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Efficacy, Structure-Activity Relationship, and Mode of Action Studies of a New Generation of Acridine/Acridone-Based Antimalarials. [PDF]

open access: yesACS Infect Dis
Maluf SEC   +23 more
europepmc   +1 more source

Ototoxicity of Chloroquine

Archives of Otolaryngology - Head and Neck Surgery, 1968
CHLOROQUINE PHOSPHATE is a valuable drug used in the control of malaria and the treatment of amebiasis. The drug was developed in the United States during World War II for use as an antimalarial agent because of the shortage of quinine; the drug had been synthesized and studied as early as 1934 in Germany.
G J, Matz, R F, Naunton
openaire   +2 more sources

Chloroquine in Amebiasis

The American Journal of Tropical Medicine, 1948
Introduction. In the treatment of intestinal amebiasis two classes of drugs, viz., iodohydroxyquinolines and arsenicals, are generally satisfactory from the standpoint of curative action and lack of toxicity. These agents are, however, essentially ineffective against extra-intestinal amebiasis, the commonest lesion of which is found in the liver as ...
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The specificity of chloroquine

Parasitology Today, 1992
(Vol. 2) (Soulsby, E.J.L., ed.), pp 115-163, CRC Press I 5 Rosas, N., Sotelo, J. and Nieto, D. (1986) Arch. Neural 43, 353-356 16 Ito, A. et al. ( 1991 ) Mol. Biochern. Parasitol. 44, 43-52 17 Harrison, L.J.S., Delgado, J. and Parkhouse, R.M.E. (1990) Parasitology 100, 459-461 t 8 Zarlenga, D.S. et af. ( 1991 )Exp. Parasitol.
D J, Krogstad   +2 more
openaire   +2 more sources

Quinine and Chloroquine

Medicine, 2003
Abstract Quinine and chloroquine are the most common antimalarial drugs encountered in acute poisoning. Their severe toxicity in overdose results from cardiotoxicity secondary to membrane-stabilizing effects.
openaire   +1 more source

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