Results 11 to 20 of about 85,533 (259)

Near Infrared Fluorophore-Tagged Chloroquine in Plasmodium falciparum Diagnostic Imaging

Molecules, 2018
Chloroquine was among the first of several effective drug treatments against malaria until the onset of chloroquine resistance. In light of diminished clinical efficacy of chloroquine as an antimalarial therapeutic, there is potential in efforts to adapt
Li Yan Chan, Joshua Ding Wei Teo, Kevin Shyong-Wei Tan, Keitaro Sou, Wei Lek Kwan, Chi-Lik Ken Lee   +5 more
doaj   +1 more source

Leveraging the effects of chloroquine on resistant malaria parasites for combination therapies

BMC Bioinformatics, 2019
Background Malaria is a major global health problem, with the Plasmodium falciparum protozoan parasite causing the most severe form of the disease. Prevalence of drug-resistant P. falciparum highlights the need to understand the biology of resistance and
Ana M. Untaroiu, Maureen A. Carey, Jennifer L. Guler, Jason A. Papin   +3 more
doaj   +1 more source

Lack of Evidence for Chloroquine-Resistant Plasmodium falciparum Malaria, Leogane, Haiti

Emerging Infectious Diseases, 2012
Plasmodium falciparum malaria in Haiti is considered chloroquine susceptible, although resistance transporter alleles associated with chloroquine resistance were recently detected.
Ami Neuberger, Kathleen Zhong, Kevin C Kain, Eli Schwartz   +3 more
doaj   +1 more source

Plasmodium vivax trophozoites insensitive to chloroquine

Malaria Journal, 2008
Background Plasmodium vivax is a major cause of malaria and is still primarily treated with chloroquine. Chloroquine inhibits the polymerization of haem to inert haemozoin. Free haem monomers are thought to catalyze oxidative damage to the Plasmodium spp.
Jaidee Anchalee, Travers Thomas, Kosaisavee Varakorn, Edstein Michael D, Lek-Uthai Usa, Suwanarusk Rossarin, Sharrock Wesley W, Sriprawat Kanlaya, Price Ric N, Nosten François, Russell Bruce   +10 more
doaj   +1 more source

Chloroquine increases phosphorylation of AMPK and Akt in myotubes

Heliyon, 2016
Aims: There are reports that ataxia telangiectasia mutated (ATM) can activate the AMP-activated protein kinase (AMPK) and also Akt, two kinases that play integral parts in cardioprotection and metabolic function.
Larry D. Spears, Andrew V. Tran, Charles Y. Qin, Supriya B. Hobbs, Cheryl A. Liang Burns, Nathaniel K. Royer, Zhihong Zhang, Lyle Ralston, Jonathan S. Fisher   +8 more
doaj   +1 more source

Synthesis, Characterization, and Acute Cytotoxicity Evaluation of Chloroquine Encapsulating Liposomes

Micro, 2023
Liposomes encapsulating chloroquine were synthesized and characterized. Cryogenic transmission electron microscopy and dynamic light scattering confirmed a liposome size of ~100 nm and uniform shape.
Nathan D. Donahue, Ellen A. Vance, Vinit Sheth, Emmy R. Francek, Stefan Wilhelm   +4 more
doaj   +1 more source

Recovery and stable persistence of chloroquine sensitivity in Plasmodium falciparum parasites after its discontinued use in Northern Uganda

Malaria Journal, 2020
Background Usage of chloroquine was discontinued from the treatment of Plasmodium falciparum infection in almost all endemic regions because of global spread of resistant parasites.
Betty Balikagala, Miki Sakurai-Yatsushiro, Shin-Ichiro Tachibana, Mie Ikeda, Masato Yamauchi, Osbert T. Katuro, Edward H. Ntege, Makoto Sekihara, Naoyuki Fukuda, Nobuyuki Takahashi, Shouki Yatsushiro, Toshiyuki Mori, Makoto Hirai, Walter Opio, Paul S. Obwoya, Denis A. Anywar, Mary A. Auma, Nirianne M. Q. Palacpac, Takafumi Tsuboi, Emmanuel I. Odongo-Aginya, Eisaku Kimura, Martin Ogwang, Toshihiro Horii, Toshihiro Mita   +23 more
doaj   +1 more source

Characterization of the commercially-available fluorescent chloroquine-BODIPY conjugate, LynxTag-CQGREEN, as a marker for chloroquine resistance and uptake in a 96-well plate assay. [PDF]

PLoS ONE, 2014
Chloroquine was a cheap, extremely effective drug against Plasmodium falciparum until resistance arose. One approach to reversing resistance is the inhibition of chloroquine efflux from its site of action, the parasite digestive vacuole.
Cheryl C Y Loh, Rossarin Suwanarusk, Yan Quan Lee, Kitti W K Chan, Kit-Ying Choy, Laurent Rénia, Bruce Russell, Martin J Lear, François H Nosten, Kevin S W Tan, Larry M C Chow   +10 more
doaj   +1 more source

Molecular surveillance of chloroquine-resistant Plasmodium falciparum in sub-Saharan African countries after withdrawal of chloroquine for treatment of uncomplicated malaria: A systematic review

Journal of Infection and Public Health, 2022
Background: A wide spread of chloroquine resistance prompted its discontinued use for treatment of uncomplicated malaria in several African countries. However, disappearances of chloroquine-resistant parasites have been reported in areas with restricted ...
Belinda J. Njiro, Ritah F. Mutagonda, Amisa T. Chamani, Tosi Mwakyandile, Deodatus Sabas, George M. Bwire   +5 more
doaj   +1 more source

Lack of significant recovery of chloroquine sensitivity in Plasmodium falciparum parasites following discontinuance of chloroquine use in Papua New Guinea

Malaria Journal, 2018
Background Chloroquine treatment for Plasmodium falciparum has been discontinued in almost all endemic regions due to the spread of resistant isolates. Reversal of chloroquine susceptibility after chloroquine discontinuation has been reported in dozens ...
Makoto Sekihara, Shin-Ichiro Tachibana, Masato Yamauchi, Shoki Yatsushiro, Steven Tiwara, Naoyuki Fukuda, Mie Ikeda, Toshiyuki Mori, Makoto Hirai, Francis Hombhanje, Toshihiro Mita   +10 more
doaj   +1 more source