Results 31 to 40 of about 108,092 (308)

Lack of significant recovery of chloroquine sensitivity in Plasmodium falciparum parasites following discontinuance of chloroquine use in Papua New Guinea

Malaria Journal, 2018
Background Chloroquine treatment for Plasmodium falciparum has been discontinued in almost all endemic regions due to the spread of resistant isolates. Reversal of chloroquine susceptibility after chloroquine discontinuation has been reported in dozens ...
Makoto Sekihara, Shin-Ichiro Tachibana, Masato Yamauchi, Shoki Yatsushiro, Steven Tiwara, Naoyuki Fukuda, Mie Ikeda, Toshiyuki Mori, Makoto Hirai, Francis Hombhanje, Toshihiro Mita   +10 more
doaj   +1 more source

Chloroquine resistant Plasmodium vivax: in vitro characterisation and association with molecular polymorphisms. [PDF]

PLoS ONE, 2007
Treatment failure of chloroquine for P. vivax infections has reached high levels in the eastern provinces of Indonesia, however, in vitro characterization of chloroquine resistance and its associated molecular profile have yet to be determined.Using a ...
Rossarin Suwanarusk, Bruce Russell, Marina Chavchich, Ferryanto Chalfein, Enny Kenangalem, Varakorn Kosaisavee, Budi Prasetyorini, Kim A Piera, Marion Barends, Alan Brockman, Usa Lek-Uthai, Nicholas M Anstey, Emiliana Tjitra, François Nosten, Qin Cheng, Ric N Price   +15 more
doaj   +1 more source

Progressive increase in point mutations associates chloroquine resistance: Even after withdrawal of chloroquine use in India

International Journal for Parasitology: Drugs and Drug Resistance, 2017
Chloroquine (CQ) is highly effective against P. vivax, due to the rapid spread of CQ resistance in P. falciparum parasites; it is no longer the drug of choice against P. falciparum. This study elucidates the scenario of chloroquine efficacy at times that
Sabyasachi Das, Satyajit Tripathy, Sourav Chattopadhayay, Balaram Das, Santanu Kar Mahapatra, Amiya Kumar Hati, Somenath Roy   +6 more
doaj   +1 more source

Assessment of the activities of Chasmanthera dependens Hochst. combined with other plants on chloroquine-sensitive and chloroquine-resistant Plasmodium berghei

Scientific African, 2022
The prevalence of Plasmodium strains resistant to conventional monotherapy drugs has necessitated the need for more effective and affordable antimalarial agents.
Awodayo O. Adepiti, Tamarau-Tenna Reuben, Inioluwa D. Odeyinka, Kemi F. Akinwunmi   +3 more
doaj   +1 more source

jwatowatson/Chloroquine-concentration-fatality: published version

, 2020
Pooled analysis of mortality and QRS widening in chloroquine self-poisoning patients and healthy volunteers: estimating safety of currently trialled chloroquine ...
James Watson
core   +1 more source

Carriage of chloroquine-resistant parasites and delay of effective treatment increase the risk of severe malaria in Gambian children. [PDF]

, 2005
Two hundred thirty-four Gambian children with severe falciparum malaria who were admitted to the pediatric ward of a rural district hospital each were matched for age with a same-sex control subject presenting as an outpatient with uncomplicated ...
Bousema, T., Ord, Rosalynn, van Niekerk, Maarten, Walraven, Gijs, Osman, E., Bousema, J Teun, Meerman, Larissa, Osman, Emilia, Niekerk, M. van, Sutherland, Colin J, Hallett, Rachel, Meerman, L., Pinder, M., Walraven, G.E., Sutherland, C.J., Pinder, Margaret, Ord, R., Hallett, R.   +17 more
core   +1 more source

Effect of chloroquine on Candida albicans biofilms and its drug resistance [PDF]

Kouqiang yixue
Objective To evaluate the effects of chloroquine alone and in combination with traditional antifungal agents on the Candida albicans biofilms and its drug resistance.
WU Qiaochu, SHI Banruo, MIAO Haochen, WEI Xin
doaj   +1 more source

The mechanism of chloroquine/hydroxychloroquine and its application in stomatological diseases

口腔疾病防治, 2021
Chloroquine and hydroxychloroquine are both classic 4-aminoquinoline antimalarial drugs with similar chemical structures and mechanisms of action.
LIN Lin, WU Kaihui, WANG Wenmei
doaj   +1 more source

Chloroquine Enhances the Radiosensitivity of Bladder Cancer Cells by Inhibiting Autophagy and Activating Apoptosis

Cellular Physiology and Biochemistry, 2017
Background/Aims: Chloroquine was formerly used as an anti-malarial agent drug but has now been proven to be useful for various diseases. This study aimed to investigate the radiosensitizing effect of chloroquine in bladder cancer, with an emphasis on ...
Feng Wang, Jinyuan Tang, Pengchao Li, Shuhui Si, Hao Yu, Xiao Yang, Jun Tao, Qiang Lv, Min Gu, Haiwei Yang, Zengjun Wang   +10 more
doaj   +1 more source

Immunoglobulin G antibodies to merozoite surface antigens are associated with recovery from chloroquine-resistant Plasmodium falciparum in Gambian children. [PDF]

, 2006
We examined the hypothesis that recovery from uncomplicated malaria in patients carrying drug-resistant Plasmodium falciparum is a measure of acquired functional immunity and may therefore be associated with humoral responses to candidate vaccine ...
Jamila Ismaili, Holder, Anthony A, Ord, Rosalyn, Sutherland, Colin J, Hallett, Rachel, Rachel Hallett, McCall, Matthew BB, Ismaili, Jamila, Paul Milligan, Pinder, M., Colin J. Sutherland, Ismaili, J., Milligan, Paul, Milligan, P., Matthew B. B. McCall, McCall, M.B.B., Sisay-Joof, F., Holder, A.A., Anthony A. Holder, Rosalyn Ord, Margaret Pinder, Sutherland, C.J., Fatoumatta Sisay-Joof, Pinder, Margaret, Ord, R., Hallett, R., Sisay-Joof, Fatoumatta   +26 more
core   +2 more sources