Results 261 to 270 of about 125,568 (336)

Activity Profiling of Nitro‐Substituted Di(Hetero)Aryl 1,3,4‐ and 1,2,4‐Oxadiazoles: Antimicrobial, Cholinesterase Inhibition and Antioxidant Potential

Archiv der Pharmazie, Volume 359, Issue 1, January 2026.
Novel nitro‐substituted diaryl 1,3,4‐ and 1,2,4‐oxadiazoles were synthesised via molecular hybridisation of bioactive heterocycles. Selected derivatives exhibited potent antimicrobial activity, including against Mycobacterium tuberculosis and Staphylococcus aureus, and cholinesterase inhibitory activity, with promising selectivity.
Enikő Šikorová, Šárka Štěpánková, Eva Frýbová, Klára Konečná, Jana Korbielová, Markéta Švarcová, Ondřej Janďourek, Václav Pflégr, Szilvia Bősze, Martin Krátký   +9 more
wiley   +1 more source

Prevalence of Molecular Markers of Resistance to Antimalarial Drugs Three Years After Perennial Malaria Chemoprevention in Sierra Leone. [PDF]

Gates Open Res
Chen H, Owusu-Kyei K, Fombah AE, Williams J, García-Fernández C, Rovira-Vallbona E, Bofill A, Quintó L, Figueroa-Romero A, Mac-Abdul F, Samai M, Mayor A, Menéndez C.   +12 more
europepmc   +1 more source

When Autoimmunity Meets Malignancy: A Rare Case of Concomitant Systemic Lupus and Multiple Myeloma

Clinical Case Reports, Volume 14, Issue 1, January 2026.
ABSTRACT The association between systemic lupus erythematosus (SLE) and multiple myeloma (MM) is rare, with fewer than 20 cases reported in the literature, raising questions about the link between chronic immune dysregulation and oncogenesis. We report the case of a 43‐year‐old Malagasy woman in whom a monoclonal β2‐globulin spike, incidentally ...
Solohery Jean Noël Ratsimbazafy, Havantsoa Nomena Fandresena Andrianarisambatra, Rajo Païdia Radinasoa, Hitsy Andraina Razafindrazaka, Tahianasoa Randriamampianina, Rija Mikhaël Miandrisoa, Fidiarivony Ralison, Hanta Marie Danielle Vololontiana   +7 more
wiley   +1 more source

Characterizing the quick-killing mechanism of action of azithromycin analogs against malaria parasites. [PDF]

Antimicrob Agents Chemother
Mao EY, Nguyen W, Jana GP, Maity BC, Pazicky S, Giannangelo C, Reader J, Famodimu MT, Birkholtz L-M, Delves MJ, Creek DJ, Bozdech Z, Laleu B, Burrows JN, Sleebs BE, Gancheva MR, Wilson DW.   +16 more
europepmc   +1 more source

A review on molecular markers of <i>Plasmodium falciparum</i>. [PDF]

J Parasit Dis
Abebe W, Woldesenbet D.
europepmc   +1 more source

The chemical structure and corresponding molecular graph of chloroquine, respectively [37].

Yeliz Kara (21395459), Yeşim Saǧlam Özkan (21395462), Asad Ullah (4524541), Yasser Salah Hamed (21395465), Melaku Berhe Belay (20036542)   +4 more
openalex   +1 more source

Exploration and Characterization of the Antimalarial Activity of Pyrimidine‐2,4‐Diamines for which Resistance is Mediated by the ABCI3 Transporter

ChemMedChem, Volume 21, Issue 1, January 2026.
Investigation of the structure‐activity relationship on W482 (1) with a pyrimidine‐2,4‐diamine scaffold culminated in analog 51 with enhanced anti‐plasmodial activity. Forward genetics and phenotypic examination revealed the ABCI3 transporter protein as a putative resistance mechanism.
Mahta Mansouri, Madeline G. Dans, Zijun Low, Katie Loi, Kate E. Jarman, Jocelyn S. Penington, Deyun Qiu, Adele M. Lehane, Benigno Crespo, Franciso‐Javier Gamo, Delphine Baud, Stephen Brand, Paul F. Jackson, Alan F. Cowman, Brad E. Sleebs   +14 more
wiley   +1 more source

Protocol for establishing primary murine colonic fibroblast culture with induction of loxP/loxP deletion using transducible TAT-Cre recombinase. [PDF]

STAR Protoc
McAninch C, Hahn A, McAninch S, Pinchuk IV, Chulkina M.   +4 more
europepmc   +1 more source

pH‐Responsive Isoprenoid‐Antitumoral Polymer Conjugates for Superior Drug Loading via Self‐Assembly and Endosomal‐Targeted Anticancer Activity

ChemMedChem, Volume 21, Issue 2, January 2026.
Polymer‐drug conjugate (PDC) entirely composed of active compounds with pH‐responsive properties. The PDC can self‐assemble into nanoparticles for intracellular delivery and endosome‐targeted efficacy. Polymer‐drug conjugates (PDCs) are a promising strategy to enhance the delivery of poorly soluble drugs, particularly in cancer therapy.
Camilla Passi, Tobias Neu, Nicole Schneider‐Daum, Claus‐Michael Lehr, Marc Schneider, Sangeun Lee   +5 more
wiley   +1 more source

APP Induces AICD-Mediated Autophagy-Dependent Axon Degeneration. [PDF]

Aging Cell
Luo J, Qiu Y, Pan Y, Xu R, Sun Y, Sun Y, Zhuang L, Xue E, Li W, Zhou Q, Lv Z, Li C, Xue L.   +12 more
europepmc   +1 more source