Results 31 to 40 of about 3,298 (171)

Amino acid mutations in the PfMDR1 isoforms included for study.

, 2022
PfMDR1, Plasmodium falciparum multidrug resistance protein 1. (PDF)
Ben Corry (135521), Sarah Heckmatt Shafik (12501305), Sashika Natasha Richards (12501308), Rowena Elizabeth Martin (12501311)   +3 more
core   +1 more source

Prevalence of molecular markers of artemisinin and lumefantrine resistance among patients with uncomplicated Plasmodium falciparum malaria in three provinces in Angola, 2015

Malaria Journal, 2018
Background Artemisinin-based combination therapy is the first-line anti-malarial treatment for uncomplicated Plasmodium falciparum infection in Angola.
Dragan Ljolje, Pedro Rafael Dimbu, Julia Kelley, Ira Goldman, Douglas Nace, Aleixo Macaia, Eric S. Halsey, Pascal Ringwald, Filomeno Fortes, Venkatachalam Udhayakumar, Eldin Talundzic, Naomi W. Lucchi, Mateusz M. Plucinski   +12 more
doaj   +1 more source

Direct measurement of the transport of fluorescent compounds via PfMDR1.

, 2022
PfMDR1, Plasmodium falciparum multidrug resistance protein 1. (PDF)
Ben Corry (135521), Sarah Heckmatt Shafik (12501305), Sashika Natasha Richards (12501308), Rowena Elizabeth Martin (12501311)   +3 more
core   +1 more source

Roles of PfMDR1 and PfCRT in the parasite’s susceptibility to lumefantrine, mefloquine, and chloroquine.

, 2022
Mechanistic explanations for how polymorphisms in pfmdr1 and pfcrt alter the parasite’s response to lumefantrine and mefloquine (a) and chloroquine (b).
Ben Corry (135521), Sarah Heckmatt Shafik (12501305), Sashika Natasha Richards (12501308), Rowena Elizabeth Martin (12501311)   +3 more
core   +1 more source

A Novel Antimalarial Agent that Inhibits Protein Synthesis in Plasmodium falciparum. [PDF]

Angew Chem Int Ed Engl
Compound 31 represents a promising avenue for the development as an antimalarial agent with a potent activity profile (PfNF54 IC50 ± s.d. = 3.9 ± 0.4 nM). It has a novel mode of action by binding to cytosolic ribosomal subunits, thereby inhibiting protein synthesis in the parasite.
Bravo P, Diamanti E, Hamed MM, Bizzarri L, Wiedemar N, Passecker A, Brancucci NMB, Albisetti A, Gumpp C, Illarionov B, Fischer M, Witschel M, Schehl T, Hahne H, Mäser P, Rottmann M, Hirsch AKH.   +16 more
europepmc   +2 more sources

Known inhibitors of human P-gp inhibit the transport of lumefantrine via PfMDR1.

, 2022
(a) Schematic showing the cis-inhibition of [3H]drug transport via human P-gp or PfMDR1 by known P-gp inhibitors in the Xenopus oocyte system. (b) The IC50 values of nicardipine, PSC833, vanadate, and verapamil against [3H]vinblastine transport via human
Ben Corry (135521), Sarah Heckmatt Shafik (12501305), Sashika Natasha Richards (12501308), Rowena Elizabeth Martin (12501311)   +3 more
core   +1 more source

Pfcrt and pfmdr1 alleles associated with chloroquine resistance in Plasmodium falciparum from Guyana, South America

Memorias do Instituto Oswaldo Cruz, 2004
Using DNA extracted from 112 parasitised blood blots, we screened for the population marker of chloroquine resistance (CQR) pfcrt K76T in Plasmodium falciparum infections from Guyana.
Wallis Best Plummer, Lexley M Pinto Pereira, Christine VF Carrington   +2 more
doaj   +1 more source

Measurement of gene amplifications related to drug resistance in Plasmodium falciparum using droplet digital PCR

Malaria Journal, 2021
Background Copy number variations (CNVs) of the Plasmodium falciparum multidrug resistance 1 (pfmdr1), P. falciparum plasmepsin2 (pfplasmepsin2) and P. falciparum GTP cyclohydrolase 1 (pfgch1) genes are associated with anti-malarial drug resistance in P.
Suttipat Srisutham, Kanokon Suwannasin, Rungniran Sugaram, Arjen M. Dondorp, Mallika Imwong   +4 more
doaj   +1 more source

Synergism between Pfcrt and Pfmdr1 genes could account for the slow recovery of chloroquine sensitive Plasmodium falciparum strains in Ghana after chloroquine withdrawal

Journal of Infection and Public Health, 2017
Summary: Unlike other countries, the chloroquine resistant marker Pfcrt T76 mutant has remained fairly stable in Ghana several years after official disuse of chloroquine.
Kwame K. Asare, Johnson N. Boampong, Nancy O. Duah, Richmond Afoakwah, Rakesh Sehgal, Neils B. Quashie   +5 more
doaj   +1 more source

Differential Prevalences of Pfmdr1 Polymorphisms in Symptomatic and Asymptomatic Plasmodium falciparum Infections in Lastoursville: A Rural Area in East-Central Gabon

Infection and Drug Resistance, 2021
Steede Seinnat Ontoua,1,* Lady Charlene Kouna,1,* Sandrine Lydie Oyegue-Liabagui,1,2 Dominique Fatima Voumbo-Matoumona,3 Diamella Nancy Moukodoum,1 Romeo Karl Imboumy-Limoukou,1 Jean Bernard Lekana-Douki1,4 1Unité d’Evolution, Epidémiologie et ...
Ontoua SS, Kouna LC, Oyegue-Liabagui SL, Voumbo-Matoumona DF, Moukodoum DN, Imboumy-Limoukou RK, Lekana-Douki JB   +6 more
doaj