Results 131 to 140 of about 4,673 (237)

Emerging Southeast Asian PfCRT mutations confer Plasmodium falciparum resistance to the first-line antimalarial piperaquine

, 2018
International audienceThe widely used antimalarial combination therapy dihydroartemisinin + piperaquine (DHA + PPQ) has failed in Cambodia. Here, we perform a genomic analysis that reveals a rapid increase in the prevalence of novel mutations in the ...
Ariey, Frederic, Yeo, Tomas, Fidock, David, Mok, Sachel, Witkowski, Benoit, Kümpornsin, Krittikorn, Ménard, Didier, Fairhurst, Rick,, Wicht, Kathryn, Takala-Harrison, Shannon, Fairhurst, Rick, M, Dhingra, Satish, Ross, Leila   +12 more
core   +1 more source

Clinical isolates of uncomplicated falciparum malaria from high and low malaria transmission areas show distinct pfcrt and pfmdr1 polymorphisms in western Ethiopia [PDF]

, 2023
Geletta Tadele, Aminata Seedy Jawara, Mary Aigbiremo Oboh, Eniyou Cheryll Oriero, Sisay Dugassa, Alfred Amambua‐Ngwa, Lemu Golassa   +6 more
openalex   +3 more sources

Gain-of-function PfAAT1 mutations compensate for impaired PfCRT function in Plasmodium falciparum [PDF]

Muhammad Hasan, Eva S. Istvan, Jack Farah, Kharizta Wiradiputri, Sydney Gavula, Elizabeth Winzeler, Manuel Llinás, David A. Fidock, Daniel E. Goldberg   +8 more
openalex   +1 more source

Chloroquine-resistance-conferring mutations in pfcrt give rise to a chloroquine-associated H+ leak from the malaria parasite's digestive vacuole.

, 2016
Chloroquine resistance in the malaria parasite Plasmodium falciparum is conferred by mutations in the P. falciparum chloroquine resistance transporter (PfCRT).
Kirk, Kiaran, Lehane, Adele
core   +1 more source

Unraveling Key Chloroquine Resistance-Associated Alleles Among Plasmodium falciparum Isolates in South Darfur State, Sudan Twelve Years After Drug Withdrawal

Infection and Drug Resistance
Abdalmoneim M Magboul,1 Bakri YM Nour,2 Abdelhakam G Tamomh,1 Rashad Abdul-Ghani,3,4 Sayed Mustafa Albushra,5 Hanan Babiker Eltahir6 1Department of Parasitology & Medical Entomology, Faculty of Medical Laboratory Sciences, University of El Imam El Mahdi,
Magboul AM, Nour BY, Tamomh AG, Abdul-Ghani R, Albushra SM, Eltahir HB   +5 more
doaj  

PA-762 Prevalence of Pfcrt K76T mutation years after chloroquine withdrawal in Lagos, Nigeria [PDF]

, 2023
Funmilayo C. Ligali, Afolabi J. Owoloye, Joshua Akinola, Yetunde M. Alo, Matthew Okorigwe, Blessing Erinwusi, Oluwagbemiga Aina, Akinniyi Adediran Osuntoki, Kolapo Muyiwa Oyebola   +8 more
openalex   +1 more source

Assessment of the polymorphic levels of Plasmodium Falciparum Pfcrt (K76T) and pfmdr 1 (N86Y) drug resistant genes in Buea, South West region of Cameroon [PDF]

, 2023
Magdany Fru
openalex   +1 more source

Biochemical and biophysical analysis of recombinant Plasmodium falciparum chloroquine resistance transporter (pfcrt)

, 2009
Thesis (Ph.D.)--Georgetown University, 2009.; Includes bibliographical references.; Text (Electronic thesis) in PDF format. Malaria caused by the Apicomplexan parasite Plasmodium falciparum is an alarming health problem due to increasing ...
Paguio, Michelle Fortaleza.
core  

Plasmodium falciparum chloroquine resistance transporter (PfCRT) [PDF]

Science-Business eXchange, 2011
openaire   +1 more source

A Plasmodium falciparum genetic cross reveals the contributions of pfcrt and plasmepsin II/III to piperaquine drug resistance [PDF]

, 2023
John W Kane, Xue Li, Sudhir Kumar, Katrina A. Button-Simons, Katelyn M. Vendrely, Haley Dahlhoff, Mackenzie A. C. Sievert, Lisa A. Checkley, Douglas A. Shoue, Puspendra P. Singh, Biley A. Abatiyow, Meseret T. Haile, Shalini Nair, Ann N. Reyes, Rupam Tripura, Tom Peto, Dysoley Lek, Stefan H. I. Kappe, Mehul Dhorda, Standwell C. Nkhoma, Ian H. Cheeseman, Ashley M. Vaughan, Timothy J. C. Anderson, Michael T. Ferdig   +23 more
openalex   +1 more source