Results 51 to 60 of about 107,140 (318)

Recent Applications of Mesoporous Silica Nanoparticles in Gene Therapy

Advanced Healthcare Materials, EarlyView.
The review summarizes the synthesis of mesoporous silica nanoparticles (MSNs) with modifiable surface properties, functionalization strategies, mechanism of therapeutic payload release, and current applications in gene therapy, focusing on their capabilities in the targeted delivery of therapeutic nucleic acids, CRISPR‐Cas systems, and other genetic ...
Tamanna Binte Huq, Punnya Anil Kumar Jeeja, Sudip Kumar Dam, Sabya Sachi Das, Juan L. Vivero‐Escoto   +4 more
wiley   +1 more source

Nanocarrier‐Based Targeting of Pattern Recognition Receptors as an Innovative Strategy for Enhancing Sepsis Therapy

Advanced Healthcare Materials, EarlyView.
This review highlights recent progress in nanocarriers targeting pattern recognition receptors (PRRs), including Toll‐like and NOD‐like receptors, for enhancing the treatment of bacterial sepsis and related complications. These nanomedicines deliver antibiotics and anti‐inflammatory agents while modulating immune responses.
Eman A. Ismail, Vincent O. Nyandoro, Calvin A. Omolo, Thirumala Govender   +3 more
wiley   +1 more source

Variation of the Chloroquine Resistance Transporter (Crt) Gene in Chloroquine-Resistant and Chloroquine-Sensitive Plasmodium berghei [PDF]

Iranian Journal of Parasitology, 2008
Background: The emergence and spread of chloroquine resistant Plasmodium falciparum in the world stimulated some investigators to consider different aspects of chloroquine resistance in human and rodent Plasmodia.
N Ghobakhloo, M Nateghpour, S Rezaee, H Hajjaran, M Mohebali, H Abedkhojasteh   +5 more
doaj   +1 more source

Chloroquine modulates antitumor immune response by resetting tumor-associated macrophages toward M1 phenotype

Nature Communications, 2018
Resetting tumor-associated macrophages (TAMs) is a promising strategy to ameliorate the immunosuppressive tumor microenvironment and improve innate and adaptive antitumor immunity.
Degao Chen, Jing Xie, R. Fiskesund, Wenqian Dong, Xiaoyu Liang, Jiadi Lv, Xun Jin, Jinyan Liu, Siqi Mo, Tianzhen Zhang, Feiran Cheng, Yabo Zhou, Huafeng Zhang, K. Tang, Jingwei Ma, Yuying Liu, Bo Huang   +16 more
semanticscholar   +1 more source

Photonic Nanomaterials for Wearable Health Solutions

Advanced Materials, EarlyView.
This review discusses the fundamentals and applications of photonic nanomaterials in wearable health technologies. It covers light‐matter interactions, synthesis, and functionalization strategies, device assembly, and sensing capabilities. Applications include skin patches and contact lenses for diagnostics and therapy. Future perspectives emphasize AI‐
Taewoong Park, Jung Woo Leem, Young L. Kim, Chi Hwan Lee   +3 more
wiley   +1 more source

Evaluation of the effect of probiotic as add-on therapy with conventional therapy and alone in malaria induced mice

BMC Research Notes, 2021
Objective Chloroquine is used as a conventional drug therapy for the treatment of malaria. The existence of resistance to chloroquine shown among various species of Plasmodium leads to the search for more efficacious therapy to treat malaria.
Eshani Mahajan, Shweta Sinha, Alka Bhatia, Rakesh Sehgal, Bikash Medhi   +4 more
doaj   +1 more source

Chloroquine-induced QTc prolongation in COVID-19 patients

Netherlands Heart Journal, 2020
Background In the battle against the SARS-CoV‑2 pandemic, chloroquine has emerged as a new potential therapeutic option for the treatment of infected patients.
M. P. H. van den Broek, J. Möhlmann, B. Abeln, M. Liebregts, V. F. van Dijk, E. M. W. van de Garde   +5 more
semanticscholar   +1 more source

Self‐Powered α Radionuclide Nanomedicine: Mitochondria‐Targeted Multimodal Energy Recycling for Amplified Radioimmunotherapy

Advanced Materials, EarlyView.
A multifunctional nanomedicine co‐loading of the α‐emitter 223RaCl2 within iron‐based MOFs is developed. Precisely targeted to mitochondria, it exploits the full decay spectrum to synchronize three therapeutic actions: direct α‐particle ionization, self‐powered catalytic H2O2 generation via secondary electrons, and immunogenic cell death induction ...
Xian Li, Chaochao Wang, Yelin Wu, Jiajia Zhang, Han Zhang, Shanshan Qin, Linglin Tang, Fei Yu   +7 more
wiley   +1 more source

Chloroquine combined with concurrent radiotherapy and temozolomide for newly diagnosed glioblastoma: a phase IB trial

Autophagy, 2020
Treatment of glioblastoma xenografts with chloroquine results in macroautophagy/autophagy inhibition, resulting in a reduction of tumor hypoxia and sensitization to radiation.
I. Compter, D. Eekers, A. Hoeben, Kasper M A Rouschop, B. Reymen, L. Ackermans, J. Beckervordersantforth, N. Bauer, M. Anten, P. Wesseling, A. Postma, D. de Ruysscher, P. Lambin   +12 more
semanticscholar   +1 more source

Tryptophan Metabolite Indole‐3‐Aldehyde Induces AhR and c‐MYC Degradation to Promote Tumor Immunogenicity

Advanced Science, EarlyView.
Tryptophan metabolite Indole‐3‐aldehyde (I3A) downregulates cytosolic AhR and p‐ERK/c‐MYC proteins, together enhancing STAT3 phosphorylation and tumor immunogenicity. Overexpression of the Trp metabolic enzyme interleukin‐4‐induced gene‐1 (IL4I1) in tumor cells increases intracellular levels of I3A and enhances tumor immunogenicity.
Lei Cui, Zining Wang, Zixuan Guo, Hongxia Zhang, Yongxiang Liu, Huanling Zhang, Huan Jin, Feifei Xu, Xiaojuan Wang, Chunyuan Xie, Hui Guo, Tiantian Wang, Yanxun Lin, Qi Zhao, Penghui Zhou, Jing Tan, Jin‐Xin Bei, Peng Huang, Jinyun Liu, Xiaojun Xia   +19 more
wiley   +1 more source