Results 21 to 30 of about 108,092 (308)

Clinical and parasitological response to oral chloroquine and primaquine in uncomplicated human Plasmodium knowlesi infections. [PDF]

, 2010
BACKGROUND: Plasmodium knowlesi is a cause of symptomatic and potentially fatal infections in humans. There are no studies assessing the detailed parasitological response to treatment of knowlesi malaria infections in man and whether antimalarial ...
Cox-Singh, J, Siti Khatijah, Binti Zakaria, Daneshvar, C., Zakaria Siti K, Paul CS Divis, Daneshvar, C, Singh Balbir, Balbir, Singh, Divis Paul CS, Rafa'ee, Mohammad Z., Singh, Balbir, Janet Cox-Singh, Daneshvar, Cyrus, Mohammad Zakri, Rafa’ee, Rafa'ee Mohammad Z, Divis, Paul C. S., Singh, B, Balbir Singh, Daneshvar Cyrus, Cox-Singh Janet, Timothy ME Davis, Siti K Zakaria, Zakaria, SK, Davis, T.M.E, Cyrus CyrusDaneshvar, Paul C, Divis, Cox Singh, Janet, Davis, TM, Davis, Timothy M. E., Rafa'ee, MZ, Davis Timothy ME, Mohammad Z Rafa'ee, Cox-Singh, J., Cyrus Daneshvar, Zakaria, Siti K., Divis, PC   +35 more
core   +1 more source

Chloroquine increases phosphorylation of AMPK and Akt in myotubes

Heliyon, 2016
Aims: There are reports that ataxia telangiectasia mutated (ATM) can activate the AMP-activated protein kinase (AMPK) and also Akt, two kinases that play integral parts in cardioprotection and metabolic function.
Larry D. Spears, Andrew V. Tran, Charles Y. Qin, Supriya B. Hobbs, Cheryl A. Liang Burns, Nathaniel K. Royer, Zhihong Zhang, Lyle Ralston, Jonathan S. Fisher   +8 more
doaj   +1 more source

Community effectiveness of chloroquine and traditional remedies in the treatment of young children with falciparum malaria in rural Burkina Faso [PDF]

, 2004
Mueller O, Razum O, Traore C, Kouyate B. Community effectiveness of chloroquine and traditional remedies in the treatment of young children with falciparum malaria in rural Burkina Faso. Malaria Journal.
Kouyate Bocar, Traore, Corneille, Razum, Oliver, Mueller, Olaf, Bocar Kouyate, Kouyate, Bocar, Mueller Olaf, Razum Oliver, Oliver Razum, Corneille Traore, Traore Corneille, Olaf Mueller   +11 more
core   +1 more source

Azithromycin-chloroquine and the intermittent preventive treatment of malaria in pregnancy. [PDF]

, 2008
In the high malaria-transmission settings of sub-Saharan Africa, malaria in pregnancy is an important cause of maternal, perinatal and neonatal morbidity.
Chandramohan, Daniel, Chico, R Matthew, Pittrof, Rudiger, Pittrof Rudiger, Daniel Chandramohan, Chico R Matthew, Greenwood Brian, Rudiger Pittrof, Greenwood, Brian, Brian Greenwood, Chandramohan Daniel, R Matthew Chico   +11 more
core   +1 more source

Plasmodium vivax trophozoites insensitive to chloroquine

Malaria Journal, 2008
Background Plasmodium vivax is a major cause of malaria and is still primarily treated with chloroquine. Chloroquine inhibits the polymerization of haem to inert haemozoin. Free haem monomers are thought to catalyze oxidative damage to the Plasmodium spp.
Jaidee Anchalee, Travers Thomas, Kosaisavee Varakorn, Edstein Michael D, Lek-Uthai Usa, Suwanarusk Rossarin, Sharrock Wesley W, Sriprawat Kanlaya, Price Ric N, Nosten François, Russell Bruce   +10 more
doaj   +1 more source

Recovery and stable persistence of chloroquine sensitivity in Plasmodium falciparum parasites after its discontinued use in Northern Uganda

Malaria Journal, 2020
Background Usage of chloroquine was discontinued from the treatment of Plasmodium falciparum infection in almost all endemic regions because of global spread of resistant parasites.
Betty Balikagala, Miki Sakurai-Yatsushiro, Shin-Ichiro Tachibana, Mie Ikeda, Masato Yamauchi, Osbert T. Katuro, Edward H. Ntege, Makoto Sekihara, Naoyuki Fukuda, Nobuyuki Takahashi, Shouki Yatsushiro, Toshiyuki Mori, Makoto Hirai, Walter Opio, Paul S. Obwoya, Denis A. Anywar, Mary A. Auma, Nirianne M. Q. Palacpac, Takafumi Tsuboi, Emmanuel I. Odongo-Aginya, Eisaku Kimura, Martin Ogwang, Toshihiro Horii, Toshihiro Mita   +23 more
doaj   +1 more source

Assessment of the molecular marker of Plasmodium falciparum chloroquine resistance (Pfcrt) in Senegal after several years of chloroquine withdrawal. [PDF]

, 2012
As a result of widespread antimalarial drug resistance, all African countries with endemic malaria have, in recent years, changed their malaria treatment policy.
Dieng, Yemou, Annie Abiola, Aminata Lo, Ndiaye, Daouda, Daouda Ndiaye, Yemou Dieng, Roger Tine, Faye, Babacar, Babacar Faye, Ndiaye, Magatte, Jean Louis Ndiaye, Lo, Aminata, Hallett, Rachel, Ndiaye, Jean Louis, Gaye, Oumar, Magatte Ndiaye, Rachel Hallett, Oumar Gaye, Michael Alifrangis, Tine, Roger, Alifrangis, Michael, Abiola, Annie   +21 more
core   +1 more source

Molecular surveillance of chloroquine-resistant Plasmodium falciparum in sub-Saharan African countries after withdrawal of chloroquine for treatment of uncomplicated malaria: A systematic review

Journal of Infection and Public Health, 2022
Background: A wide spread of chloroquine resistance prompted its discontinued use for treatment of uncomplicated malaria in several African countries. However, disappearances of chloroquine-resistant parasites have been reported in areas with restricted ...
Belinda J. Njiro, Ritah F. Mutagonda, Amisa T. Chamani, Tosi Mwakyandile, Deodatus Sabas, George M. Bwire   +5 more
doaj   +1 more source

Characterization of the commercially-available fluorescent chloroquine-BODIPY conjugate, LynxTag-CQGREEN, as a marker for chloroquine resistance and uptake in a 96-well plate assay. [PDF]

PLoS ONE, 2014
Chloroquine was a cheap, extremely effective drug against Plasmodium falciparum until resistance arose. One approach to reversing resistance is the inhibition of chloroquine efflux from its site of action, the parasite digestive vacuole.
Cheryl C Y Loh, Rossarin Suwanarusk, Yan Quan Lee, Kitti W K Chan, Kit-Ying Choy, Laurent Rénia, Bruce Russell, Martin J Lear, François H Nosten, Kevin S W Tan, Larry M C Chow   +10 more
doaj   +1 more source

Studies on the treatment of malignant tumors with fibroblast-inhibiting agent III. Effects of chloroquine on human cancers [PDF]

, 1964
A fibroblast-inhibiting agent, chloroquine, used in the treatment of animal tumors led to a reasonably good result, and this approach was extended to the treatment of human cancers.
Kimura, Ikuro, Hiraki, Kiyoshi
core   +1 more source