Results 31 to 40 of about 4,673 (237)

Analysis of the Antimalarial Drug Resistance Protein Pfcrt Expressed in Yeast [PDF]

Journal of Biological Chemistry, 2002
Mutations in the novel membrane protein Pfcrt were recently found to be essential for chloroquine resistance (CQR) in Plasmodium falciparum, the parasite responsible for most lethal human malaria (Fidock, D. A., Nomura, T., Talley, A. K., Cooper, R. A., Dzekunov, S. M., Ferdig, M. T., Ursos, L. M., Sidhu, A. B., Naude, B., Deitsch, K. W., Su, X.
Hanbang, Zhang, Ellen M, Howard, Paul D, Roepe   +2 more
openaire   +2 more sources

Drug Development Strategies for Malaria: With the Hope for New Antimalarial Drug Discovery—An Update

Advances in Medicine, Volume 2023, Issue 1, 2023., 2023
Malaria continued to be a deadly situation for the people of tropical and subtropical countries. Although there has been a marked reduction in new cases as well as mortality and morbidity rates in the last two decades, the reporting of malaria caused 247 million cases and 619000 deaths worldwide in 2021, according to the WHO (2022).
Swaroop Kumar Pandey, Uttpal Anand, Waseem A. Siddiqui, Renu Tripathi, Shunqing Liang   +4 more
wiley   +1 more source

Assessment of the molecular marker of Plasmodium falciparum chloroquine resistance (Pfcrt) in Senegal after several years of chloroquine withdrawal. [PDF]

, 2012
As a result of widespread antimalarial drug resistance, all African countries with endemic malaria have, in recent years, changed their malaria treatment policy.
Dieng, Yemou, Annie Abiola, Aminata Lo, Ndiaye, Daouda, Daouda Ndiaye, Yemou Dieng, Roger Tine, Faye, Babacar, Babacar Faye, Ndiaye, Magatte, Jean Louis Ndiaye, Lo, Aminata, Hallett, Rachel, Ndiaye, Jean Louis, Gaye, Oumar, Magatte Ndiaye, Rachel Hallett, Oumar Gaye, Michael Alifrangis, Tine, Roger, Alifrangis, Michael, Abiola, Annie   +21 more
core   +1 more source

Defining the role of PfCRT in Plasmodium falciparum chloroquine resistance [PDF]

Molecular Microbiology, 2005
SummaryRecent studies have highlighted the importance of a parasite protein referred to as the chloroquine resistance transporter (PfCRT) in the molecular basis of Plasmodium falciparum resistance to the quinoline antimalarials. PfCRT, an integral membrane protein with 10 predicted transmembrane domains, is a member of the drug/metabolite transporter ...
Bray, Patrick G., Martin, Rowena E., Tilley, Leann., Ward, Stephen A., Kirk, Kiaran., Fidock, David A.   +5 more
openaire   +2 more sources

Status of the Multidrug Resistance‐1 Gene of Plasmodium falciparum in Four Malaria Epidemiological Strata, Two Decades after the Abolition of Chloroquine as First‐Line Treatment for Uncomplicated Malaria in Cameroon

Journal of Tropical Medicine, Volume 2023, Issue 1, 2023., 2023
Drug‐resistant malaria parasites pose a threat to global malaria control efforts, and it is important to know the extent of these drug‐resistant mutations in each region to determine appropriate control measures. Chloroquine (CQ) was widely used in Cameroon for decades, but its declining clinical efficacy due to resistance prompted health authorities ...
David Denis Sofeu-Feugaing, Fabrice Nkengeh Ajonglefac, Marcel Nyuylam Moyeh, Tobias Obejum Apinjoh, Marianne Elodie Essende, Gilchrist Destin Talla Kouam, Stephen Mbigha Ghogomu, Jianbing Mu   +7 more
wiley   +1 more source

Persistence of chloroquine-resistant haplotypes of Plasmodium falciparum in children with uncomplicated Malaria in Lagos, Nigeria, four years after change of chloroquine as first-line antimalarial medicine. [PDF]

, 2015
BACKGROUND: In Nigeria, despite the change in National malaria drug policy to artemisinin combination therapy (ACT) in 2005 due to widespread chloroquine resistance, chloroquine (CQ) is still widely used in the treatment of malaria because it is cheap ...
Sutherland, Colin J, Oladipo, Oladosu O, Wellington, Oyibo A   +2 more
core   +1 more source

Exploring a Tetrahydroquinoline Antimalarial Hit from the Medicines for Malaria Pathogen Box and Identification of its Mode of Resistance as PfeEF2

