Results 51 to 60 of about 85,533 (259)
Advanced Science, EarlyView.This research identifies DTX3L as a critical tumor suppressor that inhibits epithelial‐mesenchymal transition (EMT), invasion and metastasis in gastric cancer. By functioning as an E3 ubiquitin ligase, DTX3L targets the master EMT regulator SNAI1 for GSK‐3β‐dependent proteasomal degradation.
Yang Chen +7 more
wiley +1 more source
Secreted Nonstructural Protein 3 is a Pathogenic Determinant of Orbivirus
Advanced Science, EarlyView.This study uncovers a conserved PIP2‐dependent secretory pathway of orbivirus NS3 that induces vascular leakage. Pharmacological disruption of PIP2‐NS3 interaction significantly reduces viral pathogenicity and provides protective efficacy in murine models, establishing PIP2‐mediated NS3 secretion as both a key virulence determinant and a promising ...
Junyong Guan +11 more
wiley +1 more source
Advanced Science, EarlyView.Schematic representation of the role of lipophagy in bone mesenchymal stem cells(MSCs). In healthy MSCs, functional lipophagy efficiently degrades lipid droplets to support oxidative phosphorylation and cellular energy production, thereby facilitating osteogenic differentiation and matrix mineralization.
Chaoqiang Chen +8 more
wiley +1 more source
Iranian Journal of Public Health, 2018 Background: We evaluated the anti-malarial activity of Heracleum persicum individually and in combination with chloroquine. Methods: This study was conducted at the School of Public Health, Tehran University of Medical Sciences, Tehran, Iran in 2015 ...
Nahideh MAZHARI +5 more
doaj
Chloroquine inhibits Ca2+ permeable ion channels-mediated Ca2+ signaling in primary B lymphocytes
Cell & Bioscience, 2017 Background Chloroquine, a bitter tastant, inhibits Ca2+ signaling, resulting in suppression of B cell activation; however, the inhibitory mechanism remains unclear.
Yi-Fan Wu +12 more
doaj +1 more source
CHLOROQUINE RESISTANCE IN MALARIA: A DEFICIENCY OF CHLOROQUINE BINDING [PDF]
Proceedings of the National Academy of Sciences, 1969 Chloroquine- 14 C was used to study the processes which concentrate chloroquine in mouse red blood cells infected with chloroquine-sensitive or with chloroquine-resistant Plasmodium berghei .
openaire +2 more sources
Advanced Science, EarlyView.In AKI, initial kidney injury upregulates the expression of Cav‐1, which subsequently binds to and stabilizes SERCA2 via its scaffolding domain and through deubiquitination, thereby regulating Ca2+ homeostasis and ER stress. Conversely, Cav‐1 deficiency accelerates SERCA2 degradation, triggering Ca2+ overload and ER stress, and ultimately exacerbating ...
Yan Zhang +19 more
wiley +1 more source
Parasite, 2005 Culturing fresh clinical isolates of P. falciparum and using the isotopic method, we tested separately chloroquine and isradipine – a calcium channel blocker –, and also the combination isradipine plus chloroquine.
Randrianarivelojosia M., Jambou R.
doaj +1 more source
Use of pre-packaged chloroquine for the home management of presumed malaria in Malagasy children
Malaria Journal, 2006 Objective The main objective of this study was to assess the quality of home malaria management with pre-packaged chloroquine in two areas in the Moramanga district of Madagascar.
Malvy Denis +7 more
doaj +1 more source
Synthesis, Characterization, and Anti-Plasmodium falciparum Activity of a New Copper(II) Complex Containing 2-(Tert-Butoxy)-6-(1H-imidazol-1-yl)pyridine. [PDF]
ChemMedChemThe graphical abstract illustrates the formation of a Cu(II) complex from azole‐based ligand, highlighting metal–ligand synergy. The resulting coordination compound acts as a bioactive entity against Plasmodium, where metal coordination enhances antiparasitic activity, outperforming the free ligand and demonstrating its potential as an antimalarial ...
Patiño-Cubides A +6 more
europepmc +2 more sources