Results 41 to 50 of about 11,360 (208)

Deprotective Alkylation: A Platform for Alcohol‐to‐Amine Interconversion Using Nonafluoromesitylenesulfonamides

Angewandte Chemie International Edition, EarlyView.
The straightforward conversion of alcohols to tertiary or secondary amines employing Nms‐amides in a single operation is described. The transformation features broad functional group tolerance and high stereospecificity, underscoring its utility in the synthesis of isotope‐labeled pharmaceuticals.
Jakub Brześkiewicz, Kunj Kapur, Boris Maryasin, Nuno Maulide   +3 more
wiley   +1 more source

Randomized trial of safety and effectiveness of chlorproguanil-dapsone and lumefantrine-artemether for uncomplicated malaria in children in the Gambia. [PDF]

, 2011
BACKGROUND: Chlorproguanil-dapsone (Lapdap), developed as a low-cost antimalarial, was withdrawn in 2008 after concerns about safety in G6PD deficient patients.
Njie, Fanta, Bisseye, C, Nwakanma, D, Snell, P., Walton, Robert T., Conway D., Nwakanma, Davis, Cyrille Bisseye, Joof F., Sesay, Sanie, Milligan P., Walton, R, Sanie Sesay, Snell Paul, Joof, F., Snell P., Cheung, Yin Bun, Milligan Paul, Sesay S., Sesay, S, Bisseye C., Diatta Mathurin, Bisseye, Cyrille, Njie, F, Dunyo, Samuel, Janha, R., Adiamoh, M, Adiamoh, Majidah, Njie F., Janha, Ramatoulie, Temple B., Temple, B., Diatta, Mathurin, Cheung Yin Bun, Ramatoulie Janha, Yin Bun Cheung, Nwakanma, D., Diatta M., David Conway, Temple, Beth, Snell, P, Walton R., Janha, R, Sisay Joof Fatou, Robert Walton, Sisay Joof, F, Samuel Dunyo, Conway, D., Sirugo, G, Sirugo, G., Dunyo, S., Nwakanma D., Temple, B, Sirugo, Giorgio, Janha Ramatoulie, Dunyo S., Njie, F., Dunyo, S, Nwakanma Davis, Paul Milligan, Walton Robert, Beth Temple, Conway, David, Mathurin Diatta, Paul Snell, Bisseye Cyrille, Sesay, S., Cheung, YB, Temple Beth, Janha R., Adiamoh, M., Milligan, Paul, Milligan, P., Cheung Y.B., Bisseye, C., Fatou Sisay Joof, Walton, Robert, Sesay Sanie, Diatta, M., Conway David, Sirugo G., Diatta, M, Majidah Adiamoh, Davis Nwakanma, Njie Fanta, Adiamoh M., Snell, Paul, Milligan, P, Sisay Joof, Fatou, Sirugo Giorgio, Dunyo Samuel, Conway, D, Fanta Njie, Adiamoh Majidah, Giorgio Sirugo, Cheung, Y. B.   +95 more
core   +1 more source

Safety of Prenatal Anti‐Infective Use and Offspring Outcomes: A Panoramic Assessment by Indication, Drug Class, and Exposure Characteristics

iMetaMed, EarlyView.
Based on the comprehensive, panoramic assessment of the safety of prenatal anti‐infective use across indications, drug classes, and exposure characteristics, potential safety signals associated with prenatal exposure to several widely used anti‐infective drug classes were identified, including macrolides, metronidazole, tetracyclines, sulfonamides ...
Wenling Wang, Yuezhen Li, Chunrong Liu, Chen Chen, Meng Chen, Lehana Thabane, Xin Sun, Jing Tan   +7 more
wiley   +1 more source

Knowledge among Drug Dispensers and Antimalarial Drug Prescribing Practices in Public Health Facilities in Dar es Salaam. [PDF]

, 2013
Irrational prescribing and dispensing of antimalarials has been identified as a contributing factor in the emergence of malaria parasites resistant to existing antimalarial drugs.
Kamuhabwa AA, Silumbe R, Kamuhabwa, Appolinary Ar, Silumbe, Richard   +3 more
core   +1 more source

