Results 61 to 70 of about 11,360 (208)

Usefulness of day 7 lumefantrine plasma concentration as a predictor of malaria treatment outcome in under-fives children treated with artemether-lumefantrine in Tanzania

Malaria Journal, 2020
Background Day 7 plasma lumefantrine concentration is suggested as a predictor for malaria treatment outcomes and a cut-off of ≥ 200 ng/ml is associated with day 28 cure rate in the general population. However, day 7 lumefantrine plasma concentration can
Manase Kilonzi, Omary Minzi, Ritah Mutagonda, Vito Baraka, Philip Sasi, Eleni Aklillu, Appolinary Kamuhabwa   +6 more
doaj   +1 more source

A Systematic Review of Published Physiologically Based Pharmacokinetic Models for Drug Excretion Into Human Breastmilk: Knowledge Gaps and Opportunities to Optimize Reporting and Modeling Practices

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 8, August 2026.
ABSTRACT Physiologically based pharmacokinetic (PBPK) modeling is increasingly used to predict infant exposure to medications via breast milk. Existing guidance on reporting of PBPK modeling analyses is unstructured and nonbinding to researchers. We evaluated reporting practices and modeling approaches in published PBPK modeling studies.
Joshua Kiptoo, Davies Otieno, Kenta Yoshida, Neel Deferm, Aida Nakayiwa Kawuma, Francis Williams Ojara, Adeniyi Olagunju, Jackson K. Mukonzo, Catriona Waitt   +8 more
wiley   +1 more source

Prospective evaluation of artemether-lumefantrine for the treatment of non-falciparum and mixed-species malaria in Gabon [PDF]

, 2012
Background: The recommendation of artemisinin combination therapy (ACT) as first-line treatment for uncomplicated falciparum malaria is supported by a plethora of high quality clinical trials.
Mesküre Capan, Kurth, Florian Michael, Michael Ramharter, Kurth, F., Capan, Mesküre, Fanny Joanny, Arti Basra, Mombo-Ngoma, G., Capan, M., Capan Melser, Mesküre, Adegnika, A.A., Florian Kurth, Adegnika, Ayôla Akim, Adegnika, Ayola A., Ayola A Adegnika, Kremsner, Peter, Diop, D.A., Kremsner, P.G., Würbel, Heike, Kleine, C., Basra, Arti, Kleine, Christian, Ghyslain Mombo-Ngoma, Sabine Bélard, Joanny, F., Ramharter, M., Heike Würbel, Benjamin Mordmüller, Joanny, Fanny, Mombo-Ngoma, Ghyslain, Peter G Kremsner, Akerey-Diop, Daisy, Kremsner, Peter G., Daisy A Diop, Wurbel, H., Mordmüller, Benjamin Gottlieb, Christian Kleine, Belard, S., Ramharter, Michael, Basra, A., Bélard, Sabine, Kurth, Florian, Diop, Daisy A., Mordmuller, B.   +43 more
core   +1 more source

Short‐Course Low‐Dose Primaquine for Radical Cure in G6PD‐Normal Patients in the Pre‐Elimination Context of Nepal

Tropical Medicine &International Health, Volume 31, Issue 8, Page 1028-1034, August 2026.
ABSTRACT Background Plasmodium vivax remains a challenge for malaria elimination in Nepal due to its ability to relapse. Radical cure with primaquine is effective but limited by poor adherence to the standard 14‐day low‐dose regimen. In 2022, the WHO recommended administering the same total dose (3.5 mg/kg) over 7 days to improve adherence.
Prakash Ghimire, Gokarna Dahal, Nabaraj Adhikari, Komal Raj Rijal, Sanjib Adhikari, Megha Raj Banjara, Hellen Mnjala, Grant Lee, Sophie Weston, Angela Rumaseb, Anjana Rai, Benedikt Ley, Mohammad Sharif Hossain, Julie A. Simpson, Megha Rajasekhar, Bipin Adhikari, Ric N. Price, Bibek K. Lal, Kamala Thriemer   +18 more
wiley   +1 more source

Safety of Artemether-Lumefantrine Exposure in First Trimester of Pregnancy: An Observational Cohort. [PDF]

, 2014
There is limited data available regarding safety profile of artemisinins in early pregnancy. They are, therefore, not recommended by WHO as a first-line treatment for malaria in first trimester due to associated embryo-foetal toxicity in animal studies ...
Abdulla, Salim, Sigilbert Mrema, Dominic Mosha, Salim Abdulla, Sevene, Esperanca, Mosha, D., Mrema, Sigilbert, Mazuguni, F., Abdulla, S., Esperanca Sevene, Blaise Genton, Mosha, Dominic, Mazuguni, Festo, Festo Mazuguni, Sevene, E., Genton, B., Genton, Blaise, Mrema, S.   +17 more
core   +1 more source

Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Co-administered Ruxolitinib and Artemether-Lumefantrine in Healthy Adults

, 2022
Despite repeated malaria infection, individuals living in malaria endemic areas remain vulnerable to re-infection. The Janus kinase (JAK1/2) inhibitor ruxolitinib could potentially disrupt the parasite-induced dysfunctional immune response when ...
El Gaaloul, Myriam, Kress, Anita, Wells, Timothy, van Giersbergen, Paul, McCarthy, James S, Barnes, Karen I, Abla, Nada, Chughlay, M Farouk, Griffin, Paul, Schultz, Hayley B, Tapley, Peter, Möhrle, Jörg J, Engwerda, Christian R., Reuter, Stephanie E, et al., Webster, Rebecca A   +15 more
core   +1 more source

Incompatibility of antimalarial drugs: challenges in formulating combination products for malaria

Drug Delivery
Lipophilic drugs require more advance formulation, especially if the intention is to make solutions or semisolid formulations. This also accounts for most antimalarial drugs. Although some of these antimalarial drugs are soluble in lipid vehicles, few of
Ellen K. G. Mhango, Benjamin R. Sveinbjornsson, Bergthora S. Snorradottir, Sveinbjorn Gizurarson   +3 more
doaj   +1 more source

Adherence to a Six-Dose Regimen of Artemether-Lumefantrine for Treatment of Uncomplicated Plasmodium Falciparum Malaria in Uganda. [PDF]

, 2004
Measuring baseline levels of adherence and identifying risk factors for non-adherence are important steps before the introduction of new antimalarials. In Mbarara in southwestern Uganda, we assessed adherence to artemether-lumefantrine (Coartem) in its ...
Bajunirwe, F, Bajunirwe, Francis, Guthmann, J P, Piola, P, Musabe, Joy, Namiiro, P, Piola, Patrice, Biraro, S, Checchi, F, Namiiro, Proscovia, Checchi, Francesco, Guthmann, Jean-Paul, Biraro, Samuel, Kyomugisha, A, Musabe, J, Kiguli, James, Kiguli, J, Kyomugisha, Agnes, Fogg, C, Fogg, Carole   +19 more
core   +1 more source

hplc-UV method for simultaneous quantitation of artemether and lumefantrine in fixed dose combination orodispersible tablet formulation

Pakistan Journal of Pharmaceutical Sciences, 2020
This paper describes the development and validation of a high performance liquid chromatography (HPLC-UV) method for the simultaneous quantitative determination of artemether and lumefantrine in fixed dose combination tablets.
Rabia Habib, Muhammad Harris Shoaib, Farrukh Rafiq Ahmed, Fahad Siddiqui, Rabia Ismail Yousuf, Talha Saleem, Momina Zarish Khan   +6 more
doaj   +1 more source

Malaria transmission after artemether-lumefantrine and dihydroartemisinin-piperaquine: a randomized trial. [PDF]

, 2013
BACKGROUND: Artemisinin-based combination therapy (ACT) reduces the potential for malaria transmission, compared with non-ACTs. It is unclear whether this effect differs between ACTs.
Sauerwein, Robert W, Drakeley, Chris J, Bousema, Teun, Kavishe, R.A., Kavishe, Reginald A, Hallett, Rachel L, Mweresa, Collins K, Hermsen, C.C., Sauerwein, R.W., Shekalaghe, S., Manjurano, Alphaxard, Omar, S.A., Shekalaghe, Seif A., Sawa, Patrick, Sutherland, Colin J, Baidjoe, Amrish Y, Yussuf, R.U., Mweresa, C.K., Omar, Sabah A., Okell, L., Okell, Lucy, Hermsen, Cornelus C., Schallig, Henk DFH, Bousema, T., Manjurano, A., Baidjoe, A.Y., Mweresa, Collins K., Hallett, R.L., Beshir, Khalid B., Beshir, Khalid B, Shekalaghe, Seif A, Beshir, K.B., Drakeley, Chris J., Kavishe, Reginald A., Omar, Sabah A, Sutherland, Colin J., Yussuf, Rahma U, Sawa, P., Baidjoe, Amrish Y., Schallig, H.D., Yussuf, Rahma U., Drakeley, C., Hermsen, Cornelus C, Sutherland, C.J., Schallig, Henk D. F. H., Sauerwein, Robert W., Hallett, Rachel L.   +46 more
core   +1 more source