Malaria Journal, 2020 Background Usage of chloroquine was discontinued from the treatment of Plasmodium falciparum infection in almost all endemic regions because of global spread of resistant parasites.
Betty Balikagala +23 more
doaj +1 more source
Characterization of the commercially-available fluorescent chloroquine-BODIPY conjugate, LynxTag-CQGREEN, as a marker for chloroquine resistance and uptake in a 96-well plate assay. [PDF]
PLoS ONE, 2014 Chloroquine was a cheap, extremely effective drug against Plasmodium falciparum until resistance arose. One approach to reversing resistance is the inhibition of chloroquine efflux from its site of action, the parasite digestive vacuole.
Cheryl C Y Loh +10 more
doaj +1 more source
Absent in vitro interaction between chloroquine and antifungals against Aspergillus fumigatus [PDF]
, 2017 This work was supported by Medical Mycology Section, Department of Medical Microbiology, Radboud University Medical Centre, Nijmegen, the Netherlands.
Seyedmousavi, Seyedmojtaba +3 more
core +1 more source
In vivo assessment of drug efficacy against Plasmodium falciparum malaria: duration of follow-up. [PDF]
, 2004 To determine the optimum duration of follow-up for the assessment of drug efficacy against Plasmodium falciparum malaria, 96 trial arms from randomized controlled trials (RCTs) with follow-up of 28 days or longer that were conducted between 1990 and 2003
Stepniewska, K +16 more
core +2 more sources
Chloroquine resistant Plasmodium vivax: in vitro characterisation and association with molecular polymorphisms. [PDF]
PLoS ONE, 2007 Treatment failure of chloroquine for P. vivax infections has reached high levels in the eastern provinces of Indonesia, however, in vitro characterization of chloroquine resistance and its associated molecular profile have yet to be determined.Using a ...
Rossarin Suwanarusk +15 more
doaj +1 more source
Adherence to the combination of sulphadoxine-pyrimethamine and artesunate in the Maheba refugee settlement, Zambia. [PDF]
, 2004 Artemisinin-based combination therapy (ACT) is one strategy recommended to increase cure rates in malaria and to contain resistance to Plasmodium falciparum. In the Maheba refugee settlement, children aged 5 years or younger with a confirmed diagnosis of
Balkan, S +6 more
core +2 more sources
Scientific African, 2022 The prevalence of Plasmodium strains resistant to conventional monotherapy drugs has necessitated the need for more effective and affordable antimalarial agents.
Awodayo O. Adepiti +3 more
doaj +1 more source
A strategy to combine pathway-targeted low toxicity drugs in ovarian cancer. [PDF]
, 2015 Serous Ovarian Cancers (SOC) are frequently resistant to programmed cell death. However, here we describe that these programmed death-resistant cells are nonetheless sensitive to agents that modulate autophagy.
Bartakova, Alena +10 more
core +2 more sources
The mechanism of chloroquine/hydroxychloroquine and its application in stomatological diseases
口腔疾病防治, 2021 Chloroquine and hydroxychloroquine are both classic 4-aminoquinoline antimalarial drugs with similar chemical structures and mechanisms of action.
LIN Lin, WU Kaihui, WANG Wenmei
doaj +1 more source
Autophagy processes are dependent on EGF receptor signaling [PDF]
, 2018 Autophagy is a not well-understood conserved mechanism activated during nutritional deprivation in order to maintain cellular homeostasis. In the present study, we investigated the correlations between autophagy, apoptosis and the MAPK pathways in ...
Capodifoglio, Sabrina +12 more
core +1 more source