Results 211 to 220 of about 108,092 (308)

S100A1 Promotes MDM2‐Mediated KLF15 Ubiquitination to Regulate ID1‐Driven Tubular Injury in Diabetic Kidney Disease

The FASEB Journal, Volume 40, Issue 18, 30 September 2026.
High glucose upregulates S100A1, enhancing MDM2–KLF15 interaction and K48‐linked ubiquitination of KLF15. Degradation of KLF15 relieves ID1 repression, promoting ID1 upregulation, inflammation, fibrosis, tubular injury, and DKD progression. ABSTRACT Diabetic kidney disease (DKD) is the leading cause of end‐stage renal disease globally.
Zhitao Zeng, Jiazhen Shang, Shouyu Chai, Xia Zhang, Xincong Lv, Xiaotian Han, Yifan Xu, Baoze Ma, Zhimei Lv, Rong Wang   +9 more
wiley   +1 more source

Design, Synthesis, and Evaluation of New 1,4-Naphthoquinone-1,2,3-triazoles as Antimalarial Agents. [PDF]

Chem Biodivers
Rezainia L, Sayahi MH, Vernousfaderani EK, Mirfazli SS, Morshedsolouk MH, Dastyafteh N, Nateghpour M, Farivar L, Saeedi M, Hanifian H, Mohebali M, Shafiee SM, Hassanpour G, Mahdavi M.   +13 more
europepmc   +1 more source

Unlocking the Potential of Organoaluminum Reagents for Versatile C─C Couplings Using YPhos‐Pd Catalysts

Advanced Synthesis &Catalysis, Volume 368, Issue 18, 19 September 2026.
A general C─C cross‐coupling method employing earth‐abundant organoaluminium nucleophiles is enabled by electronically highly donating and sterically demanding ylide‐substituted phosphine (YPhos) ligands under Pd catalysis. This protocol represents an organoaluminium cross‐coupling that operates with a single catalyst system across all carbon ...
Nicolas Kaiser, Julius Busse, Ben Wichmann, Viktoria H. Gessner   +3 more
wiley   +1 more source

Changes in molecular markers of Plasmodium falciparum drug resistance between 2017 and 2024 in Southern Benin. [PDF]

Int J Parasitol Drugs Drug Resist
Bohissou FET, Nahum D, Inoue J, Sondo P, Hounsou L, Sondjo G, Djègbè NDC, Woli R, Dossou S, Kpohonnou C, Tinto H, Held J.   +11 more
europepmc   +1 more source

Truncation of Samroiyotmycin: Tailored seco‐Acids as Novel Antimalaria Compounds

European Journal of Organic Chemistry, Volume 29, Issue 34, 11 September 2026.
Six truncated samroiyotmycin‐derived antimalarials were synthesized by replacing the tosyloxazole unit with electron‐deficient aryl groups. The most active seco‐acid with EWG = 2 × CF3 outperformed the natural product SamA. Its enhanced activity supports a donor–acceptor interaction involving the electron‐poor aryl unit, consistent with inhibition of ...
Anton Czuczkowski, Anja Schäfer, Juliana A. Hüther, Bianca Wank, Robert Toews, Fotios Fotakis, Andreas Köhn, Markus Rehm, Matthias Rottmann, Anna Zens, Sabine Laschat   +10 more
wiley   +1 more source

Lutein Attenuates Lipid Accumulation in Association with TFEB Nuclear Translocation and Autophagy-Lysosomal Responses in a Cellular Model of Hepatic Steatosis. [PDF]

Antioxidants (Basel)
Saud F, Cabrera D, Valladares C, De la Fuente López M, Maldonado-Agurto R, Irribarra-Tapia D, Balboa E.   +6 more
europepmc   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, Volume 16, Issue 9, Page 1786-1800, September 2026.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

Use of chloroquine, hydroxychloroquine or ivermectin for Covid-19 prevention in vulnerable Brazilian populations. [PDF]

Rev Saude Publica
Castanheira D, Torres TS, Aranha TR, Soares F, Dourado I, Veloso VG.   +5 more
europepmc   +1 more source

Impact of Selective Tyrosine Kinase 2 Inhibition With Zasocitinib (TAK‐279) on Molecular Pathways and Correlated Clinical Response in Patients With Active Psoriatic Arthritis

ACR Open Rheumatology, Volume 8, Issue 9, September 2026.
Objective This post hoc analysis evaluated the effect of zasocitinib, an investigational, oral, allosteric, highly selective, and potent tyrosine kinase 2 (TYK2) inhibitor in late‐stage clinical development, on TYK2 signaling response and disease‐related biomarkers and the association of these changes with clinical response in patients with active ...
Amit Choudhury, Jie Cheng, Jay Tang, Sachin Kumar, Banishree Saha, Vinayagam Arunachalam, Ting Hong, Ejim Mark, Håkan Wennbo, Iain B. McInnes   +9 more
wiley   +1 more source