Results 101 to 110 of about 4,673 (237)

Pfcrt K76T mutation and its associations in imported Plasmodium falciparum malaria cases

Infection, Genetics and Evolution, 2004
Over 3 years (1999-2002), 305 cases of falciparum malaria were diagnosed in Toulouse, France. After retrospective analysis, only 131 patients entered the study. The diagnosis of malaria was ensured by optical methods (QBC then thin smear examination), the results of which were checked from 1999 to mid-2001 by a conventional PCR method, replaced at that
Antoine, Berry, Aurélia, Vessière, Richard, Fabre, Françoise, Benoit-Vical, Bruno, Marchou, Patrice, Massip, Jean-François, Magnaval   +6 more
openaire   +2 more sources

Studies on antimalarial drug susceptibility in Colombia, in relation to Pfmdr1 and Pfcrt

Parasitology, 2008
SUMMARYIn Colombia, Plasmodium resistance to antimalarials such as chloroquine and antifolates is a serious problem. As a result, the national Colombian health authorities are monitoring the efficacy of alternative drugs and schemes. The study of genetic polymorphisms related with drug resistance is required in the region.
E, Restrepo-Pineda, E, Arango, A, Maestre, V E, Do Rosário, P, Cravo   +4 more
openaire   +2 more sources

Plasmodium falciparum transcription factor AP2-06B is mutated at high frequency in Southeast Asia but does not associate with drug resistance

Frontiers in Cellular and Infection Microbiology
IntroductionA continuing challenge for malaria control is the ability of Plasmodium falciparum to develop resistance to antimalarial drugs. Members within the Plasmodium transcription factor family AP2 regulate the growth and development of the parasite,
Qiyang Shi, Changhong Wang, Wenluan Yang, Xiaoqin Ma, Jianxia Tang, Jiayao Zhang, Guoding Zhu, Yinlong Wang, Yaobao Liu, Xiaoqin He   +9 more
doaj   +1 more source

Temporal trends in prevalence of Plasmodium falciparum drug resistance alleles over two decades of changing antimalarial policy in coastal Kenya

International Journal for Parasitology: Drugs and Drug Resistance, 2014
Molecular surveillance of drug resistance markers through time provides crucial information on genomic adaptations, especially in parasite populations exposed to changing drug pressures.
John Okombo, Alice W. Kamau, Kevin Marsh, Colin J. Sutherland, Lynette Isabella Ochola-Oyier   +4 more
doaj   +1 more source

Culture-adapted Plasmodium falciparum isolates from UK travellers: in vitro drug sensitivity, clonality and drug resistance markers. [PDF]

, 2013
BACKGROUND: The screening of lead compounds against in vitro parasite cultures is an essential step in the development of novel anti-malarial drugs, but currently relies on laboratory parasite lines established in vitro during the last century.
Sutherland, CJ, van Schalkwyk, DA, Wright, Stephen G, Henriques, G, Burrow, Rebekah, Beshir, Khalid B, Beshir, KB, Hasford, Christian, Hasford, C, Ding, XC, Gadalla, Nahla B, Chiodini, Peter L, Sutherland, Colin J, van Schalkwyk, Donelly A, Henriques, Gisela, Gadalla, NB, Wright, SG, Ding, Xavier C, Chiodini, PL   +18 more
core   +1 more source

Molecular analysis demonstrates high prevalence of chloroquine resistance but no evidence of artemisinin resistance in Plasmodium falciparum in the Chittagong Hill Tracts of Bangladesh

Malaria Journal, 2017
Background Artemisinin resistance is present in the Greater Mekong region and poses a significant threat for current anti-malarial treatment guidelines in Bangladesh.
Mohammad Shafiul Alam, Benedikt Ley, Maisha Khair Nima, Fatema Tuj Johora, Mohammad Enayet Hossain, Kamala Thriemer, Sarah Auburn, Jutta Marfurt, Ric N. Price, Wasif A. Khan   +9 more
doaj   +1 more source

Pfcrt K76T SNP compared against drug IC₅₀ (in nM).

, 2013
A. Comparison of Pfcrt K76T SNP against CQ IC50 stratified by year; B. Comparison of Pfcrt K76T SNP against AQ IC50 stratified by year; C. Comparison of Pfcrt K76T SNP against MQ IC50 stratified by year; D.
David Schnabel (584089), Edwin Kamau (282162), Elizabeth Wanja (584088), Norman C. Waters (584091), Hoseah M. Akala (584080), Ben Andagalu (584087), Charles Okudo (584084), Jacob D. Johnson (584092), Wallace Bulimo (584090), Luiser Ingasia (584081), Redemptah Yeda (584086), Douglas S. Walsh (257138), Angela Omondi (584083), Fredrick L. Eyase (584079), Agnes Cheruiyot (584082), Dennis Juma (584085)   +15 more
core   +1 more source

Dynamic of plasmodium falciparum chloroquine resistance transporter gene Pfcrt K76T mutation five years after withdrawal of chloroquine in Burkina Faso [PDF]

, 2016
We investigated the evolution of Pfcrt K76T mutation five years after the withdrawal of chloroquine in Burkina Faso. A total of 675 clinical isolates collected from October 2010 to September 2012 were successfully genotyped.
Nakanabo, S.D., Valea, I, Sondo, P, Sorgho, H, Ouedraogo, J, Derra, K, Guiguemde, T.R., Zampa, O, Kazienga, A, Tinto, H, Tarnagda, Z   +10 more
core   +1 more source

Distribution of pfmdr1 and pfcrt chloroquine drug resistance alleles in north-western Nigeria

MalariaWorld journal, 2017
Background. In Nigeria, decline in the sensitivity of Plasmodium falciparum to Artemisinin Combination Therapy (ACT) has prompted the unofficial use of chloroquine (CQ) for self-medication. This study was designed to determine the prevalence and distribution of CQ resistant/susceptible alleles of CQ resistance transporter (Pfcrt) and P.
Ruqayyah H, Muhammad, Ishaya H, Nock, Iliya S, Ndams, Jonathan B, George, Yusuf, Deeni   +4 more
openaire   +2 more sources

Molecular surveillance of Pfcrt and k13 propeller polymorphisms of imported Plasmodium falciparum cases to Zhejiang Province, China between 2016 and 2018

Malaria Journal, 2020
Background Resistance to anti-malarial drugs hinders malaria elimination. Monitoring the molecular markers of drug resistance helps improve malaria treatment policies.
Xiaoxiao Wang, Wei Ruan, Shuisen Zhou, Fang Huang, Qiaoyi Lu, Xinyu Feng, He Yan   +6 more
doaj   +1 more source