Results 91 to 100 of about 11,360 (208)

Severe acute malnutrition results in lower lumefantrine exposure in children treated with artemether-lumefantrine for uncomplicated malaria [PDF]

, 2019
Severe acute malnutrition (SAM) has been reported to be associated with increased malaria morbidity in Sub-Saharan African children and may affect the pharmacology of antimalarial drugs. This population pharmacokinetic (PK)-pharmacodynamic study included
Denoeud-Ndam, Lise, Ousmane Guindo, Diawara, H., Richard M. Hoglund, Baudin, Elisabeth, Etard, Jean-François, Attaher, O, Dicko, A, Guerin, Philippe J, Denoeud-Ndam, L, Halimatou Diawara, Etard, Jean François, Denoeud-Ndam, L., Dicko, Alassane, Dicko, A., Tarning, Joel, Doumbo, Ogobara K, M. Hoglund, Richard, Attaher, O., Lubbe Wiesner, Guindo, O, Diawara, Halimatou, Barnes, K. I., Tarning, J., Etard, J-F, Chotsiri, P, Elisabeth Baudin, Palang Chotsiri, Ogobara K. Doumbo, Guerin, Philippe, Chotsiri, P., Smit, M., Smit, M, Smit, Michiel, Diawara, H, Wiesner, L, Michiel Smit, Attaher, Oumar, Barnes, KI, Hoglund, R. M., Alassane Dicko, Doumbo, O. K., Baudin, E, Baudin, E., Lise Denoeud‐Ndam, Tarning, J, Jean‐Francois Etard, Wiesner, Lubbe, Guindo, Ousmane, Guerin, PJ, Guerin, P. J., Philippe J. Guerin, Oumar Attaher, Chotsiri, Palang, Karen I. Barnes, Joel Tarning, Doumbo, OK, Wiesner, L., Guindo, O., I. Barnes, Karen, Hoglund, RM   +60 more
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Solvent-less Synthesis, Antimalarial and Toxicity Evaluation of Lumefantrine-Copper Complex in Swiss Mice

Notulae Scientia Biologicae, 2016
The antimalarial efficacy and safety of mechanically induced solventlessly synthesized lumefantrine-copper complex were investigated in experimental mice. Parasite level in Plasmodium berghei-infected mice treated with lumefantrine - copper complex (LCC)
Rotimi Olusanya ARISE, Adedibu Clement TELLA, Oluyinka A. IYIOLA, Oluwakemi Mary AYENI, Samuel Tobi FAROHUNBI, Abeeb Abiodun YEKEEN   +5 more
doaj   +1 more source

Absence of association between Pfnfs1 mutation and in vitro susceptibility to lumefantrine in Plasmodium falciparum

International Journal for Parasitology: Drugs and Drug Resistance
Artemether-lumefantrine (AL) is the most widely used antimalarial drug for treating uncomplicated falciparum malaria. This study evaluated whether the K65Q mutation in the Plasmodium falciparum cysteine desulfurase IscS (Pfnfs1) gene was associated with ...
Weilin Zeng, Wei Zhao, Hao Wei, Yucheng Qin, Zheng Xiang, Yanrui Wu, Xi Chen, Yanmei Zhang, Hui Zhao, Mengxi Duan, Wenya Zhu, Kemin Sun, Yiman Wu, Tao Liang, Ye Mou, Cheng Liu, Xiuya Tang, Yaming Huang, Liwang Cui, Zhaoqing Yang   +19 more
doaj   +1 more source

Efficacy and safety properties of Lumefantrine-Trimethoprim-Copper complex in mice

Ceylon Journal of Science, 2018
Lumefantrine and trimethoprim are antimalarial and antibiotic drugs respectively. Even though, therapeutic agents have shown enhanced efficacy upon coordination to metal ion, antimalarial activity of lumefantrine-trimethoprim-copper complex drug has not ...
R.O. Arise, A. Olowo, M.A. Acho, O. Olufemi, A.A. Adewale, A.C. Tella   +5 more
doaj   +1 more source

Therapeutic failure after regimen with artemether-lumefantrine combination therapy: a report of three cases in Benin City, Nigeria

Revista da Sociedade Brasileira de Medicina Tropical, 2019
Artemisinin-based combination therapy (ACT) is recommended by the World Health Organization for the treatment of uncomplicated malaria. Currently, there appears to be a downward trend in the efficacy of ACT in some parts of sub-Saharan Africa because ...
Osamudiamen Ebohon, Francis Irabor, Linda Osahon Ebohon, Ehimwenma Sheena Omoregie   +3 more
doaj   +1 more source

