Results 71 to 80 of about 4,262 (206)

Genomic Plasticity and Molecular Mechanisms of Antimalarial Drug Resistance in Plasmodium falciparum: Implications for Treatment Failure and Genomic Surveillance

BioMed Research International, Volume 2026, Issue 1, 2026.
Malaria remains a major global public health challenge, in part because Plasmodium falciparum populations can acquire and disseminate reduced susceptibility to antimalarial drugs under selective pressure. This review synthesizes current evidence on the molecular and genomic mechanisms underlying antimalarial drug resistance and examines their ...
Anmut Assemie
wiley   +1 more source

Detection of K76T Mutation in pfcrt Gene as an Applicable Ge-netic Marker for Prediction of Chloroquine Resistant falciparum Malaria in Isolates from an Endemic District of Iran [PDF]

Iranian Journal of Parasitology, 2008
Background: This study investigated the association between pfcrt, T76 allele and chloroquine resistance in patients with falciparum malaria. Molecular assays for point mutations on drugs resistance-related genes are applied tools for monitoring emerging
A Raeisi, H Keshavarz, SR Naddaf, H Uemura, H Kanbara, MR Razavi, M Assmar, M Nateghpou, AR Esmaeili Rastaghi, M Mohebali   +9 more
doaj   +2 more sources

Unveiling Antimalarial Drug Resistance: The Role of CRISPR‐Cas Technologies in Malaria Research

Canadian Journal of Infectious Diseases and Medical Microbiology, Volume 2026, Issue 1, 2026.
Background Malaria, caused by Plasmodium parasites, remains a global health burden, with drug resistance threatening control efforts. CRISPR‐Cas technologies, particularly CRISPR‐Cas9, have transformed malaria research by enabling precise genetic manipulations to study antimalarial resistance mechanisms, develop novel therapeutics and enhance ...
Reuben Samson Dangana, Israel Ehizuelen Ebhohimen, Moses Okpeku, Jess Vergis   +3 more
wiley   +1 more source

Chlorpheniramine Analogues Reverse Chloroquine Resistance inPlasmodium falciparumby Inhibiting PfCRT [PDF]

ACS Medicinal Chemistry Letters, 2014
The emergence and spread of malaria parasites that are resistant to chloroquine (CQ) has been a disaster for world health. The antihistamine chlorpheniramine (CP) partially resensitizes CQ-resistant (CQR) parasites to CQ but possesses little intrinsic antiplasmodial activity.
Deane, Karen, Summers, Robert, Lehane, Adele, Martin, Rowena, Barrow, Russell   +4 more
openaire   +3 more sources

The Impact of pfmdr1 Gene Copy Number on the Efficacy of Dihydroartemisinin–Piperaquine in Treating Malaria in West Sumba and Kupang Districts, East Nusa Tenggara, Indonesia

Journal of Parasitology Research, Volume 2026, Issue 1, 2026.
The efficacy of antimalarial treatment, particularly artemisinin‐based combination therapy (ACT), continues to face persistent threats due to the development of drug resistance in Plasmodium falciparum. Although artemisinin derivatives remain effective, ACT regimen failure often results from decreased efficacy of the companion drug.
Irdayanti Irdayanti, Hijral Aswad, Puji B. S. Asih, Ismail E. Rozi, Herdiana Herdiana, Ajib Diptyanusa, Helen D. Prameswari, Yenni Yusuf, Bahrani Bahrani, Najdah Hidayah, I. Made Artika, Din Syafruddin, Satabdi Datta Choudhury   +12 more
wiley   +1 more source

Study on Chloroquine Resistance Transporter (pfcrt) Gene Polymorphism of Plasmodium falciparum in Malaria Patients in Lampung [PDF]

, 2014
Introduction: The prevalence of malaria in Lampung Province was increased in the last few years. One of the factors contributes to the increased rate is the widespread of the Plasmodium falciparum resistance to antimalarial drugs.
Wijayanti, Mahardika Agus, Kamelia, Marlina, -, Supargiyono   +2 more
core   +1 more source

Pfcrt and pfmdr1 alleles associated with chloroquine resistance in Plasmodium falciparum from Guyana, South America

Memorias do Instituto Oswaldo Cruz, 2004
Using DNA extracted from 112 parasitised blood blots, we screened for the population marker of chloroquine resistance (CQR) pfcrt K76T in Plasmodium falciparum infections from Guyana.
Wallis Best Plummer, Lexley M Pinto Pereira, Christine VF Carrington   +2 more
doaj   +1 more source

Experimental Evolution of Reduced Susceptibility to Artemether–Lumefantrine in Plasmodium berghei Following Serial Drug Pressure

Journal of Parasitology Research, Volume 2026, Issue 1, 2026.
Malaria remains a major global health problem, with uneven progress and the greatest disease burden clustered in sub‐Saharan Africa. Antimalarial drug resistance continues to undermine malaria control efforts, with widespread resistance reported in Plasmodium falciparum, including reduced susceptibility to artemisinin‐based combination therapies (ACTs).
Stephen Mwangi Njoroge, Shadrack Kanyonji Kimani, Teresia Wambui Ngonjo, Maureen Stella Olunga, Julius Seng′ete Wambua, Milka Wambui Waithera, Hamida Yahaya Wawa, James Ng′ang′a Waweru, Satabdi Datta Choudhury   +8 more
wiley   +1 more source

Mutations in Pfcrt and Pfmdr1.

, 2019
Mutations in Pfcrt and Pfmdr1.
Inke Lubis (6475796), Xiaodong Sun (166163), Wang Jiazhi (6475799), Susana Campino (56411), Colin J. Sutherland (257150), Taane G. Clark (106263), Jun Feng (116162), Lin-hua Tang (6475802), David C. Warhurst (250276), Ana Rita Gomes (220735), Khalid B. Beshir (816307), Fang Huang (154302), Yan He (116705), Ernest Diez Benavente (3711490)   +13 more
core   +1 more source

Novel dhps and pfcrt Polymorphisms in Plasmodium falciparum Detected by Heteroduplex Tracking Assay [PDF]

The American Journal of Tropical Medicine and Hygiene, 2009
Several single nucleotide polymorphisms (SNPs) have been linked to antimalarial drug resistance in Plasmodium falciparum. However, standard polymerase chain reaction (PCR) methods to detect these polymorphisms are unable to detect SNPs in variants representing < 20% of the parasites in a mixed infection, nor can they detect polymorphisms at nearby ...
Jonathan J, Juliano, David J, Bacon, Jianbing, Mu, Xinhua, Wang, Steven R, Meshnick   +4 more
openaire   +2 more sources