Leveraging the effects of chloroquine on resistant malaria parasites for combination therapies
BMC Bioinformatics, 2019 Background Malaria is a major global health problem, with the Plasmodium falciparum protozoan parasite causing the most severe form of the disease. Prevalence of drug-resistant P. falciparum highlights the need to understand the biology of resistance and
Ana M. Untaroiu +3 more
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Micro, 2023 Liposomes encapsulating chloroquine were synthesized and characterized. Cryogenic transmission electron microscopy and dynamic light scattering confirmed a liposome size of ~100 nm and uniform shape.
Nathan D. Donahue +4 more
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Community chloroquine distribution for malaria control in Bushenyi district of Uganda. [PDF]
, 2003 OBJECTIVE: To document successful community chloroquine distribution for malaria control in Bushenyi district, southwestern Uganda. DESIGN: A cross sectional survey immediately after a four-month community chloroquine distribution exercise.
Nuwaha, F, Okware, J, Timbyetaho, HN
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Lack of Evidence for Chloroquine-Resistant Plasmodium falciparum Malaria, Leogane, Haiti
Emerging Infectious Diseases, 2012 Plasmodium falciparum malaria in Haiti is considered chloroquine susceptible, although resistance transporter alleles associated with chloroquine resistance were recently detected.
Ami Neuberger +3 more
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The Trypanosoma cruzi enzyme TcGPXI is a glycosomal peroxidase and can be linked to trypanothione reduction by glutathione or tryparedoxin. [PDF]
, 2002 Trypanosoma cruzi glutathione-dependent peroxidase I (TcGPXI) can reduce fatty acid, phospholipid, and short chain organic hydroperoxides utilizing a novel redox cycle in which enzyme activity is linked to the reduction of trypanothione, a parasite ...
Docampo +56 more
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Chloroquine increases phosphorylation of AMPK and Akt in myotubes
Heliyon, 2016 Aims: There are reports that ataxia telangiectasia mutated (ATM) can activate the AMP-activated protein kinase (AMPK) and also Akt, two kinases that play integral parts in cardioprotection and metabolic function.
Larry D. Spears +8 more
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Studies on the treatment of malignant tumors with fibroblast-inhibiting agent III. Effects of chloroquine on human cancers [PDF]
, 1964 A fibroblast-inhibiting agent, chloroquine, used in the treatment of animal tumors led to a reasonably good result, and this approach was extended to the treatment of human cancers.
Hiraki, Kiyoshi, Kimura, Ikuro
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Malaria Journal, 2008 Background Plasmodium vivax is a major cause of malaria and is still primarily treated with chloroquine. Chloroquine inhibits the polymerization of haem to inert haemozoin. Free haem monomers are thought to catalyze oxidative damage to the Plasmodium spp.
Jaidee Anchalee +10 more
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Journal of Infection and Public Health, 2022 Background: A wide spread of chloroquine resistance prompted its discontinued use for treatment of uncomplicated malaria in several African countries. However, disappearances of chloroquine-resistant parasites have been reported in areas with restricted ...
Belinda J. Njiro +5 more
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Chloroquine plays a cell-dependent role in the response to treatment of pancreatic adenocarcinoma [PDF]
, 2018 In this study, our aim is to assess the role played by autophagy and its inhibition in the different PDAC cellular compartments, and its involvement in chemo-resistance using primary human pancreatic cancer-derived cells (PCC) and Cancer Associated ...
Bintz, Jennifer +6 more
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