Results 41 to 50 of about 4,262 (206)
Zinc-Finger Nuclease (ZFN)-mediated editing of pfcrt.
, 2022 (A) The pfcrt gene was edited using a two-plasmid approach, one containing the donor and the other expressing the pfcrt-specific ZFN. Parasites were selected on WR99210 and blasticidin (BSD) and cloned by limiting dilution.
Kathryn J. Wicht (5149904) +13 more
core +1 more source
Predicted topologies of PfMDR1 and PfCRT.
, 2022 (a) PfMDR1 consists of 1,419 amino acid residues that are arranged into 12 TMDs and 2 NBDs. The length of the loops shown surrounding the NBDs are approximate. (b) PfCRT consists of 424 amino acid residues that are arranged into 10 TMDs.
Ben Corry (135521) +3 more
core +1 more source
Genome‐Guided Discovery of Antimalarial 4‐Amino‐2,4‐Pentadienoate‐Containing Cyclolipodepsipeptides
Angewandte Chemie, Volume 138, Issue 18, 27 April 2026.Halogenated and glycosylated 4‐amino‐2,4‐pentadienoate‐containing cyclolipodepsipeptides (APD‐CLDs) exhibit potent antiplasmodial activity (IC50 = 25–161 nM) against drug‐sensitive and resistant Plasmodium falciparum strains. ABSTRACT 4‐Amino‐2,4‐pentadienoate‐containing cyclolipodepsipeptides (APD‐CLDs) represent a structurally distinctive family of ...
Hartono Candra +10 more
wiley +2 more sources
High prevalence of PfCRT K76T mutation in Plasmodium falciparum isolates in Ghana [PDF]
International Journal of Infectious Diseases, 2014 Plasmodium falciparum has successfully developed resistance to almost all currently used antimalarials. A single nucleotide polymorphism in the P. falciparum chloroquine resistance transporter (Pfcrt) gene at position 76 resulting in a change in coding from lysine to threonine (K76T) has been implicated to be the corner stone of chloroquine resistance.
Richmond Afoakwah +5 more
openaire +3 more sources
A comparative analysis reveals electrogenic properties of PfCRT and pendrin. [PDF]
J Biol ChemIon translocation is an essential process in all living cells. Most traditional approaches studying ion-translocating systems have employed cellular systems replete with native proteins that potentially interfere with the functional assessment of the protein of interest.
Gil-Iturbe E, Quick M.
europepmc +3 more sources
Genetics of chloroquine-resistant malaria: a haplotypic view
Memorias do Instituto Oswaldo Cruz, 2013 The development and rapid spread of chloroquine resistance (CQR) in Plasmodium falciparum have triggered the identification of several genetic target(s) in the P. falciparum genome.
Gauri Awasthi, Aparup Das
doaj +1 more source
FACTORS ASSOCIATED WITH REGIONAL BIAS OF PFCRT (PLASMODIUM FALCIPARUM CHLOROQUINE RESISTANCE TRANSPORTER) HAPLOTYPES IN NAPAL [PDF]
, 2020 . Evidences of reappearance of chloroquine sensitive Plasmodium falciparum haplotypes after cessation of chloroquine in many countries provide a rationale for the search of chloroquine sensitive haplotypes in P. falciparum isolates in Nepal where the use
Bias, Pfcrt, In Napal
core
Different patterns of pfcrt and pfmdr1 polymorphism in Plasmodium falciparum isolates from Tehama region, Yemen [PDF]
PeerJ, 2016 Introduction. Despite the efforts of the malaria control programme, malaria morbidity is still a common health problem in Yemen, with 60% of the population at risk. Plasmodium falciparum is responsible for 99% of malaria cases.
Wahib M. Atroosh +13 more
doaj +2 more sources
mBio, 2019 The global spread of Plasmodium falciparum chloroquine resistance transporter (PfCRT) variant haplotypes earlier caused the widespread loss of chloroquine (CQ) efficacy.
Satish K. Dhingra +6 more
doaj +1 more source
Life Sciences, Medicine and Biomedicine, 2020 Introduction: Plasmodium falciparum (P. falciparum) is a deadly protozoan that is accountable for malaria and chloroquine was the first-line antimalarial drug before its withdrawal and replaced by artemisinin.
Jing Yit Pua +4 more
doaj +1 more source