Results 51 to 60 of about 4,262 (206)

Plasmodium falciparum Drug Resistance Genes pfmdr1 and pfcrt In Vivo Co-Expression During Artemether-Lumefantrine Therapy

Frontiers in Pharmacology, 2022
Background: Artemisinin-based combination therapies (ACTs) are the global mainstay treatment of uncomplicated Plasmodium falciparum infections. PfMDR1 and PfCRT are two transmembrane transporters, associated with sensitivity to several antimalarials ...
M. Silva, M. Silva, M. Malmberg, M. Malmberg, S. D. Otienoburu, A. Björkman, B. Ngasala, A. Mårtensson, J. P. Gil, J. P. Gil, J. P. Gil, M. I. Veiga, M. I. Veiga   +12 more
doaj   +1 more source

Additional PfCRT mutations driven by selective pressure for improved fitness can result in the loss of piperaquine resistance and altered Plasmodium falciparum physiology

mBio
Malaria elimination efforts in Southeast Asia have been hindered by multidrug-resistant Plasmodium falciparum. High-grade resistance to piperaquine (PPQ, used in combination with dihydroartemisinin) is associated with PfCRT mutations that arose in ...
Laura M. Hagenah, Satish K. Dhingra, Jennifer L. Small-Saunders, Tarrick Qahash, Andreas Willems, Kyra A. Schindler, Gabriel W. Rangel, Eva Gil-Iturbe, Jonathan Kim, Emiliya Akhundova, Tomas Yeo, John Okombo, Filippo Mancia, Matthias Quick, Paul D. Roepe, Manuel Llinás, David A. Fidock   +16 more
doaj   +1 more source

Correlation of molecular markers, Pfmdr1-N86Y and Pfcrt-K76T, with in vitro chloroquine resistant Plasmodium falciparum, isolated in the malaria endemic states of Assam and Arunachal Pradesh, Northeast India.

PLoS ONE, 2014
The mechanism of chloroquine (CQ) resistance in Plasmodium falciparum is not clearly understood. However, CQ resistance has been shown to be associated with point mutations in Pfcrt and Pfmdr1.
Sandeep Kumar Shrivastava, Ravi Kumar Gupta, Jagdish Mahanta, Mohan Lal Dubey   +3 more
doaj   +1 more source

Minority-Variant pfcrt K76T Mutations and Chloroquine Resistance, Malawi

Emerging Infectious Diseases, 2007
Genotyping of the chloroquine-resistance biomarker pfcrt (Plasmodium falciparum chloroquine resistance transporter gene) suggests that, in the absence of chloroquine pressure, Plasmodium falciparum parasites in Malawi have reverted to chloroquine sensitivity. However, malaria infections in Africa are commonly polyclonal, and standard PCRs cannot detect
Jonathan J. Juliano, Jesse J. Kwiek, Kathryn M. Cappell, Victor Mwapasa, Steven R. Meshnick   +4 more
openaire   +3 more sources

Synergism between Pfcrt and Pfmdr1 genes could account for the slow recovery of chloroquine sensitive Plasmodium falciparum strains in Ghana after chloroquine withdrawal

Journal of Infection and Public Health, 2017
Summary: Unlike other countries, the chloroquine resistant marker Pfcrt T76 mutant has remained fairly stable in Ghana several years after official disuse of chloroquine.
Kwame K. Asare, Johnson N. Boampong, Nancy O. Duah, Richmond Afoakwah, Rakesh Sehgal, Neils B. Quashie   +5 more
doaj   +1 more source

Structures of Plasmodium falciparum Chloroquine Resistance Transporter (PfCRT) Isoforms and Their Interactions with Chloroquine

, 2023
Using a recently elucidated atomic-resolution cryogenic electron microscopy (cryo-EM) structure for the Plasmodium falciparum chloroquine resistance transporter (PfCRT) protein 7G8 isoform as template [Kim, J.; Nature 2019, 576, 315−320], we use Monte ...
Andreas Willems (14642768), Ayse Ecer (14642774), Amitesh Kotwal (14642777), Adrian Kalaw (14642771), Luke D. Roepe (14642780), Paul D. Roepe (484901)   +5 more
core   +1 more source

Surveillance of Plasmodium falciparum pfcrt haplotypes in southwestern Uganda by high‐resolution melt analysis

Malaria Journal, 2021
Background Chloroquine (CQ) resistance is conferred by mutations in the Plasmodium falciparum CQ resistance transporter (pfcrt). Following CQ withdrawal for anti-malarial treatment, studies across malaria-endemic countries have shown a range of responses.
Kennedy Kassaza, Anna C. Long, Jennifer M. McDaniels, Mharlove Andre, Wasswa Fredrickson, Dan Nyehangane, Patrick Orikiriza, Darwin J. Operario, Joel Bazira, Juliet A. Mwanga-Amumpaire, Christopher C. Moore, Jennifer L. Guler, Yap Boum   +12 more
doaj   +1 more source

Evidence That Mutant PfCRT Facilitates the Transmission to Mosquitoes of Chloroquine-Treated Plasmodium Gametocytes [PDF]

The Journal of Infectious Diseases, 2011
Resistance of the human malarial parasite Plasmodium falciparum to the antimalarial drug chloroquine has rapidly spread from several independent origins and is now widely prevalent throughout the majority of malaria-endemic areas. Field studies have suggested that chloroquine-resistant strains might be more infective to mosquito vectors.
Andrea, Ecker, Viswanathan, Lakshmanan, Photini, Sinnis, Isabelle, Coppens, David A, Fidock   +4 more
openaire   +2 more sources

Polymorphism in the Plasmodium falciparum chloroquine-resistance transporter protein links verapamil enhancement of chloroquine sensitivity with the clinical efficacy of amodiaquine

Malaria Journal, 2003
Background Chloroquine accumulates in the acidic digestive vacuole of the intraerythrocytic malaria parasite, and prevents the detoxication of haematin released during haemoglobin digestion.
Warhurst David C
doaj   +1 more source

Reemergence of chloroquine-sensitive pfcrt K76 Plasmodium falciparum genotype in southeastern Cameroon [PDF]

Malaria Journal, 2017
Chloroquine had been used extensively during the last five decades in Cameroon. Its decreasing clinical effectiveness, supported by high proportions of clinical isolates carrying the mutant pfcrt haplotype (CVIET), led the health authorities to resort to amodiaquine monotherapy in 2002 and artemisinin-based combination therapy (ACT) in 2004 (artesunate-
Ndam, Nicaise Tuikue, Basco, Leonardo K., Ngane, Vincent Foumane, Ayouba, Ahidjo, Ngolle, Eitel Mpoudi, Deloron, Philippe, Peeters, Martine, Tahar, Rachida   +7 more
openaire   +4 more sources