Results 211 to 220 of about 93,237 (289)

Ein neuer Malariawirkstoff hemmt die Proteinsynthese von Plasmodium falciparum

Angewandte Chemie, Volume 137, Issue 49, December 1, 2025.
Die Verbindung 31 stellt einen vielversprechenden Ansatz für die Entwicklung eines Malariawirkstoffs mit einem starken Wirkungsprofil dar (PfNF54 IC50 ± s.d. = 3,9 ± 0,4 nM). Sie hat einen neuartigen Wirkmechanismus, indem sie an zytosolische Ribosomen‐Untereinheiten bindet und dadurch die Proteinsynthese im Parasiten hemmt.
Patricia Bravo, Eleonora Diamanti, Mostafa M. Hamed, Lorenzo Bizzarri, Natalie Wiedemar, Armin Passecker, Nicolas M. B. Brancucci, Anna Albisetti, Christin Gumpp, Boris Illarionov, Markus Fischer, Matthias Witschel, Tobias Schehl, Hannes Hahne, Pascal Mäser, Matthias Rottmann, Anna K. H. Hirsch   +16 more
wiley   +1 more source

Translation of a Human-Based Malaria-on-a-Chip Phenotypic Disease Model for In Vivo Applications. [PDF]

Adv Sci (Weinh)
Rupar MJ, Hanson HM, Botlick BL, Sriram N, Rogers S, Zuniga J, Liu Z, Trimmer SJ, Ciurca JM, Long CJ, McAleer CW, Schmidt S, Favuzza P, Lowe P, Gobeau N, Hickman JJ.   +15 more
europepmc   +1 more source

A Novel Antimalarial Agent that Inhibits Protein Synthesis in Plasmodium falciparum

Angewandte Chemie International Edition, Volume 64, Issue 49, December 1, 2025.
Compound 31 represents a promising avenue for the development as an antimalarial agent with a potent activity profile (PfNF54 IC50 ± s.d. = 3.9 ± 0.4 nM). It has a novel mode of action by binding to cytosolic ribosomal subunits, thereby inhibiting protein synthesis in the parasite.
Patricia Bravo, Eleonora Diamanti, Mostafa M. Hamed, Lorenzo Bizzarri, Natalie Wiedemar, Armin Passecker, Nicolas M. B. Brancucci, Anna Albisetti, Christin Gumpp, Boris Illarionov, Markus Fischer, Matthias Witschel, Tobias Schehl, Hannes Hahne, Pascal Mäser, Matthias Rottmann, Anna K. H. Hirsch   +16 more
wiley   +1 more source

Identification of VGLUT3-expressing LTMRs-recruited spinal circuits for itch inhibition. [PDF]

Mol Brain
Su X, Wang L, Liu X, Zhang Y.
europepmc   +1 more source

A scoping review of disease‐modifying antirheumatic drug nonadherence in rheumatoid arthritis: Measurement, prevalence and implications for clinical practice

British Journal of Clinical Pharmacology, Volume 91, Issue 12, Page 3330-3340, December 2025.
Aims Adherence to disease‐modifying antirheumatic drugs (DMARDs) has been associated with improved treatment outcomes, but how adherence is reported ranges between studies. We therefore aimed to determine how nonadherence to DMARDs used to treat rheumatoid arthritis (RA) has been measured and to report the nonadherence rate with each measure identified.
Lauren Fraser, Nagham Ailabouni, Lisa Kalisch Ellett, Jiun Ming Tan, Anthea Freeman, Susanna M. Proudman, Emily Reeve, Michael D. Wiese   +7 more
wiley   +1 more source

Comparative effects of antimalarial drugs on oxidative phosphorylation, mitochondrial dynamics and mitophagy in <i>Plasmodium berghei</i>-infected mice. [PDF]

Toxicol Rep
Olanlokun JO, Yahaya OO, Babarinde CO, Oloke OM, Steenkamp P, Prinsloo G.   +5 more
europepmc   +1 more source

Vitamin D‐Mediated Hypercalcemia in a Dog With Putative Cutaneous Pythiosis

Clinical Case Reports, Volume 13, Issue 12, December 2025.
ABSTRACT A 12‐month‐old dog was diagnosed with cutaneous pythiosis after presenting with a nonhealing metatarsal wound, an inguinal mass, and regional lymphadenopathy. Both cytology of the abnormal lymph nodes and histopathology of the inguinal mass showed granulomatous inflammation. ELISA serology was positive for Pythium insidiosum. The dog developed
Jennifer Brodkin, Steven W. Frederick, Markus Rick, Peter S. Chapman   +3 more
wiley   +1 more source

Activating PIK3CA mutation promotes overgrowth of adipose tissue via inhibiting lipophagy in macrodactyly. [PDF]

Cell Death Dis
Yin Y, Zhang X, Lin S, Wang Z, Tian B, Dai X, Yu A, Li H, Mao H, Wang B.   +9 more
europepmc   +1 more source

Plasmodium falciparum isolates: ex vivo drug response. [PDF]

J Antimicrob Chemother
Adika E, Saiid S, Amoako EK, Sakyi ME, Osumanu A, Morang'a C, Dosoo D, Chirawurah JD, Awandare GA, Amambua-Ngwa A, Aniweh Y, Amenga-Etego LN.   +11 more
europepmc   +1 more source

Metabolic enzyme PFKFB3 mediates matrix stiffness‐potentiated tumour growth and radiotherapeutic resistance in HCC

Clinical and Translational Medicine, Volume 15, Issue 12, December 2025.
This study proposes a stiffness‐triggered pathway that co‐opts PFKFB3 expression and localization to fuel HCC growth and compromise radiotherapy efficacy. Specifically, matrix stiffness suppresses PFKFB3 ubiquitination by downregulating E3 ubiquitin ligase NEDD4 expression, and then enhances the stablity of PFKFB3 protein to increase glycolysis ...
Mimi Wang, Jiajun Li, Jiali Qian, Xi Zhang, Miao Li, Yingying Zhao, Zhiming Wang, Kun Guo, Dongmei Gao, Yan Zhao, Rongxin Chen, Zhenggang Ren, Taiwei Sun, Fan Wang, Jiefeng Cui   +14 more
wiley   +1 more source