Results 71 to 80 of about 4,673 (237)

Sequence analysis of coding DNA fragments of pfcrt and pfmdr-1 genes in Plasmodium falciparum isolates from Odisha, India

Memorias do Instituto Oswaldo Cruz, 2011
The global emergence and spread of malaria parasites resistant to antimalarial drugs is the major problem in malaria control. The genetic basis of the parasite's resistance to the antimalarial drug chloroquine (CQ) is well-documented, allowing for the ...
Sasmita Kumari Das Sutar, Bhavna Gupta, Manoranjan Ranjit, Shantanu Kumar Kar, Aparup Das   +4 more
doaj   +1 more source

A thirteen-year analysis of Plasmodium falciparum populations reveals high conservation of the mutant pfcrt haplotype despite the withdrawal of chloroquine from national treatment guidelines in Gabon

Malaria Journal, 2011
Background Chloroquine resistance (CR) decreased after the removal of chloroquine from national treatment guidelines in Malawi, Kenia and Tanzania. In this investigation the prevalence of the chloroquine resistance (CQR) conferring mutant pfcrt allele ...
Ngoma Ghyslain, Kombila David U, Dal-Bianco Matthias, Gabor Julian, Mayengue Pembe I, Lehners Nicola, Frank Matthias, Supan Christian, Lell Bertrand, Ntoumi Francine, Grobusch Martin P, Dietz Klaus, Kremsner Peter G   +12 more
doaj   +1 more source

BPS2025 - Glutathione transport through the malarial parasite's chloroquine resistance transporter, PfCRT

Biophysical Journal
Eva Gil‐Iturbe, Jonathan Kim, Laura M. Hagenah, Filippo Mancia, David A. Fidock, Matthias Quick   +5 more
openalex   +2 more sources

Malaria in Bangladesh, 2000–2025: Navigating the Headwinds From Control to Elimination

Health Science Reports, Volume 9, Issue 3, March 2026.
ABSTRACT Background and Aims Bangladesh has dramatically reduced its malaria burden since 2000, confining the disease to specific geographic zones. However, the national 2030 elimination goal is now threatened by a complex interplay of biological, ecological, and social factors.
Abdullaha Al Mamun, Mustafa Sarwar A. Kayenat, K. A. M. Inzamul Islam   +2 more
wiley   +1 more source

Evaluations of candidate markers of dihydroartemisinin-piperaquine resistance in Plasmodium falciparum isolates from the China–Myanmar, Thailand–Myanmar, and Thailand–Cambodia borders

Parasites & Vectors, 2022
Background The fast-declining clinical efficacy of dihydroartemisinin-piperaquine (DHA-PPQ) in Cambodia is a warning of the underlying westward dissemination of piperaquine resistance in the Greater Mekong Subregion (GMS).
Run Ye, Yilong Zhang, Dongmei Zhang
doaj   +1 more source

Tailored for swift recognition: A structural perspective on secondary active plant hormone transporters

The Plant Journal, Volume 125, Issue 5, March 2026.
Significance Statement This review synthesizes current knowledge of plant hormone transporters across five major protein superfamilies. It links structural classification to transport mechanism and substrate specificity and demonstrates that this structural perspective provides a predictive framework for understanding substrate scope, selectivity ...
Bjørn Lildal Amsinck, Ines Benhammouche, Adriana Chrenková, Alexander J.D. Snow, Bjørn Panyella Pedersen   +4 more
wiley   +1 more source

Small Molecule Kinase Inhibitors with In Vitro β‐Hematin Formation and Plasmodium falciparum Protein Kinase G Inhibitory Activity Identified Using Machine Learning

ChemMedChem, Volume 21, Issue 3, 12 February 2026.
A random forest machine learning model was used in combination with molecular docking to predict activity of small molecule kinase inhibitors against two crucial antimalarial targets, namely hemozoin crystallization and Plasmodium falciparum protein kinase G. Derazantinib shows most promise as a dual inhibitor.
Jessica L. Thibaud, Nicolaas Salomane, Sarah Harries, Kathryn J. Wicht, Lauren B. Coulson, David Kuter, Kelly Chibale, Katherine A. de Villiers   +7 more
wiley   +1 more source

Study on Chloroquine Resistance Transporter (pfcrt) Gene Polymorphism of Plasmodium falciparum in Malaria Patients in Lampung [PDF]

, 2014
Introduction: The prevalence of malaria in Lampung Province was increased in the last few years. One of the factors contributes to the increased rate is the widespread of the Plasmodium falciparum resistance to antimalarial drugs.
Wijayanti, Mahardika Agus, Kamelia, Marlina, -, Supargiyono   +2 more
core   +1 more source

Molecular Markers of Antimalarial Drug Resistance in Plasmodium falciparum From Kumasi, Ghana, 2023

Tropical Medicine &International Health, Volume 31, Issue 1, Page 43-48, January 2026.
ABSTRACT Objectives Artemisinin partial resistance has emerged in East Africa and is feared to spread across the continent, potentially compromising artemisinin‐based combination treatment. Molecular markers can serve as early warning signals for the development of specific drug resistance.
Albert Dennis Kegya, Elizabeth Oppong, Eric Darko, Kwame Ayisi Boateng, Richard Odame Phillips, Melina Heinemann, Michael Ramharter, Clement Igiraneza, Jules Minega Ndoli, Frank P. Mockenhaupt, Welmoed van Loon   +10 more
wiley   +1 more source

Unveiling Antimalarial Drug Resistance: The Role of CRISPR‐Cas Technologies in Malaria Research

Canadian Journal of Infectious Diseases and Medical Microbiology, Volume 2026, Issue 1, 2026.
Background Malaria, caused by Plasmodium parasites, remains a global health burden, with drug resistance threatening control efforts. CRISPR‐Cas technologies, particularly CRISPR‐Cas9, have transformed malaria research by enabling precise genetic manipulations to study antimalarial resistance mechanisms, develop novel therapeutics and enhance ...
Reuben Samson Dangana, Israel Ehizuelen Ebhohimen, Moses Okpeku, Jess Vergis   +3 more
wiley   +1 more source