Results 21 to 30 of about 3,298 (171)

Antimalarial drug efficacy and resistance in malaria‐endemic countries in HANMAT‐PIAM_net countries of the Eastern Mediterranean Region 2016–2020: Clinical and genetic studies

Tropical Medicine &International Health, Volume 28, Issue 10, Page 817-829, October 2023., 2023
Abstract Introduction The World Health Organization recommends regular monitoring of the efficacy of nationally recommended antimalarial drugs. We present the results of studies on the efficacy of recommended antimalarials and molecular markers of artemisinin and partner resistance in Afghanistan, Pakistan, Somalia, Sudan and Yemen.
Mariam Adam, Sami Nahzat, Qutbuddin Kakar, Methaq Assada, Benoit Witkowski, Azza Tag Eldin Elshafie, Duha Abuobaida, Naimullah Safi, Munir Ahmed Khan, Mustafa Nagi, Sayed Ali Mustafa, Khalilahmad Kohestani, Jamil Muhammad, Nimol Khim, Mohammed Al‐Hadi, Tarig Mohamed Elfaki, Muhammad Naeem Habib, Amna Khairy Abulkareem Khairy, Hamida Hamid, Zain Uddin, Yahya Amer, Abdikarim Hussein Hassan, Mousab Siddig Elhag, Ahmad Walid Sediqi, Inamullah Kakar, Rashad Abdul‐Ghani, Jamal Ghilan Hefzullah Amran, Tarig Abdalla Abdallrahim, Mohammad Shoaib Tamim, Adel Aljasari, Charlotte Rasmussen, Lina Azkoul, Marian Warsame   +32 more
wiley   +1 more source

Artemether resistance in vitro is linked to mutations in PfATP6 that also interact with mutations in PfMDR1 in travellers returning with Plasmodium falciparum infections. [PDF]

, 2012
BACKGROUND: Monitoring resistance phenotypes for Plasmodium falciparum, using in vitro growth assays, and relating findings to parasite genotype has proved particularly challenging for the study of resistance to artemisinins.
Rosalba Lepore, LEPORE, ROSALBA, Pillai, DR, Via Allegra, K. Khairnar, Khairnar Krishna, Rachel Lau, Pillai Dylan R, D. R. Pillai, VIA, ALLEGRA, Dylan R Pillai, Henry M Staines, Krishna Sanjeev, S. Krishna, Lau, R, Khairnar, K, Lau Rachel, Via, A, Staines, HM, H. M. Staines, Krishna, S, Sanjeev Krishna, Krishna Khairnar, Lepore, R, Allegra Via, R. Lau, Lepore Rosalba, Staines Henry M   +27 more
core   +1 more source

Characterization of lumefantrine, mefloquine, and chloroquine transport via PfMDR1.

, 2022
(a–c) There were significant differences in the apparent kinetic parameters of lumefantrine (a), mefloquine (b), and chloroquine (c) transport between field isoforms of PfMDR1. The concentration dependence of PfMDR1-mediated drug transport was calculated
Ben Corry (135521), Sarah Heckmatt Shafik (12501305), Sashika Natasha Richards (12501308), Rowena Elizabeth Martin (12501311)   +3 more
core   +1 more source

Impact of Drug Exposure on Resistance Selection Following Artemether‐Lumefantrine Treatment for Malaria in Children With and Without HIV in Uganda

Clinical Pharmacology &Therapeutics, Volume 113, Issue 3, Page 660-669, March 2023., 2023
Artemisinin‐based combination therapies (ACTs) are the primary treatment for malaria. It is essential to characterize the pharmacokinetics (PKs) and pharmacodynamics (PDs) of ACTs in vulnerable populations at risk of suboptimal dosing. We developed a population PK/PD model using data from our previous study of artemether‐lumefantrine in HIV‐uninfected ...
Katherine Kay, Justin Goodwin, Hanna Ehrlich, Joyce Ou, Tracey Freeman, Kaicheng Wang, Fangyong Li, Martina Wade, Jonathan French, Liusheng Huang, Francesca Aweeka, Norah Mwebaza, Richard Kajubi, Matthew Riggs, Ana Ruiz‐Garcia, Sunil Parikh   +15 more
wiley   +1 more source

Rates of PfMDR1-mediated drug transport.

