Results 21 to 30 of about 3,285 (205)

Role of the pfmdr1 Gene in Plasmodium falciparum Resistance to Antimalarial Treatment [PDF]

, 2012
Plasmodium falciparum is an intracellular protozoan that causes the most severe form of malaria. A major hindrance to disease control efforts is the spread of drug resistant parasite populations, which has been linked to the Plasmodium falciparum multidrug resistance (pfmdr1) gene.
Bohorquez, Elaine Brooks
openaire   +2 more sources

Selective sweeps and genetic lineages of Plasmodium falciparum multi-drug resistance (pfmdr1) gene in Kenya

Malaria Journal, 2018
Background There are concerns that resistance to artemisinin-based combination therapy might emerge in Kenya and sub-Saharan Africa (SSA) in the same pattern as was with chloroquine and sulfadoxine–pyrimethamine. Single nucleotide polymorphisms (SNPs) in
Peninah Muiruri, Denis W. Juma, Luicer A. Ingasia, Lorna J. Chebon, Benjamin Opot, Bidii S. Ngalah, Jelagat Cheruiyot, Ben Andagalu, Hoseah M. Akala, Venny C. S. Nyambati, Joseph K. Ng’ang’a, Edwin Kamau   +11 more
doaj   +2 more sources

Prevalence and Implications of Plasmodium Falciparum Multidrug Resistance Gene Mutations (pfmdr1) Among Pediatric Patients with Malaria in Kano, Nigeria

UMYU Journal of Microbiology Research
Study’s Excerpt: • fmdr1 gene mutations were assessed in falciparum from pediatric malaria patients in Kano. • Only 3.2% of amplified samples showed the pfmdr1 N86Y mutation linked to drug resistance.
Ummukulsum Mustapha, Ado Shehu, Ahmad Yunusa, Usman Usman Sanusi, Yusuf Misau Abdu, Attahir Ayuba Sa’ad, Aliyu Maigoro Muhammad, Abdullahi Haruna Ibrahim, Haddad Muhammad Mahfuz, Fatima Yakubu Zubairu   +9 more
doaj   +4 more sources

Molecular Method Optimization to Identify Plasmodium falciparum Multidrug Resistance 1 (pfmdr1) gene as a Predictor of Antimalarial Resistance [PDF]

Biology, Medicine & Natural Product Chemistry
Several approaches have been designed to control malaria, a disease with high morbidity and mortality, but they face some hurdles. Antimalarial resistance is one of the major challenges for malaria elimination, so the detection of antimalarial resistance
Erma Sulistyaningsih, Rosita Dewi, Sheilla Rachmania, Irawan Fajar Kusuma, Muhammad Rizqi Kholifaturrohmy, Yunita Armiyanti, Sakinatus Sariroh Kholifaturrohmah, Made Prasanti Andriani   +7 more
doaj   +2 more sources

Molecular surveillance of the Pfmdr1 N86Y allele among Congolese pregnant women with asymptomatic malaria

Malaria Journal, 2020
Background Malaria in pregnancy is associated with considerable morbidity and mortality. Regular surveillance of artemisinin-based combination therapy tolerance, or molecular makers of resistance, is vital for effective malaria treatment, control and ...
Louis Regis Dossou-Yovo, Francine Ntoumi, Felix Koukouikila-Koussounda, Jeannhey Christevy Vouvoungui, Ayodele Adedoja, David Nderu, Thirumalaisamy P. Velavan, Arsène Lenga   +7 more
doaj   +1 more source

Different patterns of pfcrt and pfmdr1 polymorphism in Plasmodium falciparum isolates from Tehama region, Yemen [PDF]

PeerJ, 2016
Introduction. Despite the efforts of the malaria control programme, malaria morbidity is still a common health problem in Yemen, with 60% of the population at risk. Plasmodium falciparum is responsible for 99% of malaria cases.
Wahib M. Atroosh, Hesham M. Al-Mekhlafi, Adel Al-Jasari, Hany Sady, Salwa S. Dawaki, Fatin N. Elyana, Mona A. Al-Areeqi, Nabil A. Nasr, Awatif M. Abdulsalam, Lahvanya R. Subramaniam, Meram Azzani, Init Ithoi, Yee Ling Lau, Johari Surin   +13 more
doaj   +2 more sources

Expansion of a Specific Plasmodium falciparum PfMDR1 Haplotype in Southeast Asia with Increased Substrate Transport

mBio, 2020
Artemisinin-based combination therapies (ACTs) have been vital in reducing malaria mortality rates since the 2000s. Their efficacy, however, is threatened by the emergence and spread of artemisinin resistance in Southeast Asia.
Carla Calçada, Miguel Silva, Vitória Baptista, Vandana Thathy, Rita Silva-Pedrosa, Diana Granja, Pedro Eduardo Ferreira, José Pedro Gil, David A. Fidock, Maria Isabel Veiga   +9 more
doaj   +1 more source

Chemo‐proteomics in antimalarial target identification and engagement

Medicinal Research Reviews, Volume 43, Issue 6, Page 2303-2351, November 2023., 2023
Abstract Humans have lived in tenuous battle with malaria over millennia. Today, while much of the world is free of the disease, areas of South America, Asia, and Africa still wage this war with substantial impacts on their social and economic development.
Brodie L. Bailey, William Nguyen, Alan F. Cowman, Brad E. Sleebs   +3 more
wiley   +1 more source

Antimalarial drug efficacy and resistance in malaria‐endemic countries in HANMAT‐PIAM_net countries of the Eastern Mediterranean Region 2016–2020: Clinical and genetic studies

Tropical Medicine &International Health, Volume 28, Issue 10, Page 817-829, October 2023., 2023
Abstract Introduction The World Health Organization recommends regular monitoring of the efficacy of nationally recommended antimalarial drugs. We present the results of studies on the efficacy of recommended antimalarials and molecular markers of artemisinin and partner resistance in Afghanistan, Pakistan, Somalia, Sudan and Yemen.
Mariam Adam, Sami Nahzat, Qutbuddin Kakar, Methaq Assada, Benoit Witkowski, Azza Tag Eldin Elshafie, Duha Abuobaida, Naimullah Safi, Munir Ahmed Khan, Mustafa Nagi, Sayed Ali Mustafa, Khalilahmad Kohestani, Jamil Muhammad, Nimol Khim, Mohammed Al‐Hadi, Tarig Mohamed Elfaki, Muhammad Naeem Habib, Amna Khairy Abulkareem Khairy, Hamida Hamid, Zain Uddin, Yahya Amer, Abdikarim Hussein Hassan, Mousab Siddig Elhag, Ahmad Walid Sediqi, Inamullah Kakar, Rashad Abdul‐Ghani, Jamal Ghilan Hefzullah Amran, Tarig Abdalla Abdallrahim, Mohammad Shoaib Tamim, Adel Aljasari, Charlotte Rasmussen, Lina Azkoul, Marian Warsame   +32 more
wiley   +1 more source

Lack of multiple copies of pfmdr1 gene in Papua New Guinea [PDF]

Transactions of the Royal Society of Tropical Medicine and Hygiene, 2008
We describe here the results of an analysis of Plasmodium falciparum multidrug resistance protein 1 (pfmdr1) gene copy number from 440 field isolates from Papua New Guinea. No multiple copies of the gene were found, which corresponds to the lack of usage of mefloquine. These data extend regional knowledge about the distribution of multidrug-resistant P.
Hodel EM, Marfurt J, Müller D, Rippert A, Borrmann S, Müller I, Reeder JC, Siba P, Genton B, Beck HP   +9 more
openaire   +3 more sources