Results 61 to 70 of about 8,298 (167)

Therapeutic failure after regimen with artemether-lumefantrine combination therapy: a report of three cases in Benin City, Nigeria

Revista da Sociedade Brasileira de Medicina Tropical, 2019
Artemisinin-based combination therapy (ACT) is recommended by the World Health Organization for the treatment of uncomplicated malaria. Currently, there appears to be a downward trend in the efficacy of ACT in some parts of sub-Saharan Africa because ...
Osamudiamen Ebohon, Francis Irabor, Linda Osahon Ebohon, Ehimwenma Sheena Omoregie   +3 more
doaj   +1 more source

Solubility enhancing lipid-based vehicles for artemether and lumefantrine destined for the possible treatment of induced malaria and inflammation: in vitro and in vivo evaluations

Beni-Suef University Journal of Basic and Applied Sciences
Background The lipid self-emulsifying system has been advanced as a promising delivery vehicle for improving the solubility and bioavailability of artemether and lumefantrine. However, the observed kinetic instability (propensity of lumefantrine to rapid
Onyinyechi Lydia Ugorji, Ikechukwu Virgilius Onyishi, Julie Ngozichukwuka Onwodi, Christiania Moji Adeyeye, Uzochukwu Gospel Ukachukwu, Nicholas Chinedu Obitte   +5 more
doaj   +1 more source

Plasmodium falciparum and Schistosoma mansoni coinfection and the side benefit of artemether-lumefantrine in malaria patients

Journal of Infection in Developing Countries, 2013
Introduction: The distribution of both malaria and schistosomiasis exhibits a large geographical overlap in tropical environments, particularly in sub-Saharan Africa. This part of the world currently harbours more than 85% of the estimated global burden
Solomon M Abay, Mulugeta Tilahun, Nigus Fikrie, Abiy Habtewold   +3 more
doaj   +1 more source

Simultaneous Estimation of Artemether and Lumefantrine by RP-HPLC Method Development in Pharmaceutical Tablet Dosage Form

RGUHS Journal of Pharmaceutical Sciences
Background Artemether and Lumefantrine are widely used antimalarial agents whose simultaneous quantification in tablet formulations is essential for quality control.Objectives To develop and validate a simple accurate and robust ...
Lekhana A M, Paul Richards M, Vishwanath BA   +2 more
doaj   +1 more source

A randomized, open-label, comparative efficacy trial of artemether-lumefantrine suspension versus artemether-lumefantrine tablets for treatment of uncomplicated Plasmodium falciparum malaria in children in western Kenya

Malaria Journal, 2008
Background Artemether/lumefantrine (AL) has been adopted as the treatment of choice for uncomplicated malaria in Kenya and other countries in the region.
Akhwale Willis S, Obonyo Charles O, Juma Elizabeth A, Ogutu Bernhards R   +3 more
doaj   +1 more source

Physiologically based pharmacokinetic modelling to predict artemether and lumefantrine exposure in neonates weighing less than 5 kg treated with artemether–lumefantrine to supplement the clinical data from the CALINA study

Tropical Medicine and Health
Background Evidence-based recommendations for malaria treatment in patients weighing 
Helen Gu, Nada Abla, Vinay Kumar Venishetty, Birgit Schoeberl, Julia Zack, Heidi J. Einolf   +5 more
doaj   +1 more source

Usefulness of combined screening methods for rapid detection of falsified and/or substandard medicines in the absence of a confirmatory method

Malaria Journal, 2019
Background The influx of substandard and falsified medicines is a global public health challenge and its rapid detection is a key solution to the menace. This study used three screening methods and one confirmatory method for the quality assessment of 25
Kwabena Frimpong-Manso Opuni, Henry Nettey, Marvin Adjei Larbi, Salome Naa Amerley Amartey, Gifty Nti, Abraham Dzidonu, Patrick Owusu-Danso, Nicholas Amoah Owusu, Alexander Kwadwo Nyarko   +8 more
doaj   +1 more source

Pharmacokinetics, safety and efficacy of an optimized dose of artemether–lumefantrine in the treatment of acute uncomplicated Plasmodium falciparum malaria in neonates and infants of less than 5 kg body weight: a multicentre, open-label, single-arm phase 2/3 study (CALINA)

Tropical Medicine and Health
Background Treatment recommendations for malaria in infants of 
Gildas Wounounou, Alfred B. Tiono, Bernhards Ogutu, Christine Manyando, Issaka Sagara, Stefan Schneitter, Quique Bassat, Myriam El Gaaloul, Anne Claire Marrast, Ivan Demin, Cornelis Winnips, Celine Risterucci, Sophie Hugot, Georg Hofstetter, Zhiyan Qian, Guoqin Su, Jie Zhang, Katalin Csermak Renner, Marc Cousin, Vinay Kumar Venishetty, Sarfaraz Sayyed, Preetam Gandhi, Berenger Kabore, The CALINA study group   +23 more
doaj   +1 more source

Lumefantrine quantification on pre-treated filter paper dried blood spots for clinical field trials. [PDF]

Malar J
Blessborn D, Kaewkhao N, Tarning J.
europepmc   +1 more source

Emergence and spread of Plasmodium falciparum PX1 polymorphisms associated with decreased susceptibility to antimalarials in Uganda. [PDF]

Nat Med
Niaré K, Tafesse B, Treat M, Sadler JM, Okitwi M, Orena S, Asua V, Kreutzfeld O, Legac J, Marglous J, Nsobya SL, Yeka A, Richard D, Ferdig MT, Mukherjee A, Rosenthal PJ, Juliano JJ, Bailey JA, Conrad MD.   +18 more
europepmc   +1 more source