Results 261 to 270 of about 178,293 (355)

Reimagining Social Value to Consider the Environment: How Should We Judge the Magnitude of Benefits in Health Research?

Bioethics, Volume 39, Issue 9, Page 821-833, November 2025.
ABSTRACT Growing recognition of intersections between our health and the environment, healthcare systems and the environment, and health research and the environment has led bioethics scholars to advocate that the field readopt a broader perspective that considers nature.
Bridget Pratt, Rieke van der Graaf
wiley   +1 more source

Identification of VGLUT3-expressing LTMRs-recruited spinal circuits for itch inhibition. [PDF]

Mol Brain
Su X, Wang L, Liu X, Zhang Y.
europepmc   +1 more source

Protein binding of chloroquine enantiomers and desethylchloroquine. [PDF]

, 1986
David Ofori‐Adjei, Örjan Ericsson, Björn Lindström, Folke Sjöqvist   +3 more
openalex   +1 more source

Structure‐based discovery of thiamine uptake inhibitors

British Journal of Pharmacology, Volume 182, Issue 22, Page 5611-5626, November 2025.
Background and Purpose Thiamine (vitamin B1) is an essential coenzyme and catalyses various reactions in central metabolic pathways. Since mammals have lost the ability to synthesise thiamine de novo, this micronutrient has to be imported via the high affinity solute carriers SLC19A2 and A3 across the plasma membrane.
Florian Gabriel, Björn Windshügel, Christian Löw   +2 more
wiley   +1 more source

Activating PIK3CA mutation promotes overgrowth of adipose tissue via inhibiting lipophagy in macrodactyly. [PDF]

Cell Death Dis
Yin Y, Zhang X, Lin S, Wang Z, Tian B, Dai X, Yu A, Li H, Mao H, Wang B.   +9 more
europepmc   +1 more source

CXCL1 Promotes Osteoblast Autophagy and Inhibits Ferroptosis Through the Activation of the TGF‐β/Smad Signalling Pathway

Journal of Cellular and Molecular Medicine, Volume 29, Issue 21, November 2025.
ABSTRACT Osteoblast dysfunction plays a central role in osteoporosis. CXC chemokine ligand 1 (CXCL1), a known inflammatory mediator, is increasingly recognised for its role in bone homeostasis. However, its influence on osteoblast survival mechanisms such as ferroptosis and autophagy remains unclear.
Zhiqiang Zhou, Yi Wang, Zhiqi Gao, Qiong Chen, Han Wu, Jiao Sun, Huilan Li, Dong Liu, Yixin Shen   +8 more
wiley   +1 more source

Antimalarial activity of root extract of Tephrosia villosa L. Pers. (Fabaceae) on Plasmodium berghei-infected mice. [PDF]

Sci Rep
Alemu MA, Moges TA, Ketsela Zeleke T, Abebe RB, Zewdu WS.   +4 more
europepmc   +1 more source

Protein binding of chloroquine in the presence of aspirin. [PDF]

, 1982
SA Adelusi, LA Salako
openalex   +1 more source

Nickel‐Catalyzed P‐Arylation of HP(= O)(R/OR)2 Nucleophiles with (Hetero)Aryl Chlorides Enabled by DalPhos Ligation

Chemistry – A European Journal, Volume 31, Issue 59, October 22, 2025.
The development of broadly useful C‐P cross‐couplings of (hetero)aryl chlorides and HP(O)(R/OR)2 nucleophiles by use of nickel/DalPhos‐based catalysts is described, along with findings from DFT studies that confirm the preference for C‐P bond formation in this system arising from three‐cantered reductive elimination through substrate PV pathways ...
Michael J. Cotnam, T. Kieran Redpath, Catherine E. Weetman, Patrick L. DeRoy, David J. Nelson, Mark Stradiotto   +5 more
wiley   +1 more source

Quinoline derivatives' biological interest for anti-malarial and anti-cancer activities: an overview. [PDF]

RSC Adv
Chavan ND, Sarveswari S, Vijayakumar V.
europepmc   +1 more source