Results 181 to 190 of about 85,533 (259)

Chloroquine Potentiates the Chemotherapeutic Effect of Carboplatin and ATR/Chk1 Inhibitors by Increasing the Replication Stress. [PDF]

Int J Mol Sci
Zamkova M, Persiyantseva N, Vikhrova S, Kazansky D.   +3 more
europepmc   +1 more source

Repurposed Medicines for Viruses With Epidemic or Pandemic Potential: A Horizon Scan

Pharmacology Research &Perspectives, Volume 14, Issue 3, June 2026.
ABSTRACT Viruses such as Ebola, Marburg, influenza, mpox, MERS‐CoV, SARS‐CoV, and SARS‐CoV‐2 may be considered pathogens of epidemic or pandemic concern. Developing novel antiviral medicines can be time‐consuming and resource intensive. Repurposing existing medicines with known or potential antiviral activity offers a faster, cost‐effective strategy to
Sola Akinbolade, Rhiannon Potter, Alex Inskip, Jane Nesworthy, Kirsti Brock, Gill Norman   +5 more
wiley   +1 more source

Synergistic inhibition of metastatic melanoma by carvacrol and chloroquine: an in vitro and in silico investigation of apoptosis and molecular targets. [PDF]

Med Oncol
Kłos P, Dabravolski S, Perużyńska M, Przekop A, Kostka P, Dziedziejko V, Droździk M, Chlubek D, Safranow K.   +8 more
europepmc   +1 more source

Senescent Myoblasts Exhibit ROS‐Dependent Akt‐mTORC1 Dysregulation and Are Susceptible to Reductive Stress‐Induced Cell Death

Aging Cell, Volume 25, Issue 6, June 2026.
Senescent myoblasts exhibit dysregulated Akt/mTORC1 signalling. Antioxidants can alleviate this dysregulation, as well as other downstream senescent phenotypes. Moreover, prolonged antioxidant treatment can selectively induce cell death in senescent myoblasts, suggesting that these cells are more susceptible to reductive stress.
Vladimir Belhac, Alex Dillingham, Emilia Coward, Bradley Teal, Mark C. Turner, Stephanie D. Gagnon, Jiani Qian, Harry Wilford, Ella Warren, Natalie Moger, Bernadette Carroll, Owen G. Davies, Hannah F. Dugdale, Neil R. W. Martin   +13 more
wiley   +1 more source

Predicted antiviral potential of phytochemicals prolific in Cleistanthus bracteosus Jabl. and essential oils of Artemisia scoparia and Thuja orientalis against Nipah virus and Human metapneumovirus: An AI-driven in-silico study. [PDF]

PLoS One
Dassanayake MK, Khoo TJ, Chong CH, Ansari MT, Di Martino P, Zanchi FB, Figiel A, Szumny A, Elfar OA, Wiart C, Symonds R.   +10 more
europepmc   +1 more source

Fenofibrate potentiates the therapeutic efficacy of EZH2 inhibitors on melanoma via TRIM21‐ and OTUD4‐mediated EZH2 ubiquitination

British Journal of Pharmacology, Volume 183, Issue 11, Page 2675-2694, June 2026.
Background and Purpose EZH2 (enhancer of zeste homologue 2) inhibitors are an emerging class of drugs that target epigenetic regulation. However, their efficacy in solid tumours has been limited, partly due to drug‐induced upregulation of fatty acid synthesis.
Rui Cheng, Yuanjun Tang, Xuedi Cao, Xiaotong Yu, Zhanya Huang, Yunyun Guo, Renjing Jin, Yan Wang, Yang Liu, Lixiang Xue, Yuqing Wang   +10 more
wiley   +1 more source

Effect of Stereochemistry on the Antiplasmodial Activity and Metabolomic Profile of Novel Tadalafil Analogues. [PDF]

ACS Med Chem Lett
Elhalawaty EA, Alseedy HA, Woodland JG, Wicht KJ, Swart T, Rangel GW, Hoppe HC, Chibale K, Llinás M, Abadi AH, Ahmed NS.   +10 more
europepmc   +1 more source

Antimalarial cabamiquine inhibits blood-stage of different field isolates of Plasmodium species. [PDF]

BMC Infect Dis
Dembele L, Aniweh Y, Soulama A, Sogore F, Diakité O, Diallo F, Dao F, Amenga-Etego LN, Demarta-Gatsi C, Spangenberg T, Djimde AA.   +10 more
europepmc   +1 more source

Antiplasmodial activity, phytochemical analysis and in silico study of the leaf extract of Chenopodium opulifolium Koch & Ziz used in Uganda. [PDF]

BMC Complement Med Ther
Saidi J, Namukobe J, Bunalema L, Chama MA, Dziwornu GA, Akala H, Amoah LE, Addotey JN.   +7 more
europepmc   +1 more source

Persistence of legacy antimalarial resistance markers in The Gambia from a malaria genomic surveillance study

Diop MF, Amambua-Ngwa BN, Demba MA, Bah M, Njie BK, Cham F, Mendy M, Bojang F, Ndiath MO, Correa A, Ünlü ES, Mains A, Mohammed NI, D’Alessandro U, Simpson VJ, Rajatileka S, Samateh W, Gibba B, Oriero EC, Amambua-Ngwa A.   +19 more
europepmc   +1 more source