Results 21 to 30 of about 85,827 (258)

Lack of significant recovery of chloroquine sensitivity in Plasmodium falciparum parasites following discontinuance of chloroquine use in Papua New Guinea

Malaria Journal, 2018
Background Chloroquine treatment for Plasmodium falciparum has been discontinued in almost all endemic regions due to the spread of resistant isolates. Reversal of chloroquine susceptibility after chloroquine discontinuation has been reported in dozens ...
Makoto Sekihara, Shin-Ichiro Tachibana, Masato Yamauchi, Shoki Yatsushiro, Steven Tiwara, Naoyuki Fukuda, Mie Ikeda, Toshiyuki Mori, Makoto Hirai, Francis Hombhanje, Toshihiro Mita   +10 more
doaj   +1 more source

Assessment of the activities of Chasmanthera dependens Hochst. combined with other plants on chloroquine-sensitive and chloroquine-resistant Plasmodium berghei

Scientific African, 2022
The prevalence of Plasmodium strains resistant to conventional monotherapy drugs has necessitated the need for more effective and affordable antimalarial agents.
Awodayo O. Adepiti, Tamarau-Tenna Reuben, Inioluwa D. Odeyinka, Kemi F. Akinwunmi   +3 more
doaj   +1 more source

Progressive increase in point mutations associates chloroquine resistance: Even after withdrawal of chloroquine use in India

International Journal for Parasitology: Drugs and Drug Resistance, 2017
Chloroquine (CQ) is highly effective against P. vivax, due to the rapid spread of CQ resistance in P. falciparum parasites; it is no longer the drug of choice against P. falciparum. This study elucidates the scenario of chloroquine efficacy at times that
Sabyasachi Das, Satyajit Tripathy, Sourav Chattopadhayay, Balaram Das, Santanu Kar Mahapatra, Amiya Kumar Hati, Somenath Roy   +6 more
doaj   +1 more source

Effect of chloroquine on Candida albicans biofilms and its drug resistance [PDF]

Kouqiang yixue
Objective To evaluate the effects of chloroquine alone and in combination with traditional antifungal agents on the Candida albicans biofilms and its drug resistance.
WU Qiaochu, SHI Banruo, MIAO Haochen, WEI Xin
doaj   +1 more source

The mechanism of chloroquine/hydroxychloroquine and its application in stomatological diseases

口腔疾病防治, 2021
Chloroquine and hydroxychloroquine are both classic 4-aminoquinoline antimalarial drugs with similar chemical structures and mechanisms of action.
LIN Lin, WU Kaihui, WANG Wenmei
doaj   +1 more source

Chloroquine Enhances the Radiosensitivity of Bladder Cancer Cells by Inhibiting Autophagy and Activating Apoptosis

Cellular Physiology and Biochemistry, 2017
Background/Aims: Chloroquine was formerly used as an anti-malarial agent drug but has now been proven to be useful for various diseases. This study aimed to investigate the radiosensitizing effect of chloroquine in bladder cancer, with an emphasis on ...
Feng Wang, Jinyuan Tang, Pengchao Li, Shuhui Si, Hao Yu, Xiao Yang, Jun Tao, Qiang Lv, Min Gu, Haiwei Yang, Zengjun Wang   +10 more
doaj   +1 more source

Chloroquine reduces arylsulphatase B activity and increases chondroitin-4-sulphate: implications for mechanisms of action and resistance

Malaria Journal, 2009
Background The receptors for adhesion of Plasmodium falciparum-infected red blood cells (RBC) in the placenta have been identified as chondroitin-4-sulphate (C4S) proteoglycans, and the more sulphate-rich chondroitin oligosaccharides have been reported ...
Linhardt Robert J, Zhang Zhenqing, Solakyildirim Kemal, Bhattacharyya Sumit, Tobacman Joanne K   +4 more
doaj   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

No difference in biomarkers of ischemic heart injury and heart failure in patients with COVID-19 who received treatment with chloroquine phosphate and those who did not.

PLoS ONE, 2021
BackgroundChloroquine was promoted as a COVID-19 therapeutic early in the pandemic. Most countries have since discontinued the use of chloroquine due to lack of evidence of any benefit and the risk of severe adverse events.
Josefine Beck-Friis, Susannah Leach, Elmir Omerovic, Rickard Zeijlon, Magnus Gisslen, Aylin Yilmaz   +5 more
doaj   +1 more source

Hypertension related toxicity of chloroquine explains its failure against COVID-19: Based on rat model

Frontiers in Pharmacology, 2022
Chloroquine was once thought to be a promising treatment for COVID-19 but it quickly failed due to its inefficiency and association with increased mortality. Further, comorbidities such as hypertension may have contributed this failure.
Junqi Wang, Junqi Wang, Xian Jing, Xian Jing, Lizhong Hua, Yuling Zheng, Yuling Zheng, Shiheng Hu, Shiheng Hu, Jing Xiao, Jing Xiao, Dawei Guo, Dawei Guo, Wenda Wu, Wenda Wu, Hui Ji, Hui Ji, Lin Peng, Lin Peng, Shanxiang Jiang, Shanxiang Jiang, Xiuge Gao, Xiuge Gao   +22 more
doaj   +1 more source