Results 91 to 100 of about 3,285 (205)

Artemisinin resistance in Plasmodium falciparum malaria. [PDF]

, 2009
BACKGROUND: Artemisinin-based combination therapies are the recommended first-line treatments of falciparum malaria in all countries with endemic disease.
Yi, Poravuth, Singhasivanon, Pratap, Day, Nicholas PJ, Ariey, Frederic, Lindegardh, Niklas, Lim, Pharath, Dondorp, Arjen M, Ringwald, Pascal, Socheat, Duong, Hanpithakpong, Warunee, Silamut, Kamolrat, Lwin, Khin Maung, Imwong, Mallika, Phyo, Aung Phae, Das, Debashish, Lee, Sue J, Herdman, Trent, White, Nicholas J, Chotivanich, Kesinee, Yeung, Shunmay, Tarning, Joel, Nosten, François, An, Sen Sam   +22 more
core   +2 more sources

The Malaria Burden: A South African Perspective

Journal of Tropical Medicine, Volume 2024, Issue 1, 2024.
Malaria is a deadly disease caused by protozoan pathogens of the Plasmodium parasite. Transmission to humans occurs through the bite of an infected female Anopheles mosquito. According to the World Health Organization (WHO), an estimated 247 million cases of malaria were recorded worldwide in 2021, with approximately 619 000 malaria deaths. The initial
Marissa Balmith, Charlise Basson, Sarel J. Brand, Jianbing Mu   +3 more
wiley   +1 more source

In-silico identification of antimalarial compounds targeting PfMDR1 of Plasmodium falciparum

In Silico Pharmacology
PfMDR1, a key transporter protein in Plasmodium falciparum, contributes to antimalarial drug resistance by actively expelling drugs like chloroquine from the parasite's digestive vacuole, lowering their intracellular efficacy. In this study, our aim was to identify the antimalarial compounds with unknown targets on the basis of cellular assays from the
T. Lakshmi Preetha, Vikas Yadav, Naidu Subbarao   +2 more
openaire   +2 more sources

Analytic Approaches in Genomic Epidemiological Studies of Parasitic Protozoa

Transboundary and Emerging Diseases, Volume 2024, Issue 1, 2024.
Whole genome sequencing (WGS) plays an important role in the advanced characterization of pathogen transmission and is widely used in studies of major bacterial and viral diseases. Although protozoan parasites cause serious diseases in humans and animals, WGS data on them are relatively scarce due to the large genomes and lack of cultivation techniques
Tianpeng Wang, Ziding Zhang, Yaoyu Feng, Lihua Xiao, Long-Xian Zhang   +4 more
wiley   +1 more source

Prevalence of pfmdr1, pfcrt, pfdhfr and pfdhps mutations associated with drug resistance, in Luanda, Angola [PDF]

Malaria Journal, 2008
Malaria is the infectious disease causing the highest morbidity and mortality in Angola and due to widespread chloroquine (CQ) resistance, the country has recently changed its first-line treatment recommendations for uncomplicated malaria, from CQ to artemisinin combination therapies (ACT) in adults, and sulphadoxine/pyrimethamine (S/P) in pregnant ...
Varandas Luís, do Rosário Virgílio E, Bernardino Luís, Lopes Dinora, Benchimol Carla, Figueiredo Paula, Nogueira Fátima   +6 more
openaire   +3 more sources

Distribution of pfmdr1 and pfcrt chloroquine drug resistance alleles in north-western Nigeria

MalariaWorld journal, 2017
Background. In Nigeria, decline in the sensitivity of Plasmodium falciparum to Artemisinin Combination Therapy (ACT) has prompted the unofficial use of chloroquine (CQ) for self-medication. This study was designed to determine the prevalence and distribution of CQ resistant/susceptible alleles of CQ resistance transporter (Pfcrt) and P.
Ruqayyah H, Muhammad, Ishaya H, Nock, Iliya S, Ndams, Jonathan B, George, Yusuf, Deeni   +4 more
openaire   +2 more sources

Mosquitoes as a feasible sentinel group for anti-malarial resistance surveillance by Next Generation Sequencing of Plasmodium falciparum

Malaria Journal, 2019
Background Plasmodium falciparum drug resistance surveillance is key to successful disease control and eradication. Contemporary methods that only allow determination of prevalence of resistance are expensive, time consuming and require ethical ...
Rebecca Smith-Aguasca, Himanshu Gupta, Estefania Uberegui, Mara Maquina, Francisco Saute, Krijn P. Paaijmans, Alfredo Mayor, Silvie Huijben   +7 more
doaj   +1 more source

Heterologous Expression and ATPase Activity of Mutant versus Wild Type PfMDR1 Protein^†

, 2016
Mutation of the P. falciparum chloroquine resistance transporter (PfCRT) causes resistance to chloroquine (CQ) and other antimalarial drugs. Mutation and/or overexpression of one of the multidrug resistance protein homologues found in this malarial ...
Linda E. Amoah (2491204), Jacqueline K. Lekostaj (2417041), Paul D. Roepe (484901)   +2 more
core   +1 more source

Prevalence and mutational spectrum of the Pfmdr1 gene linked to antimalarial resistance in Plasmodium falciparum clinical isolates from southeastern Nigeria

Egyptian Journal of Medical Human Genetics
Background The Plasmodium falciparum multidrug resistance 1 (Pfmdr1) gene is a critical molecular marker of antimalarial drug resistance. Monitoring Pfmdr1 mutations is essential for guiding treatment strategies and preventing the spread of resistant ...
Juliet Chidimma Ogugor, Kenechukwu Chibuike Onyekwelu, Amechi Uchenna Katchy, Godwill Azeh Engwa, Stanley Obinna Ezeadichie, Osah Martins Onwuka   +5 more
doaj   +1 more source

Declining Artesunate-Mefloquine Efficacy against Falciparum Malaria on the Cambodia–Thailand Border

Emerging Infectious Diseases, 2008
Resistance to many antimalaria drugs developed on the Cambodia–Thailand border long before developing elsewhere. Because antimalaria resistance is now a global problem, artemisinin-based combination therapies (ACTs) are the first-line therapies in most ...
Chansuda Wongsrichanalai, Steven R Meshnick   +1 more
doaj   +1 more source