Results 91 to 100 of about 3,298 (171)

Polymorphisms in the pfcrt and pfmdr1 genes in Plasmodium falciparum isolates from South Sumatera, Indonesia [PDF]

, 2014
Background: Over the past decade, antimalarial drug resistance has rapidly become a major public health problem in South East Asia region including South Sumatra.
Handayani, Dwi, Anwar, Chairil, Saleh, Irsan   +2 more
core   +1 more source

Artesunate-Amodiaquine and Artemether-Lumefantrine Therapies and Selection of Pfcrt and Pfmdr1 Alleles in Nanoro, Burkina Faso.

PLoS ONE, 2016
The adoption of Artemisinin based combination therapies (ACT) constitutes a basic strategy for malaria control in sub-Saharan Africa. Moreover, since cases of ACT resistance have been reported in South-East Asia, the need to understand P.
Paul Sondo, Karim Derra, Seydou Diallo Nakanabo, Zekiba Tarnagda, Adama Kazienga, Odile Zampa, Innocent Valéa, Hermann Sorgho, Ellis Owusu-Dabo, Jean-Bosco Ouédraogo, Tinga Robert Guiguemdé, Halidou Tinto   +11 more
doaj   +1 more source

Characterization of Plasmodium falciparum genes associated with drug resistance in Hodh Elgharbi, a malaria hotspot near Malian–Mauritanian border

Malaria Journal, 2017
Background A malaria hotspot in the southeastern region of Mauritania, near the Malian border, may hamper malaria control strategies. The objectives were to estimate the prevalence of genetic polymorphisms associated with drug resistance in Plasmodium ...
Mohamed Salem Ould Ahmedou Salem, Khadijetou Mint Lekweiry, Houssem Bouchiba, Aurelie Pascual, Bruno Pradines, Ali Ould Mohamed Salem Boukhary, Sébastien Briolant, Leonardo K. Basco, Hervé Bogreau   +8 more
doaj   +1 more source

Low prevalence of copy number variation in pfmdr1 and pfpm2 in Plasmodium falciparum isolates from southern Angola

Malaria Journal
Background Malaria is the parasitic disease with the highest global morbidity and mortality. According to estimates from the World Health Organization (WHO), there were around 249 million cases in 2022, with 3.4% occurring in Angola.
Denise Duarte, Francisco Manuel, Ana Dias, Esmeralda Sacato, Elsa Taleingue, Elsa Daniel, Francisco Simão, Luis Varandas, Maria Lina Antunes, Fatima Nogueira   +9 more
doaj   +1 more source

CQ IC₅₀s, PfCRT and Pgh1 polymorphisms, and pfmdr1 copy number.

, 2014
CQ IC50s, PfCRT and Pgh1 polymorphisms, and pfmdr1 copy number.
François H. Nosten (315303), Bruce Russell (35525), Martin J. Lear (649334), Kit-Ying Choy (649333), Yan Quan Lee (649331), Laurent Rénia (2935842), Rossarin Suwanarusk (35524), Kevin S. W. Tan (160329), Larry M. C. Chow (649335), Cheryl C. Y. Loh (649330), Kitti W. K. Chan (649332)   +10 more
core   +1 more source

Deamplification of pfmdr1containing amplicon on chromosome 5 in Plasmodium falciparum is associated with reduced resistance to artelinic acid in vitro. Antimicrob Agents Chemother 54: 3395

, 2010
Amplification of the Plasmodium falciparum multidrug resistance 1 gene (pfmdr1) has been implicated in multidrug resistance, including in vitro resistance to artelinic acid (AL). The stability and fitness of having multiple copies of pfmdr1 are important
Peters, Jennifer M., Cheng, Qin, Jennifer M. Peters, Dennis E. Kyle, Nanhua Chen, Marina Chavchich, Qin Cheng, Michelle L. Gatton, Chavchich, Marina, Gatton, Michelle L., Kyle, Dennis E., Chen, Nanhua   +11 more
core   +1 more source

Increased pfmdr1 gene copy number and the decline in pfcrt and pfmdr1 resistance alleles in Ghanaian Plasmodium falciparum isolates after the change of anti-malarial drug treatment policy

, 2013
Increased pfmdr1 gene copy number and the decline in pfcrt and pfmdr1 resistance alleles in Ghanaian Plasmodium falciparum isolates after the change of anti-malarial drug treatment ...
Charles Narh (15902474), B Abuaku (21992567), KC Kronmann (21992573), NB Quashie (21992564), C Duplessis (21992570), VS Opoku (21992558), DK De Souza (21992549), NO Duah (21992543), DD Binnah (21992552), KA Koram (21992576), MM Tamakloe (21992555), CO Onwona (21992561), SA Matrevi (21992546)   +12 more
core  

The role of Pfmdr1 and Pfcrt in changing chloroquine, amodiaquine, mefloquine and lumefantrine susceptibility in western-Kenya P. falciparum samples during 2008-2011.

PLoS ONE, 2013
Single Nucleotide Polymorphisms (SNPs) in the Pfmdr1, and Pfcrt, genes of Plasmodium falciparum may confer resistance to a number of anti-malaria drugs. Pfmdr1 86Y and haplotypes at Pfcrt 72-76 have been linked to chloroquine (CQ) as well as amodiaquine (
Fredrick L Eyase, Hoseah M Akala, Luiser Ingasia, Agnes Cheruiyot, Angela Omondi, Charles Okudo, Dennis Juma, Redemptah Yeda, Ben Andagalu, Elizabeth Wanja, Edwin Kamau, David Schnabel, Wallace Bulimo, Norman C Waters, Douglas S Walsh, Jacob D Johnson   +15 more
doaj   +1 more source

Prevalence of Pfcrt and Pfmdr1 alleles before and after treatment with ASAQ % (n/N).

, 2016
Prevalence of Pfcrt and Pfmdr1 alleles before and after treatment with ASAQ % (n/N).
Odile Zampa (3214464), Innocent Valéa (257166), Ellis Owusu-Dabo (264364), Halidou Tinto (257156), Jean-Bosco Ouédraogo (3159024), Paul Sondo (3214458), Hermann Sorgho (3214473), Seydou Diallo Nakanabo (3214467), Zekiba Tarnagda (3214461), Adama Kazienga (795702), Tinga Robert Guiguemdé (3214470), Karim Derra (3214455)   +11 more
core   +1 more source

Short Report: Association Between Chloroquine and Amodiaquine Resistance and Allelic Variation in the Plasmodium Falciparum Multiple Drug Resistance 1 Gene and the Chloroquine Resistance Transporter Gene in Isolates from the Upper Nile in Southern Sudan. [PDF]

, 2003
Amodiaquine, a 4-aminoquinoline compound, is being considered as an alternative to chloroquine and pyrimethamine/sulfadoxine where resistance in Plasmodium falciparum to both drugs has been selected.
Nzila, A, van den Broek, I, Keus, K, Ochong, E   +3 more
core