Results 41 to 50 of about 4,673 (237)

An Allosteric Inhibitory Potential of Triterpenes from Combretum racemosum on the Structural and Functional Dynamics of Plasmodium falciparum Lactate Dehydrogenase Binding Landscape

Chemistry &Biodiversity, Volume 19, Issue 2, February 2022., 2022
Abstract Multidrug resistance is a significant drawback in malaria treatment, and mutations in the active sites of the many critical antimalarial drug targets have remained challenging. Therefore, this has necessitated the global search for new drugs with new mechanisms of action. Plasmodium falciparum lactate dehydrogenase (pfLHD), a glycolytic enzyme,
Wande M. Oluyemi, Babatunde B. Samuel, Adeniyi T. Adewumi, Yemi A. Adekunle, Mahmoud E. S. Soliman, Liselotte Krenn   +5 more
wiley   +1 more source

Microsatellite polymorphism within pfcrt provides evidence of continuing evolution of chloroquine-resistant alleles in Papua New Guinea

Malaria Journal, 2007
Background Polymorphism in the pfcrt gene underlies Plasmodium falciparum chloroquine resistance (CQR), as sensitive strains consistently carry lysine (K), while CQR strains carry threonine (T) at the codon 76.
Sharma Yagya D, Reeder John, Mueller Ivo, Michon Pascal, Mehlotra Rajeev K, DaRe Jeana T, Stoneking Mark, Zimmerman Peter A   +7 more
doaj   +1 more source

Mutations in the Plasmodium falciparum chloroquine resistance transporter, PfCRT, enlarge the parasite's food vacuole and alter drug sensitivities [PDF]

, 2015
Mutations in the Plasmodium falciparum chloroquine resistance transporter, PfCRT, are the major determinant of chloroquine resistance in this lethal human malaria parasite. Here, we describe P.
Staines, Henry M., Mu, Jianbing, Lee, Andrew H., Pulcini, Serena, Daley, Daniel A., Fidock, David A., Cooper, Roland A., Shafik, Sarah H., Altenhofen, Lindsey M., Krishna, Sanjeev, Martin, Rowena E., Painter, Heather J., Hoke, Matthew J., Llinás, Manuel, Moore, Catherine M., Bouyer, Guillaume, Ferguson, David J.P.   +16 more
core   +1 more source

Localization of PfCRT variants on the oocyte plasma membrane.

, 2023
Immunofluorescence images of fixed PfCRT -expressing oocytes and water-injected control oocytes. First panel from the left, fluorescence image of PfCRT using a specific guinea pig antiserum primary antibody (α-PfCRT) and the Alexa Fluor 633 anti-guinea ...
Fiona Berger (16053112), Guillermo M. Gomez (16053109), Giulia D’Arrigo (3359570), Rebecca C. Wade (170810), Cecilia P. Sanchez (2449579), Michael Lanzer (564520)   +5 more
core   +1 more source

PfCRT-Mediated Drug Transport in Malarial Parasites [PDF]

Biochemistry, 2010
A wide range of drug transport studies using intact infected red blood cells, isolated malarial parasites, heterologous expression systems, and purified protein, combined with elegant genetic experiments, have suggested that chloroquine transport by the Plasmodium falciparum chloroquine resistance transporter (PfCRT) is a key aspect of the molecular ...
openaire   +2 more sources

Invasion of Africa by a single pfcrt allele of South East Asian type [PDF]

Malaria Journal, 2006
Because of its dramatic public health impact, Plasmodium falciparum resistance to chloroquine (CQ) has been documented early on. Chloroquine-resistance (CQR) emerged in the late 1950's independently in South East Asia and South America and progressively spread over all malaria areas.
Ariey, Frédéric, Fandeur, Thierry, Durand, Remy, Randrianarivelojosia, Milijaona, Jambou, Ronan, Legrand, Eric, Ekala, Marie Thérèse, Bouchier, Christiane, Cojean, Sandrine, Duchemin, Jean Bernard, Robert, Vincent, Le Bras, Jacques, Mercereau-Puijalon, Odile   +12 more
openaire   +7 more sources

Dynamic of plasmodium falciparum chloroquine resistance transporter gene Pfcrt K76T mutation five years after withdrawal of chloroquine in Burkina Faso

The Pan African Medical Journal, 2015
We investigated the evolution of Pfcrt K76T mutation five years after the withdrawal of chloroquine in Burkina Faso. A total of 675 clinical isolates collected from October 2010 to September 2012 were successfully genotyped.
Paul Sondo, Karim Derra, Zekiba Tarnagda, Seydou Diallo Nakanabo, Odile Zampa, Adama Kazienga, Innocent Valea, Hermann Sorgho, Jean-Bosco Ouedraogo, Tinga Robert Guiguemde, Halidou Tinto   +10 more
doaj   +1 more source

Predicted topologies of PfMDR1 and PfCRT.

, 2022
(a) PfMDR1 consists of 1,419 amino acid residues that are arranged into 12 TMDs and 2 NBDs. The length of the loops shown surrounding the NBDs are approximate. (b) PfCRT consists of 424 amino acid residues that are arranged into 10 TMDs.
Ben Corry (135521), Sarah Heckmatt Shafik (12501305), Sashika Natasha Richards (12501308), Rowena Elizabeth Martin (12501311)   +3 more
core   +1 more source

Significant geographical differences in prevalence of mutations associated with Plasmodium falciparum and Plasmodium vivax drug resistance in two regions from Papua New Guinea [PDF]

, 2015
Drug resistance remains a major obstacle to malaria treatment and control. It can arise and spread rapidly, and vary substantially even at sub-national level.
Jonah Iga (175169), Barnadas, Céline, Zimmerman, Peter A., Timinao, Lincoln, Koepfli, Cristian, Peter Siba (112258), Sarah Javati (464175), John Reeder (3400391), Kiniboro, Benson, Ivo Mueller (46609), Senn, Nicolas, Javati, Sarah, Iga, Jonah, Malau, Elisheba, Rare, Lawrence, Mueller, Ivo, Elisheba Malau (3518690), Benson Kiniboro (191309), Lincoln Timinao (423264), CĂŠline Barnadas (3506528), Siba, Peter, Timothy Davis (268628), Harin Karunajeewa (336719), Davis, Timothy M., Leanne Robinson (175144), Reeder, John C., Nicolas Senn (137902), Peter Zimmerman (34037), Robinson, Leanne J., Siba, Peter M., Karunajeewa, Harin, Cristian Koepfli (191306), Lawrence Rare (377507)   +32 more
core   +1 more source

The natural function of the malaria parasite’s chloroquine resistance transporter

Nature Communications, 2020
Plasmodium falciparum chloroquine resistance transporter (PfCRT) mediates multidrug resistance, but its natural function remains unclear. Here, Shafik et al.
Sarah H. Shafik, Simon A. Cobbold, Kawthar Barkat, Sashika N. Richards, Nicole S. Lancaster, Manuel Llinás, Simon J. Hogg, Robert L. Summers, Malcolm J. McConville, Rowena E. Martin   +9 more
doaj   +1 more source