Results 71 to 80 of about 3,298 (171)

Targeting Plasmodium Falciparum Asexual and Sexual Stages with Melatonin‐Based Indole Compounds

ChemistrySelect, Volume 10, Issue 41, November 3, 2025.
This study presents a comprehensive pipeline for screening melatonin‐inspired compounds synthesized via copper(I)‐catalyzed azide‐alkyne cycloaddition (CuAAC) “Click Chemistry” against Plasmodium falciparum. The pipeline evaluates activity against asexual and sexual stages, cytotoxicity, and potential interference with parasite melatonin signaling ...
Abhinab Mohanty, Lamark Carlos I, Euzébio Guimarães Barbosa, Alessandro Kappel Jordão, Celia R. S. Garcia   +4 more
wiley   +1 more source

Synthesis of New Enantiopure Aminoalcohol Fluorenes as Promising Antimalarial Compounds

ChemMedChem, Volume 20, Issue 6, March 15, 2025.
Considering the importance of developing new antimalarial drugs, we provide new insights in enantiopure aminoalcohol fluorenes as simplified analogs of lumefantrine. All compounds possess potent in vitro antimalarial activity against two strains of P. falciparum and good selectivity indexes. Structure‐activity relationship studies identified one hit 10
Camille Tisnerat, Jérémy Schneider, Romain Mustière, Aurélie Herrero, René Momha, Céline Damiani, Patrice Agnamey, Anne Totet, Mathieu Marchivie, Jean Guillon, Alexandra Dassonville‐Klimpt, Pascal Sonnet   +11 more
wiley   +1 more source

PFMDR1 AND IN VIVO RESISTANCE TO ARTESUNATE-MEFLOQUINE IN FALCIPARUM MALARIA ON THE CAMBODIAN–THAI BORDER [PDF]

, 2007
Artemisinin combination therapies (ACTs) have recently been adopted as first-line therapy for Plasmodium falciparum infections in most malaria-endemic countries.
FANDEUR, Thierry, ALKER, Alisa, SEM, Rithy, LIM, Pharath, MEY BOUTH, Denis, ARIEY, Frederic, MAGUIRE, Jason, WONGSRICHANALAI, Chansuda, YI, Poravuth, TSUYUOKA, Reiko, MESHNICK, Steven, SHAH, Naman   +11 more
core   +1 more source

Mosquitoes as a feasible sentinel group for anti-malarial resistance surveillance by Next Generation Sequencing of Plasmodium falciparum

Malaria Journal, 2019
Background Plasmodium falciparum drug resistance surveillance is key to successful disease control and eradication. Contemporary methods that only allow determination of prevalence of resistance are expensive, time consuming and require ethical ...
Rebecca Smith-Aguasca, Himanshu Gupta, Estefania Uberegui, Mara Maquina, Francisco Saute, Krijn P. Paaijmans, Alfredo Mayor, Silvie Huijben   +7 more
doaj   +1 more source

The Malaria Burden: A South African Perspective

Journal of Tropical Medicine, Volume 2024, Issue 1, 2024.
Malaria is a deadly disease caused by protozoan pathogens of the Plasmodium parasite. Transmission to humans occurs through the bite of an infected female Anopheles mosquito. According to the World Health Organization (WHO), an estimated 247 million cases of malaria were recorded worldwide in 2021, with approximately 619 000 malaria deaths. The initial
Marissa Balmith, Charlise Basson, Sarel J. Brand, Jianbing Mu   +3 more
wiley   +1 more source

Heterologous expression of functional human P-gp and PfMDR1 in Xenopus oocytes.

, 2022
(a) Schematic showing the transport of a [3H]drug via human P-gp or PfMDR1 in the Xenopus oocyte system. (b) The relationship between the quantity of human P-gp cRNA injected into the oocyte and the level of human P-gp–mediated [3H]vinblastine transport ...
Ben Corry (135521), Sarah Heckmatt Shafik (12501305), Sashika Natasha Richards (12501308), Rowena Elizabeth Martin (12501311)   +3 more
core   +1 more source

Prevalence and mutational spectrum of the Pfmdr1 gene linked to antimalarial resistance in Plasmodium falciparum clinical isolates from southeastern Nigeria

Egyptian Journal of Medical Human Genetics
Background The Plasmodium falciparum multidrug resistance 1 (Pfmdr1) gene is a critical molecular marker of antimalarial drug resistance. Monitoring Pfmdr1 mutations is essential for guiding treatment strategies and preventing the spread of resistant ...
Juliet Chidimma Ogugor, Kenechukwu Chibuike Onyekwelu, Amechi Uchenna Katchy, Godwill Azeh Engwa, Stanley Obinna Ezeadichie, Osah Martins Onwuka   +5 more
doaj   +1 more source

Declining Artesunate-Mefloquine Efficacy against Falciparum Malaria on the Cambodia–Thailand Border

Emerging Infectious Diseases, 2008
Resistance to many antimalaria drugs developed on the Cambodia–Thailand border long before developing elsewhere. Because antimalaria resistance is now a global problem, artemisinin-based combination therapies (ACTs) are the first-line therapies in most ...
Chansuda Wongsrichanalai, Steven R Meshnick   +1 more
doaj   +1 more source

Molecular surveillance of anti-malarial resistance pfcrt, pfmdr1, and pfk13 polymorphisms in African Plasmodium falciparum imported parasites to Wuhan, China

Malaria Journal, 2021
Background Imported malaria parasites with anti-malarial drug resistance (ADR) from Africa is a serious public health challenge in non-malarial regions, including Wuhan, China.
Weijia Cheng, Xiaonan Song, Huabing Tan, Kai Wu, Jian Li   +4 more
doaj   +1 more source

Analytic Approaches in Genomic Epidemiological Studies of Parasitic Protozoa

Transboundary and Emerging Diseases, Volume 2024, Issue 1, 2024.
Whole genome sequencing (WGS) plays an important role in the advanced characterization of pathogen transmission and is widely used in studies of major bacterial and viral diseases. Although protozoan parasites cause serious diseases in humans and animals, WGS data on them are relatively scarce due to the large genomes and lack of cultivation techniques
Tianpeng Wang, Ziding Zhang, Yaoyu Feng, Lihua Xiao, Long-Xian Zhang   +4 more
wiley   +1 more source