Results 101 to 110 of about 3,285 (205)

Molecular surveillance of anti-malarial resistance pfcrt, pfmdr1, and pfk13 polymorphisms in African Plasmodium falciparum imported parasites to Wuhan, China

Malaria Journal, 2021
Background Imported malaria parasites with anti-malarial drug resistance (ADR) from Africa is a serious public health challenge in non-malarial regions, including Wuhan, China.
Weijia Cheng, Xiaonan Song, Huabing Tan, Kai Wu, Jian Li   +4 more
doaj   +1 more source

Altered Plasmodium falciparum Sensitivity to the Antiretroviral Protease Inhibitor Lopinavir Associated with Polymorphisms in pfmdr1 [PDF]

Antimicrobial Agents and Chemotherapy, 2017
ABSTRACT The HIV protease inhibitor lopinavir inhibits Plasmodium falciparum aspartic proteases (plasmepsins) and parasite development, and children receiving lopinavir-ritonavir experienced fewer episodes of malaria than those receiving other antiretroviral regimens. Resistance to lopinavir was selected
Ebere Sonoiki, Christian Nsanzabana, Jennifer Legac, Kirthana M. V. Sindhe, Joseph DeRisi, Philip J. Rosenthal   +5 more
openaire   +4 more sources

Correlations between rates of drug transport via PfMDR1 in Xenopus oocytes and in vitro parasite drug resistance indices.

, 2022
The rates of PfMDR1-mediated transport of lumefantrine, mefloquine, chloroquine, and quinine (Figs 2 and 4, and S1 Data) were plotted against the in vitro resistance index for the relevant drug and parasite strain (S3 Table).
Ben Corry (135521), Sarah Heckmatt Shafik (12501305), Sashika Natasha Richards (12501308), Rowena Elizabeth Martin (12501311)   +3 more
core   +1 more source

Plasmodium falciparum multidrug resistance 1 gene polymorphisms associated with outcomes after anti-malarial treatment

Malaria Journal
Background Plasmodium falciparum multidrug resistance transporter 1 (Pfmdr1) gene mutations are associated with altered response to artemisinin-based combination therapy (ACT), particularly the combinations containing the partner drugs lumefantrine and ...
Veronika R. Laird, Mateusz M. Plucinski, Meera Venkatesan, Kelsey A. Rondini, Milijaona Randrianarivelojosia, Mauricette N. Andriamananjara, Hawela Moonga, Deus S. Ishengoma, Arlindo Chidimatembue, Pedro Rafael Dimbu, Adicatou-Laï Adeothy, Abdoul Habib Beavogui, Simon Kariuki, Sam L. Nsobya, Aline Uwimana, Gauthier Mesia Kahunu, Ashenafi Assefa, Ousmane A. Koita, Naomi W. Lucchi, Samaly S. Svigel Souza, Zhiyong Zhou, Leah F. Moriarty, Eric S. Halsey   +22 more
doaj   +1 more source

Polymorphisms of pfcrt, pfmdr1, and K13-propeller genes in imported falciparum malaria isolates from Africa in Guizhou province, China

BMC Infectious Diseases, 2020
Background Imported falciparum malaria from Africa has become a key public health challenge in Guizhou Province since 2012. Understanding the polymorphisms of molecular markers of drug resistance can guide selection of antimalarial drugs for the ...
Danya She, Zhengyan Wang, Qiuguo Liang, Lidan Lu, Yuting Huang, Ke Zhang, Dong An, Jiahong Wu   +7 more
doaj   +1 more source

Use of artemether-lumefantrine in the treatment of asymptomatic-malaria infection in HIV-positive and HIVnegative Nigerian adults. [PDF]

Malaria /HIV co-infection is a major challenge to public health in developing countries and yet potential drug-drug interactions between antimalarial and antiviral regimens have not been adequately investigated in people with both HIV and Plasmodium ...
Chijioke-Nwauche, IN
core   +1 more source

High prevalence of pfmdr1 and pfpm2 amplification and pfmdr1 haplotypes in Plasmodium falciparum isolates circulating in Ghana

Background In Ghana, artemether-lumefantrine (AL), and artesunate-amodiaquine (AS-AQ) are the main first-line ACTs for uncomplicated malaria, with dihydroartemisinin-piperaquine (DHA-PPQ) as an alternative ...
Collins Misita Morang’a, Silas Nkansah Yeboah, Dominic S. Y. Amuzu, Gordon A. Awandare, Abdul Rashid Kassim, Stephen Tetteh Addo, Lucas Naam-Kayagre Amenga-Etego, Mona-Liza Ebiere Sakyi, Ignatus Nunana Dorvi, Isaiah Debrah, Priscilla Akuba Younge, Yaw Aniweh, Samirah Saiid, Osumanu Ahmed, Albert Yao Kudakpo, Charles Mensah   +15 more
core   +1 more source

Studies on antimalarial drug susceptibility in Colombia, in relation to Pfmdr1 and Pfcrt

Parasitology, 2008
SUMMARYIn Colombia, Plasmodium resistance to antimalarials such as chloroquine and antifolates is a serious problem. As a result, the national Colombian health authorities are monitoring the efficacy of alternative drugs and schemes. The study of genetic polymorphisms related with drug resistance is required in the region.
E, Restrepo-Pineda, E, Arango, A, Maestre, V E, Do Rosário, P, Cravo   +4 more
openaire   +2 more sources

Mutations in Pfcrt and Pfmdr1.

, 2019
Mutations in Pfcrt and Pfmdr1.
Inke Lubis (6475796), Xiaodong Sun (166163), Wang Jiazhi (6475799), Susana Campino (56411), Colin J. Sutherland (257150), Taane G. Clark (106263), Jun Feng (116162), Lin-hua Tang (6475802), David C. Warhurst (250276), Ana Rita Gomes (220735), Khalid B. Beshir (816307), Fang Huang (154302), Yan He (116705), Ernest Diez Benavente (3711490)   +13 more
core   +1 more source

Pfmdr1 N86Y SNP compared against drug IC₅₀s (in nM).

, 2013
A. Comparison of Pfmdr1 N86Y SNP against CQ IC50 stratified by year; B. Comparison of Pfmdr1 N86Y SNP against AQ IC50 stratified by year; C. Comparison of Pfmdr1 N86Y SNP against MQ IC50 stratified by year; D.
David Schnabel (584089), Edwin Kamau (282162), Elizabeth Wanja (584088), Norman C. Waters (584091), Hoseah M. Akala (584080), Ben Andagalu (584087), Charles Okudo (584084), Jacob D. Johnson (584092), Wallace Bulimo (584090), Luiser Ingasia (584081), Redemptah Yeda (584086), Douglas S. Walsh (257138), Angela Omondi (584083), Fredrick L. Eyase (584079), Agnes Cheruiyot (584082), Dennis Juma (584085)   +15 more
core   +1 more source