Results 81 to 90 of about 3,285 (205)

Sequence analysis of pfcrt and pfmdr1 genes and its association with chloroquine resistance in Southeast Indian Plasmodium falciparum isolates

Genomics Data, 2016
Background: Due to the widespread resistance of Plasmodium falciparum to chloroquine drug, artemisinin-based combination therapy (ACT) has been recommended as the first-line treatment. This study aims to evaluate the extent of chloroquine resistance in P.
Hiasindh Ashmi Antony, Sindhusuta Das, Subhash Chandra Parija, Sanghamitra Padhi   +3 more
doaj   +1 more source

Ein neuer Malariawirkstoff hemmt die Proteinsynthese von Plasmodium falciparum

Angewandte Chemie, Volume 137, Issue 49, December 1, 2025.
Die Verbindung 31 stellt einen vielversprechenden Ansatz für die Entwicklung eines Malariawirkstoffs mit einem starken Wirkungsprofil dar (PfNF54 IC50 ± s.d. = 3,9 ± 0,4 nM). Sie hat einen neuartigen Wirkmechanismus, indem sie an zytosolische Ribosomen‐Untereinheiten bindet und dadurch die Proteinsynthese im Parasiten hemmt.
Patricia Bravo, Eleonora Diamanti, Mostafa M. Hamed, Lorenzo Bizzarri, Natalie Wiedemar, Armin Passecker, Nicolas M. B. Brancucci, Anna Albisetti, Christin Gumpp, Boris Illarionov, Markus Fischer, Matthias Witschel, Tobias Schehl, Hannes Hahne, Pascal Mäser, Matthias Rottmann, Anna K. H. Hirsch   +16 more
wiley   +1 more source

Known inhibitors of human P-gp inhibit the transport of lumefantrine via PfMDR1.

, 2022
(a) Schematic showing the cis-inhibition of [3H]drug transport via human P-gp or PfMDR1 by known P-gp inhibitors in the Xenopus oocyte system. (b) The IC50 values of nicardipine, PSC833, vanadate, and verapamil against [3H]vinblastine transport via human
Ben Corry (135521), Sarah Heckmatt Shafik (12501305), Sashika Natasha Richards (12501308), Rowena Elizabeth Martin (12501311)   +3 more
core   +1 more source

Polymorphisms in K13, pfcrt, pfmdr1, pfdhfr, and pfdhps in parasites isolated from symptomatic malaria patients in Burkina Faso

Parasite, 2016
Background: The emergence of resistance to artemisinin derivatives in western Cambodia is threatening to revert the recent advances made toward global malaria control and elimination.
Somé Anyirékun Fabrice, Sorgho Hermann, Zongo Issaka, Bazié Thomas, Nikiéma Frédéric, Sawadogo Amadé, Zongo Moussa, Compaoré Yves-Daniel, Ouédraogo Jean-Bosco   +8 more
doaj   +1 more source

Temporal trends in prevalence of Plasmodium falciparum drug resistance alleles over two decades of changing antimalarial policy in coastal Kenya

International Journal for Parasitology: Drugs and Drug Resistance, 2014
Molecular surveillance of drug resistance markers through time provides crucial information on genomic adaptations, especially in parasite populations exposed to changing drug pressures.
John Okombo, Alice W. Kamau, Kevin Marsh, Colin J. Sutherland, Lynette Isabella Ochola-Oyier   +4 more
doaj   +1 more source

Targeting Plasmodium Falciparum Asexual and Sexual Stages with Melatonin‐Based Indole Compounds

ChemistrySelect, Volume 10, Issue 41, November 3, 2025.
This study presents a comprehensive pipeline for screening melatonin‐inspired compounds synthesized via copper(I)‐catalyzed azide‐alkyne cycloaddition (CuAAC) “Click Chemistry” against Plasmodium falciparum. The pipeline evaluates activity against asexual and sexual stages, cytotoxicity, and potential interference with parasite melatonin signaling ...
Abhinab Mohanty, Lamark Carlos I, Euzébio Guimarães Barbosa, Alessandro Kappel Jordão, Celia R. S. Garcia   +4 more
wiley   +1 more source

Molecular analysis demonstrates high prevalence of chloroquine resistance but no evidence of artemisinin resistance in Plasmodium falciparum in the Chittagong Hill Tracts of Bangladesh

Malaria Journal, 2017
Background Artemisinin resistance is present in the Greater Mekong region and poses a significant threat for current anti-malarial treatment guidelines in Bangladesh.
Mohammad Shafiul Alam, Benedikt Ley, Maisha Khair Nima, Fatema Tuj Johora, Mohammad Enayet Hossain, Kamala Thriemer, Sarah Auburn, Jutta Marfurt, Ric N. Price, Wasif A. Khan   +9 more
doaj   +1 more source

Decreased prevalence of the Plasmodium falciparum Pfcrt K76T and Pfmdr1 and N86Y mutations post-chloroquine treatment withdrawal in Katete District, Eastern Zambia

Malaria Journal, 2021
Background In 2002, Zambia withdrew chloroquine as first-line treatment for Plasmodium falciparum malaria due to increased treatment failure and worldwide spread of chloroquine resistance.
Mwenda C. Mulenga, Lungowe Sitali, Ilinca I. Ciubotariu, Moonga B. Hawela, Busiku Hamainza, James Chipeta, Sungano Mharakurwa   +6 more
doaj   +1 more source

Synthesis of New Enantiopure Aminoalcohol Fluorenes as Promising Antimalarial Compounds

ChemMedChem, Volume 20, Issue 6, March 15, 2025.
Considering the importance of developing new antimalarial drugs, we provide new insights in enantiopure aminoalcohol fluorenes as simplified analogs of lumefantrine. All compounds possess potent in vitro antimalarial activity against two strains of P. falciparum and good selectivity indexes. Structure‐activity relationship studies identified one hit 10
Camille Tisnerat, Jérémy Schneider, Romain Mustière, Aurélie Herrero, René Momha, Céline Damiani, Patrice Agnamey, Anne Totet, Mathieu Marchivie, Jean Guillon, Alexandra Dassonville‐Klimpt, Pascal Sonnet   +11 more
wiley   +1 more source

The perils of PCR: can we accurately 'correct' antimalarial trials? [PDF]

, 2010
During follow-up in antimalarial drug trials, treated subjects can be newly infected. PCR correction is used to distinguish this re-infection from drug failure (recrudescence) and to adjust final drug efficacy estimates.
Sutherland, Colin J, Juliano, Jonathan J, Gadalla, Nahla, Meshnick, Steven R., Meshnick, Steven R, Juliano, Jonathan J., Sutherland, Colin J.   +6 more
core   +1 more source