Results 81 to 90 of about 3,298 (171)

Analisis Mutasi Gen Pfmdr1 1246 pada Penderita Malaria di Mamuju Sulawesi Barat [PDF]

, 2015
Parasit Plasmodium falciparum dapat mengembangkan mekanisme resistensi terhadap obat anti-malaria melalui mutasi gen yang terjadi pada parasit tersebut, termasuk gen Plasmodium falciparum multi-drug resistance protein 1 (Pfmdr1). Mutasi pada gen tersebut
. Hartono, . Syafruddin, Yenny Yusuf
core   +1 more source

Plasmodium falciparum multidrug resistance 1 gene polymorphisms associated with outcomes after anti-malarial treatment

Malaria Journal
Background Plasmodium falciparum multidrug resistance transporter 1 (Pfmdr1) gene mutations are associated with altered response to artemisinin-based combination therapy (ACT), particularly the combinations containing the partner drugs lumefantrine and ...
Veronika R. Laird, Mateusz M. Plucinski, Meera Venkatesan, Kelsey A. Rondini, Milijaona Randrianarivelojosia, Mauricette N. Andriamananjara, Hawela Moonga, Deus S. Ishengoma, Arlindo Chidimatembue, Pedro Rafael Dimbu, Adicatou-Laï Adeothy, Abdoul Habib Beavogui, Simon Kariuki, Sam L. Nsobya, Aline Uwimana, Gauthier Mesia Kahunu, Ashenafi Assefa, Ousmane A. Koita, Naomi W. Lucchi, Samaly S. Svigel Souza, Zhiyong Zhou, Leah F. Moriarty, Eric S. Halsey   +22 more
doaj   +1 more source

Polymorphisms of pfcrt, pfmdr1, and K13-propeller genes in imported falciparum malaria isolates from Africa in Guizhou province, China

BMC Infectious Diseases, 2020
Background Imported falciparum malaria from Africa has become a key public health challenge in Guizhou Province since 2012. Understanding the polymorphisms of molecular markers of drug resistance can guide selection of antimalarial drugs for the ...
Danya She, Zhengyan Wang, Qiuguo Liang, Lidan Lu, Yuting Huang, Ke Zhang, Dong An, Jiahong Wu   +7 more
doaj   +1 more source

Plasmodium falciparum pfmdr1 amplification, mefloquine resistance, and parasite fitness.

, 2009
Mefloquine is widely used in combination with artemisinin derivatives for the treatment of falciparum malaria. Mefloquine resistance in Plasmodium falciparum has been related to increased copy numbers of multidrug-resistant gene 1 (pfmdr1).
Pongtavornpinyo, W, Imwong, Mallika, Pukrittayakamee, S, Chotivanich, K, Day, Nicholas, White, Nicholas, Preechapornkul, P, Dondorp, Adrianus   +7 more
core   +1 more source

Quinine localizes to a non-acidic compartment within the food vacuole of the malaria parasite Plasmodium falciparum

Malaria Journal, 2012
Background The naturally fluorescent compound quinine has long been used to treat malaria infections. Although some evidence suggests that quinine acts in the parasite food vacuole, the mechanism of action of quinine has not yet been resolved.
Bohórquez Elaine B, Chua Michael, Meshnick Steven R   +2 more
doaj   +1 more source

Pfmdr1 N86Y SNP compared against drug IC₅₀s (in nM).

, 2013
A. Comparison of Pfmdr1 N86Y SNP against CQ IC50 stratified by year; B. Comparison of Pfmdr1 N86Y SNP against AQ IC50 stratified by year; C. Comparison of Pfmdr1 N86Y SNP against MQ IC50 stratified by year; D.
David Schnabel (584089), Edwin Kamau (282162), Elizabeth Wanja (584088), Norman C. Waters (584091), Hoseah M. Akala (584080), Ben Andagalu (584087), Charles Okudo (584084), Jacob D. Johnson (584092), Wallace Bulimo (584090), Luiser Ingasia (584081), Redemptah Yeda (584086), Douglas S. Walsh (257138), Angela Omondi (584083), Fredrick L. Eyase (584079), Agnes Cheruiyot (584082), Dennis Juma (584085)   +15 more
core   +1 more source

In vitro activities of piperaquine, lumefantrine, and dihydroartemisinin in Kenyan Plasmodium falciparum isolates and polymorphisms in pfcrt and pfmdr1.

, 2016
We have analyzed the in vitro chemosensitivity profiles of 115 Kenyan isolates for chloroquine (CQ), piperaquine, lumefantrine (LM), and dihydroartemisinin in association with polymorphisms in pfcrt at codon 76 and pfmdr1 at codon 86, as well as with ...

core   +1 more source

Effects of amino-terminal or carboxyl-terminal epitope tags on the expression and function of PfMDR1 in Xenopus oocytes.

, 2022
PfMDR1, Plasmodium falciparum multidrug resistance protein 1. (PDF)
Ben Corry (135521), Sarah Heckmatt Shafik (12501305), Sashika Natasha Richards (12501308), Rowena Elizabeth Martin (12501311)   +3 more
core   +1 more source

Identification of chloroquine resistance Pfcrt-K76T and determination of Pfmdr1-N86Y copy number by SYBR Green I qPCR

Asian Pacific Journal of Tropical Biomedicine, 2015
Objective: To identify prevalence of chloroquine resistance point mutation at (Pfcrt, K76T) and (Pfmdr1, N86Y) copy number variation. Methods: SYBR Green I based real time PCR was used. One hundred and thirty-three samples were analyzed for (Pfcrt, K76T)
Addimas Tajebe, Mulugeta Aemero, Kimani Francis, Gabriel Magoma   +3 more
doaj   +1 more source

Analysis of anti-malarial resistance markers in pfmdr1 and pfcrt across Southeast Asia in the Tracking Resistance to Artemisinin Collaboration [PDF]

, 2016
Additional file 4.
Pharath Lim, Pharath Lim (251083), Rick M. Fairhurst, Dominic Kwiatkowski (35064), Olivo Miotto (36337), Mallika Imwong (151642), Olivo Miotto, Charles J. Woodrow, Krongkan Srimuang (3582701), Dominic P. Kwiatkowski, Mallika Imwong, Charles Woodrow (140489), null null, Rick Fairhurst (3405836), for the Tracking Resistance to Artemisinin Collaboration, Krongkan Srimuang   +15 more
core   +1 more source