Results 91 to 100 of about 4,673 (237)

The Malaria Burden: A South African Perspective

Journal of Tropical Medicine, Volume 2024, Issue 1, 2024.
Malaria is a deadly disease caused by protozoan pathogens of the Plasmodium parasite. Transmission to humans occurs through the bite of an infected female Anopheles mosquito. According to the World Health Organization (WHO), an estimated 247 million cases of malaria were recorded worldwide in 2021, with approximately 619 000 malaria deaths. The initial
Marissa Balmith, Charlise Basson, Sarel J. Brand, Jianbing Mu   +3 more
wiley   +1 more source

Alta frecuencia de mutaciones puntuales en pfcrt de Plasmodium falciparum y emergencia de nuevos haplotipos mutantes en Colombia [PDF]

, 2008
Introducción. Los estudios en epidemiología molecular de resistencia a antipalúdicos constituyen una herramienta útil para comprender eventos involucrados en la falla al tratamiento y la resistencia en paludismo por Plasmodium falciparum en Colombia ...
Jaime Carmona-Fonseca, Amanda Maestre, Carmona-Fonseca, Jaime, Maestre, Amanda   +3 more
core   +1 more source

Epidemiology of malaria and chloroquine resistance in Mizoram, northeastern India, a malaria-endemic region bordering Myanmar

Malaria Journal, 2020
Background Mizoram, a northeastern state in India, shares international borders with Myanmar and Bangladesh and is considered to be one of the key routes through which drug-resistant parasites of Southeast Asia enter mainland India. Despite its strategic
Rita Zomuanpuii, Christopher L. Hmar, Khawlhring Lallawmzuala, Lal Hlimpuia, Praveen Balabaskaran Nina, Nachimuthu Senthil Kumar   +5 more
doaj   +1 more source

Analytic Approaches in Genomic Epidemiological Studies of Parasitic Protozoa

Transboundary and Emerging Diseases, Volume 2024, Issue 1, 2024.
Whole genome sequencing (WGS) plays an important role in the advanced characterization of pathogen transmission and is widely used in studies of major bacterial and viral diseases. Although protozoan parasites cause serious diseases in humans and animals, WGS data on them are relatively scarce due to the large genomes and lack of cultivation techniques
Tianpeng Wang, Ziding Zhang, Yaoyu Feng, Lihua Xiao, Long-Xian Zhang   +4 more
wiley   +1 more source

Beninese Plant Extracts with Antiplasmodial Activity Select New Allele Variants Msp1 and Msp2 in Plasmodium falciparum

Journal of Parasitology Research, Volume 2024, Issue 1, 2024.
Background. Natural medicinal products are commonly used as a remedy against malaria infections in African populations and have become a major source of information for the screening of new and more effective antiplasmodial molecules. Therefore, in vitro studies are needed to validate the efficacy of these medicinal products and to explore the ...
Hamirath O. Lagnika, Adandé A. Medjigbodo, Oswald Y. Djihinto, Helga M. Saïzonou, Wassiyath A. Mousse, Romaric Akoton, Laurette Djossou, Doris N. Vodounkpe, Latifou Lagnika, Luc S. Djogbénou, Bernard Marchand   +10 more
wiley   +1 more source

The perils of PCR: can we accurately 'correct' antimalarial trials? [PDF]

, 2010
During follow-up in antimalarial drug trials, treated subjects can be newly infected. PCR correction is used to distinguish this re-infection from drug failure (recrudescence) and to adjust final drug efficacy estimates.
Sutherland, Colin J, Juliano, Jonathan J, Gadalla, Nahla, Meshnick, Steven R., Meshnick, Steven R, Juliano, Jonathan J., Sutherland, Colin J.   +6 more
core   +1 more source

Detection of K76T Mutation in pfcrt Gene as an Applicable Ge-netic Marker for Prediction of Chloroquine Resistant falciparum Malaria in Isolates from an Endemic District of Iran [PDF]

Iranian Journal of Parasitology, 2008
Background: This study investigated the association between pfcrt, T76 allele and chloroquine resistance in patients with falciparum malaria. Molecular assays for point mutations on drugs resistance-related genes are applied tools for monitoring emerging
A Raeisi, H Keshavarz, SR Naddaf, H Uemura, H Kanbara, MR Razavi, M Assmar, M Nateghpou, AR Esmaeili Rastaghi, M Mohebali   +9 more
doaj   +2 more sources

New haplotypes of the Plasmodium falciparum chloroquine resistance transporter (pfcrt) gene among chloroquine-resistant parasite isolates

, 2003
Mutations in the Plasmodium falciparum chloroquine resistance transporter (pfcrt) gene were examined to assess their associations with chloroquine resistance in clinical samples from Armopa (Papua) and Papua New Guinea.
Jessica McGuire (20016762), K Baird (9872564), Nagesh Hadya (20016747), G Casey (11161569), K Rieckmann (20016750), B Laksana (20016756), C J (20016759), D Fryauff (20016753)   +7 more
core   +2 more sources

Stable high frequencies of sulfadoxine–pyrimethamine resistance associated mutations and absence of K13 mutations in Plasmodium falciparum 3 and 4 years after the introduction of artesunate plus sulfadoxine–pyrimethamine in Ujjain, Madhya Pradesh, India

Malaria Journal, 2020
Background Artesunate plus sulfadoxine–pyrimethamine (ASP) is first-line treatment for uncomplicated Plasmodium falciparum malaria in most of India, except for six North-eastern provinces where treatment failure rates were high. In Ujjain, central India,
Ashish Pathak, Andreas Mårtensson, Sudhir Gawariker, Ashish Sharma, Vishal Diwan, Manju Purohit, Johan Ursing   +6 more
doaj   +1 more source

Pfcrt and pfmdr1 alleles associated with chloroquine resistance in Plasmodium falciparum from Guyana, South America

Memorias do Instituto Oswaldo Cruz, 2004
Using DNA extracted from 112 parasitised blood blots, we screened for the population marker of chloroquine resistance (CQR) pfcrt K76T in Plasmodium falciparum infections from Guyana.
Wallis Best Plummer, Lexley M Pinto Pereira, Christine VF Carrington   +2 more
doaj   +1 more source