Pfcrt haplotypes and the evolutionary history of chloroquine-resistant Plasmodium falciparum [PDF]
Memorias do Instituto Oswaldo Cruz, 2012 Mutations in the Pfcrt gene that change the resulting amino acids and form different haplotypes are common and correlate with the prevalence of chloroquine resistant (CQR) field isolates of the malaria parasite, Plasmodium falciparum.
Gauri Awasthi +2 more
doaj +5 more sources
PfCRT and its role in antimalarial drug resistance [PDF]
Trends in Parasitology, 2016 Plasmodium falciparum resistance to chloroquine, the former gold standard antimalarial drug, is mediated primarily by mutant forms of the chloroquine resistance transporter (PfCRT).
Clain, Jerome +3 more
core +4 more sources
Glutathione transport: a new role for PfCRT in chloroquine resistance [PDF]
Antioxidants & Redox Signaling, 2013 Aims: Chloroquine (CQ) kills Plasmodium falciparum by binding heme, preventing its detoxification to hemozoin in the digestive vacuole (DV) of the parasite. CQ resistance (CQR) is associated with mutations in the DV membrane protein P.
Murray, James A.H. +14 more
core +5 more sources
Functional characterization of the Plasmodium falciparum chloroquine-resistance transporter (PfCRT) in transformed Dictyostelium discoideum vesicles. [PDF]
PLoS ONE, 2012 Chloroquine (CQ)-resistant Plasmodium falciparum malaria has been a global health catastrophe, yet much about the CQ resistance (CQR) mechanism remains unclear.
Janni Papakrivos +2 more
doaj +2 more sources
Pfcrt mutant haplotypes may not correspond with chloroquine resistance
Journal of Infection in Developing Countries, 2014 Introduction: Chloroquine resistance in Plasmodium falciparum is associated with mutations in pfcrt and pfmdr1 genes. The frequency distribution of pfcrt K76T and pfmdr1 N86Y mutations and their association with chloroquine susceptibility was studied in ...
Diganta Goswami +6 more
doaj +4 more sources
Dissecting the molecular basis of PfCRT-mediated antimalarial drug resistance [PDF]
, 2016 The protozoan parasite Plasmodium falciparum is responsible for the deadliest form of malaria, which causes 584,000 fatalities annually and whose complications include coma, anemia, respiratory distress, and renal failure.
Gabryszewski, Stanislaw J.
core +3 more sources
Identification of PfCRT interacting proteins
, 2014 The lethal form of human malaria is caused by the most prominent human protozoan parasite, Plasmodium falciparum, responsible for an estimated ~1 million deaths annually. Malaria treatment and, prevention heavily rely on antimalarial drugs. The synthetic
Baakdah, Fadi
core +2 more sources
Pfcrt Gene in Plasmodium falciparum Field Isolates from Muzaffargarh, Pakistan
Journal of Arthropod-Borne Diseases, 2015 Background: The aim of the study was to identify the prevalence of different species of Plasmodium and haplotypes of pfcrt in Plasmodium falciparum from the selected area.
Sumrin Sahar +4 more
doaj +2 more sources
Polymorphisms in Plasmodium falciparum chloroquine resistance transporter and multidrug resistance 1 genes: parasite risk factors that affect treatment outcomes for P. falciparum malaria after artemether-lumefantrine and artesunate-amodiaquine. [PDF]
, 2014 Adequate clinical and parasitologic cure by artemisinin combination therapies relies on the artemisinin component and the partner drug. Polymorphisms in the Plasmodium falciparum chloroquine resistance transporter (pfcrt) and P.
Kamugisha, Erasmus +82 more
core +2 more sources
Effects of Drug Resistance on the Global Spread of Malaria: A Systematic Literature Review. [PDF]
Health Sci RepABSTRACT Background and Aims Malaria remains a major health crisis in tropical regions, with Sub‐Saharan Africa bearing the heaviest burden. While insecticide‐treated nets and artemisinin‐based combination therapies (ACTs) have reduced cases, emerging parasite resistance to artemisinin threatens these gains. This review synthesizes evidence on how drug
Woime AW.
europepmc +2 more sources