No Robust Evidence of Lumefantrine Resistance [PDF]

Antimicrobial Agents and Chemotherapy, 2015
Plucinski and colleagues ([1][1]) recently published the results of a therapeutic efficacy study of artemether-lumefantrine (AL) and dihydroartemisinin-piperaquine (DP) in Zaire and Uige Provinces in Angola and concluded that there was evidence of increased lumefantrine resistance in Zaire.
Kamal Hamed, Kelli Kuhen
openaire   +2 more sources

Hydroxamic Acids as HDAC Inhibitor Drug Leads for Malaria

Medicinal Research Reviews, EarlyView.
ABSTRACT Malaria is a global health threat, with an estimated 282 million cases and 610,000 malaria‐associated deaths reported in 2024. Most mortality is due to infection by Plasmodium falciparum parasites, with the highest burden occurring in Sub‐Saharan Africa.
Wisam A. Dawood, Jacinta R. Macdonald, Christian Anzenhofer, Tina S. Skinner‐Adams, Robert C. Reid, Thomas Kurz, David P. Fairlie, Katherine T. Andrews   +7 more
wiley   +1 more source

Primacy of effective communication and its influence on adherence to artemether-lumefantrine treatment for children under five years of age: a qualitative study. [PDF]

, 2012
Prompt access to artemesinin-combination therapy (ACT) is not adequate unless the drug is taken according to treatment guidelines. Adherence to the treatment schedule is important to preserve efficacy of the drug.
Deodatus Kakoko, Simba, Daudi O, Simba Daudi O, Daudi O Simba, Kakoko, Deodatus, Kakoko Deodatus   +5 more
core   +2 more sources

Genome‐Guided Discovery of Antimalarial 4‐Amino‐2,4‐Pentadienoate‐Containing Cyclolipodepsipeptides

Angewandte Chemie, Volume 138, Issue 18, 27 April 2026.
Halogenated and glycosylated 4‐amino‐2,4‐pentadienoate‐containing cyclolipodepsipeptides (APD‐CLDs) exhibit potent antiplasmodial activity (IC50 = 25–161 nM) against drug‐sensitive and resistant Plasmodium falciparum strains. ABSTRACT 4‐Amino‐2,4‐pentadienoate‐containing cyclolipodepsipeptides (APD‐CLDs) represent a structurally distinctive family of ...
Hartono Candra, Xue‐Jiao Wang, Ka Diam Go, Li Feng, Miaomiao Cai, Guang‐Lei Ma, Clarissa Widyantoro, Lik Tong Tan, Zbynek Bozdech, Zhe Wang, Zhao‐Xun Liang   +10 more
wiley   +2 more sources

Efficacy of 3-day low dose quinine plus clindamycin versus artemether-lumefantrine for the treatment of uncomplicated Plasmodium falciparum malaria in Kenyan children (CLINDAQUINE): an open-label randomized trial

Malaria Journal, 2022
Background The World Health Organization recommends quinine plus clindamycin as first-line treatment of malaria in the first trimester of pregnancy and as a second-line treatment for uncomplicated falciparum malaria when artemisinin-based drug ...
Charles O. Obonyo, Elizabeth A. Juma, Vincent O. Were, Bernhards R. Ogutu   +3 more
doaj   +1 more source

Malaria‐Associated Secondary Hematophagocytic Lymphohistocytosis—A Case Report and Comprehensive Literature Review (sHLH)

Clinical Case Reports, Volume 14, Issue 9, September 2026.
ABSTRACT Malaria‐associated secondary HLH, though rare, is often overlooked. Clinicians should maintain a high‐index of suspicion in travelers returning from malaria‐endemic regions who develop severe to rapidly worsening inflammatory illness, as early recognition is critical for survival.
Indresh Yadav, Sulav Kumar Jha, Sweta Singh, Dipesh Kumar Mandal, Saurav Jha   +4 more
wiley   +1 more source