The Molecular Basis of the Action of Chloroquine in Porphyria Cutanea Tarda
, 1973 Perry L. Scholnick +2 more
openalex +1 more source
Decreased sensitivity of artesunate and chloroquine of Plasmodium falciparum infecting hemoglobin H and/or hemoglobin constant spring erythrocytes. [PDF]
, 1989 Yongyuth Yuthavong +3 more
openalex +1 more source
The Alzheimer's Disease Gene SORL1 Regulates Lysosome Function in Human Microglia
Glia, Volume 73, Issue 7, Page 1329-1348, July 2025.Main Points The AD gene SORL1 is important for maintaining lysosomal homeostasis in microglia. SORL1 KO hiPSC‐derived microglia show mis‐trafficking of lysosomal enzymes, impaired lysosomal degradation and exocytosis, and changes in neuroimmune responses.
Swati Mishra +6 more
wiley +1 more source
Chloroquine inhibits lysosomal enzyme pinocytosis and enhances lysosomal enzyme secretion by impairing receptor recycling. [PDF]
, 1980 Alfonso González‐Noriega +3 more
openalex +1 more source
Glutamine Metabolism: Molecular Regulation, Biological Functions, and Diseases
MedComm, Volume 6, Issue 7, July 2025.Tumor cells adapt to nutrient‐poor environments by altering metabolism to acquire essential nutrients. They convert glutamine into glutamate and α‐ketoglutarate, supporting mTOR activation and sugar biosynthesis. Disruption of mTORC1 signaling is linked to disease, while glutamine and leucine activation promotes cell growth and inhibits autophagy ...
Mudasir A. Kumar +10 more
wiley +1 more source
<i>Diospyros lotus</i> leaf extract and its main component, myricitrin, inhibit both histamine‑dependent and histamine‑independent itching. [PDF]
Exp Ther MedShin JY, Kim BM, Jang SI.
europepmc +1 more source
Identification of the acidic compartment of Plasmodium falciparum-infected human erythrocytes as the target of the antimalarial drug chloroquine. [PDF]
, 1984 Avner Yayon +2 more
openalex +1 more source
A dose‐ranging study of the pharmacokinetics of hydroxy‐chloroquine following intravenous administration to healthy volunteers. [PDF]
, 1988 S. E. Tett +3 more
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G protein‐coupled receptor‐mediated autophagy in health and disease
British Journal of Pharmacology, Volume 182, Issue 14, Page 3151-3162, July 2025.G protein‐coupled receptors (GPCRs) constitute the largest and most diverse superfamily of mammalian transmembrane proteins. These receptors are involved in a wide range of physiological functions and are targets for more than a third of available drugs in the market. Autophagy is a cellular process involved in degrading damaged proteins and organelles
Devrim Öz‐Arslan +2 more
wiley +1 more source
Redistribution of mannose-6-phosphate receptors induced by tunicamycin and chloroquine. [PDF]
, 1984 Wendy J. Brown +2 more
openalex +1 more source