Results 111 to 120 of about 4,262 (206)

Chloroquine-resistance-conferring mutations in pfcrt give rise to a chloroquine-associated H+ leak from the malaria parasite's digestive vacuole.

, 2016
Chloroquine resistance in the malaria parasite Plasmodium falciparum is conferred by mutations in the P. falciparum chloroquine resistance transporter (PfCRT).
Kirk, Kiaran, Lehane, Adele
core   +1 more source

Multiplex PCR–RFLP methods for pfcrt, pfmdr1 and pfdhfr mutations in Plasmodium falciparum

Molecular and Cellular Probes, 2006
Plasmodium falciparum drug resistance is a major factor for the death toll of malaria. Resistance has been associated with specific single nucleotide polymorphisms (SNPs) in the parasite genes pfmdr1 (N86Y) and pfcrt (K76T) associated with quionoline antimalarial resistance, and pfdhfr (N51I, C59R, S108N) correlated with resistance of the antifolate ...
Maria Isabel, Veiga, Pedro Eduardo, Ferreira, Anders, Björkman, José Pedro, Gil   +3 more
openaire   +2 more sources

Return of chloroquine sensitivity to Africa? Surveillance of African Plasmodium falciparum chloroquine resistance through malaria imported to China

Parasites & Vectors, 2017
Background Chloroquine (CQ) was the cornerstone of anti-malarial treatment in Africa for almost 50 years, but has been widely withdrawn due to the emergence and spread of resistance.
Feng Lu, Meihua Zhang, Richard L. Culleton, Sui Xu, Jianxia Tang, Huayun Zhou, Guoding Zhu, Yaping Gu, Chao Zhang, Yaobao Liu, Weiming Wang, Yuanyuan Cao, Julin Li, Xinlong He, Jun Cao, Qi Gao   +15 more
doaj   +1 more source

Evidence for a central role for PfCRT in conferring Plasmodium falciparum resistance to diverse antimalarial agents

, 2004
Chloroquine resistance in Plasmodium falciparum is primarily conferred by mutations in pfcrt. Parasites resistant to chloroquine can display hypersensitivity to other antimalarials; however, the patterns of cross-resistance are complex, and the genetic ...
Johnson, David J., Sidhu, Amar Bir Singh, Lakshmanan, Viswanathan, Ward, Steve, Bray, Patrick G., Fidock, David A., Mungthin, Mathirut   +6 more
core   +1 more source

Genetic backgrounds of the Plasmodium falciparum chloroquine resistant transporter (pfcrt) alleles in Pakistan

Infection, Genetics and Evolution, 2012
Chloroquine (CQ) resistance in Plasmodium falciparum has been associated with point mutations in the P. falciparum CQ resistance transporter gene (pfcrt). Previous studies have shown 4-5 independent origins for CQ resistant pfcrt alleles globally, two in South America, one each in Southeast Asia, Papua New Guinea (PNG) and Philippines.
Rawasia, Wasiq Faraz, Sridaran, Sankar, Patel, Jaymin C., Abdallah, Joseph, Ghanchi, Najia Karim, Barnwell, John W., Escalante, Ananias A., Udhayakumar, Venkatachalam, Beg, Mohammad Asim   +8 more
openaire   +2 more sources

Sequence and gene expression of chloroquine resistance transporter (pfcrt) in the association of in vitro drugs resistance of Plasmodium falciparum

Malaria Journal, 2011
Background Plasmodium falciparum chloroquine resistance (CQR) transporter protein (PfCRT) is known to be the important key of CQR. Recent studies have definitively demonstrated a link between mutations in the gene pfcrt and resistance to chloroquine in P.
Bray Patrick G, Owen Andrew, Johnson David, Mungthin Mathirut, Ward Stephen A, Chaijaroenkul Wanna, Na-Bangchang Kesara   +6 more
doaj   +1 more source

Glutathione Transport by the Malaria Parasite's Chloroquine Resistance Transporter, PfCRT

This dataset contains the input structures and representative output frames from a series of molecular dynamics (MD) simulations of the Plasmodium falciparum Chloroquine Resistance Transporter (PfCRT). The data is organized into two main directories: structures and PfCRT-trajectories.
Gil-Iturbe, Eva, Kelich, Payam, Kim, Jonathan, Mancia, Filippo, Fidock, David A., Tajkhorshid, Emad, Quick, Matthias   +6 more
openaire   +4 more sources

Structure and Drug Resistance of the Plasmodium Falciparum Transporter PfCRT [PDF]

Biophysical Journal, 2020
Jonathan Kim, Yong Zi Tan, Kathryn J. Wicht, Satchal K. Erramilli, Satish K. Dhingra, John Okombo, Jeremie P. Vendome, Laura M. Hagenah, Sabrina I. Giacometti, Clinton S. Potter, Bridget Carragher, Anthony A. Kossiakoff, Matthias Quick, David A. Fidock, Filippo Mancia   +14 more
openaire   +1 more source

PfCRT and the trans-vacuolar proton electrochemical gradient: regulating the access of chloroquine to ferriprotoporphyrin IX.

, 2006
It is accepted that resistance of Plasmodium falciparum to chloroquine (CQ) is caused primarily by mutations in the pfcrt gene. However, a consensus has not yet been reached on the mechanism by which resistance is achieved.
Hastings, Ian M, Stocks, Paul A, Hughes, Ruth H, Viswanathan Lakshmanan, Bray, Patrick G., O'Neill, Paul M., Stephen A. Ward, Stocks, Paul A., Fidock, David A., Hastings, Ian, Johnson, David J., Hughes, Ruth H., Ruth H. Hughes, Warhurst, David C., Biagini, Giancarlo A, Dauda K. Saidu, Ward, Steve, Bray, Patrick G, Johnson, David J, Ward, Stephen A, Paul A. Stocks, Giancarlo A. Biagini, Lakshmanan, Viswanathan, David A. Fidock, Patrick G. Bray, Saidu, Dauda K, Ian M. Hastings, Mungthin, Mathirut, Mathirut Mungthin, Saidu, Dauda K., Biagini, Giancarlo; id_orcid, David J. Johnson, Paul M. O'Neill, Warhurst, David C, O'Neill, Paul M, Fidock, David A, David C. Warhurst   +36 more
core   +1 more source

Determinación de la mutación K76T de la proteína transportadora resistente a Cloroquina de Plasmodium falciparum (PFCRT) en individuos con malaria en una zona de transmisión moderada del Caribe colombiano

Salud Uninorte, 2010
Introducción: La resistencia de Plasmodium falciparum a los antimalaricos, está relacionada con mutaciones puntuales en proteínas esenciales en la biología del parásito.
Gina Domínguez Moré, Diana Santander Altamar, Alfredo Lagares Guzmán, Dary Luz Mendoza Meza   +3 more
doaj