Results 121 to 130 of about 3,285 (205)

Prevalence of polymorphisms at position 86 of the Pfmdr1 gene in Plasmodium falciparum parasites

Parasitologists United Journal, 2016
Background Malaria is one of the major public health problems in India. The majority of cases are because of Plasmodium falciparum. A sudden increase in chloroquine (CQ) resistance in P. falciparum cases has been noted. Of the various genetic alteration genes known, Pfmdr1 has been shown to be associated with CQ resistance.
Deepak Kumar, Vidyut Prakash, Gopal Nath
openaire   +1 more source

The role of Pfmdr1 and Pfcrt in changing chloroquine, amodiaquine, mefloquine and lumefantrine susceptibility in western-Kenya P. falciparum samples during 2008-2011.

PLoS ONE, 2013
Single Nucleotide Polymorphisms (SNPs) in the Pfmdr1, and Pfcrt, genes of Plasmodium falciparum may confer resistance to a number of anti-malaria drugs. Pfmdr1 86Y and haplotypes at Pfcrt 72-76 have been linked to chloroquine (CQ) as well as amodiaquine (
Fredrick L Eyase, Hoseah M Akala, Luiser Ingasia, Agnes Cheruiyot, Angela Omondi, Charles Okudo, Dennis Juma, Redemptah Yeda, Ben Andagalu, Elizabeth Wanja, Edwin Kamau, David Schnabel, Wallace Bulimo, Norman C Waters, Douglas S Walsh, Jacob D Johnson   +15 more
doaj   +1 more source

Lack of selection of antimalarial drug resistance markers after intermittent preventive treatment of schoolchildren (IPTsc) against malaria in northeastern Tanzania

International Journal of Infectious Diseases
Objective: Intermittent Preventive Treatment of schoolchildren (IPTsc) is recommended by WHO as a strategy to protect against malaria; to explore whether IPTsc with dihydroartemisinin-piperaquine (DP) or artesunate-amodiaquine (ASAQ) cause a selection of
Frederik Von Wowern, Geofrey Makenga, Sarah Wellmann Thomsen, Louise Wellmann Thomsen, Emma Filtenborg Hocke, Vito Baraka, Benjamin H. Opot, Daniel T.R. Minja, John P.A. Lusingu, Jean-Pierre Van-geertruyden, Helle Hansson, Michael Alifrangis   +11 more
doaj   +1 more source

Unraveling Key Chloroquine Resistance-Associated Alleles Among Plasmodium falciparum Isolates in South Darfur State, Sudan Twelve Years After Drug Withdrawal

Infection and Drug Resistance
Abdalmoneim M Magboul,1 Bakri YM Nour,2 Abdelhakam G Tamomh,1 Rashad Abdul-Ghani,3,4 Sayed Mustafa Albushra,5 Hanan Babiker Eltahir6 1Department of Parasitology & Medical Entomology, Faculty of Medical Laboratory Sciences, University of El Imam El Mahdi,
Magboul AM, Nour BY, Tamomh AG, Abdul-Ghani R, Albushra SM, Eltahir HB   +5 more
doaj  

Sequence Diversity of pfmdr1 and Sequence Conserve of pldh in Plasmodium falciparum from Indonesia: Its implications on Designing a Novel Antimalarial Drug with Less Prone to Resistance

Iranian Journal of Parasitology, 2013
Background: pfmdr1 and its variants are molecular marker which are responsible for antibiotics resistance in Plasmodium falciparum, a parasitic carrier for malaria dis-ease. A novel strategy to treat malaria disease is by disrupting parasite lactate dehy-
Muhamad Ali, Tetrawindu A Hidayatullah, Zulfikar Alimuddin, Yunita Sabrina   +3 more
doaj  

Evolutionary diversity of the pfmdr1 hinge region and association with antimalarial drug resistance mutations post ACT introduction. [PDF]

Int J Parasitol Drugs Drug Resist
Hocke EF, Hansson H, Chopo-Pizarro A, Wellmann L, Kahunu GM, Mavoko HM, Nkoli PM, Sompwe EM, Mbongi D, Mitashi P, Ali IM, Nji A, Mbacham W, Moussiliou A, Dandonougbo C, Kpemasse A, Affoukou C, Akogbeto M, Ngufor C, Beshir K, Mousa A, Roper C, Sutherland CJ, Alifrangis M.   +23 more
europepmc   +1 more source

Spatio-temporal trends of the prevalence of Plasmodium falciparum antimalarial drug resistance markers across sub-Saharan Africa from 2010 to 2024: a systematic review and meta-analysis. [PDF]

BMC Infect Dis
Towanou Bohissou FE, Wilfried Nassa GJ, Inoue J, Sondo P, Rouamba T, Yessinou J, Held J, Tinto H.   +7 more
europepmc   +1 more source

Changes in molecular markers of Plasmodium falciparum drug resistance between 2017 and 2024 in Southern Benin. [PDF]

Int J Parasitol Drugs Drug Resist
Bohissou FET, Nahum D, Inoue J, Sondo P, Hounsou L, Sondjo G, Djègbè NDC, Woli R, Dossou S, Kpohonnou C, Tinto H, Held J.   +11 more
europepmc   +1 more source

Genomic profiling of drug resistance markers in Plasmodium falciparum samples from the Democratic Republic of the Congo (2017) and Tanzania (2020-2021). [PDF]

J Antimicrob Chemother
Khote FL, Muhindo Mavoko H, Mitashi P, Mandoko P, Mbongi D, Makenga G, Minja DTR, Francis F, Kavishe R, van Geertruyden JP, Kahunu GM, Menard D, Baraka V.   +12 more
europepmc   +1 more source

Molecular surveillance of antimalarial drug resistance markers in the pfcrt, pfmdr1 and pfmrp1 genes of Plasmodium falciparum isolates from southeastern Iran. [PDF]

Malar J
Jafari M, Rezapour R, Nemati F, Mehrizi AA, Pirahmadi S.   +4 more
europepmc   +1 more source