Results 111 to 120 of about 4,673 (237)

Functional characterization illustrates distinct CQ and PPQ transport properties for the China C PfCRT protein.

, 2022
(A, B) Time course of (A) 93 nM 3H-CQ and (B) 75 nM 3H-PPQ uptake measured with proteoliposomes containing the indicated PfCRT variants. Data are means ± SEM. N =  4.
Kathryn J. Wicht (5149904), Eva Gil-Iturbe (12055287), Filippo Mancia (240803), Satish K. Dhingra (3340959), Laura M. Hagenah (12055284), Jeremie Vendome (4529773), Paul D. Roepe (484901), Ioanna Deni (10182782), Monica Mehta (10652087), Margaret J. Eppstein (11060432), Jonathan Kim (2601136), Jennifer L. Small-Saunders (12055281), Matthias Quick (498709), David A. Fidock (248990)   +13 more
core   +1 more source

PfCRT status of lines employed in this study.

, 2016
PfCRT status of lines employed in this study.
Philipp P. Henrich (1830658), Ian A. Lewis (505358), Jill M. Combrinck (2000779), Nina F. Gnädig (238649), Stanislaw J. Gabryszewski (3340962), Satish K. Dhingra (3340959), Lise Musset (248987), Paul D. Roepe (484901), Andrew H. Lee (352386), Amila Siriwardana (487425), Matthew R. Hassett (3340965), Paul S. Callaghan (3340968), Timothy J. Egan (262760), Manuel Llinás (14834), David A. Fidock (248990)   +14 more
core   +1 more source

Mutations in Pfcrt and Pfmdr1.

, 2019
Mutations in Pfcrt and Pfmdr1.
Inke Lubis (6475796), Xiaodong Sun (166163), Wang Jiazhi (6475799), Susana Campino (56411), Colin J. Sutherland (257150), Taane G. Clark (106263), Jun Feng (116162), Lin-hua Tang (6475802), David C. Warhurst (250276), Ana Rita Gomes (220735), Khalid B. Beshir (816307), Fang Huang (154302), Yan He (116705), Ernest Diez Benavente (3711490)   +13 more
core   +1 more source

Image1_Plasmodium falciparum Drug Resistance Genes pfmdr1 and pfcrt In Vivo Co-Expression During Artemether-Lumefantrine Therapy.jpeg

, 2022
Background: Artemisinin-based combination therapies (ACTs) are the global mainstay treatment of uncomplicated Plasmodium falciparum infections. PfMDR1 and PfCRT are two transmembrane transporters, associated with sensitivity to several antimalarials ...
A. Björkman (6249143), A. Mårtensson (6249191), S. D. Otienoburu (12611293), M. Silva (7447316), J. P. Gil (12611299), M. Malmberg (12611290), B. Ngasala (12611296), M. I. Veiga (12611302)   +7 more
core   +1 more source

Plasmodium falciparum resistance to piperaquine driven by PfCRT [PDF]

The Lancet Infectious Diseases, 2019
Dhingra, Satish, Small-Saunders, Jennifer, Ménard, Didier, Fidock, David   +3 more
openaire   +2 more sources

Lack of significant recovery of chloroquine sensitivity in Plasmodium falciparum parasites following discontinuance of chloroquine use in Papua New Guinea

Malaria Journal, 2018
Background Chloroquine treatment for Plasmodium falciparum has been discontinued in almost all endemic regions due to the spread of resistant isolates. Reversal of chloroquine susceptibility after chloroquine discontinuation has been reported in dozens ...
Makoto Sekihara, Shin-Ichiro Tachibana, Masato Yamauchi, Shoki Yatsushiro, Steven Tiwara, Naoyuki Fukuda, Mie Ikeda, Toshiyuki Mori, Makoto Hirai, Francis Hombhanje, Toshihiro Mita   +10 more
doaj   +1 more source

Mosquitoes as a feasible sentinel group for anti-malarial resistance surveillance by Next Generation Sequencing of Plasmodium falciparum

Malaria Journal, 2019
Background Plasmodium falciparum drug resistance surveillance is key to successful disease control and eradication. Contemporary methods that only allow determination of prevalence of resistance are expensive, time consuming and require ethical ...
Rebecca Smith-Aguasca, Himanshu Gupta, Estefania Uberegui, Mara Maquina, Francisco Saute, Krijn P. Paaijmans, Alfredo Mayor, Silvie Huijben   +7 more
doaj   +1 more source

Multiplex PCR–RFLP methods for pfcrt, pfmdr1 and pfdhfr mutations in Plasmodium falciparum

Molecular and Cellular Probes, 2006
Plasmodium falciparum drug resistance is a major factor for the death toll of malaria. Resistance has been associated with specific single nucleotide polymorphisms (SNPs) in the parasite genes pfmdr1 (N86Y) and pfcrt (K76T) associated with quionoline antimalarial resistance, and pfdhfr (N51I, C59R, S108N) correlated with resistance of the antifolate ...
Maria Isabel, Veiga, Pedro Eduardo, Ferreira, Anders, Björkman, José Pedro, Gil   +3 more
openaire   +2 more sources

Genetic backgrounds of the Plasmodium falciparum chloroquine resistant transporter (pfcrt) alleles in Pakistan

Infection, Genetics and Evolution, 2012
Chloroquine (CQ) resistance in Plasmodium falciparum has been associated with point mutations in the P. falciparum CQ resistance transporter gene (pfcrt). Previous studies have shown 4-5 independent origins for CQ resistant pfcrt alleles globally, two in South America, one each in Southeast Asia, Papua New Guinea (PNG) and Philippines.
Rawasia, Wasiq Faraz, Sridaran, Sankar, Patel, Jaymin C., Abdallah, Joseph, Ghanchi, Najia Karim, Barnwell, John W., Escalante, Ananias A., Udhayakumar, Venkatachalam, Beg, Mohammad Asim   +8 more
openaire   +2 more sources

Return of chloroquine sensitivity to Africa? Surveillance of African Plasmodium falciparum chloroquine resistance through malaria imported to China

Parasites & Vectors, 2017
Background Chloroquine (CQ) was the cornerstone of anti-malarial treatment in Africa for almost 50 years, but has been widely withdrawn due to the emergence and spread of resistance.
Feng Lu, Meihua Zhang, Richard L. Culleton, Sui Xu, Jianxia Tang, Huayun Zhou, Guoding Zhu, Yaping Gu, Chao Zhang, Yaobao Liu, Weiming Wang, Yuanyuan Cao, Julin Li, Xinlong He, Jun Cao, Qi Gao   +15 more
doaj   +1 more source