Results 91 to 100 of about 4,262 (206)

CQ_GREEN uptake by Dd2 PfCRT microsomes.

, 2014
Total uptake of CQGREEN was measured at various CQGREEN concentrations in microsomes carrying Dd2 PfCRT. Non-specific uptake of CQGREEN was measured with pre-treatment of excess unlabelled CQ. Specific uptake was estimated as the difference between total
François H. Nosten (315303), Bruce Russell (35525), Martin J. Lear (649334), Kit-Ying Choy (649333), Yan Quan Lee (649331), Laurent Rénia (2935842), Rossarin Suwanarusk (35524), Kevin S. W. Tan (160329), Larry M. C. Chow (649335), Cheryl C. Y. Loh (649330), Kitti W. K. Chan (649332)   +10 more
core   +1 more source

Dynamic of plasmodium falciparum chloroquine resistance transporter gene Pfcrt K76T mutation five years after withdrawal of chloroquine in Burkina Faso [PDF]

, 2016
We investigated the evolution of Pfcrt K76T mutation five years after the withdrawal of chloroquine in Burkina Faso. A total of 675 clinical isolates collected from October 2010 to September 2012 were successfully genotyped.
Nakanabo, S.D., Valea, I, Sondo, P, Sorgho, H, Ouedraogo, J, Derra, K, Guiguemde, T.R., Zampa, O, Kazienga, A, Tinto, H, Tarnagda, Z   +10 more
core   +1 more source

Sequence analysis of pfcrt and pfmdr1 genes and its association with chloroquine resistance in Southeast Indian Plasmodium falciparum isolates

Genomics Data, 2016
Background: Due to the widespread resistance of Plasmodium falciparum to chloroquine drug, artemisinin-based combination therapy (ACT) has been recommended as the first-line treatment. This study aims to evaluate the extent of chloroquine resistance in P.
Hiasindh Ashmi Antony, Sindhusuta Das, Subhash Chandra Parija, Sanghamitra Padhi   +3 more
doaj   +1 more source

Polymorphisms in K13, pfcrt, pfmdr1, pfdhfr, and pfdhps in parasites isolated from symptomatic malaria patients in Burkina Faso

Parasite, 2016
Background: The emergence of resistance to artemisinin derivatives in western Cambodia is threatening to revert the recent advances made toward global malaria control and elimination.
Somé Anyirékun Fabrice, Sorgho Hermann, Zongo Issaka, Bazié Thomas, Nikiéma Frédéric, Sawadogo Amadé, Zongo Moussa, Compaoré Yves-Daniel, Ouédraogo Jean-Bosco   +8 more
doaj   +1 more source

PfCRT haplotypes and PPQ and CQ phenotypes of lines used herein.

, 2022
PfCRT haplotypes and PPQ and CQ phenotypes of lines used herein.
John Okombo (561448), Tomas Yeo (10134672), Tarrick Qahash (14026400), Jade Bath (5955668), Imhoi Koo (1538677), Lindsey M. Orchard (5676110), Istvan Albert (634554), Sachel Mok (258479), Edward Owens (14026403), Manuel Llinás (14834), David A. Fidock (248990)   +10 more
core   +1 more source

Pfcrt K76T mutation and its associations in imported Plasmodium falciparum malaria cases

Infection, Genetics and Evolution, 2004
Over 3 years (1999-2002), 305 cases of falciparum malaria were diagnosed in Toulouse, France. After retrospective analysis, only 131 patients entered the study. The diagnosis of malaria was ensured by optical methods (QBC then thin smear examination), the results of which were checked from 1999 to mid-2001 by a conventional PCR method, replaced at that
Antoine, Berry, Aurélia, Vessière, Richard, Fabre, Françoise, Benoit-Vical, Bruno, Marchou, Patrice, Massip, Jean-François, Magnaval   +6 more
openaire   +2 more sources

Primers used for the mutagenesis of pfcrt onto the codon-optimized pfcrt^Dd2 sequence in the pSP64T vector backbone.

, 2023
Primers used for the mutagenesis of pfcrt onto the codon-optimized pfcrtDd2 sequence in the pSP64T vector backbone.
Fiona Berger (16053112), Guillermo M. Gomez (16053109), Giulia D’Arrigo (3359570), Rebecca C. Wade (170810), Cecilia P. Sanchez (2449579), Michael Lanzer (564520)   +5 more
core   +1 more source

Temporal trends in prevalence of Plasmodium falciparum drug resistance alleles over two decades of changing antimalarial policy in coastal Kenya

International Journal for Parasitology: Drugs and Drug Resistance, 2014
Molecular surveillance of drug resistance markers through time provides crucial information on genomic adaptations, especially in parasite populations exposed to changing drug pressures.
John Okombo, Alice W. Kamau, Kevin Marsh, Colin J. Sutherland, Lynette Isabella Ochola-Oyier   +4 more
doaj   +1 more source

Studies on antimalarial drug susceptibility in Colombia, in relation to Pfmdr1 and Pfcrt

Parasitology, 2008
SUMMARYIn Colombia, Plasmodium resistance to antimalarials such as chloroquine and antifolates is a serious problem. As a result, the national Colombian health authorities are monitoring the efficacy of alternative drugs and schemes. The study of genetic polymorphisms related with drug resistance is required in the region.
E, Restrepo-Pineda, E, Arango, A, Maestre, V E, Do Rosário, P, Cravo   +4 more
openaire   +2 more sources

Molecular analysis demonstrates high prevalence of chloroquine resistance but no evidence of artemisinin resistance in Plasmodium falciparum in the Chittagong Hill Tracts of Bangladesh

Malaria Journal, 2017
Background Artemisinin resistance is present in the Greater Mekong region and poses a significant threat for current anti-malarial treatment guidelines in Bangladesh.
Mohammad Shafiul Alam, Benedikt Ley, Maisha Khair Nima, Fatema Tuj Johora, Mohammad Enayet Hossain, Kamala Thriemer, Sarah Auburn, Jutta Marfurt, Ric N. Price, Wasif A. Khan   +9 more
doaj   +1 more source