, 2022
PfMDR1, Plasmodium falciparum multidrug resistance protein 1. (XLSX)
Ben Corry (135521), Sarah Heckmatt Shafik (12501305), Sashika Natasha Richards (12501308), Rowena Elizabeth Martin (12501311)   +3 more
core   +1 more source

Drug Development Strategies for Malaria: With the Hope for New Antimalarial Drug Discovery—An Update

Advances in Medicine, Volume 2023, Issue 1, 2023., 2023
Malaria continued to be a deadly situation for the people of tropical and subtropical countries. Although there has been a marked reduction in new cases as well as mortality and morbidity rates in the last two decades, the reporting of malaria caused 247 million cases and 619000 deaths worldwide in 2021, according to the WHO (2022).
Swaroop Kumar Pandey, Uttpal Anand, Waseem A. Siddiqui, Renu Tripathi, Shunqing Liang   +4 more
wiley   +1 more source

Predicted topologies of PfMDR1 and PfCRT.

, 2022
(a) PfMDR1 consists of 1,419 amino acid residues that are arranged into 12 TMDs and 2 NBDs. The length of the loops shown surrounding the NBDs are approximate. (b) PfCRT consists of 424 amino acid residues that are arranged into 10 TMDs.
Ben Corry (135521), Sarah Heckmatt Shafik (12501305), Sashika Natasha Richards (12501308), Rowena Elizabeth Martin (12501311)   +3 more
core   +1 more source

Plasmodium falciparum multidrug resistance gene-1 polymorphisms in Northern Nigeria: implications for the continued use of artemether-lumefantrine in the region

Malaria Journal, 2020
Background The analysis of single nucleotide polymorphism (SNPs) in drug-resistance associated genes is a commonly used strategy for the surveillance of anti-malarial drug resistance in populations of parasites.
Auwal Adamu, Mahmoud Suleiman Jada, Hauwa Mohammed Sani Haruna, Bassa Obed Yakubu, Mohammed Auwal Ibrahim, Emmanuel Oluwadare Balogun, Takaya Sakura, Daniel Ken Inaoka, Kiyoshi Kita, Kenji Hirayama, Richard Culleton, Mohammed Nasir Shuaibu   +11 more
doaj   +1 more source

Efficient One‐Pot Synthesis of Novel Caffeic Acid Derivatives as Potential Antimalarials

Journal of Parasitology Research, Volume 2023, Issue 1, 2023., 2023
New protocol for the preparation of the novel caffeic acid derivatives using the Wittig reaction has been applied to follow the principles of green chemistry. The compounds have been evaluated against chloroquine‐sensitive and chloroquine‐resistant P. falciparum strains.
Katarzyna Sidoryk, Silvia Parapini, Nicoletta Basilico, Magdalena Zaremba-Czogalla, Marek Kubiszewski, Marcin Cybulski, Jerzy Gubernator, Agnieszka Zagórska, Anna Jaromin, Lizandra Guidi Magalhães   +9 more
wiley   +1 more source

Persistence of chloroquine-resistant haplotypes of Plasmodium falciparum in children with uncomplicated Malaria in Lagos, Nigeria, four years after change of chloroquine as first-line antimalarial medicine. [PDF]

, 2015
BACKGROUND: In Nigeria, despite the change in National malaria drug policy to artemisinin combination therapy (ACT) in 2005 due to widespread chloroquine resistance, chloroquine (CQ) is still widely used in the treatment of malaria because it is cheap ...
Sutherland, Colin J, Oladipo, Oladosu O, Wellington, Oyibo A   +2 more
core   +1 more source