Functional characterization of the Plasmodium falciparum chloroquine-resistance transporter (PfCRT) in transformed Dictyostelium discoideum vesicles. [PDF]
PLoS ONE, 2012 Chloroquine (CQ)-resistant Plasmodium falciparum malaria has been a global health catastrophe, yet much about the CQ resistance (CQR) mechanism remains unclear.
Janni Papakrivos +2 more
doaj +2 more sources
Investigation of the Plasmodium falciparum food vacuole through inducible expression of the chloroquine resistance transporter (PfCRT). [PDF]
PLoS ONE, 2012 Haemoglobin degradation during the erythrocytic life stages is the major function of the food vacuole (FV) of Plasmodium falciparum and the target of several anti-malarial drugs that interfere with this metabolic pathway, killing the parasite.
Florian Ehlgen +4 more
doaj +4 more sources
Large-scale survey for novel genotypes of
Malaria Journal, 2012 Background In Plasmodium falciparum, resistance to chloroquine (CQ) is conferred by a K to T mutation at amino acid position 76 (K76T) in the P. falciparum CQ transporter (PfCRT).
Takahashi Nobuyuki +14 more
doaj +2 more sources
Effects of Drug Resistance on the Global Spread of Malaria: A Systematic Literature Review. [PDF]
Health Sci RepABSTRACT Background and Aims Malaria remains a major health crisis in tropical regions, with Sub‐Saharan Africa bearing the heaviest burden. While insecticide‐treated nets and artemisinin‐based combination therapies (ACTs) have reduced cases, emerging parasite resistance to artemisinin threatens these gains. This review synthesizes evidence on how drug
Woime AW.
europepmc +2 more sources
Evolution of Fitness Cost-Neutral Mutant PfCRT Conferring P. falciparum 4-Aminoquinoline Drug Resistance Is Accompanied by Altered Parasite Metabolism and Digestive Vacuole Physiology. [PDF]
PLoS Pathogens, 2016 Southeast Asia is an epicenter of multidrug-resistant Plasmodium falciparum strains. Selective pressures on the subcontinent have recurrently produced several allelic variants of parasite drug resistance genes, including the P.
Stanislaw J Gabryszewski +14 more
doaj +1 more source
Structure and drug resistance of the Plasmodium falciparum transporter PfCRT [PDF]
Nature, 2019 The emergence and spread of drug-resistant Plasmodium falciparum impedes global efforts to control and eliminate malaria. For decades, treatment of malaria has relied on chloroquine (CQ), a safe and affordable 4-aminoquinoline that was highly effective against intra-erythrocytic asexual blood-stage parasites, until resistance arose in Southeast Asia ...
Kim, Jonathan +17 more
openaire +2 more sources
Residues involved in proton-coupled transport of antimalarial drugs by PfCRT [PDF]
Biophysical Journal, 2023 Ali Rasouli +4 more
openalex +2 more sources
No seasonal accumulation of resistant P. falciparum when high-dose chloroquine is used. [PDF]
PLoS ONE, 2009 Potentially chloroquine resistant P. falciparum, identified by the 76T haplotype in the chloroquine resistance transporter (pfcrt 76T), are highly prevalent throughout Africa.
Johan Ursing +3 more
doaj +1 more source
Clinical Pharmacology &Therapeutics, Volume 113, Issue 3, Page 660-669, March 2023., 2023 Artemisinin‐based combination therapies (ACTs) are the primary treatment for malaria. It is essential to characterize the pharmacokinetics (PKs) and pharmacodynamics (PDs) of ACTs in vulnerable populations at risk of suboptimal dosing. We developed a population PK/PD model using data from our previous study of artemether‐lumefantrine in HIV‐uninfected ...
Katherine Kay +15 more
wiley +1 more source
PfCRT-mutant PPQ parasites show increased susceptibility to aminopeptidase M17 inhibition.
, 2022 Dose–response plots illustrate susceptibility of PfCRT mutants to aminopeptidase inhibition. Half maximal inhibitory concentrations (IC50 and IC90) are presented as the mean ± SEM (N, n = 4, 2) for (A) MMV1557817; (B) E-64; (C) ALLN; and (D) pepstatin,
John Okombo (561448) +10 more
core +1 more source