Results 101 to 110 of about 4,262 (206)

Molecular surveillance of Pfcrt and k13 propeller polymorphisms of imported Plasmodium falciparum cases to Zhejiang Province, China between 2016 and 2018

Malaria Journal, 2020
Background Resistance to anti-malarial drugs hinders malaria elimination. Monitoring the molecular markers of drug resistance helps improve malaria treatment policies.
Xiaoxiao Wang, Wei Ruan, Shuisen Zhou, Fang Huang, Qiaoyi Lu, Xinyu Feng, He Yan   +6 more
doaj   +1 more source

Differential drug efflux or accumulation does not explain variation in the chloroquine response of Plasmodium falciparum strains expressing the same isoform of mutant PfCRT [PDF]

, 2011
Mutant forms of the Plasmodium falciparum chloroquine resistance transporter (PfCRT) mediate chloroquine resistance by effluxing the drug from the parasite's digestive vacuole, the acidic organelle in which chloroquine exerts its parasiticidal effect ...
Kiaran Kirk, David A. Fidock, Kirk, Kiaran, Adele M. Lehane, Donelly A. van Schalkwyk, Valderramos, Stephanie G, Lehane, Adele, Van Schalkwyk, Donelly, Stephanie G. Valderramos, Fidock, David A   +9 more
core   +1 more source

Distribution of pfmdr1 and pfcrt chloroquine drug resistance alleles in north-western Nigeria

MalariaWorld journal, 2017
Background. In Nigeria, decline in the sensitivity of Plasmodium falciparum to Artemisinin Combination Therapy (ACT) has prompted the unofficial use of chloroquine (CQ) for self-medication. This study was designed to determine the prevalence and distribution of CQ resistant/susceptible alleles of CQ resistance transporter (Pfcrt) and P.
Ruqayyah H, Muhammad, Ishaya H, Nock, Iliya S, Ndams, Jonathan B, George, Yusuf, Deeni   +4 more
openaire   +2 more sources

Plasmodium falciparum resistance to piperaquine driven by PfCRT [PDF]

The Lancet Infectious Diseases, 2019
Dhingra, Satish, Small-Saunders, Jennifer, Ménard, Didier, Fidock, David   +3 more
openaire   +2 more sources

Lack of significant recovery of chloroquine sensitivity in Plasmodium falciparum parasites following discontinuance of chloroquine use in Papua New Guinea

Malaria Journal, 2018
Background Chloroquine treatment for Plasmodium falciparum has been discontinued in almost all endemic regions due to the spread of resistant isolates. Reversal of chloroquine susceptibility after chloroquine discontinuation has been reported in dozens ...
Makoto Sekihara, Shin-Ichiro Tachibana, Masato Yamauchi, Shoki Yatsushiro, Steven Tiwara, Naoyuki Fukuda, Mie Ikeda, Toshiyuki Mori, Makoto Hirai, Francis Hombhanje, Toshihiro Mita   +10 more
doaj   +1 more source

Short Report: Association Between Chloroquine and Amodiaquine Resistance and Allelic Variation in the Plasmodium Falciparum Multiple Drug Resistance 1 Gene and the Chloroquine Resistance Transporter Gene in Isolates from the Upper Nile in Southern Sudan. [PDF]

, 2003
Amodiaquine, a 4-aminoquinoline compound, is being considered as an alternative to chloroquine and pyrimethamine/sulfadoxine where resistance in Plasmodium falciparum to both drugs has been selected.
Nzila, A, van den Broek, I, Keus, K, Ochong, E   +3 more
core  

Pfcrt K76T SNP compared against drug IC₅₀ (in nM).

, 2013
A. Comparison of Pfcrt K76T SNP against CQ IC50 stratified by year; B. Comparison of Pfcrt K76T SNP against AQ IC50 stratified by year; C. Comparison of Pfcrt K76T SNP against MQ IC50 stratified by year; D.
David Schnabel (584089), Edwin Kamau (282162), Elizabeth Wanja (584088), Norman C. Waters (584091), Hoseah M. Akala (584080), Ben Andagalu (584087), Charles Okudo (584084), Jacob D. Johnson (584092), Wallace Bulimo (584090), Luiser Ingasia (584081), Redemptah Yeda (584086), Douglas S. Walsh (257138), Angela Omondi (584083), Fredrick L. Eyase (584079), Agnes Cheruiyot (584082), Dennis Juma (584085)   +15 more
core   +1 more source

Mosquitoes as a feasible sentinel group for anti-malarial resistance surveillance by Next Generation Sequencing of Plasmodium falciparum

Malaria Journal, 2019
Background Plasmodium falciparum drug resistance surveillance is key to successful disease control and eradication. Contemporary methods that only allow determination of prevalence of resistance are expensive, time consuming and require ethical ...
Rebecca Smith-Aguasca, Himanshu Gupta, Estefania Uberegui, Mara Maquina, Francisco Saute, Krijn P. Paaijmans, Alfredo Mayor, Silvie Huijben   +7 more
doaj   +1 more source

In vivo selection of Plasmodium falciparum Pfcrt and Pfmdr1 variants by artemether-lumefantrine and dihydroartemisinin-piperaquine in Burkina Faso.

, 2014
Plasmodium falciparum Pfcrt-76 and Pfmdr1-86 gene polymorphisms were determined during a clinical trial in Burkina Faso comparing the efficacies of dihydroartemisinin-piperaquine (DHA-PPQ) and artemether-lumefantrine (AL).
Mbonye, Martin K, Erhart, Annette, Delgado-Ratto, Christopher, Van Overmeir, Chantal, Baraka, Vito, Van Geertruyden, Jean-Pierre, Tinto, Halidou, Rosanas-Urgell, Anna, Valea, Innocent, D'Alessandro, Umberto, Fitzhenry, Robert, Delgado Ratto, Christopher, Mbonye, Martin K., et al.   +13 more
core   +1 more source

Plasmodium falciparum transcription factor AP2-06B is mutated at high frequency in Southeast Asia but does not associate with drug resistance

Frontiers in Cellular and Infection Microbiology
IntroductionA continuing challenge for malaria control is the ability of Plasmodium falciparum to develop resistance to antimalarial drugs. Members within the Plasmodium transcription factor family AP2 regulate the growth and development of the parasite,
Qiyang Shi, Changhong Wang, Wenluan Yang, Xiaoqin Ma, Jianxia Tang, Jiayao Zhang, Guoding Zhu, Yinlong Wang, Yaobao Liu, Xiaoqin He   +9 more
doaj   +1 more source