Results 61 to 70 of about 3,285 (205)
Amino acid mutations in the PfMDR1 isoforms included for study.
, 2022 PfMDR1, Plasmodium falciparum multidrug resistance protein 1. (PDF)
Ben Corry (135521) +3 more
core +1 more source
pfmdr1 Amplification Is Related to Increased Plasmodium falciparum In Vitro Sensitivity to the Bisquinoline Piperaquine [PDF]
Antimicrobial Agents and Chemotherapy, 2012 ABSTRACT The 4-aminoquinoline bisquinoline piperaquine is an important partner drug in one of the presently recommended artemisinin combination therapies. Recent clinical trials have confirmed its high efficacy in combination with dihydroartemisinin. Resistance to piperaquine alone has, however, been documented.
Veiga, M. I. +6 more
openaire +4 more sources
Direct measurement of the transport of fluorescent compounds via PfMDR1.
, 2022 PfMDR1, Plasmodium falciparum multidrug resistance protein 1. (PDF)
Ben Corry (135521) +3 more
core +1 more source
Pfmdr1 Alleles and Response to Ultralow-Dose Mefloquine Treatment in Gabonese Patients [PDF]
Antimicrobial Agents and Chemotherapy, 2002 ABSTRACT The identification of parasite molecular markers involved in resistance to antimalarial compounds is of great interest for monitoring the development and spread of resistance in the field. Polymorphisms in Plasmodium falciparum multidrug resistance gene 1 ( pfmdr1 ) have ...
Denise P, Mawili-Mboumba +4 more
openaire +2 more sources
Frontiers in Public Health, 2023 ObjectivesThe widespread occurrence of anti-malarial drug resistance threatens the current efforts to control malaria in African regions. Molecular marker surveillance helps to track the emergence and spread of drug-resistant malaria cases.MethodsA total
Wenjie Xu +6 more
doaj +1 more source
PLoS ONE, 2018 BackgroundThe emergence of resistance against artemisinin combination treatment is a major concern for malaria control. ACTs are recommended as the rescue treatment, however, there is limited evidence as to whether treatment and re-treatment with ACTs ...
Vito Baraka +6 more
doaj +1 more source
Influence of the pfmdr1 Gene on In Vitro Sensitivities of Piperaquine in Thai Isolates of Plasmodium falciparum [PDF]
The American Society of Tropical Medicine and Hygiene, 2017 Piperaquine combined with dihydroartemisinin is one of the artemisinin derivative combination therapies, which can replace artesunate–mefloquine in treating uncomplicated falciparum malaria in Thailand. The aim of this study was to determine the in vitro sensitivity of Thai Plasmodium falciparum isolates against piperaquine and the influence of the ...
Mathirut, Mungthin +5 more
openaire +2 more sources
PLoS ONE, 2014 The mechanism of chloroquine (CQ) resistance in Plasmodium falciparum is not clearly understood. However, CQ resistance has been shown to be associated with point mutations in Pfcrt and Pfmdr1.
Sandeep Kumar Shrivastava +3 more
doaj +1 more source
Malaria Journal, 2020 Background Mizoram, a northeastern state in India, shares international borders with Myanmar and Bangladesh and is considered to be one of the key routes through which drug-resistant parasites of Southeast Asia enter mainland India. Despite its strategic
Rita Zomuanpuii +5 more
doaj +1 more source
Tropical Medicine &International Health, Volume 31, Issue 9, Page 1273-1283, September 2026.ABSTRACT Background Acute febrile illnesses in sub‐Saharan Africa are often attributed to malaria, yet many patients test negative for malaria parasites. The aetiology of nonmalarial fevers remains understudied. Here, we examine likely causes of febrile illnesses and their association with poor clinical outcomes in Angola.
Helga E. M. Gonçalves +3 more
wiley +1 more source