163), Jean François Faucher (5374172), Timothy M. E. Davis (112260), Rajesh Bakshi (5374160), Rose McGready (17231)   +39 more
core   +1 more source

Correct Dosing of Artemether-Lumefantrine for Management of Uncomplicated Malaria in Rural Tanzania: Do facility and Patient Characteristics Matter? [PDF]

, 2013
Use of artemisinin-based combination therapy (ACT), such as artemether-lumefantrine (AL), requires a strict dosing schedule that follows the drugs' pharmacokinetic properties.
Amuri, Baraka, de Savigny, Don, Kachur, S. Patrick, Irene M Masanja, Kajungu, Dan, Dan Kajungu, S Kachur, Selemani, Majige, Khatib, Rashid A., Kuepfer, Irene, Jacek Skarbinski, Rashid A Khatib, Kachur, S Patrick, Irene Kuepfer, Masanja, Irene M, Skarbinski, Jacek, Baraka Amuri, Don de Savigny, Masanja, Irene M., Majige Selemani, Khatib, Rashid A   +20 more
core   +1 more source

Simultaneous Estimation of Artemether and Lumefantrine by RP-HPLC Method Development in Pharmaceutical Tablet Dosage Form

RGUHS Journal of Pharmaceutical Sciences
Background Artemether and Lumefantrine are widely used antimalarial agents whose simultaneous quantification in tablet formulations is essential for quality control.Objectives To develop and validate a simple accurate and robust ...
Lekhana A M, Paul Richards M, Vishwanath BA   +2 more
doaj   +1 more source

A randomized, open-label, comparative efficacy trial of artemether-lumefantrine suspension versus artemether-lumefantrine tablets for treatment of uncomplicated Plasmodium falciparum malaria in children in western Kenya

Malaria Journal, 2008
Background Artemether/lumefantrine (AL) has been adopted as the treatment of choice for uncomplicated malaria in Kenya and other countries in the region.
Akhwale Willis S, Obonyo Charles O, Juma Elizabeth A, Ogutu Bernhards R   +3 more
doaj   +1 more source

Physiologically based pharmacokinetic modelling to predict artemether and lumefantrine exposure in neonates weighing less than 5 kg treated with artemether–lumefantrine to supplement the clinical data from the CALINA study

Tropical Medicine and Health
Background Evidence-based recommendations for malaria treatment in patients weighing 
Helen Gu, Nada Abla, Vinay Kumar Venishetty, Birgit Schoeberl, Julia Zack, Heidi J. Einolf   +5 more
doaj   +1 more source

Drug interactions between dolutegravir and artemether-lumefantrine or artesunate-amodiaquine [PDF]

, 2018
Across sub-Saharan Africa, patients with HIV on antiretrovirals often get malaria and need cotreatment with artemisinin-containing therapies. We undertook two pharmacokinetic studies in healthy volunteers, using standard adult doses of artemether ...
Mohammed Lamorde, Julian Kaboggoza, Alieu Amara, Walimbwa, SI, Else, L, Winterberg, Markus, Chiong, J, Byakika-Kibwika, P, Stephen I Walimbwa, Catriona Waitt, Tarning, J, Joshua Gini, Lamorde, M, Tarning, Joel, Justin Chiong, Pauline Byakika-Kibwika, Amara, A, Kaboggoza, J, Markus Winterberg, Saye H Khoo, Joel Tarning, Waitt, C, Winterberg, M, Gini, J, Khoo, SH, Laura Else   +25 more
core   +1 more source

Population pharmacokinetics of lumefantrine in pregnant women treated with artemether-lumefantrine for uncomplicated Plasmodium falciparum malaria.

, 2009
Artemether-lumefantrine has become one of the most widely used antimalarial drugs in the world. The objective of this study was to determine the population pharmacokinetic properties of lumefantrine in pregnant women with uncomplicated multidrug ...
Kamanikom, B, Annerberg, A, Stepniewska, K, Singhasivanon, P, Mcgready, Rose, Day, Nicholas, Lindegardh, N, Pimanpanarak, M, Tarning, J, White, Nicholas, Nosten, F, Ashley, EA   +11 more
core   +1 more source

Artemether-lumefantrine for treating uncomplicated falciparum malaria.

, 2003
BACKGROUND: Artemether-lumefantrine is being promoted by the World Health Organization for treating uncomplicated malaria. It is expensive. We sought evidence of its superiority over existing treatment regimens.
Omari, A. A., Gamble, Carrol, Garner, P.; id_orcid   +2 more
core   +1 more source

Usefulness of combined screening methods for rapid detection of falsified and/or substandard medicines in the absence of a confirmatory method

Malaria Journal, 2019
Background The influx of substandard and falsified medicines is a global public health challenge and its rapid detection is a key solution to the menace. This study used three screening methods and one confirmatory method for the quality assessment of 25
Kwabena Frimpong-Manso Opuni, Henry Nettey, Marvin Adjei Larbi, Salome Naa Amerley Amartey, Gifty Nti, Abraham Dzidonu, Patrick Owusu-Danso, Nicholas Amoah Owusu, Alexander Kwadwo Nyarko   +8 more
doaj   +1 more source

High Efficacy of Two Artemisinin-Based Combinations (Artesunate + Amodiaquine and Artemether + Lumefantrine) in Caala, Central Angola. [PDF]

, 2006
In April 2004, 137 children 6-59 months of age with uncomplicated Plasmodium falciparum (Pf) malaria (Caala, Central Angola) were randomized to receive either artemether-lumefantrine (Coartem) or artesunate + amodiaquine (ASAQ).
Guthmann, J P, Noël, F, Balkan, S, Rigutto, C, Cohuet, S, Mulemba, M, Saraiva, N, Kyomuhendo, J, Fortes, F, Kiguli, J, Francis, M   +10 more
core