Results 51 to 60 of about 3,285 (205)

Pfcrt and pfmdr1 alleles associated with chloroquine resistance in Plasmodium falciparum from Guyana, South America

Memorias do Instituto Oswaldo Cruz, 2004
Using DNA extracted from 112 parasitised blood blots, we screened for the population marker of chloroquine resistance (CQR) pfcrt K76T in Plasmodium falciparum infections from Guyana.
Wallis Best Plummer, Lexley M Pinto Pereira, Christine VF Carrington   +2 more
doaj   +1 more source

Measurement of gene amplifications related to drug resistance in Plasmodium falciparum using droplet digital PCR

Malaria Journal, 2021
Background Copy number variations (CNVs) of the Plasmodium falciparum multidrug resistance 1 (pfmdr1), P. falciparum plasmepsin2 (pfplasmepsin2) and P. falciparum GTP cyclohydrolase 1 (pfgch1) genes are associated with anti-malarial drug resistance in P.
Suttipat Srisutham, Kanokon Suwannasin, Rungniran Sugaram, Arjen M. Dondorp, Mallika Imwong   +4 more
doaj   +1 more source

Genetic linkage of pfmdr1 with food vacuolar solute import in Plasmodium falciparum [PDF]

The EMBO Journal, 2006
The P-glycoprotein homolog of the human malaria parasite Plasmodium falciparum (Pgh-1) has been implicated in decreased susceptibility to several antimalarial drugs, including quinine, mefloquine and artemisinin. Pgh-1 mainly resides within the parasite's food vacuolar membrane.
Rohrbach, Petra, Sanchez, Cecilia P., Hayton, Karen, Friedrich, Oliver, Patel, Jigar, Sidhu, Amar Bir Singh, Ferdig, Michael T., Fidock, David A., Lanzer, Michael   +8 more
openaire   +5 more sources

Changing Pattern of Plasmodium falciparum pfmdr1 Gene Polymorphisms in Southern Rwanda

Antimicrobial Agents and Chemotherapy, 2021
Plasmodium falciparum multidrug resistance-1 gene ( pfmdr1 ) polymorphisms associate with altered antimalarial susceptibility. Between 2010 and 2018/2019, we observed that the prevalence of the wild-type allele N86 and the wild-type combination NYD increased 10-fold (4% versus 40%) and more ...
Welmoed van Loon, Clara Bergmann, Felix Habarugira, Costanza Tacoli, Darius Savelsberg, Rafael Oliveira, Djibril Mbarushimana, Jules Ndoli, Augustin Sendegeya, Claude Bayingana, Frank P. Mockenhaupt   +10 more
openaire   +3 more sources

Balanced impacts of fitness and drug pressure on the evolution of PfMDR1 polymorphisms in Plasmodium falciparum [PDF]

Malaria Journal, 2021
Abstract Background Anti-malarial drug resistance may be limited by decreased fitness in resistant parasites. Important contributors to resistance are mutations in the Plasmodium falciparum putative drug transporter PfMDR1.
Marvin Duvalsaint, Melissa D. Conrad, Stephen Tukwasibwe, Patrick K Tumwebaze, Jennifer Legac, Roland A. Cooper, Philip J. Rosenthal   +6 more
openaire   +5 more sources

Differential Prevalences of Pfmdr1 Polymorphisms in Symptomatic and Asymptomatic Plasmodium falciparum Infections in Lastoursville: A Rural Area in East-Central Gabon

Infection and Drug Resistance, 2021
Steede Seinnat Ontoua,1,* Lady Charlene Kouna,1,* Sandrine Lydie Oyegue-Liabagui,1,2 Dominique Fatima Voumbo-Matoumona,3 Diamella Nancy Moukodoum,1 Romeo Karl Imboumy-Limoukou,1 Jean Bernard Lekana-Douki1,4 1Unité d’Evolution, Epidémiologie et ...
Ontoua SS, Kouna LC, Oyegue-Liabagui SL, Voumbo-Matoumona DF, Moukodoum DN, Imboumy-Limoukou RK, Lekana-Douki JB   +6 more
doaj  

Synergism between Pfcrt and Pfmdr1 genes could account for the slow recovery of chloroquine sensitive Plasmodium falciparum strains in Ghana after chloroquine withdrawal

Journal of Infection and Public Health, 2017
Summary: Unlike other countries, the chloroquine resistant marker Pfcrt T76 mutant has remained fairly stable in Ghana several years after official disuse of chloroquine.
Kwame K. Asare, Johnson N. Boampong, Nancy O. Duah, Richmond Afoakwah, Rakesh Sehgal, Neils B. Quashie   +5 more
doaj   +1 more source

Synergy of mefloquine activity with atorvastatin, but not chloroquine and monodesethylamodiaquine, and association with the pfmdr1 gene [PDF]

Journal of Antimicrobial Chemotherapy, 2010
The aim of the study was to assess the in vitro potentiating effects of atorvastatin, a 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor, in combination with mefloquine, chloroquine or monodesethylamodiaquine against Plasmodium falciparum and to evaluate whether the effects of atorvastatin could be associated with mutations or gene ...
Nathalie, Wurtz, Sébastien, Briolant, Marine, Gil, Véronique, Parquet, Maud, Henry, Eric, Baret, Rémy, Amalvict, Lionel, Almeras, Christophe, Rogier, Bruno, Pradines   +9 more
openaire   +2 more sources

Efficacy of artemether-lumefantrine for treating uncomplicated Plasmodium falciparum cases and molecular surveillance of drug resistance genes in Western Myanmar

Malaria Journal, 2020
Background Currently, artemisinin-based combination therapy (ACT) is the first-line anti-malarial treatment in malaria-endemic areas. However, resistance in Plasmodium falciparum to artemisinin-based combinations emerging in the Greater Mekong Sub-region
Yanrui Wu, Myat Thut Soe, Pyae Linn Aung, Luyi Zhao, Weilin Zeng, Lynette Menezes, Zhaoqing Yang, Myat Phone Kyaw, Liwang Cui   +8 more
doaj   +1 more source

K13 mutations and pfmdr1 copy number variation in Plasmodium falciparum malaria in Myanmar [PDF]

Malaria Journal, 2016
La polythérapie à base d'artémisinine est le traitement de première intention du paludisme à falciparum au Myanmar depuis 2005. La grande étendue de la résistance à l'artémisinine dans la sous-région du Grand Mékong et la présence de résistance à la méfloquine à la frontière entre le Myanmar et la Thaïlande soulèvent des inquiétudes quant aux schémas ...
Win, AA, Imwong, M, Kyaw, MP, Woodrow, CJ, Chotivanich, K, Hanboonkunupakarn, B, Pukrittayakamee, S   +6 more
openaire   +3 more sources