Results 81 to 90 of about 4,673 (237)

Over-expression of sensitive and resistant form of PfCRT as GFP-fusion protein.

, 2013
(A) Schematic representation of the inducible expression plasmid pT150KPfCRTGFP. Expression of the transcription activator TATi3 is under the control of the 5' UTR of PTEX150.
Tania de Koning-Ward (319633), Stuart A. Ralph (132226), Alan F. Cowman (136852), James S. Pham (319632), Florian Ehlgen (260266)   +4 more
core   +1 more source

Chlorpheniramine Analogues Reverse Chloroquine Resistance inPlasmodium falciparumby Inhibiting PfCRT [PDF]

ACS Medicinal Chemistry Letters, 2014
The emergence and spread of malaria parasites that are resistant to chloroquine (CQ) has been a disaster for world health. The antihistamine chlorpheniramine (CP) partially resensitizes CQ-resistant (CQR) parasites to CQ but possesses little intrinsic antiplasmodial activity.
Deane, Karen, Summers, Robert, Lehane, Adele, Martin, Rowena, Barrow, Russell   +4 more
openaire   +3 more sources

The Impact of pfmdr1 Gene Copy Number on the Efficacy of Dihydroartemisinin–Piperaquine in Treating Malaria in West Sumba and Kupang Districts, East Nusa Tenggara, Indonesia

Journal of Parasitology Research, Volume 2026, Issue 1, 2026.
The efficacy of antimalarial treatment, particularly artemisinin‐based combination therapy (ACT), continues to face persistent threats due to the development of drug resistance in Plasmodium falciparum. Although artemisinin derivatives remain effective, ACT regimen failure often results from decreased efficacy of the companion drug.
Irdayanti Irdayanti, Hijral Aswad, Puji B. S. Asih, Ismail E. Rozi, Herdiana Herdiana, Ajib Diptyanusa, Helen D. Prameswari, Yenni Yusuf, Bahrani Bahrani, Najdah Hidayah, I. Made Artika, Din Syafruddin, Satabdi Datta Choudhury   +12 more
wiley   +1 more source

Sequence analysis of pfcrt and pfmdr1 genes and its association with chloroquine resistance in Southeast Indian Plasmodium falciparum isolates

Genomics Data, 2016
Background: Due to the widespread resistance of Plasmodium falciparum to chloroquine drug, artemisinin-based combination therapy (ACT) has been recommended as the first-line treatment. This study aims to evaluate the extent of chloroquine resistance in P.
Hiasindh Ashmi Antony, Sindhusuta Das, Subhash Chandra Parija, Sanghamitra Padhi   +3 more
doaj   +1 more source

Targeting Plasmodium Falciparum Asexual and Sexual Stages with Melatonin‐Based Indole Compounds

ChemistrySelect, Volume 10, Issue 41, November 3, 2025.
This study presents a comprehensive pipeline for screening melatonin‐inspired compounds synthesized via copper(I)‐catalyzed azide‐alkyne cycloaddition (CuAAC) “Click Chemistry” against Plasmodium falciparum. The pipeline evaluates activity against asexual and sexual stages, cytotoxicity, and potential interference with parasite melatonin signaling ...
Abhinab Mohanty, Lamark Carlos I, Euzébio Guimarães Barbosa, Alessandro Kappel Jordão, Celia R. S. Garcia   +4 more
wiley   +1 more source

Monitoring for multidrug-resistant Plasmodium falciparum isolates and analysis of pyrimethamine resistance evolution in Uige province, Angola.

, 2009
OBJECTIVES: To assess the extent of drug resistance in Uige through molecular genetic analysis and to test whether the dhfr triple mutant alleles present in Angola are of southeast Asian origin.
Inojosa WO, Roper C, Bisoffi, Zeno, Bisoffi Z, Ord, Rosalynn, Roper, Cally, Abel PM, Severini C, Pisani, Vincenzo, Matondo A, Warhurst DC, Pisani V, Pearce RJ, Matondo, Alexandre, Warhurst, David C, Severini, Carlo, Menegon M, Menegon, Michela, Inojosa, Walter O, Abel, Paulo M, Majori, Giancarlo, Majori G, Ord R, Pearce, Richard J   +23 more
core   +1 more source

Novel dhps and pfcrt Polymorphisms in Plasmodium falciparum Detected by Heteroduplex Tracking Assay [PDF]

The American Journal of Tropical Medicine and Hygiene, 2009
Several single nucleotide polymorphisms (SNPs) have been linked to antimalarial drug resistance in Plasmodium falciparum. However, standard polymerase chain reaction (PCR) methods to detect these polymorphisms are unable to detect SNPs in variants representing < 20% of the parasites in a mixed infection, nor can they detect polymorphisms at nearby ...
Jonathan J, Juliano, David J, Bacon, Jianbing, Mu, Xinhua, Wang, Steven R, Meshnick   +4 more
openaire   +2 more sources

UHPLC/MS Profile and Antimalarial Potency of Enantia chlorantha Oliv. (Annonaceae) Stem Bark Aqueous Extract

Advances in Pharmacological and Pharmaceutical Sciences, Volume 2025, Issue 1, 2025.
The escalating challenge of malaria management, primarily driven by antimalarial drug resistance, necessitates the urgent exploration of novel therapeutic agents. This investigation focused on characterizing the therapeutic efficacy of an aqueous stem bark extract derived from Enantia chlorantha Oliv (Annonaceae) against the parasitic burden of ...
Abel Narcisse Messi Betene, Raceline Gounoue Kamkumo, Patrick Valère Tsouh Fokou, Florence Ngueguim Tsofack, Michel Arnaud Mbock, Eugenie Aimée Madiesse Kemgne, Albertine Ngako, Loic Steve Ngwem Tenlep, Marius Jaures Tsakem Nangap, Roberto Fokou, Darline Dize, Pascal Owona, Mariscal Brice Tchatat Tali, Fabrice Fekam Boyom, Théophile Dimo, Koteshwara Mudigonda   +15 more
wiley   +1 more source

Prevalence of pfmdr1, pfcrt, pfdhfr and pfdhps mutations associated with drug resistance, in Luanda, Angola [PDF]

Malaria Journal, 2008
Malaria is the infectious disease causing the highest morbidity and mortality in Angola and due to widespread chloroquine (CQ) resistance, the country has recently changed its first-line treatment recommendations for uncomplicated malaria, from CQ to artemisinin combination therapies (ACT) in adults, and sulphadoxine/pyrimethamine (S/P) in pregnant ...
Varandas Luís, do Rosário Virgílio E, Bernardino Luís, Lopes Dinora, Benchimol Carla, Figueiredo Paula, Nogueira Fátima   +6 more
openaire   +3 more sources

Polymorphisms in K13, pfcrt, pfmdr1, pfdhfr, and pfdhps in parasites isolated from symptomatic malaria patients in Burkina Faso

Parasite, 2016
Background: The emergence of resistance to artemisinin derivatives in western Cambodia is threatening to revert the recent advances made toward global malaria control and elimination.
Somé Anyirékun Fabrice, Sorgho Hermann, Zongo Issaka, Bazié Thomas, Nikiéma Frédéric, Sawadogo Amadé, Zongo Moussa, Compaoré Yves-Daniel, Ouédraogo Jean-Bosco   +8 more
doaj   +1 more source