Results 111 to 120 of about 3,285 (205)
Roles of PfMDR1 in modulating the parasite’s response to a range of antimalarial drugs.
, 2022 PfMDR1, Plasmodium falciparum multidrug resistance protein 1. (PDF)
Ben Corry (135521) +3 more
core +1 more source
Malaria Journal, 2012 Background The naturally fluorescent compound quinine has long been used to treat malaria infections. Although some evidence suggests that quinine acts in the parasite food vacuole, the mechanism of action of quinine has not yet been resolved.
Bohórquez Elaine B +2 more
doaj +1 more source
Heterologous expression of functional human P-gp and PfMDR1 in Xenopus oocytes.
, 2022 (a) Schematic showing the transport of a [3H]drug via human P-gp or PfMDR1 in the Xenopus oocyte system. (b) The relationship between the quantity of human P-gp cRNA injected into the oocyte and the level of human P-gp–mediated [3H]vinblastine transport ...
Ben Corry (135521) +3 more
core +1 more source
Intrahost selection of Plasmodium falciparum pfmdr1 alleles after antimalarial treatment on the northwestern border of Thailand. [PDF]
, 2006 BACKGROUND: Increased pfmdr1 copy number is associated with reduced susceptibility to structurally unrelated antimalarial drugs. We assessed how administration of different antimalarial drugs altered pfmdr1 polymorphism in parasites from patients who ...
Rose McGready +19 more
core +1 more source
Alignment of MDR1 proteins used to generate the PfMDR1 homology model.
, 2022 PfMDR1, Plasmodium falciparum multidrug resistance protein 1. (PDF)
Ben Corry (135521) +3 more
core +1 more source
Iron chelator IV does not affect drug transport via PfMDR1.
, 2022 Measurements of [3H]dihydroartemisinin transport via PfMDR1 were made in the presence of the iron chelator IV to bind any free iron present in the oocyte.
Ben Corry (135521) +3 more
core +1 more source
Malaria Journal, 2017 Background A malaria hotspot in the southeastern region of Mauritania, near the Malian border, may hamper malaria control strategies. The objectives were to estimate the prevalence of genetic polymorphisms associated with drug resistance in Plasmodium ...
Mohamed Salem Ould Ahmedou Salem +8 more
doaj +1 more source
PLoS ONE, 2016 The adoption of Artemisinin based combination therapies (ACT) constitutes a basic strategy for malaria control in sub-Saharan Africa. Moreover, since cases of ACT resistance have been reported in South-East Asia, the need to understand P.
Paul Sondo +11 more
doaj +1 more source
Asian Pacific Journal of Tropical Biomedicine, 2015 Objective: To identify prevalence of chloroquine resistance point mutation at (Pfcrt, K76T) and (Pfmdr1, N86Y) copy number variation. Methods: SYBR Green I based real time PCR was used. One hundred and thirty-three samples were analyzed for (Pfcrt, K76T)
Addimas Tajebe +3 more
doaj +1 more source
Malaria JournalBackground Malaria is the parasitic disease with the highest global morbidity and mortality. According to estimates from the World Health Organization (WHO), there were around 249 million cases in 2022, with 3.4% occurring in Angola.
Denise Duarte +9 more
doaj +1 more source