Results 121 to 130 of about 4,673 (237)

Pfcrt copy number amplification detected in a Plasmodium falciparum outbreak [PDF]

Sarah Auburn, Anjana Rai, Chiyun Lee, Hidayat Trimarsanto, Ashley A. Osborne, Kian Soon Hoon, Jacob A. F. Westaway, Giri Shan Rajahram, June Haidee Acuna-Lariosa, Maria Lourdes Macalinao, Jennifer Luchavez, Mary Grace Baylon, Dave Tangcalagan, Sherwin Galit, Jenarun Jelip, Anisah Jantim, Kim Piera, Fe Esperanza Espino, Timothy William, David A. Fidock, Dominic P. Kwiatkowski, Nicholas Anstey, Bridget E. Barber, Richard D. Pearson, Matthew J. Grigg   +24 more
openalex   +3 more sources

Sequence and gene expression of chloroquine resistance transporter (pfcrt) in the association of in vitro drugs resistance of Plasmodium falciparum

Malaria Journal, 2011
Background Plasmodium falciparum chloroquine resistance (CQR) transporter protein (PfCRT) is known to be the important key of CQR. Recent studies have definitively demonstrated a link between mutations in the gene pfcrt and resistance to chloroquine in P.
Bray Patrick G, Owen Andrew, Johnson David, Mungthin Mathirut, Ward Stephen A, Chaijaroenkul Wanna, Na-Bangchang Kesara   +6 more
doaj   +1 more source

No genetic bottleneck in Plasmodium falciparum wild-type Pfcrt alleles reemerging in Hainan Island, China, following high-level chloroquine resistance

, 2008
Chloroquine-resistant Plasmodium falciparum was highly prevalent in Hainan, China, in the 1970s. Twenty-five years after cessation of chloroquine therapy, the prevalence of P.
Gao, Qi, Cheng, Qin, Wang, Shanqing, Gatton, Michelle L., Chen, Nanhua, Wang, Guangze   +5 more
core   +1 more source

CQ_GREEN uptake by Dd2 PfCRT microsomes.

, 2014
Total uptake of CQGREEN was measured at various CQGREEN concentrations in microsomes carrying Dd2 PfCRT. Non-specific uptake of CQGREEN was measured with pre-treatment of excess unlabelled CQ. Specific uptake was estimated as the difference between total
François H. Nosten (315303), Bruce Russell (35525), Martin J. Lear (649334), Kit-Ying Choy (649333), Yan Quan Lee (649331), Laurent Rénia (2935842), Rossarin Suwanarusk (35524), Kevin S. W. Tan (160329), Larry M. C. Chow (649335), Cheryl C. Y. Loh (649330), Kitti W. K. Chan (649332)   +10 more
core   +1 more source

Structure and Drug Resistance of the Plasmodium Falciparum Transporter PfCRT [PDF]

Biophysical Journal, 2020
Jonathan Kim, Yong Zi Tan, Kathryn J. Wicht, Satchal K. Erramilli, Satish K. Dhingra, John Okombo, Jeremie P. Vendome, Laura M. Hagenah, Sabrina I. Giacometti, Clinton S. Potter, Bridget Carragher, Anthony A. Kossiakoff, Matthias Quick, David A. Fidock, Filippo Mancia   +14 more
openaire   +1 more source

Large-scale survey for novel genotypes of Plasmodium falciparum chloroquine-resistance gene pfcrt [PDF]

Background. In Plasmodium falciparum, resistance to chloroquine (CQ) is conferred by a K to T mutation at amino acid position 76 (K76T) in the P. falciparum CQ transporter (PfCRT).
Kaneko, Akira, Kobayashi, Jun, Tanabe, Kazuyuki, Khamlome, Boualam, Mita, Toshihiro, Takahashi, Nobuyuki, Sattabongkot, Jetsumon, Tsukahara, Takahiro, Endo, Hiroyoshi, Dysoley, Lek, Dzodzomenyo, Mawuli, Hombhanje, Francis, Nakamura, Masatoshi, Sakurai, Miki, Tsuboi, Takafumi   +14 more
core  

Glutathione Transport by the Malaria Parasite's Chloroquine Resistance Transporter, PfCRT

This dataset contains the input structures and representative output frames from a series of molecular dynamics (MD) simulations of the Plasmodium falciparum Chloroquine Resistance Transporter (PfCRT). The data is organized into two main directories: structures and PfCRT-trajectories.
Gil-Iturbe, Eva, Kelich, Payam, Kim, Jonathan, Mancia, Filippo, Fidock, David A., Tajkhorshid, Emad, Quick, Matthias   +6 more
openaire   +2 more sources

Rapid and supersensitive allele detection of Plasmodium falciparum chloroquine resistance via a Pyrococcus furiosus argonaute-triggered dual-signal biosensing platform

Parasites & Vectors
Background Malaria remains a serious public health problem worldwide, particularly in Africa. Resistance to antimalarial drugs is an essential issue for malaria control and elimination.
Liying Chen, Wencheng Chen, Huagui Wei, Wenai Lin, Cheng Zhang, Hongfei Hu, Chunfang Wang, Jiangtao Chen, Xueyan Liang, Daiqian Zhu, Junli Wang, Zongyun Lin, Yuxia Wei, Jian Li, Min Lin   +14 more
doaj   +1 more source

Determinación de la mutación K76T de la proteína transportadora resistente a Cloroquina de Plasmodium falciparum (PFCRT) en individuos con malaria en una zona de transmisión moderada del Caribe colombiano

Salud Uninorte, 2010
Introducción: La resistencia de Plasmodium falciparum a los antimalaricos, está relacionada con mutaciones puntuales en proteínas esenciales en la biología del parásito.
Gina Domínguez Moré, Diana Santander Altamar, Alfredo Lagares Guzmán, Dary Luz Mendoza Meza   +3 more
doaj  

Short Report: Association Between Chloroquine and Amodiaquine Resistance and Allelic Variation in the Plasmodium Falciparum Multiple Drug Resistance 1 Gene and the Chloroquine Resistance Transporter Gene in Isolates from the Upper Nile in Southern Sudan. [PDF]

, 2003
Amodiaquine, a 4-aminoquinoline compound, is being considered as an alternative to chloroquine and pyrimethamine/sulfadoxine where resistance in Plasmodium falciparum to both drugs has been selected.
Nzila, A, van den Broek, I, Keus, K, Ochong, E   +3 more
core