Results 51 to 60 of about 3,298 (171)

Selective sweeps and genetic lineages of Plasmodium falciparum multi-drug resistance (pfmdr1) gene in Kenya

Malaria Journal, 2018
Background There are concerns that resistance to artemisinin-based combination therapy might emerge in Kenya and sub-Saharan Africa (SSA) in the same pattern as was with chloroquine and sulfadoxine–pyrimethamine. Single nucleotide polymorphisms (SNPs) in
Peninah Muiruri, Denis W. Juma, Luicer A. Ingasia, Lorna J. Chebon, Benjamin Opot, Bidii S. Ngalah, Jelagat Cheruiyot, Ben Andagalu, Hoseah M. Akala, Venny C. S. Nyambati, Joseph K. Ng’ang’a, Edwin Kamau   +11 more
doaj   +1 more source

Epidemiology of malaria and chloroquine resistance in Mizoram, northeastern India, a malaria-endemic region bordering Myanmar

Malaria Journal, 2020
Background Mizoram, a northeastern state in India, shares international borders with Myanmar and Bangladesh and is considered to be one of the key routes through which drug-resistant parasites of Southeast Asia enter mainland India. Despite its strategic
Rita Zomuanpuii, Christopher L. Hmar, Khawlhring Lallawmzuala, Lal Hlimpuia, Praveen Balabaskaran Nina, Nachimuthu Senthil Kumar   +5 more
doaj   +1 more source

Prevalence and Implications of Plasmodium Falciparum Multidrug Resistance Gene Mutations (pfmdr1) Among Pediatric Patients with Malaria in Kano, Nigeria

UMYU Journal of Microbiology Research
Study’s Excerpt: • fmdr1 gene mutations were assessed in falciparum from pediatric malaria patients in Kano. • Only 3.2% of amplified samples showed the pfmdr1 N86Y mutation linked to drug resistance.
Ummukulsum Mustapha, Ado Shehu, Ahmad Yunusa, Usman Usman Sanusi, Yusuf Misau Abdu, Attahir Ayuba Sa’ad, Aliyu Maigoro Muhammad, Abdullahi Haruna Ibrahim, Haddad Muhammad Mahfuz, Fatima Yakubu Zubairu   +9 more
doaj   +3 more sources

Molecular monitoring of plasmodium falciparum drug susceptibility at the time of the introduction of artemisinin-based combination therapy in Yaoundé, Cameroon: Implications for the future

Malaria Journal, 2012
Background Regular monitoring of the levels of anti-malarial resistance of Plasmodium falciparum is an essential policy to adapt therapy and improve malaria control.
Menard Sandie, Morlais Isabelle, Tahar Rachida, Sayang Collins, Mayengue Pembe, Iriart Xavier, Benoit-Vical Françoise, Lemen Brigitte, Magnaval Jean-François, Awono-Ambene Parfait, Basco Leonardo K, Berry Antoine   +11 more
doaj   +1 more source

Stable high frequencies of sulfadoxine–pyrimethamine resistance associated mutations and absence of K13 mutations in Plasmodium falciparum 3 and 4 years after the introduction of artesunate plus sulfadoxine–pyrimethamine in Ujjain, Madhya Pradesh, India

Malaria Journal, 2020
Background Artesunate plus sulfadoxine–pyrimethamine (ASP) is first-line treatment for uncomplicated Plasmodium falciparum malaria in most of India, except for six North-eastern provinces where treatment failure rates were high. In Ujjain, central India,
Ashish Pathak, Andreas Mårtensson, Sudhir Gawariker, Ashish Sharma, Vishal Diwan, Manju Purohit, Johan Ursing   +6 more
doaj   +1 more source

Polymorphism analysis of pfmdr1 gene in Plasmodium falciparum isolates 11 years post-adoption of artemisinin-based combination therapy in Saudi Arabia

Scientific Reports, 2022
A total of 227 Plasmodium falciparum isolates from Jazan region, southwestern Saudi Arabia were amplified for the P. falciparum multi-drug resistance 1 (pfmdr1) gene to detect point mutations 11 years after the introduction of artemisinin-based ...
Hesham M. Al-Mekhlafi, Aymen M. Madkhali, Ahmed A. Abdulhaq, Wahib M. Atroosh, Ahmad Hassn Ghzwani, Khalid Ammash Zain, Khalid Y. Ghailan, Hassan A. Hamali, Abdullah A. Mobarki, Talal H. Alharazi, Zaki M. Eisa, Yee-Ling Lau   +11 more
doaj   +1 more source

Malaria in Bangladesh, 2000–2025: Navigating the Headwinds From Control to Elimination

Health Science Reports, Volume 9, Issue 3, March 2026.
ABSTRACT Background and Aims Bangladesh has dramatically reduced its malaria burden since 2000, confining the disease to specific geographic zones. However, the national 2030 elimination goal is now threatened by a complex interplay of biological, ecological, and social factors.
Abdullaha Al Mamun, Mustafa Sarwar A. Kayenat, K. A. M. Inzamul Islam   +2 more
wiley   +1 more source

Genomic Plasticity and Molecular Mechanisms of Antimalarial Drug Resistance in Plasmodium falciparum: Implications for Treatment Failure and Genomic Surveillance

BioMed Research International, Volume 2026, Issue 1, 2026.
Malaria remains a major global public health challenge, in part because Plasmodium falciparum populations can acquire and disseminate reduced susceptibility to antimalarial drugs under selective pressure. This review synthesizes current evidence on the molecular and genomic mechanisms underlying antimalarial drug resistance and examines their ...
Anmut Assemie
wiley   +1 more source

Generation of PfMDR1 coding sequences for expression in Xenopus oocytes.

, 2022
PfMDR1, Plasmodium falciparum multidrug resistance protein 1. (PDF)
Ben Corry (135521), Sarah Heckmatt Shafik (12501305), Sashika Natasha Richards (12501308), Rowena Elizabeth Martin (12501311)   +3 more
core   +1 more source

Prevalence and factors associated with carriage of Pfmdr1 polymorphisms among pregnant women receiving intermittent preventive treatment with sulfadoxine-pyrimethamine (IPTp-SP) and artemether-lumefantrine for malaria treatment in Burkina Faso

Malaria Journal, 2020
Background Single nucleotide polymorphisms occurring in the Plasmodium falciparum multidrug resistant gene 1 (pfmdr1) are known to be associated with aminoquinoline resistance and, therefore, represent key P.
Hamtandi Magloire Natama, Rouamba Toussaint, Djamina Line Cerine Bazié, Sékou Samadoulougou, Maminata Coulibaly-Traoré, Halidou Tinto, Fati Kirakoya-Samadoulougou   +6 more
doaj   +1 more source