Results 41 to 50 of about 3,285 (205)

Plasmodium falciparum multidrug resistance gene-1 polymorphisms in Northern Nigeria: implications for the continued use of artemether-lumefantrine in the region

Malaria Journal, 2020
Background The analysis of single nucleotide polymorphism (SNPs) in drug-resistance associated genes is a commonly used strategy for the surveillance of anti-malarial drug resistance in populations of parasites.
Auwal Adamu, Mahmoud Suleiman Jada, Hauwa Mohammed Sani Haruna, Bassa Obed Yakubu, Mohammed Auwal Ibrahim, Emmanuel Oluwadare Balogun, Takaya Sakura, Daniel Ken Inaoka, Kiyoshi Kita, Kenji Hirayama, Richard Culleton, Mohammed Nasir Shuaibu   +11 more
doaj   +1 more source

Exploring a Tetrahydroquinoline Antimalarial Hit from the Medicines for Malaria Pathogen Box and Identification of its Mode of Resistance as PfeEF2

ChemMedChem, Volume 17, Issue 22, November 18, 2022., 2022
Toolkit expansion: We report an exploration of the antimalarial compound MMV692140. The mode of resistance was identified as PfeEF2. The structural motif was explored in a chemistry program, resulting in the identification of MMV1919557, an analog with significantly improved antimalarial potency.
Benoît Laleu, Kelly Rubiano, Tomas Yeo, Irene Hallyburton, Mark Anderson, Benigno Crespo‐Fernandez, Francisco‐Javier Gamo, Yevgeniya Antonova‐Koch, Pamela Orjuela‐Sanchez, Sergio Wittlin, Gouranga P. Jana, Bikash C. Maity, Elodie Chenu, James Duffy, Peter Sjö, David Waterson, Elizabeth Winzeler, Eric Guantai, David A. Fidock, Thomas G. Hansson   +19 more
wiley   +1 more source

Efficacy of Artemether-Lumefantrine in Treatment of Malaria Among Under-Fives and Prevalence of Drug Resistance Markers in Igombe-Mwanza, North-Western Tanzania. [PDF]

, 2012
\ud \ud Drug resistance to anti-malarials is a major public health problem worldwide. This study aimed at establishing the efficacy of artemether-lumefantrine (ACT) in Igombe-Mwanza, north-western Tanzania after a few years of ACT use, and establish the ...
Kamugisha, Erasmus, Minde Mercy, Kataraihya Johaness, Kironde, Fred, Kamugisha Erasmus, Erasmus Kamugisha, Jing, Sun, Kongola Gilbert, Mercy Minde, Kironde Fred, Jing Sun, Swedberg, Göte, Johaness Kataraihya, Kataraihya, Johaness, Swedberg Göte, Sun Jing, Gilbert Kongola, Kongola, Gilbert, Minde, Mercy, Fred Kironde, Göte Swedberg   +20 more
core   +1 more source

Rapid microarray-based method for monitoring of all currently known single-nucleotide polymorphisms associated with parasite resistance to antimalaria drugs. [PDF]

, 2007
Parasite drug resistance is partly conferred by single-nucleotide polymorphisms (SNPs), and monitoring them has been proposed as an alternative to monitoring drug resistance.
Regös, Attila, Beck, Hans-Peter, Puijalon, Odile, Huber, E., Crameri, A., Regos, A., Crameri, Andreas, Mugittu, K., Felger, Ingrid, Sismeiro, Odile, Laubscher, Daniel, Marfurt, J., Genton, B., Laubscher, D., Puijalon, O., Felger, I., Burki, Richard, Beck, H. P., Coppee, Jean Yves, Genton, Blaise, Maire, N., Coppee, J. Y., Marfurt, Jutta, Mugittu, Kefas, Maire, Nicolas, Burki, R., Huber, Eric, Sismeiro, O.   +27 more
core   +1 more source

Characterization of lumefantrine, mefloquine, and chloroquine transport via PfMDR1.

, 2022
(a–c) There were significant differences in the apparent kinetic parameters of lumefantrine (a), mefloquine (b), and chloroquine (c) transport between field isoforms of PfMDR1. The concentration dependence of PfMDR1-mediated drug transport was calculated
Ben Corry (135521), Sarah Heckmatt Shafik (12501305), Sashika Natasha Richards (12501308), Rowena Elizabeth Martin (12501311)   +3 more
core   +1 more source

Prevalence of molecular markers of artemisinin and lumefantrine resistance among patients with uncomplicated Plasmodium falciparum malaria in three provinces in Angola, 2015

Malaria Journal, 2018
Background Artemisinin-based combination therapy is the first-line anti-malarial treatment for uncomplicated Plasmodium falciparum infection in Angola.
Dragan Ljolje, Pedro Rafael Dimbu, Julia Kelley, Ira Goldman, Douglas Nace, Aleixo Macaia, Eric S. Halsey, Pascal Ringwald, Filomeno Fortes, Venkatachalam Udhayakumar, Eldin Talundzic, Naomi W. Lucchi, Mateusz M. Plucinski   +12 more
doaj   +1 more source

Distribution of pfmdr1 polymorphisms in Plasmodium falciparum isolated from Southern Thailand [PDF]

Malaria Journal, 2014
تعتبر مقاومة الأدوية في المتصورة المنجلية مشكلة رئيسية في مكافحة الملاريا خاصة على طول الحدود التايلاندية- الميانمارية والتايلاندية- الكمبودية. حتى الآن، تم تحديد عدد قليل من العلامات الجزيئية لمقاومة الملاريا في P. falciparum، بما في ذلك ناقل مقاومة الكلوروكين P. falciparum (pfcrt) ومقاومة الأدوية المتعددة P. falciparum 1 (pfmdr1).
Mathirut Mungthin, Somchai Intanakom, Nantana Suwandittakul, Preeyaporn Suida, Sakultip Amsakul, Naruemon Sitthichot, Suwich Thammapalo, Saovanee Leelayoova   +7 more
openaire   +2 more sources

Rates of PfMDR1-mediated drug transport.

, 2022
PfMDR1, Plasmodium falciparum multidrug resistance protein 1. (XLSX)
Ben Corry (135521), Sarah Heckmatt Shafik (12501305), Sashika Natasha Richards (12501308), Rowena Elizabeth Martin (12501311)   +3 more
core   +1 more source

Predicted topologies of PfMDR1 and PfCRT.

, 2022
(a) PfMDR1 consists of 1,419 amino acid residues that are arranged into 12 TMDs and 2 NBDs. The length of the loops shown surrounding the NBDs are approximate. (b) PfCRT consists of 424 amino acid residues that are arranged into 10 TMDs.
Ben Corry (135521), Sarah Heckmatt Shafik (12501305), Sashika Natasha Richards (12501308), Rowena Elizabeth Martin (12501311)   +3 more
core   +1 more source

PfCRT and PfMDR1 modulate interactions of artemisinin derivatives and ion channel blockers [PDF]

Scientific Reports, 2016
AbstractTreatment of the symptomatic asexual stage of Plasmodium falciparum relies almost exclusively on artemisinin (ART) combination therapies (ACTs) in endemic regions. ACTs combine ART or its derivative with a long-acting partner drug to maximize efficacy during the typical three-day regimen.
Richard T. Eastman, Pwint Khine, Ruili Huang, Craig J. Thomas, Xin-zhuan Su   +4 more
openaire   +2 more sources