Safety and tolerability of combination antimalarial therapies for uncomplicated falciparum malaria in Ugandan children. [PDF]

, 2008
BACKGROUND: Combination antimalarial therapy is recommended for the treatment of uncomplicated falciparum malaria in Africa; however, some concerns about the safety and tolerability of new regimens remain.
Njama-Meya Denise, Staedke Sarah G, Catherine Maiteki-Sebuguzi, Denise Njama-Meya, Moses R Kamya, Sarah G Staedke, Maiteki-Sebuguzi Catherine, Grant Dorsey, Yau, Vincent M, Jagannathan, Prasanna, Dorsey, Grant, Talisuna, Ambrose O, Dorsey Grant, Ambrose O Talisuna, Rosenthal Philip J, Jagannathan Prasanna, Maiteki-Sebuguzi, Catherine, Rosenthal, Philip J, Tamara D Clark, Clark Tamara D, Nzarubara Bridget, Staedke, Sarah G, Prasanna Jagannathan, Yau Vincent M, Nzarubara, Bridget, Vincent M Yau, Philip J Rosenthal, Njama-Meya, Denise, Clark, Tamara D, Kamya Moses R, Bridget Nzarubara, Kamya, Moses R, Talisuna Ambrose O   +32 more
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Lumefantrine and desbutyl-lumefantrine population pharmacokinetic-pharmacodynamic relationships in pregnant women with uncomplicated Plasmodium falciparum malaria on the Thailand-Myanmar border [PDF]

, 2015
Artemether-lumefantrine is the most widely used antimalarial artemisinin-based combination treatment. Recent studies have suggested that day 7 plasma concentrations of the potent metabolite desbutyl-lumefantrine correlate better with treatment outcomes ...
Kloprogge, Frank, Blessborn, D, Day, Nicholas P., McGready, R, Kloprogge, F, Hanpithakpong, Warunee, Blessborn, Daniel, Hanpithakpong, W, Nosten, Francois, Tarning, J, Day, NP, White, NJ, White, Nicholas, Nosten, F, Tarning, Joel, McGready, Rose   +15 more
core   +1 more source

Solubility enhancing lipid-based vehicles for artemether and lumefantrine destined for the possible treatment of induced malaria and inflammation: in vitro and in vivo evaluations

Beni-Suef University Journal of Basic and Applied Sciences
Background The lipid self-emulsifying system has been advanced as a promising delivery vehicle for improving the solubility and bioavailability of artemether and lumefantrine. However, the observed kinetic instability (propensity of lumefantrine to rapid
Onyinyechi Lydia Ugorji, Ikechukwu Virgilius Onyishi, Julie Ngozichukwuka Onwodi, Christiania Moji Adeyeye, Uzochukwu Gospel Ukachukwu, Nicholas Chinedu Obitte   +5 more
doaj   +1 more source

Plasmodium falciparum and Schistosoma mansoni coinfection and the side benefit of artemether-lumefantrine in malaria patients

Journal of Infection in Developing Countries, 2013
Introduction: The distribution of both malaria and schistosomiasis exhibits a large geographical overlap in tropical environments, particularly in sub-Saharan Africa. This part of the world currently harbours more than 85% of the estimated global burden
Solomon M Abay, Mulugeta Tilahun, Nigus Fikrie, Abiy Habtewold   +3 more
doaj   +1 more source

Repeated treatment of recurrent uncomplicated Plasmodium falciparum malaria in Senegal with fixed-dose artesunate plus amodiaquine versus fixed-dose artemether plus lumefantrine: a randomized, open-label trial. [PDF]

, 2011
BACKGROUND: The use of artemisinin-based combination therapy (ACT) is currently recommended for treating uncomplicated malaria. The objective was to assess the efficacy and safety of repeated administrations of two fixed-dose presentations of ACT ...
Gaye Oumar, Ali Gueye, Corinne Tchania, Cissé, Badara, Tchania Corinne, Ibrahima Ndiaye, Barry Aichatou, Tine Roger, Gueye Ali, Tine, Roger, Ndiaye Daouda, Ndiaye, Ibrahima, Ndiaye, Daouda, Daouda Ndiaye, Valérie Lameyre, Gueye, Ali, Ndiaye Jean-Louis A, Roger Tine, Aichatou Barry, Tchania, Corinne, Faye, Babacar, Babacar Faye, Lameyre, Valérie, Cissé Badara, Ndiaye Ibrahima, Barry, Aichatou, Gaye, Oumar, Oumar Gaye, Faye Babacar, Ndiaye, Jean-Louis A, Jean-Louis A Ndiaye, Lameyre Valérie, Badara Cissé   +32 more
core   +1 more source