ChemMedChem, Volume 17, Issue 22, November 18, 2022., 2022
Toolkit expansion: We report an exploration of the antimalarial compound MMV692140. The mode of resistance was identified as PfeEF2. The structural motif was explored in a chemistry program, resulting in the identification of MMV1919557, an analog with significantly improved antimalarial potency.
Benoît Laleu, Kelly Rubiano, Tomas Yeo, Irene Hallyburton, Mark Anderson, Benigno Crespo‐Fernandez, Francisco‐Javier Gamo, Yevgeniya Antonova‐Koch, Pamela Orjuela‐Sanchez, Sergio Wittlin, Gouranga P. Jana, Bikash C. Maity, Elodie Chenu, James Duffy, Peter Sjö, David Waterson, Elizabeth Winzeler, Eric Guantai, David A. Fidock, Thomas G. Hansson   +19 more
wiley   +1 more source

Polymorphisms in Plasmodium falciparum chloroquine resistance transporter and multidrug resistance 1 genes: parasite risk factors that affect treatment outcomes for P. falciparum malaria after artemether-lumefantrine and artesunate-amodiaquine. [PDF]

, 2014
Adequate clinical and parasitologic cure by artemisinin combination therapies relies on the artemisinin component and the partner drug. Polymorphisms in the Plasmodium falciparum chloroquine resistance transporter (pfcrt) and P.
Kamugisha, Erasmus, Piola, Patrice, Faucher, Jean-François, El-Sayed, Badria, Houzé, Sandrine, Somé, A Fabrice, Sutherland, Colin, Checchi, Francesco, Plowe, Christopher, V, Sutherland, Colin J, Otienoburu, Sabina Dahlström, Berens-Riha, Nicole, Grivoyannis, Anastasia, Davis, Timothy ME, Björkman, Anders, Asaq Molecular Marker Study Group, Rosenthal, Philip, Eyase, Frederick, Malmberg, Maja, Kariuki, Simon, Mårtensson, Andreas,, Hamour, Sally, Ogutu, Bernhards, Davis, Timothy, Wong, Rina, Sibley, Carol Hopkins, Gadalla, Nahla B, Ngasala, Billy, Ménard, Didier, Oguike, Mary, Venkatesan, Meera, Arze, Cesar, Djimdé, Abdoulaye A, Baliraine, Frederick N, Fröberg, Gabrielle, Ursing, Johan, LeBras, Jacques, Desai, Meghna, Mårtensson, Andreas, Ouédraogo, Jean-Bosco, El-Sayed, Badria B, Mwai, Leah, Thwing, Julie, Kironde, Fred, Djimde, Abdoulaye, Price, Ric, Dorsey, Grant, Johnson, Jacob, Guérin, Philippe, Somé, A. Fabrice, Oguike, Alexis Nzila Mary, LeBras, Poul-Erik Kofoed Jacques, Moriera, Clarissa, Kiechel, Jean-René, Kofoed, Poul-Erik, Dahal, Prabin, Nsanzabana, Christian, Nzila, Alexis, Wong, Rina PM, Rosenthal, Philip J, Ademowo, George, Falade, Catherine, Nsobya, Samuel L, Schramm, Birgit, Zongo, Issaka, Gadalla, Nahla, Wong, Rina P M, Plowe, Christopher V, Eshetu, Teferi, Davis, Timothy M E, Dhorda, Meghna Desai Mehul, Plowe, Christopher,, Rombo, Lars,, Dhorda, Mehul, Stepniewska, Kasia, Adam, Ishag, Price, Ric N, Borrmann, Steffen, Nosten, Francois, Rombo, Lars, Baliraine, Frederick, Zeynudin, Ahmed, Nsobya, Samuel   +82 more
core   +1 more source

In vitro selection of Plasmodium falciparum Pfcrt and Pfmdr1 variants by artemisinin [PDF]

Malaria Journal, 2016
Anti-malarial drugs are the major focus in the prevention and treatment of malaria. Artemisinin-based combination therapy (ACT) is the WHO recommended first-line treatment for Plasmodium falciparum malaria across the endemic world. Also ACT is increasingly relied upon in treating Plasmodium vivax malaria where chloroquine is failing.
Njokah, Muturi J., Kang’ethe, Joseph N., Kinyua, Johnson, Kariuki, Daniel, Kimani, Francis T.   +4 more
openaire   +2 more sources

Evidence for the early emergence of piperaquine-resistant Plasmodium falciparum malaria and modeling strategies to mitigate resistance.

PLoS Pathogens, 2022
Multidrug-resistant Plasmodium falciparum parasites have emerged in Cambodia and neighboring countries in Southeast Asia, compromising the efficacy of first-line antimalarial combinations.
Jennifer L Small-Saunders, Laura M Hagenah, Kathryn J Wicht, Satish K Dhingra, Ioanna Deni, Jonathan Kim, Jeremie Vendome, Eva Gil-Iturbe, Paul D Roepe, Monica Mehta, Filippo Mancia, Matthias Quick, Margaret J Eppstein, David A Fidock   +13 more
doaj   +1 more source