Results 11 to 20 of about 4,673 (237)
Identification of a mutant PfCRT-mediated chloroquine tolerance phenotype in Plasmodium falciparum. [PDF]
PLoS Pathogens, 2010 Mutant forms of the Plasmodium falciparum transporter PfCRT constitute the key determinant of parasite resistance to chloroquine (CQ), the former first-line antimalarial, and are ubiquitous to infections that fail CQ treatment.
Stephanie G Valderramos +6 more
doaj +6 more sources
Pfcrt haplotypes and the evolutionary history of chloroquine-resistant Plasmodium falciparum [PDF]
Memorias do Instituto Oswaldo Cruz, 2012 Mutations in the Pfcrt gene that change the resulting amino acids and form different haplotypes are common and correlate with the prevalence of chloroquine resistant (CQR) field isolates of the malaria parasite, Plasmodium falciparum.
Gauri Awasthi +2 more
doaj +5 more sources
A comparative analysis reveals electrogenic properties of PfCRT and pendrin. [PDF]
J Biol ChemIon translocation is an essential process in all living cells. Most traditional approaches studying ion-translocating systems have employed cellular systems replete with native proteins that potentially interfere with the functional assessment of the protein of interest.
Gil-Iturbe E, Quick M.
europepmc +4 more sources
PfCRT and its role in antimalarial drug resistance [PDF]
Trends in Parasitology, 2016 Plasmodium falciparum resistance to chloroquine, the former gold standard antimalarial drug, is mediated primarily by mutant forms of the chloroquine resistance transporter (PfCRT).
Clain, Jerome +3 more
core +4 more sources
Glutathione transport: a new role for PfCRT in chloroquine resistance [PDF]
Antioxidants & Redox Signaling, 2013 Aims: Chloroquine (CQ) kills Plasmodium falciparum by binding heme, preventing its detoxification to hemozoin in the digestive vacuole (DV) of the parasite. CQ resistance (CQR) is associated with mutations in the DV membrane protein P.
Murray, James A.H. +14 more
core +5 more sources
Pfcrt mutant haplotypes may not correspond with chloroquine resistance
Journal of Infection in Developing Countries, 2014 Introduction: Chloroquine resistance in Plasmodium falciparum is associated with mutations in pfcrt and pfmdr1 genes. The frequency distribution of pfcrt K76T and pfmdr1 N86Y mutations and their association with chloroquine susceptibility was studied in ...
Diganta Goswami +6 more
doaj +4 more sources
Biochemistry, 2023 Using a recently elucidated atomic-resolution cryogenic electron microscopy (cryo-EM) structure for the Plasmodium falciparum chloroquine resistance transporter (PfCRT) protein 7G8 isoform as template [Kim, J.; Nature 2019, 576, 315−320], we use Monte ...
Andreas V. Willems +5 more
core +4 more sources
Pfcrt Gene in Plasmodium falciparum Field Isolates from Muzaffargarh, Pakistan [PDF]
Journal of Arthropod-Borne Diseases, 2015 Background: The aim of the study was to identify the prevalence of different species of Plasmodium and haplotypes of pfcrt in Plasmodium falciparum from the selected area.
Sumrin Sahar +4 more
doaj +3 more sources
Dissecting the molecular basis of PfCRT-mediated antimalarial drug resistance [PDF]
, 2016 The protozoan parasite Plasmodium falciparum is responsible for the deadliest form of malaria, which causes 584,000 fatalities annually and whose complications include coma, anemia, respiratory distress, and renal failure.
Gabryszewski, Stanislaw J.
core +3 more sources
Identification of PfCRT interacting proteins
, 2014 The lethal form of human malaria is caused by the most prominent human protozoan parasite, Plasmodium falciparum, responsible for an estimated ~1 million deaths annually. Malaria treatment and, prevention heavily rely on antimalarial drugs. The synthetic
Baakdah, Fadi
core +2 more sources