Results 41 to 50 of about 3,298 (171)

Efficacy of artemether-lumefantrine for treating uncomplicated Plasmodium falciparum cases and molecular surveillance of drug resistance genes in Western Myanmar

Malaria Journal, 2020
Background Currently, artemisinin-based combination therapy (ACT) is the first-line anti-malarial treatment in malaria-endemic areas. However, resistance in Plasmodium falciparum to artemisinin-based combinations emerging in the Greater Mekong Sub-region
Yanrui Wu, Myat Thut Soe, Pyae Linn Aung, Luyi Zhao, Weilin Zeng, Lynette Menezes, Zhaoqing Yang, Myat Phone Kyaw, Liwang Cui   +8 more
doaj   +1 more source

Monitoring PfMDR1 transport in Plasmodium falciparum [PDF]

, 2015
The Plasmodium falciparum multidrug resistance 1 transporter, PfMDR1, contains five amino acid polymorphisms that are suggested to be involved in altered drug transport from the parasite’s cytosol into the digestive vacuole (DV). Transport of a substrate
Rohrbach, Petra, Petra Rohrbach, Sarah J Reiling, Reiling, Sarah J.   +3 more
core   +1 more source

Alignment of MDR1 proteins used to generate the PfMDR1 homology model.

, 2022
PfMDR1, Plasmodium falciparum multidrug resistance protein 1. (PDF)
Ben Corry (135521), Sarah Heckmatt Shafik (12501305), Sashika Natasha Richards (12501308), Rowena Elizabeth Martin (12501311)   +3 more
core   +1 more source

Role of the pfmdr1 Gene in Plasmodium falciparum Resistance to Antimalarial Treatment [PDF]

, 2012
Plasmodium falciparum is an intracellular protozoan that causes the most severe form of malaria. A major hindrance to disease control efforts is the spread of drug resistant parasite populations, which has been linked to the Plasmodium falciparum ...
Bohorquez, Elaine Brooks
core   +1 more source

Roles of PfMDR1 in modulating the parasite’s response to a range of antimalarial drugs.

, 2022
PfMDR1, Plasmodium falciparum multidrug resistance protein 1. (PDF)
Ben Corry (135521), Sarah Heckmatt Shafik (12501305), Sashika Natasha Richards (12501308), Rowena Elizabeth Martin (12501311)   +3 more
core   +1 more source

Pfmdr1 copy number and arteminisin derivatives combination therapy failure in falciparum malaria in Cambodia

Malaria Journal, 2009
Background The combination of artesunate and mefloquine was introduced as the national first-line treatment for Plasmodium falciparum malaria in Cambodia in 2000.
Wongsrichanalai Chansuda, Meshnick Steven R, Puijalon Odile, Bouchier Christiane, Bouth Denis, Yi Poravuth, Doung Socheat, Incardona Sandra, Shah Naman K, Khim Nimol, Alker Alisa P, Lim Pharath, Fandeur Thierry, Le Bras Jacques, Ringwald Pascal, Ariey Frédéric   +15 more
doaj   +1 more source

Molecular markers associated with drug resistance in Plasmodium falciparum parasites in central Africa between 2016 and 2021

Frontiers in Public Health, 2023
ObjectivesThe widespread occurrence of anti-malarial drug resistance threatens the current efforts to control malaria in African regions. Molecular marker surveillance helps to track the emergence and spread of drug-resistant malaria cases.MethodsA total
Wenjie Xu, Xuan Zhang, Hualiang Chen, Jiaqi Zhang, Qiaoyi Lu, Wei Ruan, Xiaoxiao Wang   +6 more
doaj   +1 more source

Correlations between rates of drug transport via PfMDR1 in Xenopus oocytes and in vitro parasite drug resistance indices.

, 2022
The rates of PfMDR1-mediated transport of lumefantrine, mefloquine, chloroquine, and quinine (Figs 2 and 4, and S1 Data) were plotted against the in vitro resistance index for the relevant drug and parasite strain (S3 Table).
Ben Corry (135521), Sarah Heckmatt Shafik (12501305), Sashika Natasha Richards (12501308), Rowena Elizabeth Martin (12501311)   +3 more
core   +1 more source

Impact of treatment and re-treatment with artemether-lumefantrine and artesunate-amodiaquine on selection of Plasmodium falciparum multidrug resistance gene-1 polymorphisms in the Democratic Republic of Congo and Uganda.

PLoS ONE, 2018
BackgroundThe emergence of resistance against artemisinin combination treatment is a major concern for malaria control. ACTs are recommended as the rescue treatment, however, there is limited evidence as to whether treatment and re-treatment with ACTs ...
Vito Baraka, Hypolite Muhindo Mavoko, Carolyn Nabasumba, Filbert Francis, Pascal Lutumba, Michael Alifrangis, Jean-Pierre Van Geertruyden   +6 more
doaj   +1 more source

Age‐Related and Seasonal Variation in Malaria and Other Causes of Fever and Their Association With Clinical Outcomes in Southern Angola: A Hospital‐Based Study

Tropical Medicine &International Health, Volume 31, Issue 9, Page 1273-1283, September 2026.
ABSTRACT Background Acute febrile illnesses in sub‐Saharan Africa are often attributed to malaria, yet many patients test negative for malaria parasites. The aetiology of nonmalarial fevers remains understudied. Here, we examine likely causes of febrile illnesses and their association with poor clinical outcomes in Angola.
Helga E. M. Gonçalves, Maria Lina Antunes, Jorge Seixas, Marcelo U. Ferreira   +3 more
wiley   +1 more source