Results 211 to 220 of about 125,568 (336)

Plasmodium falciparum gametogenesis essential protein 1 (GEP1) is a transmission‐blocking target

FEBS Letters, Volume 600, Issue 2, Page 239-250, January 2026.
This study shows Plasmodium falciparum GEP1 is vital for activating sexual stages of malarial parasites even independently of a mosquito factor. Knockout parasites completely fail gamete formation even when a phosphodiesterase inhibitor is added. Two single‐nucleotide polymorphisms (V241L and S263P) are found in 12%–20% of field samples.
Frederik Huppertz, Milagros Siebeck Caturelli, Lina S. Lehmann, Florian Kurth, Alexander G. Maier, Kai Matuschewski   +5 more
wiley   +1 more source

Reassessing the Conduct of Patch Clamp Cardiac Ion Channel Assays to Improve Nonclinical Data Translation to Clinical ECG Changes and Proarrythmia Risk. [PDF]

Clin Transl Sci
Alvarez Baron C, Zhao J, Guo D, Mistry S, De Palma R, Ismaiel OA, Wu WW.   +6 more
europepmc   +1 more source

Co-delivery of Gefitinib and chloroquine by chitosan nanoparticles for overcoming the drug acquired resistance

, 2016
Liang Zhao, Guang Yang, Yijie Shi, Chang Su, Jin Woo Chang   +4 more
openalex   +2 more sources

Targeting EZH2 reverses thyroid cell dedifferentiation and enhances iodide uptake in anaplastic thyroid cancer

FEBS Letters, Volume 600, Issue 2, Page 215-225, January 2026.
Anaplastic thyroid cancer (ATC) lacks iodide uptake ability due to MAPK activation increasing the expression of the histone methyltransferase EZH2, which represses thyroid differentiation genes (TDGs) such as the sodium iodide symporter (NIS). Dual inhibition of MAPK (U0126) and EZH2 (EPZ6438/Tazemetostat) reverses this mechanism, thus restoring TDG ...
Diego Claro de Mello, Marcella Maringolo Cristovão, Guilherme Henrique, Vinicius Gonçalves Rodrigues, Caroline Serrano‐Nascimento, Edna Teruko Kimura, Cesar Seigi Fuziwara   +6 more
wiley   +1 more source

Management of malaria in newborns: a systematic review. [PDF]

BMC Infect Dis
Sultanli A, Beck JS, Kremp M, Sondermann H, Bonitz M, Honkpehedji YJ, Remppis J, Adegnika AA, Esen M, Bélard S.   +9 more
europepmc   +1 more source

CHLOROQUINE-RESISTANT FALCIPARUM MALARIA INFECTED IN WEST IRIAN AND EAST KALIMANTAN

, 1974
I Ebisawa, T Fukuyama, G. Mitsui
openalex   +2 more sources

Aplasia and leukaemia following chloroquine therapy [PDF]

, 1978
N Nagaratnam, A.D. Chetiyawardana, S. Rajiyah   +2 more
openalex   +1 more source

Differentiation Treatment Applied to Lung Cancer Model Reduces Pathogenic Traits in Vitro

Advanced Biology, Volume 10, Issue 1, January 2026.
Non‐small cell lung cancer cells (A549) treated with a differentiation medium showed strong reduction in proliferation, migration, clonogenicity, spheroid formation and stemness markers, with enhanced adhesion properties and alveolar features, all pointing to a notably less aggressive phenotype in support of differentiation therapy as a promising ...
Alice Grossi, Paola Fulghieri, Abdurakhmon Aduvaliev, Karen Soffiantini, Irene Oldrati, Margherita Cavallo, Marco Biggiogera, Giorgia Pellavio, Umberto Laforenza, Monica Savio, Virginie Sottile   +10 more
wiley   +1 more source

Novel heterospirocyclic antimalarials with activity against artemisinin- and multidrug-resistant P. falciparum malaria. [PDF]

Int J Parasitol Drugs Drug Resist
Theodoridis L, Giannangelo C, El-Saafin F, Prabhath MR, Macraild CA, Sharma P, Merino D, Creek DJ, Carvalho TG.   +8 more
europepmc   +1 more source

The effect of sulfamonomethoxine on both chloroquine sensitive and resistant Plasmodium falciparum and Plasmodium vivax infections.

, 1972
O. L. Ramos, B. D. Cabrera
openalex   +1 more source