Results 81 to 90 of about 4,262 (206)

Targeting Plasmodium Falciparum Asexual and Sexual Stages with Melatonin‐Based Indole Compounds

ChemistrySelect, Volume 10, Issue 41, November 3, 2025.
This study presents a comprehensive pipeline for screening melatonin‐inspired compounds synthesized via copper(I)‐catalyzed azide‐alkyne cycloaddition (CuAAC) “Click Chemistry” against Plasmodium falciparum. The pipeline evaluates activity against asexual and sexual stages, cytotoxicity, and potential interference with parasite melatonin signaling ...
Abhinab Mohanty, Lamark Carlos I, Euzébio Guimarães Barbosa, Alessandro Kappel Jordão, Celia R. S. Garcia   +4 more
wiley   +1 more source

CQ_GREEN uptake by resistant-type PfCRT is inhibited by mibefradil in a dose-dependent manner.

, 2014
Microsomes were preincubated with varying concentrations of the PfCRT inhibitor mibefradil prior to addition of CQGREEN. At the highest concentration of 10 µM, mibefradil drastically suppressed CQGREEN uptake in PfCRT-Dd2 microsomes but had no ...
François H. Nosten (315303), Bruce Russell (35525), Martin J. Lear (649334), Kit-Ying Choy (649333), Yan Quan Lee (649331), Laurent Rénia (2935842), Rossarin Suwanarusk (35524), Kevin S. W. Tan (160329), Larry M. C. Chow (649335), Cheryl C. Y. Loh (649330), Kitti W. K. Chan (649332)   +10 more
core   +1 more source

Prevalence of pfmdr1, pfcrt, pfdhfr and pfdhps mutations associated with drug resistance, in Luanda, Angola [PDF]

Malaria Journal, 2008
Malaria is the infectious disease causing the highest morbidity and mortality in Angola and due to widespread chloroquine (CQ) resistance, the country has recently changed its first-line treatment recommendations for uncomplicated malaria, from CQ to artemisinin combination therapies (ACT) in adults, and sulphadoxine/pyrimethamine (S/P) in pregnant ...
Varandas Luís, do Rosário Virgílio E, Bernardino Luís, Lopes Dinora, Benchimol Carla, Figueiredo Paula, Nogueira Fátima   +6 more
openaire   +3 more sources

Epidemiology of malaria and chloroquine resistance in Mizoram, northeastern India, a malaria-endemic region bordering Myanmar

Malaria Journal, 2020
Background Mizoram, a northeastern state in India, shares international borders with Myanmar and Bangladesh and is considered to be one of the key routes through which drug-resistant parasites of Southeast Asia enter mainland India. Despite its strategic
Rita Zomuanpuii, Christopher L. Hmar, Khawlhring Lallawmzuala, Lal Hlimpuia, Praveen Balabaskaran Nina, Nachimuthu Senthil Kumar   +5 more
doaj   +1 more source

UHPLC/MS Profile and Antimalarial Potency of Enantia chlorantha Oliv. (Annonaceae) Stem Bark Aqueous Extract

Advances in Pharmacological and Pharmaceutical Sciences, Volume 2025, Issue 1, 2025.
The escalating challenge of malaria management, primarily driven by antimalarial drug resistance, necessitates the urgent exploration of novel therapeutic agents. This investigation focused on characterizing the therapeutic efficacy of an aqueous stem bark extract derived from Enantia chlorantha Oliv (Annonaceae) against the parasitic burden of ...
Abel Narcisse Messi Betene, Raceline Gounoue Kamkumo, Patrick Valère Tsouh Fokou, Florence Ngueguim Tsofack, Michel Arnaud Mbock, Eugenie Aimée Madiesse Kemgne, Albertine Ngako, Loic Steve Ngwem Tenlep, Marius Jaures Tsakem Nangap, Roberto Fokou, Darline Dize, Pascal Owona, Mariscal Brice Tchatat Tali, Fabrice Fekam Boyom, Théophile Dimo, Koteshwara Mudigonda   +15 more
wiley   +1 more source

The Malaria Burden: A South African Perspective

Journal of Tropical Medicine, Volume 2024, Issue 1, 2024.
Malaria is a deadly disease caused by protozoan pathogens of the Plasmodium parasite. Transmission to humans occurs through the bite of an infected female Anopheles mosquito. According to the World Health Organization (WHO), an estimated 247 million cases of malaria were recorded worldwide in 2021, with approximately 619 000 malaria deaths. The initial
Marissa Balmith, Charlise Basson, Sarel J. Brand, Jianbing Mu   +3 more
wiley   +1 more source

PfCRT status of lines employed in this study.

, 2016
PfCRT status of lines employed in this study.
Philipp P. Henrich (1830658), Ian A. Lewis (505358), Jill M. Combrinck (2000779), Nina F. Gnädig (238649), Stanislaw J. Gabryszewski (3340962), Satish K. Dhingra (3340959), Lise Musset (248987), Paul D. Roepe (484901), Andrew H. Lee (352386), Amila Siriwardana (487425), Matthew R. Hassett (3340965), Paul S. Callaghan (3340968), Timothy J. Egan (262760), Manuel Llinás (14834), David A. Fidock (248990)   +14 more
core   +1 more source

Stable high frequencies of sulfadoxine–pyrimethamine resistance associated mutations and absence of K13 mutations in Plasmodium falciparum 3 and 4 years after the introduction of artesunate plus sulfadoxine–pyrimethamine in Ujjain, Madhya Pradesh, India

Malaria Journal, 2020
Background Artesunate plus sulfadoxine–pyrimethamine (ASP) is first-line treatment for uncomplicated Plasmodium falciparum malaria in most of India, except for six North-eastern provinces where treatment failure rates were high. In Ujjain, central India,
Ashish Pathak, Andreas Mårtensson, Sudhir Gawariker, Ashish Sharma, Vishal Diwan, Manju Purohit, Johan Ursing   +6 more
doaj   +1 more source

Analytic Approaches in Genomic Epidemiological Studies of Parasitic Protozoa

Transboundary and Emerging Diseases, Volume 2024, Issue 1, 2024.
Whole genome sequencing (WGS) plays an important role in the advanced characterization of pathogen transmission and is widely used in studies of major bacterial and viral diseases. Although protozoan parasites cause serious diseases in humans and animals, WGS data on them are relatively scarce due to the large genomes and lack of cultivation techniques
Tianpeng Wang, Ziding Zhang, Yaoyu Feng, Lihua Xiao, Long-Xian Zhang   +4 more
wiley   +1 more source

Beninese Plant Extracts with Antiplasmodial Activity Select New Allele Variants Msp1 and Msp2 in Plasmodium falciparum

Journal of Parasitology Research, Volume 2024, Issue 1, 2024.
Background. Natural medicinal products are commonly used as a remedy against malaria infections in African populations and have become a major source of information for the screening of new and more effective antiplasmodial molecules. Therefore, in vitro studies are needed to validate the efficacy of these medicinal products and to explore the ...
Hamirath O. Lagnika, Adandé A. Medjigbodo, Oswald Y. Djihinto, Helga M. Saïzonou, Wassiyath A. Mousse, Romaric Akoton, Laurette Djossou, Doris N. Vodounkpe, Latifou Lagnika, Luc S. Djogbénou, Bernard Marchand   +10 more
wiley   +1 more source