Results 31 to 40 of about 4,262 (206)
PfCRT-Mediated Drug Transport in Malarial Parasites [PDF]
Biochemistry, 2010 A wide range of drug transport studies using intact infected red blood cells, isolated malarial parasites, heterologous expression systems, and purified protein, combined with elegant genetic experiments, have suggested that chloroquine transport by the Plasmodium falciparum chloroquine resistance transporter (PfCRT) is a key aspect of the molecular ...
openaire +2 more sources
Invasion of Africa by a single pfcrt allele of South East Asian type [PDF]
Malaria Journal, 2006 Because of its dramatic public health impact, Plasmodium falciparum resistance to chloroquine (CQ) has been documented early on. Chloroquine-resistance (CQR) emerged in the late 1950's independently in South East Asia and South America and progressively spread over all malaria areas.
Ariey, Frédéric +12 more
openaire +7 more sources
The Pan African Medical Journal, 2015 We investigated the evolution of Pfcrt K76T mutation five years after the withdrawal of chloroquine in Burkina Faso. A total of 675 clinical isolates collected from October 2010 to September 2012 were successfully genotyped.
Paul Sondo +10 more
doaj +1 more source
Persistence of chloroquine-resistant haplotypes of Plasmodium falciparum in children with uncomplicated Malaria in Lagos, Nigeria, four years after change of chloroquine as first-line antimalarial medicine. [PDF]
, 2015 BACKGROUND: In Nigeria, despite the change in National malaria drug policy to artemisinin combination therapy (ACT) in 2005 due to widespread chloroquine resistance, chloroquine (CQ) is still widely used in the treatment of malaria because it is cheap ...
Sutherland, Colin J +2 more
core +1 more source
Amino acid mutations in the PfCRT isoforms included for study.
, 2022 PfCRT, Plasmodium falciparum chloroquine resistance transporter. (PDF)
Ben Corry (135521) +3 more
core +1 more source
Large-scale survey for novel genotypes of
Malaria Journal, 2012 Background In Plasmodium falciparum, resistance to chloroquine (CQ) is conferred by a K to T mutation at amino acid position 76 (K76T) in the P. falciparum CQ transporter (PfCRT).
Takahashi Nobuyuki +14 more
doaj +1 more source
The natural function of the malaria parasite’s chloroquine resistance transporter
Nature Communications, 2020 Plasmodium falciparum chloroquine resistance transporter (PfCRT) mediates multidrug resistance, but its natural function remains unclear. Here, Shafik et al.
Sarah H. Shafik +9 more
doaj +1 more source
Localization of PfCRT variants on the oocyte plasma membrane.
, 2023 Immunofluorescence images of fixed PfCRT -expressing oocytes and water-injected control oocytes. First panel from the left, fluorescence image of PfCRT using a specific guinea pig antiserum primary antibody (α-PfCRT) and the Alexa Fluor 633 anti-guinea ...
Fiona Berger (16053112) +5 more
core +1 more source
PfCRT and PfMDR1 modulate interactions of artemisinin derivatives and ion channel blockers [PDF]
Scientific Reports, 2016 AbstractTreatment of the symptomatic asexual stage of Plasmodium falciparum relies almost exclusively on artemisinin (ART) combination therapies (ACTs) in endemic regions. ACTs combine ART or its derivative with a long-acting partner drug to maximize efficacy during the typical three-day regimen.
Richard T. Eastman +4 more
openaire +2 more sources
Malaria Journal, 2012 Background Malaria is still a public health problem in Malaysia with chloroquine (CQ) being the first-line drug in the treatment policy of uncomplicated malaria.
Atroosh Wahib M +3 more
doaj +1 more source