Results 191 to 200 of about 108,092 (308)

Indole-based hybrids target both asexual parasites and gametocytes of <i>Plasmodium falciparum</i> and synergize with lumefantrine. [PDF]

Antimicrob Agents Chemother
Mohanty A, Nakabashi M, Dias BKM, Maiolini P, Delgado JAC, Quaglio KdS, Paixão MW, Garcia CRS.   +7 more
europepmc   +1 more source

Evaluation of Antiplasmodial Activity of Quinoline Derivatives Incorporating Arylnitro and Aminochalcone Moieties. [PDF]

Pharmaceuticals (Basel)
Ariefta NR, Beteck RM, Legoabe LJ, Nishikawa Y.   +3 more
europepmc   +1 more source

RNF13 regulates the endolysosomal pathway through interaction with the small GTPase Arl8B

The FEBS Journal, EarlyView.
The E3 ubiquitin ligase RNF13 functions as a regulatory scaffold, organizing Arl8B‐dependent complexes and tuning downstream signaling that controls endolysosomal organization and trafficking. In this model, wild‐type RNF13 associates with Arl8B on endolysosomes, whereas Arl8B (E22D/F55A) or RNF13 (L244A) variants weaken complex assembly, potentially ...
Audrey M. Sénécal, Valérie C. Cabana, Antoine Y. Bouchard, Laurent Cappadocia, Marc P. Lussier   +4 more
wiley   +1 more source

Antiplasmodial Compounds from <i>Eurycoma harmandiana</i> Pierre and <i>Eurycoma longifolia</i> Jack Against Drug-Resistant <i>Plasmodium falciparum</i>: An Integrated In Vitro and In Silico Study. [PDF]

Int J Mol Sci
Konyanee A, Wahab HA, Kamarulzaman EE, Suhaimi AMM, Ismail AG, Chaniad P, Plirat W, Phuwajaroanpong A, Juengwatanatrakul T, Kanchanapoom T, Yusakul G, Punsawad C.   +11 more
europepmc   +1 more source

A live‐cell autophagy reporter reveals reversible vacuolation in naked mole‐rat skin fibroblasts under lysosomal stress

The FEBS Journal, EarlyView.
A tandem fluorescent mCherry–EGFP–LC3 reporter enables live‐cell visualisation of autophagy–lysosome dynamics in naked mole‐rat skin fibroblasts. Chloroquine‐induced lysosomal stress promotes accumulation of neutral LC3‐positive compartments and triggers pronounced LC3‐associated vacuolation.
Fangze Tong, Mateo P. Hoare, Laura J. Grundy, Filomena Gallo, Karin H. Müller, Ewan St. John Smith, Janet R. Kumita   +6 more
wiley   +1 more source

Preclinical and Clinical Evidence on Chloroquine or Hydroxychloroquine in Covid-19. [PDF]

Clin Transl Sci
Pasquier D.
europepmc   +1 more source

Placental malperfusion and angiogenesis‐related proteins are associated with small‐for‐gestational‐age in systemic lupus erythematosus

Journal of Internal Medicine, EarlyView.
Abstract Background Although systemic lupus erythematosus (SLE) pregnancy frequently results in small for gestational age (SGA) infants, the understanding of underlying mechanisms is limited. We aimed to identify specific histological patterns of placental injury in SGA in SLE and to explore whether an altered balance of angiogenesis‐related proteins ...
Marit Stockfelt, Henri Puttonen, Ing‐Marie Fyhr, Agnes Torell, Kerstin Andersson, Iva Gunnarsson, Elisabet Svenungsson, Agneta Zickert, Maria Majczuk Sennström, Estelle Trysberg, Anders A. Bengtsson, Andreas Jönsen, Helena Strevens, Christopher Sjöwall, Muna Saleh, Sofia Pihl, Dag Leonard, Lars Rönnblom, Tansim Akhter, Bo Jacobsson, Anna‐Carin Lundell, Anna Rudin   +21 more
wiley   +1 more source

Development and evaluation of glycine conjugated polypropyleneimine dendrimers for targeted chloroquine delivery. [PDF]

Discov Nano
Saraogi GK, Parashar AK, Yasin HKA, Ahirwar J, Kumari M.   +4 more
europepmc   +1 more source

Porphyromonas gingivalis GroEL accelerates abdominal aortic aneurysm formation by matrix metalloproteinase‐2 SUMOylation in vascular smooth muscle cells: A novel finding for the activation of MMP‐2

Molecular Oral Microbiology, EarlyView.
Abstract Infection is a known cause of abdominal aortic aneurysm (AAA), and matrix metalloproteases‐2 (MMP‐2) secreted by vascular smooth muscle cells (SMCs) plays a key role in the structural disruption of the middle layer of the arteries during AAA progression.
Yi‐Wen Lin, Feng‐Yen Lin, Ze‐Hao Lai, Chien‐Sung Tsai, Yi‐Ting Tsai, Yen‐Sung Huang, Chen‐Wei Liu   +6 more
wiley   +1 more source

Sex- and <i>APOE</i>-specific transcriptomic drug repurposing identifies four candidate therapeutics for Alzheimer's disease. [PDF]

Alzheimers Dement (N Y)
Vitali F, Raikes AC, Merlini S, Shang Y, Torrandell-Haro G, Hernandez GD, Yin F.   +6 more
europepmc   +1 more source