Results 51 to 60 of about 4,673 (237)
PfCRT and PfMDR1 modulate interactions of artemisinin derivatives and ion channel blockers [PDF]
Scientific Reports, 2016 AbstractTreatment of the symptomatic asexual stage of Plasmodium falciparum relies almost exclusively on artemisinin (ART) combination therapies (ACTs) in endemic regions. ACTs combine ART or its derivative with a long-acting partner drug to maximize efficacy during the typical three-day regimen.
Richard T. Eastman +4 more
openaire +2 more sources
Malaria Journal, 2012 Background Malaria is still a public health problem in Malaysia with chloroquine (CQ) being the first-line drug in the treatment policy of uncomplicated malaria.
Atroosh Wahib M +3 more
doaj +1 more source
Genome‐Guided Discovery of Antimalarial 4‐Amino‐2,4‐Pentadienoate‐Containing Cyclolipodepsipeptides
Angewandte Chemie, Volume 138, Issue 18, 27 April 2026.Halogenated and glycosylated 4‐amino‐2,4‐pentadienoate‐containing cyclolipodepsipeptides (APD‐CLDs) exhibit potent antiplasmodial activity (IC50 = 25–161 nM) against drug‐sensitive and resistant Plasmodium falciparum strains. ABSTRACT 4‐Amino‐2,4‐pentadienoate‐containing cyclolipodepsipeptides (APD‐CLDs) represent a structurally distinctive family of ...
Hartono Candra +10 more
wiley +2 more sources
High prevalence of PfCRT K76T mutation in Plasmodium falciparum isolates in Ghana [PDF]
International Journal of Infectious Diseases, 2014 Plasmodium falciparum has successfully developed resistance to almost all currently used antimalarials. A single nucleotide polymorphism in the P. falciparum chloroquine resistance transporter (Pfcrt) gene at position 76 resulting in a change in coding from lysine to threonine (K76T) has been implicated to be the corner stone of chloroquine resistance.
Richmond Afoakwah +5 more
openaire +3 more sources
Genetics of chloroquine-resistant malaria: a haplotypic view
Memorias do Instituto Oswaldo Cruz, 2013 The development and rapid spread of chloroquine resistance (CQR) in Plasmodium falciparum have triggered the identification of several genetic target(s) in the P. falciparum genome.
Gauri Awasthi, Aparup Das
doaj +1 more source
Zinc-Finger Nuclease (ZFN)-mediated editing of pfcrt.
, 2022 (A) The pfcrt gene was edited using a two-plasmid approach, one containing the donor and the other expressing the pfcrt-specific ZFN. Parasites were selected on WR99210 and blasticidin (BSD) and cloned by limiting dilution.
Kathryn J. Wicht (5149904) +13 more
core +1 more source
Malaria Journal, 2021 Background Chloroquine (CQ) resistance is conferred by mutations in the Plasmodium falciparum CQ resistance transporter (pfcrt). Following CQ withdrawal for anti-malarial treatment, studies across malaria-endemic countries have shown a range of responses.
Kennedy Kassaza +12 more
doaj +1 more source
FACTORS ASSOCIATED WITH REGIONAL BIAS OF PFCRT (PLASMODIUM FALCIPARUM CHLOROQUINE RESISTANCE TRANSPORTER) HAPLOTYPES IN NAPAL [PDF]
, 2020 . Evidences of reappearance of chloroquine sensitive Plasmodium falciparum haplotypes after cessation of chloroquine in many countries provide a rationale for the search of chloroquine sensitive haplotypes in P. falciparum isolates in Nepal where the use
Bias, Pfcrt, In Napal
core
mBio, 2019 The global spread of Plasmodium falciparum chloroquine resistance transporter (PfCRT) variant haplotypes earlier caused the widespread loss of chloroquine (CQ) efficacy.
Satish K. Dhingra +6 more
doaj +1 more source
Malaria Journal, 2020 Background Currently, artemisinin-based combination therapy (ACT) is the first-line anti-malarial treatment in malaria-endemic areas. However, resistance in Plasmodium falciparum to artemisinin-based combinations emerging in the Greater Mekong Sub-region
Yanrui Wu +8 more
doaj +1 more source